公开(公告)号：US20070077657A1

公开(公告)日：2007-04-05

申请号：US11389621

申请日：2006-03-24

申请人： Eric Carlson ,  Peijun Cong ,  William Chandler ,  Henry Chau ,  Earl Danielson ,  Peter Desrosiers ,  Robert Doolen ,  Luping Wu ,  C. Ramberg ,  Thomas Crevier ,  Ralph Nielsen ,  Colin Masui ,  John Varni

发明人： Eric Carlson ,  Peijun Cong ,  William Chandler ,  Henry Chau ,  Earl Danielson ,  Peter Desrosiers ,  Robert Doolen ,  Luping Wu ,  C. Ramberg ,  Thomas Crevier ,  Ralph Nielsen ,  Colin Masui ,  John Varni

IPC分类号： G01N31/00

CPC分类号： B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G16C20/20 ,  G16C20/90 ,  Y10T117/10

摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.

摘要翻译： 本发明提供了用于进行候选药物的盐和多晶型物的高通量制备和筛选的方法，装置和系统。 本发明旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定基本上发现可从特定药物候选物形成的每个多晶型物的合适的盐和方法的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为基于例如由计算机系统生成的库模型来合成多个库成员。 另一种装置可以过滤合成的溶液以提供可以进行盐或多晶型测试的基本上纯的混合物。 可以使用另一种装置将混合物在基底上结晶，使得结晶的混合物可以被一个或多个筛选装置筛选。

公开(公告)号：US20050211622A1

公开(公告)日：2005-09-29

申请号：US11131277

申请日：2005-05-16

申请人： Eric Carlson ,  Peijun Cong ,  William Chandler ,  Peter Desrosiers ,  J. Freitag ,  John Varni

发明人： Eric Carlson ,  Peijun Cong ,  William Chandler ,  Peter Desrosiers ,  J. Freitag ,  John Varni

IPC分类号： G01N21/64 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L7/00 ,  C07B61/00 ,  C07D209/20 ,  C07D293/00 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  G01N5/04 ,  G01N13/00 ,  G01N21/23 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/47 ,  G01N21/65 ,  G01N21/78 ,  G01N24/08 ,  G01N25/04 ,  G01N30/88 ,  G01N33/15 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N35/02 ,  G01N37/00 ,  B01D29/88

CPC分类号： B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.

公开(公告)号：US20060218996A1

公开(公告)日：2006-10-05

申请号：US11433265

申请日：2006-05-12

申请人： Leonid Matsiev ,  James Bennett ,  Daniel Pinkas ,  Mikhail Spitkovsky ,  Oleg Kolosov ,  Shenheng Guan ,  Mark Uhrich ,  G. Dales ,  John Varni ,  Blake Walker ,  Vladimir Gammer ,  Dave Padowitz ,  Eric Low

发明人： Leonid Matsiev ,  James Bennett ,  Daniel Pinkas ,  Mikhail Spitkovsky ,  Oleg Kolosov ,  Shenheng Guan ,  Mark Uhrich ,  G. Dales ,  John Varni ,  Blake Walker ,  Vladimir Gammer ,  Dave Padowitz ,  Eric Low

IPC分类号： G01N29/00

CPC分类号： F02D41/021 ,  F02D2200/0611 ,  F02D2250/11 ,  G01F23/2966 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/30 ,  G01N29/348 ,  G01N2291/014 ,  G01N2291/0226 ,  G01N2291/02416 ,  G01N2291/02818 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

摘要： A sensor for sensing one or more properties of a vehicle fluid has a tuning fork resonator adapted to contact the fluid. The tuning fork resonator comprises two tines and is operable to oscillate so that the two tines move in opposite phase at a frequency of less than 1 MHz while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. In another aspect, a sensor includes a substrate and a flexural resonator on the substrate and adapted to contact the fluid. Circuitry for operation of the resonator is on the substrate. The resonator is adapted to receive an input signal and to oscillate while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. One suitable application for the invention is monitoring the condition of a vehicle engine oil.

摘要翻译： 用于感测车辆流体的一个或多个特性的传感器具有适于接触流体的音叉谐振器。 音叉谐振器包括两个齿并且可操作以振荡，使得两个尖齿以小于1MHz的频率以相反相位移动，同时接触流体以产生指示流体的一个或多个特性的谐振器响应。 在另一方面，传感器包括衬底和在衬底上的弯曲谐振器并且适于接触流体。 用于谐振器操作的电路在基板上。 谐振器适于接收输入信号并且在接触流体时振荡以产生指示流体的一个或多个特性的谐振器响应。 本发明的一个合适的应用是监测车辆发动机油的状态。

公开(公告)号：US20050145019A1

公开(公告)日：2005-07-07

申请号：US10951252

申请日：2004-09-27

申请人： Leonid Matsiev ,  Oleg Kolosov ,  Mark Uhrich ,  William Rust ,  John Feland ,  John Varni ,  Blake Walker

发明人： Leonid Matsiev ,  Oleg Kolosov ,  Mark Uhrich ,  William Rust ,  John Feland ,  John Varni ,  Blake Walker

IPC分类号： F25B49/00 ,  G01N3/56 ,  G01N9/00 ,  G01N11/00 ,  G01N11/10 ,  G01N11/16 ,  G01N19/02 ,  G01N27/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/22 ,  G01N29/30 ,  G01N29/34 ,  G01N29/44 ,  G01N33/487

CPC分类号： G01N29/343 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N29/223 ,  G01N29/228 ,  G01N29/30 ,  G01N2009/006 ,  G01N2291/014 ,  G01N2291/0226 ,  G01N2291/0253 ,  G01N2291/0254 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0422 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2291/101

摘要： A sensor system and method for analyzing a fluid contained within an environmental control system, comprising the steps of providing a system including a passage for containing a thermal change fluid; placing a sensor including a mechanical resonator in the passage; operating the resonator to have at least a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. A preferred sensor includes a tuning fork resonator.

摘要翻译： 一种用于分析环境控制系统中包含的流体的传感器系统和方法，包括以下步骤：提供包括用于容纳热变换流体的通道的系统; 将包括机械谐振器的传感器放置在通道中; 操作所述谐振器以使其至少一部分翻转通过所述流体; 以及监测谐振器对通道中的流体的响应。 优选的传感器包括音叉谐振器。

公开(公告)号：US20070052970A1

公开(公告)日：2007-03-08

申请号：US10550075

申请日：2004-03-19

申请人： Oleg Kolosov ,  Leonid Matsiev ,  John Varni ,  G. Dales ,  Olaf Ludtke ,  Dirk Wullner ,  Andreas Buhrdorf ,  Heiko Dobrinski

发明人： Oleg Kolosov ,  Leonid Matsiev ,  John Varni ,  G. Dales ,  Olaf Ludtke ,  Dirk Wullner ,  Andreas Buhrdorf ,  Heiko Dobrinski

IPC分类号： G01B9/02

CPC分类号： G01F23/2966 ,  G01N2009/006 ,  G01N2291/0427 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/4908

摘要： An improved method and assembly, wherein the method generally includes the steps of providing a coated or uncoated sensor element having an exposed sensing surface; attaching the sensor element to a platform so that the exposed sensing surface is spaced from the platform; and optionally applying a protective layer over the platform while maintaining the sensing surface as exposed. The assembly includes a resonator having a free portion with a sensing surface is incorporated onto a platform, components of the sensor are physically shielded from harsh operating conditions, the requisite space is maintained between the free portion of the resonator and the platform, and the sensing surface of the resonator remains exposed for sensing.

摘要翻译： 一种改进的方法和组件，其中所述方法通常包括以下步骤：提供具有暴露的感测表面的涂覆或未涂覆的传感器元件; 将传感器元件附接到平台，使得暴露的感测表面与平台间隔开; 并且可选地在平台上施加保护层，同时保持感测表面暴露。 该组件包括具有感测表面的自由部分的谐振器被并入到平台上，传感器的部件在物理上不受恶劣的操作条件的影响，在谐振器的自由部分和平台之间保持必要的空间，并且感测 谐振器的表面保持暴露以进行感测。

公开(公告)号：US20070272209A1

公开(公告)日：2007-11-29

申请号：US11837415

申请日：2007-08-10

申请人： Leonid Matsiev ,  James Bennett ,  Daniel Pinkas ,  Mikhail Spitkovsky ,  Oleg Kolosov ,  Shenheng Guan ,  Mark Uhrich ,  G. Dales ,  John Varni ,  Blake Walker ,  Vladimir Gammer ,  Dave Padowitz ,  Eric Low

发明人： Leonid Matsiev ,  James Bennett ,  Daniel Pinkas ,  Mikhail Spitkovsky ,  Oleg Kolosov ,  Shenheng Guan ,  Mark Uhrich ,  G. Dales ,  John Varni ,  Blake Walker ,  Vladimir Gammer ,  Dave Padowitz ,  Eric Low

IPC分类号： F02D45/00 ,  G01N29/02

CPC分类号： F02D41/021 ,  F02D2200/0611 ,  F02D2250/11 ,  G01F23/2966 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/30 ,  G01N29/348 ,  G01N2291/014 ,  G01N2291/0226 ,  G01N2291/02416 ,  G01N2291/02818 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

摘要： A sensor for sensing one or more properties of a vehicle fluid has a tuning fork resonator adapted to contact the fluid. The tuning fork resonator comprises two tines and is operable to oscillate so that the two tines move in opposite phase at a frequency of less than 1 MHz while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. In another aspect, a sensor includes a substrate and a flexural resonator on the substrate and adapted to contact the fluid. Circuitry for operation of the resonator is on the substrate. The resonator is adapted to receive an input signal and to oscillate while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. One suitable application for the invention is monitoring the condition of a vehicle engine oil.

摘要翻译： 用于感测车辆流体的一个或多个特性的传感器具有适于接触流体的音叉谐振器。 音叉谐振器包括两个齿并且可操作以振荡，使得两个齿在小于1MHz的频率下以相反相位移动，同时接触流体以产生指示流体的一个或多个特性的谐振器响应。 在另一方面，传感器包括衬底和在衬底上的弯曲谐振器并且适于接触流体。 用于谐振器操作的电路在基板上。 谐振器适于接收输入信号并且在接触流体时振荡以产生指示流体的一个或多个特性的谐振器响应。 本发明的一个合适的应用是监测车辆发动机油的状态。