摘要:
The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.
摘要:
A device for the generation of specific colored light including white light by luminescent down conversion and additive color mixing based on a light-emitting diode (LED) comprising a semiconductor light-emitting layer emitting near UV light about 370-420 nm or blue light about 420-480 nm and phosphors which absorb completely or partly the light emitted by the light-emitting component and emit light of wavelengths longer than that of the absorbed primary light, wherein the light emitting layer of the light emitting component is preferably a Ga(In)N-based semiconductor; and at least one of the phosphors contains a metal sulfide fluorescent material activated with europium containing at least one element selected from the group consisting of Ba, Sr, Ca, Mg and Zn; and/or at least another phosphor which contains a complex thiometalate fluorescent material activated with either europium, cerium or both europium and cerium containing 1) at least one element selected from the group consisting of Ba, Sr, Ca, Mg and Zn and 2) at least one element selected from the group consisting of Al, Ga, In, Y, La and Gd.
摘要:
Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetizaton, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems are also provided as well as their application to screening libraries of different materials.
摘要:
Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems are also provided as well as their application to screening libraries of different materials.
摘要:
Mesoscopically ordered, hydrothermally stable metal oxide-block copolymer composite or mesoporous materials are described herein that are formed by using amphiphilic block copolymers which act as structure directing agents for the metal oxide in a self-assembling system.
摘要:
Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems are also provided as well as their application to screening libraries of different materials.
摘要:
Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems are also provided as well as their application to screening libraries of different materials.
摘要:
This invention relates generally to new luminescent materials. Specifically, this invention relates to the discovery of phosphor materials in the forms of A2BX4, ABX4-y:M and A3-zB5X12:Mz. More specifically, this invention relates to the discovery of phosphor materials having compositions of matter in the forms, Sr2CeO4, (Y0.82Al0.07La0.06)VO4:Eu0.05 and (Y0.5Gd0.5)2.97(Al0.5Gd0.5)5O12:Ce0.03.
摘要:
This invention relates generally to new luminescent materials. Specifically, this invention relates to the discovery of phosphor materials in the forms of A.sub.2 BX.sub.4, ABX.sub.4-y :M and A.sub.3-z B.sub.5 X.sub.12 :M.sub.z. More specifically, this invention relates to the discovery of phosphor materials having compositions of matter in the forms, Sr.sub.2 CeO.sub.4, (Y.sub.0.82 Al.sub.0.07 La.sub.0.06)VO.sub.4 :Eu.sub.0.05 and (Y.sub.0.5 Gd.sub.0.5).sub.2.97 (Al.sub.0.5 Ga.sub.0.5).sub.5 O.sub.12 :CeO.sub.0.03.
摘要:
An electrochemical deposition and testing system consisting of individually addressable electrode arrays, a fully automated deposition head, and a parallel screening apparatus is described. The system is capable of synthesizing and screening millions of new compositions at an unprecedented rate.