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    Processes and intermediates for preparing benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
    4.
    发明授权
    Processes and intermediates for preparing benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP 失效
    制备用于抑制ACE和NEP的苯并稠合氮杂酮和哌啶酮化合物的方法和中间体

    公开(公告)号：US06235922B1

    公开(公告)日：2001-05-22

    申请号：US09205316

    申请日：1998-12-04

    申请人： Jeffrey A. Robl ,  Chong-Qing Sun

    发明人： Jeffrey A. Robl ,  Chong-Qing Sun

    IPC分类号： C07C32734

    CPC分类号： C07K5/06139 ,  A61K38/00 ,  C07K5/0606 ,  C07K5/06191

    摘要： Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: wherein: Y1 and Y2 are each independently hydrogen, alkyl, aryl, halogen, or alkoxy; X is O or S(O)t; A is t is zero, one or two; m and n are independently zero or one; and wherein R, R5, R5a, R5b, R6, R7, R11, q and r are defined herein.

    摘要翻译： 具有下式I的化合物及其药学上可接受的盐，包括ACE和NEP的双重抑制剂和选择性ACE抑制剂：其中：Y1和Y2各自独立地为氢，烷基，芳基，卤素或烷氧基; X为O或S（ O）t; A ist为零，一个或两个; m和n独立地为0或1;并且其中R，R 5，R 5a，R 5b，R 6，R 7，R 11，q和r在本文中定义。

    HMG-CoA reductase inhibitors and method
    6.
    发明授权
    HMG-CoA reductase inhibitors and method 有权
    HMG-CoA还原酶抑制剂及方法

    公开(公告)号：US06812345B2

    公开(公告)日：2004-11-02

    申请号：US10602752

    申请日：2003-06-24

    申请人： Jeffrey A. Robl ,  Bang-Chi Chen ,  Chong-Qing Sun

    发明人： Jeffrey A. Robl ,  Bang-Chi Chen ,  Chong-Qing Sun

    IPC分类号： C07D491044

    CPC分类号： C07D471/04 ,  C07D491/04 ,  C07D491/10 ,  C07D495/04

    摘要： Compounds of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids such as lowering LDL cholesterol and/or increasing HDl cholesterol, and treating hyperlipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis and pharmaceutically acceptable salts thereof, wherein X is O, S, SO, SO2 or NR7; Z is n is 0 or 1; R1 and R2 are the same or different and are independently selected from alkyl, arylalkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, heteroaryl or cycloheteroalkyl; and R3 to R10 are as defined herein.

    摘要翻译： 以下结构的化合物是HMG CoA还原酶抑制剂，因此具有抑制胆固醇生物合成，调节血清脂质如降低LDL胆固醇和/或增加HDL胆固醇和治疗高脂血症，高胆固醇血症，高甘油三酯血症和动脉粥样硬化及其药学上可接受的盐的活性，其中 X是O，S，SO，SO 2或NR 7; Z isn是0或1; R 1和R 2相同或不同，并且独立地选自烷基，芳基烷基，环烷基，烯基，环烯基，芳基，杂芳基或环杂烷基; 和R 3至R 10如本文所定义。