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    Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate
    5.
    发明授权
    Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate 有权
    用于制备放射性标记的复合物或生物分子缀合物的微反应器和方法

    公开(公告)号：US08980185B2

    公开(公告)日：2015-03-17

    申请号：US13818569

    申请日：2011-08-25

    申请人： David E. Reichert ,  Paul J. A. Kenis ,  Tobias D. Wheeler ,  Amit V. Desai ,  Dexing Zeng ,  Birce C. Önal

    发明人： David E. Reichert ,  Paul J. A. Kenis ,  Tobias D. Wheeler ,  Amit V. Desai ,  Dexing Zeng ,  Birce C. Önal

    IPC分类号： G21C1/00 ,  C07K1/13 ,  C07B59/00 ,  B01J19/00 ,  C07K1/107

    CPC分类号： B01J19/0093 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00889 ,  C07B59/00 ,  C07B59/008 ,  C07K1/1077 ,  C07K1/13

    摘要： A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.

    摘要翻译： 用于制备放射性标记的复合物或生物分子缀合物的微反应器包括用于流体流动的微通道，其中微通道包括包含一个或多个被动混合元件的混合部分和用于孵育混合流体的储存器。 储存器与微通道流体连通并且设置在混合部分的下游。 制备放射性标记的复合物的方法包括使包含金属放射性核素的放射性金属溶液流过微通道的下游混合部分，其中下游混合部分包括一个或多个被动混合元件，并使包含双功能螯合剂的配体溶液流过下游 混合部分。 配体溶液和放射性金属溶液在下游混合部分被动混合，以引发金属放射性核素和双功能螯合剂之间的螯合反应。 完成螯合反应以形成放射性标记的复合物。

    NUCLEIC ACID-MEDIATED SHAPE CONTROL OF NANOPARTICLES FOR BIOMEDICAL APPLICATIONS
    7.
    发明申请
    NUCLEIC ACID-MEDIATED SHAPE CONTROL OF NANOPARTICLES FOR BIOMEDICAL APPLICATIONS 审中-公开
    用于生物医学应用的纳米颗粒的核酸介导形状控制

    公开(公告)号：US20120107242A1

    公开(公告)日：2012-05-03

    申请号：US13249070

    申请日：2011-09-29

    申请人： Zidong Wang ,  Yi Lu ,  Jieqian Zhang ,  Paul J. A. Kenis ,  Ngo Yin Wong

    发明人： Zidong Wang ,  Yi Lu ,  Jieqian Zhang ,  Paul J. A. Kenis ,  Ngo Yin Wong

    IPC分类号： A61K9/51 ,  A61K49/00 ,  C12N5/071 ,  B32B5/16 ,  A61M37/00 ,  B05D7/00 ,  C12Q1/02 ,  A61K31/7088 ,  B82Y5/00

    CPC分类号： A61K31/7088 ,  A61K9/5115 ,  A61K41/0052 ,  A61K47/6923 ,  A61K47/6929 ,  Y10T428/2991

    摘要： Embodiments of a method for nucleic acid-mediated control of a nanoparticle shape are disclosed. In some embodiments, one or more nucleic acid oligomers are adsorbed to a metal nanoseed, and additional metal is deposited onto the nanoseed to produce a shaped nanoparticle. In certain embodiments, the nanoseed is gold and the oligomers are 5-100 nucleotides in length. The nanoparticle shape is determined at least in part by the nucleic acid sequence of the oligomer(s). Shaped nanoparticles produced by embodiments of the method include nanoflowers, nanospheres, nanostars, and nanoplates. Embodiments for using the shaped nanoparticles also are disclosed.

    摘要翻译： 公开了核酸介导的纳米颗粒形状的控制方法的实施方案。 在一些实施方案中，一种或多种核酸低聚物被吸附到金属纳米籽粒上，并且另外的金属沉积到纳米籽粒上以产生成形的纳米颗粒。 在某些实施方案中，纳米籽粒是金，寡聚体长度为5-100个核苷酸。 至少部分地由寡聚体的核酸序列确定纳米颗粒形状。 通过该方法的实施方案制备的成形纳米微粒包括纳米花粉，纳米球，纳米棒和纳米片。 公开了使用成形纳米颗粒的实施方案。

    System of distributed electrochemical cells integrated with microelectronic structures
    8.
    发明授权
    System of distributed electrochemical cells integrated with microelectronic structures 失效
    与微电子结构集成的分布式电化学电池系统

    公开(公告)号：US07892681B2

    公开(公告)日：2011-02-22

    申请号：US11489274

    申请日：2006-07-18

    申请人： Walter E. Pelton ,  Paul J. A. Kenis

    发明人： Walter E. Pelton ,  Paul J. A. Kenis

    IPC分类号： H01M8/04 ,  H01M8/10

    CPC分类号： H01M8/1097 ,  H01M4/8605 ,  H01M8/04201

    摘要： An electrochemical cell includes an anode half-cell and a cathode half-cell. A separator, such as a membrane, is formed between the two half-cells, and a gate electrode may be configured to influence the properties of the separator. Electricity is generated by flowing a liquid fuel through conduits, while applying an electric field to the gated membrane such that the membrane conducts protons. Complementary half cell reactions take place at an anode and a cathode.

    摘要翻译： 电化学电池包括阳极半电池和阴极半电池。 在两个半电池之间形成隔膜（例如膜），并且栅电极可以被配置成影响隔膜的性质。 通过使液体燃料通过导管产生电，同时向门控膜施加电场，使得膜传导质子。 互补的半电池反应发生在阳极和阴极。