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1.发明申请公开(公告)号：US20090215646A1
公开(公告)日：2009-08-27
申请号：US11994353
申请日：2006-06-30
申请人： Eric V. Anslyn , John T. McDevitt , Jason B. Shear , Dean P. Neikirk , Aaron T. Wright , Zhenlin Zhong
发明人： Eric V. Anslyn , John T. McDevitt , Jason B. Shear , Dean P. Neikirk , Aaron T. Wright , Zhenlin Zhong
CPC分类号： G01N33/54313 , G01N33/54386
摘要： Methods and systems for detecting the presence of analytes are described. A fluid or gas sample containing one or more analytes may pass through a particle-based sensor array. Detection and analysis techniques may be applied to determine the identity and quantity of the analytes.
摘要翻译： 描述了用于检测分析物存在的方法和系统。 含有一种或多种分析物的流体或气体样品可以通过基于粒子的传感器阵列。 可以应用检测和分析技术来确定分析物的身份和数量。
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公开(公告)号：US20090258791A1
公开(公告)日：2009-10-15
申请号：US12372414
申请日：2009-02-17
IPC分类号： C40B30/04
CPC分类号： G01N21/77 , B01J2219/00317 , B01J2219/00648 , B01J2219/00659 , C40B60/14 , Y10S435/808 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10S436/807 , Y10S436/809 , Y10T436/25
摘要： A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
摘要翻译： 在一个实施例中，用于快速表征多分析物流体的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施例中，一系列化学敏感的颗粒位于空腔内。 当与颗粒偶联的受体与分析物相互作用时，颗粒可被配置成产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。
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公开(公告)号：US07316899B2
公开(公告)日：2008-01-08
申请号：US09775343
申请日：2001-01-31
CPC分类号： G01N21/6452 , B01J2219/005 , B01J2219/00576 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01L3/0289 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/027 , B01L2200/0657 , B01L2200/0668 , B01L2200/12 , B01L2300/0636 , B01L2400/0415 , B01L2400/049 , B01L2400/0633 , B01L2400/0638 , C07B2200/11 , C12Q1/34 , C12Q1/37 , C40B40/00 , G01N21/253 , G01N21/6428 , G01N21/6454 , G01N21/6458 , G01N21/6486 , G01N21/77 , G01N33/54313 , G01N33/54366 , G01N33/54373 , G01N2001/021 , G01N2021/6417 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00564 , G01N2201/062 , G01N2201/0627 , G06F19/00 , Y02A90/26 , Y10S977/924 , Y10T436/2575
摘要： A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
摘要翻译： 在一个实施例中，用于快速表征多分析物流体的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施例中，一系列化学敏感的颗粒位于空腔内。 当与颗粒偶联的受体与分析物相互作用时，颗粒可被配置成产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。
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4.发明授权Sensor arrays for the measurement and identification of multiple analytes in solutions 有权用于测量和识别溶液中多种分析物的传感器阵列公开(公告)号：US06680206B1
公开(公告)日：2004-01-20
申请号：US09354882
申请日：1999-07-16
IPC分类号： G01N2176
CPC分类号： G01N21/77 , B01J2219/00317 , B01J2219/00648 , B01J2219/00659 , C40B60/14 , Y10S435/808 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10S436/807 , Y10S436/809 , Y10T436/25
摘要： A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
摘要翻译： 在一个实施例中，用于快速表征多分析物流体的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施例中，一系列化学敏感的颗粒位于空腔内。 当与颗粒偶联的受体与分析物相互作用时，颗粒可被配置成产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。
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公开(公告)号：US06602702B1
公开(公告)日：2003-08-05
申请号：US09616355
申请日：2000-07-14
IPC分类号： C12M134
CPC分类号： G01N21/77 , B01L3/502761 , B01L2200/0668 , B01L2300/0636 , B01L2300/0819 , B01L2300/0877 , B01L2400/049 , G01N21/253 , G01N21/6452 , G01N21/78 , G01N2021/7786
摘要： A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
摘要翻译： 在一个实施例中，用于快速表征多分析物流体的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施例中，一系列化学敏感的颗粒位于空腔内。 当与颗粒偶联的受体与分析物相互作用时，颗粒可被配置成产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。
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公开(公告)号：US07491552B2
公开(公告)日：2009-02-17
申请号：US11039054
申请日：2005-01-20
IPC分类号： G01N33/543
CPC分类号： G01N21/77 , B01J2219/00317 , B01J2219/00648 , B01J2219/00659 , C40B60/14 , Y10S435/808 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10S436/807 , Y10S436/809 , Y10T436/25
摘要： A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
摘要翻译： 在一个实施例中，用于快速表征多分析物流体的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施例中，一系列化学敏感的颗粒位于空腔内。 当与颗粒偶联的受体与分析物相互作用时，颗粒可被配置成产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。
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公开(公告)号：US06908770B1
公开(公告)日：2005-06-21
申请号：US09287248
申请日：1999-04-07
IPC分类号： C40B60/14 , G01N21/77 , G01N33/53 , G01N33/543
CPC分类号： G01N21/77 , B01J2219/00317 , B01J2219/00648 , B01J2219/00659 , C40B60/14 , Y10S435/808 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10S436/807 , Y10S436/809 , Y10T436/25
摘要： A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
摘要翻译： 在一个实施例中，用于快速表征多分析物流体的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施例中，一系列化学敏感的颗粒位于空腔内。 当与颗粒偶联的受体与分析物相互作用时，颗粒可被配置成产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。
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8.发明授权Method and apparatus for the delivery of samples to a chemical sensor array 有权用于将样品递送到化学传感器阵列的方法和装置公开(公告)号：US06713298B2
公开(公告)日：2004-03-30
申请号：US09775048
申请日：2001-01-31
IPC分类号： C12M140
CPC分类号： G01N21/6452 , B01J2219/005 , B01J2219/00576 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01L3/0289 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/027 , B01L2200/0657 , B01L2200/0668 , B01L2200/12 , B01L2300/0636 , B01L2400/0415 , B01L2400/049 , B01L2400/0633 , B01L2400/0638 , C07B2200/11 , C12Q1/34 , C12Q1/37 , C40B40/00 , G01N21/253 , G01N21/6428 , G01N21/6454 , G01N21/6458 , G01N21/6486 , G01N21/77 , G01N33/54313 , G01N33/54366 , G01N33/54373 , G01N2001/021 , G01N2021/6417 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00564 , G01N2201/062 , G01N2201/0627 , G06F19/00 , Y02A90/26 , Y10S977/924 , Y10T436/2575
摘要： A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
摘要翻译： 在一个实施例中，用于快速表征多分析物流体的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施例中，一系列化学敏感的颗粒位于空腔内。 当与颗粒偶联的受体与分析物相互作用时，颗粒可被配置成产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。
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公开(公告)号：US20110251075A1
公开(公告)日：2011-10-13
申请号：US12940898
申请日：2010-11-05
IPC分类号： C40B30/00
CPC分类号： G01N21/6452 , B01J2219/005 , B01J2219/00576 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01L3/0289 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/027 , B01L2200/0657 , B01L2200/0668 , B01L2200/12 , B01L2300/0636 , B01L2400/0415 , B01L2400/049 , B01L2400/0633 , B01L2400/0638 , C07B2200/11 , C12Q1/34 , C12Q1/37 , C40B40/00 , G01N21/253 , G01N21/6428 , G01N21/6454 , G01N21/6458 , G01N21/6486 , G01N21/77 , G01N33/54313 , G01N33/54366 , G01N33/54373 , G01N2001/021 , G01N2021/6417 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00564 , G01N2201/062 , G01N2201/0627 , Y02A90/26 , Y10S977/924 , Y10T436/2575
摘要： A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
摘要翻译： 在一个实施例中，用于快速表征多分析物流体的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施例中，一系列化学敏感的颗粒位于空腔内。 当与颗粒偶联的受体与分析物相互作用时，颗粒可被配置成产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。
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公开(公告)号：US07651868B2
公开(公告)日：2010-01-26
申请号：US11010816
申请日：2004-12-13
IPC分类号： G01N21/00 , G01N33/00 , G01N21/64 , C12M1/34 , C12M3/00 , G01N33/566 , G01N33/543 , G01N33/545 , G01N21/76 , G01N33/92 , G01N33/44
CPC分类号： G01N33/5304 , B01J19/0046 , B01J2219/00317 , B01J2219/005 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L2300/0819 , B01L2300/0877 , B01L2400/0487 , C40B40/10 , C40B60/14 , G01N21/6428 , G01N21/6454 , G01N21/77 , G01N33/54313 , G01N33/544 , G01N33/552 , G01N33/6887 , G01N33/92 , G01N2021/7783 , G01N2021/7786 , G01N2201/024 , G01N2800/32 , Y10S436/807 , Y10S436/809
摘要： A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.
摘要翻译： 用于快速表征唾液中分析物的系统。 在一个实施例中，用于检测分析物的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施例中，一系列化学敏感性颗粒位于空腔内。 当与颗粒偶联的受体与心血管危险因子分析物相互作用并且使用可视化试剂显现颗粒 - 分析物复合物时，颗粒可产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。 在一个实施例中，多个空腔的每个空腔被设计成捕获并容纳特定尺寸的颗粒。 可以将柔性突出部定位在每个空腔上，以提供颗粒在空腔中的保持。
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