公开(公告)号：US11733151B2

公开(公告)日：2023-08-22

申请号：US17284083

申请日：2020-04-06

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wu Chou ,  Xing Li ,  Hongbing Li ,  Yuecheng Zhang ,  Mingquan Wu ,  Wei Ding ,  Jun Tian

IPC: G01N15/14 ,  G06T7/62 ,  G06T7/00 ,  G06T7/40 ,  G06T7/10 ,  G06N20/00

CPC classification number: G01N15/1475 ,  G06N20/00 ,  G06T7/0012 ,  G06T7/10 ,  G06T7/40 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/30004 ,  G06T2207/30024 ,  G06T2207/30204

Abstract: The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments the errors are random.

公开(公告)号：US12248533B2

公开(公告)日：2025-03-11

申请号：US18101109

申请日：2023-01-24

Applicant: Essenlix Corporation

Inventor： Xing Li ,  Wu Chou ,  Stephen Y. Chou ,  Wei Ding ,  Ji Qi

IPC: G06F18/214 ,  G06N3/042 ,  G06N3/045 ,  G06N3/08 ,  G06T5/50 ,  G06T7/00 ,  G06T7/11 ,  G06T7/70 ,  G06V10/22

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.

公开(公告)号：US20240159999A1

公开(公告)日：2024-05-16

申请号：US18539243

申请日：2023-12-13

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Yuechang Zhang ,  Wu Chou ,  Mingquan Wu ,  Xing Li ,  Jun Tian

IPC: G02B21/34 ,  G01N33/543

CPC classification number: G02B21/34 ,  G01N33/54386 ,  G01N33/5094 ,  G01N2496/05

Abstract: A method of assaying an analyte in a sample is disclosed. The method includes having a sample holder with a sample contact area for contacting a sample with an analyte, having a plurality of calibration structures on the sample contact area of the sample holder, imaging a part of the sample contact area that has the calibration structures, and using an algorithm that includes an image, calibration structures in the image, and artificial intelligence and/or machine learning to identify the analyte and/or determine the analyte concentration.

公开(公告)号：US20230169151A1

公开(公告)日：2023-06-01

申请号：US18101109

申请日：2023-01-24

Applicant: Essenlix Corporation

Inventor： Xing Li ,  Wu CHOU ,  Stephen Y. CHOU ,  Wei DING ,  Ji QI

IPC: G06F18/214 ,  G06T7/11 ,  G06T7/70 ,  G06V10/22 ,  G06N3/08 ,  G06T5/50 ,  G06T7/00 ,  G06N3/042 ,  G06N3/045

CPC classification number: G06F18/2148 ,  G06T7/11 ,  G06T7/70 ,  G06V10/22 ,  G06N3/08 ,  G06T5/50 ,  G06T7/0002 ,  G06N3/042 ,  G06N3/045 ,  G06T2207/20021 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/20221 ,  G06T2207/30204

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.

公开(公告)号：US11593590B2

公开(公告)日：2023-02-28

申请号：US17431345

申请日：2020-11-25

Applicant: Essenlix Corporation

Inventor： Xing Li ,  Wu Chou ,  Stephen Y. Chou ,  Wei Ding

IPC: G06K9/62 ,  G06N3/04 ,  G06T5/50 ,  G06T7/00 ,  G06T7/11 ,  G06T7/70 ,  G06V10/22 ,  G06N3/08

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.

公开(公告)号：US20220148177A1

公开(公告)日：2022-05-12

申请号：US17616178

申请日：2020-06-02

Applicant: Essenlix Corporation

Inventor： Wu Chou ,  Hongbing Li ,  Susan Y. Sun ,  Xing Li ,  Wei Ding ,  Stephen Y. Chou

IPC: G06T7/00 ,  G01N1/31 ,  G01N1/28 ,  G01N21/64

Abstract: Among other things, the present invention provides devices and methods that stain a sample simply (e.g. one step) and quickly (e.g.

公开(公告)号：US20200033579A1

公开(公告)日：2020-01-30

申请号：US16526864

申请日：2019-07-30

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Yuechang Zhang ,  Wu Chou ,  Mingquan Wu ,  Xing Li ,  Jun Tian

IPC: G02B21/34 ,  G01N33/543

Abstract: A method of assaying an analyte in a sample is disclosed. The method includes having a sample holder with a sample contact area for contacting a sample with an analyte, having a plurality of calibration structures on the sample contact area of the sample holder, imaging a part of the sample contact area that has the calibration structures, and using an algorithm that includes an image, calibration structures in the image, and artificial intelligence and/or machine learning to identify the analyte and/or determine the analyte concentration.

公开(公告)号：US12007320B2

公开(公告)日：2024-06-11

申请号：US18215302

申请日：2023-06-28

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wu Chou ,  Xing Li ,  Hongbing Li ,  Yuecheng Zhang ,  Mingquan Wu ,  Wei Ding ,  Jun Tian

IPC: G01N15/1433 ,  G06N20/00 ,  G06T7/00 ,  G06T7/10 ,  G06T7/40 ,  G06T7/62

CPC classification number: G01N15/1433 ,  G06N20/00 ,  G06T7/0012 ,  G06T7/10 ,  G06T7/40 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/30004 ,  G06T2207/30024 ,  G06T2207/30204

Abstract: The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments the errors are random.

公开(公告)号：US11885952B2

公开(公告)日：2024-01-30

申请号：US16526864

申请日：2019-07-30

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Yuecheng Zhang ,  Wu Chou ,  Mingquan Wu ,  Xing Li ,  Jun Tian

IPC: G02B21/34 ,  G01N33/543 ,  G01N33/50

CPC classification number: G02B21/34 ,  G01N33/54386 ,  G01N33/5094 ,  G01N2496/05

Abstract: A method of assaying an analyte in a sample is disclosed. The method includes having a sample holder with a sample contact area for contacting a sample with an analyte, having a plurality of calibration structures on the sample contact area of the sample holder, imaging a part of the sample contact area that has the calibration structures, and using an algorithm that includes an image, calibration structures in the image, and artificial intelligence and/or machine learning to identify the analyte and/or determine the analyte concentration.

公开(公告)号：US11719618B2

公开(公告)日：2023-08-08

申请号：US17268847

申请日：2019-08-28

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Wu Chou ,  Jun Tian ,  Yuecheng Zhang ,  Mingquan Wu ,  Xing Li

IPC: G01N15/14 ,  G02B21/34 ,  G06T7/00 ,  G06V10/34 ,  G06V10/44 ,  G06V20/69 ,  G06F18/2413 ,  G06V10/764 ,  G06V10/82 ,  G01N15/10

CPC classification number: G01N15/1475 ,  G02B21/34 ,  G06F18/24143 ,  G06T7/0012 ,  G06V10/34 ,  G06V10/44 ,  G06V10/454 ,  G06V10/764 ,  G06V10/82 ,  G06V20/69 ,  G01N2015/1006 ,  G06T2207/30004

Abstract: One aspect of the present invention is to provide systems and methods that improve the accuracy of an assay that comprise at least one or more parameters each having a random error.