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14 条记录 (耗时 0.036 秒)

    Negatively charged minor groove binders
    6.
    发明申请
    Negatively charged minor groove binders 有权
    带负电荷的小槽粘合剂

    公开(公告)号：US20050187383A1

    公开(公告)日：2005-08-25

    申请号：US10507267

    申请日：2003-03-11

    申请人： Eugeny Lukhtanov ,  Sergey Lokhov ,  Nicolaas Vermeulen

    发明人： Eugeny Lukhtanov ,  Sergey Lokhov ,  Nicolaas Vermeulen

    IPC分类号： C07H21/00 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C07H21/04 ,  C07H21/00

    摘要： The present invention provides a negatively charged minor groove binding compound, oligonucleotide conjugates comprising the same, and methods for using the same. The negatively charged minor groove binding compounds of the present invention comprises an acidic moiety that is capable of being ionized under physiological conditions. In particular, the negatively charged minor groove binding compound of the present invention comprises a binding moiety that binds preferentially into a minor groove of a double, triple or higher stranded DNA, RNA, PNA or hybrids thereof. The binding moiety comprises at least one aryl moiety and an acidic moiety which is covalently attached to a phenyl portion of the aryl moiety or to a heteroatom of a heteroaryl portion of the aryl moiety.

    摘要翻译： 本发明提供带负电荷的小沟结合化合物，包含其的寡核苷酸缀合物及其使用方法。 本发明的带负电荷的小沟结合化合物包含能够在生理条件下电离的酸性部分。 特别地，本发明的带负电荷的小沟结合化合物包含优先结合双重，三重或更高链DNA，RNA，PNA或其杂交体的小沟的结合部分。 结合部分包含至少一个芳基部分和酸性部分，其共价连接到芳基部分的苯基部分或芳基部分的杂芳基部分的杂原子。

    Methods and apparatus for promoting hair growth using adipose cell based therapies
    7.
    发明申请
    Methods and apparatus for promoting hair growth using adipose cell based therapies 审中-公开
    使用基于脂肪细胞的疗法促进头发生长的方法和装置

    公开(公告)号：US20070258956A1

    公开(公告)日：2007-11-08

    申请号：US11417302

    申请日：2006-05-02

    申请人： Joel Higgins ,  Felipe Palacios ,  Nicolaas Vermeulen

    发明人： Joel Higgins ,  Felipe Palacios ,  Nicolaas Vermeulen

    IPC分类号： A61K35/12 ,  C12N5/08

    CPC分类号： A61K35/28 ,  A61K35/35 ,  A61K35/36 ,  A61K2300/00

    摘要： Methods and compositions for use in the treatment of androgenetic alopecia and other forms of hair loss by inducing and expediting the growth of hair in the scalp of a patient. Methods comprise the steps of isolating adipose-derived cells and hair follicles from the patient and implanting the combined cells and follicles into the scalp in areas requiring new growth of hair. Use of differentiated and undifferentiated adipose-derived cells with processed and grafted hair follicles for the therapeutic and cosmetic treatment of hair loss in vivo is disclosed.

    摘要翻译： 用于治疗雄激素性脱发和其它形式脱发的方法和组合物，其通过诱导和加速患者头皮中毛发的生长。 方法包括从患者中分离脂肪来源的细胞和毛囊并将合并的细胞和卵泡植入需要头发新生长的区域中的头皮中的步骤。 公开了分化和未分化脂肪来源的细胞与加工的和接种的毛囊用于体内脱发的治疗和美容治疗的用途。

    Systems and methods for isolating stromal cells from adipose tissue and uses thereof
    8.
    发明申请
    Systems and methods for isolating stromal cells from adipose tissue and uses thereof 审中-公开
    用于从脂肪组织分离基质细胞的系统和方法及其用途

    公开(公告)号：US20060051865A1

    公开(公告)日：2006-03-09

    申请号：US11217087

    申请日：2005-08-31

    申请人： Joel Higgins ,  Michael Leach ,  Felipe Palacios ,  Nicolaas Vermeulen

    发明人： Joel Higgins ,  Michael Leach ,  Felipe Palacios ,  Nicolaas Vermeulen

    IPC分类号： C12N5/08

    CPC分类号： C12M45/07 ,  A61K35/28 ,  A61L27/3834 ,  C12M45/05 ,  C12M47/04 ,  C12N5/0667

    摘要： Methods of isolating cells from adipose tissue that have potential to differentiate into cells of mesenchymal origin, including cells of chondrogenic, osteogenic, adipogenic, and/or myogenic origin, comprising: (a) subjecting adipose tissue to an electromagnetic, sonic, or other wave energy source; and (b) centrifuging the tissue to form a pellet comprising stem cells. In various embodiments, the method is carried out without any enzymatic digestion of the adipose tissue. In other embodiments, the method additionally comprises enzymatically digesting the tissue. In various embodiments, methods comprise subjecting the tissue to ultrasonic energy. In some embodiments, the method does not comprise enzymatic digestion of the adipose tissue. In other embodiments, the method additionally comprises enzymatically digesting the tissue. Methods are also provided for intraoperative harvest and delivery of autologous stem cells to the site of acute or chronic wounds. In one embodiment, an autologous supply of stem cells is provided for operative use.

    摘要翻译： 从具有潜在分化成间充质来源的细胞的脂肪组织分离细胞的方法，包括软骨形成，成骨，脂肪形成和/或肌原性来源的细胞，包括：（a）使脂肪组织进行电磁，声波或其它波 能量源; 和（b）离心组织以形成包含干细胞的丸粒。 在各种实施方案中，该方法不进行任何酶消化的脂肪组织。 在其它实施方案中，该方法还包括酶促消化组织。 在各种实施例中，方法包括使组织经受超声能量。 在一些实施方案中，该方法不包括脂肪组织的酶消化。 在其它实施方案中，该方法还包括酶促消化组织。 还提供了用于术中收获和将自体干细胞递送至急性或慢性伤口部位的方法。 在一个实施例中，提供干细胞的自体供应用于操作使用。