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11 条记录 (耗时 0.047 秒)

    Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use
    1.
    发明申请
    Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use 有权
    噻吩并[2,3-d]嘧啶和噻吩并哒嗪化合物及其使用方法

    公开(公告)号：US20080032988A1

    公开(公告)日：2008-02-07

    申请号：US11789189

    申请日：2007-04-23

    申请人： Fang-Tsao Hong ,  James Falsey ,  Robert Rzasa ,  Seifu Tadesse ,  Andrew Tasker

    发明人： Fang-Tsao Hong ,  James Falsey ,  Robert Rzasa ,  Seifu Tadesse ,  Andrew Tasker

    IPC分类号： A61K31/50 ,  A61P19/02 ,  C07D237/00

    CPC分类号： C07D495/04

    摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

    摘要翻译： 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。 化合物具有通式I，其中A 1，A 2，B，R 2和R 3是 本文定义。 本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备 一级方程式

    Vanilloid receptor ligands and their use in treatments
    7.
    发明申请
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US20060089360A1

    公开(公告)日：2006-04-27

    申请号：US11256427

    申请日：2005-10-21

    申请人： Mark Norman ,  Vassil Ognyanov ,  Robert Rzasa

    发明人： Mark Norman ,  Vassil Ognyanov ,  Robert Rzasa

    IPC分类号： A61K31/506 ,  C07D403/02 ,  C07D405/02

    CPC分类号： C07D401/04 ,  C07D403/04 ,  C07D405/04

    摘要： Substituted nitrogen-containing heterocycles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    摘要翻译： 取代的含氮杂环和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，紧张性头痛，一般炎症，关节炎，风湿 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛， 咳嗽痛，交感神经痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道紊乱 胃溃疡，十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    Compounds and methods of uses
    9.
    发明授权
    Compounds and methods of uses 有权
    化合物和使用方法

    公开(公告)号：US06822097B1

    公开(公告)日：2004-11-23

    申请号：US10360226

    申请日：2003-02-06

    申请人： Mark H. Norman ,  Hui-Ling Wang ,  Robert Rzasa ,  Wenge Zhong ,  Thomas Nguyen ,  Matthew Kaller ,  Hu Liu

    发明人： Mark H. Norman ,  Hui-Ling Wang ,  Robert Rzasa ,  Wenge Zhong ,  Thomas Nguyen ,  Matthew Kaller ,  Hu Liu

    IPC分类号： C07D21516

    CPC分类号： C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04

    摘要： Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

    摘要翻译： 选择的化合物对于治疗疾病如细胞增殖或细胞凋亡介导的疾病是有效的。 本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及中风，癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

    Compounds and methods of use
    10.
    发明申请
    Compounds and methods of use 审中-公开
    化合物和使用方法

    公开(公告)号：US20070032518A1

    公开(公告)日：2007-02-08

    申请号：US10936538

    申请日：2004-09-09

    申请人： Mark Norman ,  Hui-Ling Wang ,  Robert Rzasa ,  Wenge Zhong ,  Thomas Nguyen ,  Matthew Kaller ,  Hu Liu

    发明人： Mark Norman ,  Hui-Ling Wang ,  Robert Rzasa ,  Wenge Zhong ,  Thomas Nguyen ,  Matthew Kaller ,  Hu Liu

    IPC分类号： C07D471/02 ,  C07D491/02 ,  C07D498/02

    CPC分类号： C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04

    摘要： Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

    摘要翻译： 选择的化合物对于治疗疾病如细胞增殖或细胞凋亡介导的疾病是有效的。 本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及中风，癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。