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    Substituted heterocyclic compounds and methods of use
    3.
    发明申请
    Substituted heterocyclic compounds and methods of use 有权
    取代的杂环化合物及其使用方法

    公开(公告)号：US20050182072A1

    公开(公告)日：2005-08-18

    申请号：US11034042

    申请日：2005-01-11

    申请人： Guo-Qiang Cao ,  Jian Chen ,  Celia Dominguez ,  Anthony Reed ,  Kelvin Sham ,  Maya Thaman ,  Dawei Zhang ,  Bradley Herberich

    发明人： Guo-Qiang Cao ,  Jian Chen ,  Celia Dominguez ,  Anthony Reed ,  Kelvin Sham ,  Maya Thaman ,  Dawei Zhang ,  Bradley Herberich

    IPC分类号： C07D213/56 ,  C07D239/95 ,  C07D401/04 ,  C07D401/14 ,  C07D417/14 ,  C07D487/06 ,  C07D487/08 ,  C07D519/00 ,  A61K31/519 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/513 ,  A61K31/517 ,  C07D487/02

    CPC分类号： C07D487/06 ,  C07D213/56 ,  C07D239/95 ,  C07D401/04 ,  C07D401/14 ,  C07D417/14

    摘要： The present invention relates to therapeutic diazobicyclo pyridines and their use in the treatment of arthritis, rheumatoid arthritis, psoriatic arthritis or osteoarthritis, organ transplant, acute transplant or heterograft and homograft rejection, ischemic and reperfusion injury, transplantation tolerance induction, multiple sclerosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, lupus, graft vs. host diseases, T -cell mediated hypersensitivity diseases, contact hypersensitivity, delayed-type hypersensitivity, gluten-sensitive enteropathy, Type 1 diabetes, psoriasis, contact dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Graves' Disease, Addison's disease, autoimmune polyglandular disease, autoimmune alopecia, pernicious anemia, vitiligo, autoimmune hypopituatarism, Guillain-Barre syndrome, autoimmune diseases, glomerulonephritis, serum sickness, uticaria, respiratory allergies, asthma, hayfever, allergic rhinitis, skin allergies, scleracielma, mycosis flugoides, acute inflammatory responses, acute respiratory distress syndrome, dermatomyositis, alopecia areata, chronic actinic dermatitis, eczema, Behcet's disease, Pustulosis palmoplanteris, Pyoderma gangrenum, Sezary's syndrome, atopic dermatitis, systemic schlerosis, morphea, Type II diabetes and cancers where PKC theta or other PKC-family kinases are activated, overexpressed or facilitate tumor growth or survival of tumor cells, T cell leukemia, thymoma, T and B cell lymphoma, colon carcinoma, breast carcinoma and lung carcinoma or provides resistance to chemotherapeutic drugs.

    摘要翻译： 本发明涉及治疗性重氮二环吡啶及其在治疗关节炎，类风湿性关节炎，银屑病关节炎或骨关节炎，器官移植，急性移植或异种移植和同种异体移植排斥，缺血和再灌注损伤，移植耐受诱导，多发性硬化，炎性肠中的用途 疾病，溃疡性结肠炎，克罗恩病，狼疮，移植物抗宿主病，T细胞介导的超敏反应性疾病，接触性超敏反应，延迟型超敏反应，麸质敏感性肠病，1型糖尿病，牛皮癣，接触性皮炎，桥本氏甲状腺炎，干燥综合征 ，自身免疫性甲状腺功能亢进症，格雷夫斯病，艾迪生病，自身免疫性多腺病，自身免疫性脱发，恶性贫血，白癜风，自身免疫性低分化症，吉兰巴利综合征，自身免疫性疾病，肾小球肾炎，血清病，荨麻疹，呼吸道过敏，哮喘，过敏性鼻炎，过敏性鼻炎 ，皮肤过敏 es，scleracielma，真菌性感冒，急性炎症反应，急性呼吸窘迫综合征，皮肌炎，斑秃，慢性光化性皮炎，湿疹，Behcet氏病，脓疱疮，新生皮炎，Sezary综合征，特应性皮炎，全身性硬化症，morphea，II型糖尿病 和PKCθ或其他PKC家族激酶被激活，过度表达或促进肿瘤细胞，T细胞白血病，胸腺瘤，T细胞和B细胞淋巴瘤，结肠癌，乳腺癌和肺癌的肿瘤生长或存活的癌症，或提供对化学治疗的抗性 药物

    2-Quinazolinone compounds and methods of use
    5.
    发明申请
    2-Quinazolinone compounds and methods of use 失效
    2-喹唑啉酮化合物及其使用方法

    公开(公告)号：US20080032973A1

    公开(公告)日：2008-02-07

    申请号：US11879243

    申请日：2007-07-16

    申请人： Fang-Tsao Hong ,  Kelvin Sham ,  Seifu Tadesse ,  Andrew Tasker

    发明人： Fang-Tsao Hong ,  Kelvin Sham ,  Seifu Tadesse ,  Andrew Tasker

    IPC分类号： C07D239/80 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P19/00 ,  C07D413/14 ,  C07D471/04 ,  C07D413/02 ,  A61P3/00 ,  A61P31/12 ,  A61P7/00

    CPC分类号： C07D471/04 ,  C07D239/82

    摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, s, T, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use such as treatment of kinase mediated diseases by administering the compounds of Formula I or compositions including the compounds of Formula I, and intermediates and processes useful for the preparation of compounds of Formula I.

    摘要翻译： 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。 化合物具有通式I，其中A 1，A 2，B，s，T，R 1，R 2， / SUP>，R 3和R 4在本文中定义。 本发明还包括药物组合物，其包含一种或多种式I化合物，使用方法，例如通过施用式I化合物或包含式I化合物的组合物治疗激酶介导的疾病，以及可用于制备 式Ⅰ的化合物。