公开(公告)号：US20210292823A1

公开(公告)日：2021-09-23

申请号：US16894664

申请日：2020-06-05

申请人： Feng Zhang ,  Jonathan Gootenberg ,  Omar Abudayyeh ,  Julia Joung ,  Alim Ladha ,  Han Altae-Tran ,  Guilhem Faure

发明人： Feng Zhang ,  Jonathan Gootenberg ,  Omar Abudayyeh ,  Julia Joung ,  Alim Ladha ,  Han Altae-Tran ,  Guilhem Faure

IPC分类号： C12Q1/6844 ,  B01L7/00 ,  B01L3/00

摘要： Systems and methods for rapid diagnostics related to the use of isothermal amplification reagents for detection of microbial species, including coronavirus, and methods of use, are provided.

公开(公告)号：US20210292824A1

公开(公告)日：2021-09-23

申请号：US16894670

申请日：2020-06-05

申请人： Feng Zhang ,  Jonathan Gootenberg ,  Omar Abudayyeh ,  Julia Joung ,  Alim Ladha ,  Han Altae-Tran ,  Guilhem Faure

发明人： Feng Zhang ,  Jonathan Gootenberg ,  Omar Abudayyeh ,  Julia Joung ,  Alim Ladha ,  Han Altae-Tran ,  Guilhem Faure

IPC分类号： C12Q1/6844 ,  C12N9/22 ,  C12Q1/6806

摘要： Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.

公开(公告)号：US20210292721A1

公开(公告)日：2021-09-23

申请号：US16894678

申请日：2020-06-05

申请人： Feng Zhang ,  Jonathan Gootenberg ,  Omar Abudayyeh ,  Julia Joung ,  Alim Ladha ,  Han Altae-Tran ,  Guilhem Faure

发明人： Feng Zhang ,  Jonathan Gootenberg ,  Omar Abudayyeh ,  Julia Joung ,  Alim Ladha ,  Han Altae-Tran ,  Guilhem Faure

IPC分类号： C12N9/22 ,  C12N9/12 ,  C12N9/78

摘要： Engineered or non-naturally occurring systems and compositions comprising a novel Cas12b and a guide molecule. Also provided include methods of use the systems and compositions, including in treating and diagnosing diseases.

公开(公告)号：USD1049124S1

公开(公告)日：2024-10-29

申请号：US29839353

申请日：2022-05-20

申请人： Feng Zhang

设计人： Feng Zhang

摘要： FIG. 1 is a perspective view of a mouse mover showing my new design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a top view thereof;
FIG. 7 is a bottom view thereof; and,
FIG. 8 is a rear side perspective view thereof.
The broken lines in the drawings depict portions of the mouse mover that form no part of the claimed design.

公开(公告)号：US20240304619A1

公开(公告)日：2024-09-12

申请号：US18181155

申请日：2023-03-09

申请人： Guowei Xu ,  Chiao-Ti Huang ,  Robin Chao ,  Tao Chu ,  Feng Zhang ,  Yang Zhang ,  Biswajeet Guha ,  Oleg Golonzka

发明人： Guowei Xu ,  Chiao-Ti Huang ,  Robin Chao ,  Tao Chu ,  Feng Zhang ,  Yang Zhang ,  Biswajeet Guha ,  Oleg Golonzka

IPC分类号： H01L27/088 ,  H01L21/8234 ,  H01L29/06 ,  H01L29/417 ,  H01L29/66 ,  H01L29/778 ,  H01L29/78

CPC分类号： H01L27/0886 ,  H01L21/823431 ,  H01L29/0665 ,  H01L29/41791 ,  H01L29/66795 ,  H01L29/778 ,  H01L29/7851

摘要： An IC device includes a backside FTI separating a first transistor from a second transistor. The FTI may be between a source region of the first transistor and a drain region of the second transistor. The source region of the first transistor and the drain region of the second transistor may be different portions of a semiconductor structure, e.g., a fin or nanoribbon. The IC device may also include a frontside metal layer. The semiconductor structure may have a first surface and a second surface opposing the first surface. The first surface of the semiconductor structure may be closer to the metal layer and larger than the second surface of the semiconductor structure. The FTI may have a first surface and a second surface opposing the first surface. The first surface of the FTI may be closer to the metal layer but smaller than the second surface of the FTI.

公开(公告)号：US11408978B2

公开(公告)日：2022-08-09

申请号：US16871006

申请日：2020-05-10

申请人： Fengyu Wang ,  Beibei Wang ,  Chenshu Wu ,  Feng Zhang ,  K. J. Ray Liu ,  Oscar Chi-Lim Au

发明人： Fengyu Wang ,  Beibei Wang ,  Chenshu Wu ,  Feng Zhang ,  K. J. Ray Liu ,  Oscar Chi-Lim Au

IPC分类号： G01S7/41 ,  A61B5/08 ,  A61B5/024 ,  A61B5/00 ,  A61B5/11 ,  G01S13/00 ,  A61B5/0245 ,  A61B5/05

摘要： Methods, apparatus and systems for wireless vital signs monitoring are described. In one embodiment, a described system comprises: a transmitter, a receiver, a processor. The transmitter transmits, using N1 transmit antennas, a wireless signal through a wireless multipath channel of a venue, while a first object in the venue is having a first repetitive motion. The receiver receives, using N2 receive antennas, the wireless signal through the wireless multipath channel, and extracts a plurality of time series of channel information (TSCI) of the wireless multipath channel from the wireless signal. N1 and N2 are positive integers. Each of the plurality of TSCI is associated with a transmit antenna of the transmitter and a receive antenna of the receiver. The processor computes a first information of the first repetitive motion based on the plurality of TSCI, and monitors the first repetitive motion of the first object based on the first information.

公开(公告)号：US20210215789A1

公开(公告)日：2021-07-15

申请号：US17214841

申请日：2021-03-27

申请人： Yuqian Hu ,  Beibei Wang ,  Muhammed Zahid Ozturk ,  Feng Zhang ,  K. J. Ray Liu ,  Oscar Chi-Lim Au ,  Xiaolu Zeng ,  Chenshu Wu ,  Fengyu Wang

发明人： Yuqian Hu ,  Beibei Wang ,  Muhammed Zahid Ozturk ,  Feng Zhang ,  K. J. Ray Liu ,  Oscar Chi-Lim Au ,  Xiaolu Zeng ,  Chenshu Wu ,  Fengyu Wang

IPC分类号： G01S7/00 ,  G01S13/00 ,  G01S13/56 ,  G01S7/41

摘要： Methods, apparatus and systems for wireless proximity sensing are described. In one example, a described system comprises: a transmitter configured for transmitting a first wireless signal through a wireless multipath channel of a venue; a receiver configured for receiving a second wireless signal through the wireless multipath channel; and a processor. The second wireless signal differs from the first wireless signal due to the wireless multipath channel that is impacted by a movement of an object in the venue. The processor is configured for: obtaining a time series of channel information (TSCI) of the wireless multipath channel based on the second wireless signal, wherein each channel information (CI) of the TSCI comprises a plurality of CI components, each of which is associated with an index; computing an inter-component statistics based on the plurality of CI components; computing, based on the inter-component statistics, a proximity information of the object with respect to a reference location in the venue; and performing a task based on the proximity information of the object.

公开(公告)号：US11012285B2

公开(公告)日：2021-05-18

申请号：US16127151

申请日：2018-09-10

申请人： Chen Chen ,  Beibei Wang ,  Yi Han ,  Feng Zhang ,  Hung-Quoc Duc Lai ,  Yan Chen ,  K. J. Ray Liu ,  Oscar Chi-Lim Au

发明人： Chen Chen ,  Beibei Wang ,  Yi Han ,  Feng Zhang ,  Hung-Quoc Duc Lai ,  Yan Chen ,  K. J. Ray Liu ,  Oscar Chi-Lim Au

IPC分类号： H04L27/36 ,  H04W72/04 ,  H04B1/38 ,  H04L5/00

摘要： The present teaching relates to vital sign detection and monitoring based on channel state information (CSI). In one example, an apparatus for vital sign detection is disclosed. The apparatus comprises a receiver, a processor and a memory communicatively coupled with the processor. The receiver is configured for receiving at least one wireless signal from a multipath channel that can be impacted by a vital sign of at least one living being. The processor is configured for: extracting a time series of channel state information (CSI) for the multipath channel from the at least one wireless signal, obtaining one or more periodic fluctuations based on a spectral analysis of the time series of CSI, and determining whether the vital sign is present based on the one or more periodic fluctuations.

公开(公告)号：US09603848B2

公开(公告)日：2017-03-28

申请号：US11760592

申请日：2007-06-08

申请人： Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Catherine Tachdjian ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

发明人： Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Catherine Tachdjian ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

IPC分类号： A61K31/495 ,  A61K31/517 ,  A61K31/519 ,  C07D239/80 ,  C07D239/95 ,  C07D239/96 ,  C07D285/15 ,  C07D487/04 ,  C07D491/04 ,  G01N33/74 ,  G06F19/16 ,  G06F19/18

CPC分类号： A61K31/495 ,  A61K31/517 ,  A61K31/519 ,  C07D239/80 ,  C07D239/95 ,  C07D239/96 ,  C07D285/15 ,  C07D487/04 ,  C07D491/04 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/04 ,  G06F19/16 ,  G06F19/18

摘要： The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

公开(公告)号：US09370551B2

公开(公告)日：2016-06-21

申请号：US13557988

申请日：2012-07-25

申请人： Le Cong ,  Ann Marie Egloff ,  Levi A. Garraway ,  Jennifer Rubin Grandis ,  Eric S. Lander ,  Nicholas Stransky ,  Aaron D. Tward ,  Feng Zhang

发明人： Le Cong ,  Ann Marie Egloff ,  Levi A. Garraway ,  Jennifer Rubin Grandis ,  Eric S. Lander ,  Nicholas Stransky ,  Aaron D. Tward ,  Feng Zhang

IPC分类号： C12N15/85 ,  A61K38/16 ,  A61K38/46 ,  A61K45/06 ,  C07K14/47 ,  C12N9/22 ,  C12N15/90 ,  A61K48/00

CPC分类号： A61K38/164 ,  A61K38/465 ,  A61K45/06 ,  A61K48/005 ,  C07K14/4703 ,  C07K14/4705 ,  C07K2319/00 ,  C07K2319/70 ,  C07K2319/71 ,  C07K2319/80 ,  C12N9/22 ,  C12N15/907 ,  C12N2710/20011 ,  C12N2800/22 ,  C12N2999/007

摘要： The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features methods which may specifically target HNSCC-associated genes and alter gene expression to treat or alleviate a symptom of HNSCC, or its related premalignant lesions. These methods may involve decreasing the function of an HNSCC-associated gene with aberrant gain-of-function; or increasing the function of an HNSCC-associated gene with aberrant loss-of-function.

摘要翻译： 本发明提供了与头颈鳞状细胞癌（HNSCC）及其相关的恶化前病变相关的方法。 特别地，本发明的特征在于可以特异性靶向HNSCC相关基因并改变基因表达以治疗或缓解HNSCC或其相关的恶化前病变的症状的方法。 这些方法可能涉及降低具有异常增殖功能的HNSCC相关基因的功能; 或增加具有异常功能丧失的HNSCC相关基因的功能。