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14 条记录 (耗时 0.026 秒)

    Novel phenoxyaliphatylphenyleneoxyalkyl esters and amides
    1.
    发明授权
    Novel phenoxyaliphatylphenyleneoxyalkyl esters and amides 失效
    新型苯氧基亚芳基苯基氧基烷基酯和酰胺

    公开(公告)号：US4818766A

    公开(公告)日：1989-04-04

    申请号：US75156

    申请日：1987-07-20

    申请人： Franz Ostermayer ,  Markus Zimmermann

    发明人： Franz Ostermayer ,  Markus Zimmermann

    IPC分类号： A61K31/44 ,  A61K31/4427 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/02 ,  C07D211/90 ,  C07D401/12 ,  C07D413/12 ,  A61K31/455

    CPC分类号： C07D211/90

    摘要： The invention relates to novel 1,4-dihydropyridine-3-carboxylic acid phenoxyaliphatylphenyleneoxyalkyl esters of the formula ##STR1## in which Ac represents an acyl group, X represents oxy or optionally substituted imino, A represents a divalent aliphatic hydrocarbon radical interrupted by a group --X.sub.1 --Ph--X.sub.2 -- in which at least one of the radicals X.sub.1 and X.sub.2 represents oxy and a radical X.sub.1 or X.sub.2 that is other than oxy represents a direct bond, and Ph represents an optionally substituted phenylene radical, and R represents an optionally substituted phenyl, pyridyl or 1-oxidopyridyl, (1,3-dioxa)indanyl or benzofurazanyl radical, R.sub.1 represents an optionally substituted phenyl or indolyl radical, R.sub.2 represents an aliphatic hydrocarbon radical and R.sub.3 represents an aliphatic radical, cyano or amino, and acid addition salts thereof.

    摘要翻译： 本发明涉及式（Ⅰ）的新颖的1,4-二氢吡啶-3-羧酸苯氧基苯基苯基氧基烷基酯，其中Ac代表酰基，X代表氧基或任意取代的亚氨基，A代表二价脂族烃基中断 基团-X1-Ph-X2-，其中基团X1和X2中的至少一个表示氧，并且除氧以外的基团X 1或X 2表示直接键，并且Ph表示任选取代的亚苯基，R 表示任选取代的苯基，吡啶基或1-氧化吡啶基，（1,3-二氧杂）茚满基或苯并呋喃基，R1表示任选取代的苯基或吲哚基，R 2表示脂族烃基，R 3表示脂族基，氰基或氨基 ，及其酸加成盐。

    N-Alkylated aminoalcohols and their pharmaceutical compositions useful for the treatment of cardiac insufficiency
    6.
    发明授权
    N-Alkylated aminoalcohols and their pharmaceutical compositions useful for the treatment of cardiac insufficiency 失效
    N-烷基化氨基醇及其用于治疗心功能不全的药物组合物

    公开(公告)号：US4460580A

    公开(公告)日：1984-07-17

    申请号：US391814

    申请日：1982-06-24

    申请人： Franz Ostermayer ,  Markus Zimmermann

    发明人： Franz Ostermayer ,  Markus Zimmermann

    IPC分类号： A61K31/165 ,  A61P9/04 ,  A61P25/02 ,  C07C67/00 ,  C07C229/38 ,  C07C231/00 ,  C07C231/12 ,  C07C231/14 ,  C07C235/46 ,  C07C237/30 ,  C07D213/38 ,  C07D265/22 ,  C07D307/52 ,  C07D333/20 ,  C07D213/56 ,  A61K31/44

    CPC分类号： C07D265/22 ,  C07C229/38 ,  C07D213/38 ,  C07D307/52 ,  C07D333/20

    摘要： The invention relates to novel N-alkylated aminoalcohols of the formula ##STR1## in which Ar is a radical of aromatic character which is unsubstituted or substituted by hydroxyl, n has the values nought or 1 and Alk is an alkylene radical having 2 to 5 carbon atoms and the nitrogen atom and the oxygen atom or, if n is nought, the salicylamide radical are separated from one another by at least two carbon atoms in the straight-chain, and their salts. The main action of the novel compounds consists in a stimulation of cardiac .beta.-receptors; the compounds also effect a blockage of adrenergic .alpha.-receptors and a lowering in the blood pressure. They can therefore be used as .beta.-stimulators, especially as agents having a positively inotropic action for the treatment of cardiac insufficiency. Compounds of the formula I in which Ar is phenyl, unsubstituted or substituted by 1 or 2 hydroxyl groups, Alk is an alkylene radical having 2 to 4 carbon atoms, n has the value 1, and the nitrogen atom and the oxygen atom are separated from one another by at least 2 carbon atoms in the straight-chain, or salts thereof, exhibit effects on the central nervous system, which are reflected for example in the suppression of the symptoms of impaired sympathetic functions and in the suppression of lack of initiative. Such compounds of the formula I therefore can be used for the treatment of reactive or endogenic states of depression of varying degrees of severity, and also for the treatment of neurotic or other psychic disturbances involving loss of initiative and depressive disorders. Such compounds can also be used for the short-term treatment of post-partum or postoperative depression, or of depression of different origin. Such compounds of the formula I can be used on their own or in combination with other antidepressants.

    摘要翻译： 本发明涉及式（I）的新型N-烷基化氨基醇，其中Ar是未被取代或被羟基取代的芳族基团，n的值不为1，Alk为具有2个的亚烷基 至5个碳原子和氮原子和氧原子，或者如果n无效，则水杨酰胺基团通过直链中的至少两个碳原子和它们的盐彼此分离。 新化合物的主要作用在于刺激心脏β受体; 该化合物还会影响肾上腺素α受体的阻断和降低血压。 因此，它们可以用作β-刺激剂，特别是作为具有正性肌力作用的药物用于治疗心功能不全。 其中Ar为未取代或被1或2个羟基取代的苯基的式I化合物，Alk为碳原子数2〜4的亚烷基，n为1，氮原子和氧原子与 直链中至少有2个碳原子或其盐，彼此之间呈现对中枢神经系统的作用，例如反映在抑制交感神经功能受损症状和抑制缺乏主动性的作用。 因此，式I的这种化合物可用于治疗不同程度的严重程度的抑郁症的反应性或内源性状态，并且还可用于治疗涉及主动性和抑郁障碍丧失的神经质或其他心理障碍。 这些化合物也可用于短期治疗产后或术后抑郁症或不同来源的抑郁症。 式I化合物可以单独使用或与其它抗抑郁药组合使用。

    N-Oxide compounds useful in the treatment of cardiovascular ailments
    7.
    发明授权
    N-Oxide compounds useful in the treatment of cardiovascular ailments 失效
    可用于治疗心血管疾病的N-氧化物化合物

    公开(公告)号：US4497808A

    公开(公告)日：1985-02-05

    申请号：US453393

    申请日：1982-12-27

    申请人： Markus Zimmermann ,  Hans Kuhnis

    发明人： Markus Zimmermann ,  Hans Kuhnis

    IPC分类号： A61K31/445 ,  C07D213/89 ,  C07D401/04 ,  C07D491/04 ,  C07D491/048 ,  A61K31/44

    CPC分类号： C07D213/89 ,  C07D401/04 ,  C07D491/04

    摘要： The present invention relates to novel N-oxide compounds that have cardiovascular properties, especially antihypertensive activity, and that correspond to the formula ##STR1## in which Py represents an unsubstituted or substituted N-oxidopyridyl radical, R.sub.1 represents hydrogen or unsubstituted or substituted lower alkyl, one of the radicals R.sub.2 and R.sub.3 represents lower alkyl and the other represents hydrogen; lower alkyl; lower alkyl containing free, etherified or esterified hydroxy, oxo, functionally modified carboxy or free or substituted amino or imino; functionally modified carboxy; or free or substituted amino, it being possible for an amino group R.sub.2 or R.sub.3 to be bonded to a lower alkyl radical R.sub.1 or, if R.sub.2 or R.sub.3 represents, for example, hydroxy-lower alkyl, for this hydroxy-lower alkyl, together with the adjacent acyl radical Ac.sub.1 or Ac.sub.2, to form a 2-oxa-1-oxo-lower alkylene radical, the carbonyl group of which is bonded to the 3- or 5-ring carbon atom of the 1,4-dihydropyridine ring, and each of the groups Ac.sub.1 and Ac.sub.2 represents, independently of the other, the acyl radical of an acid, and salts of compounds of the formula I having salt-forming groups, processes for the manufacture of these compounds, the use of these compounds and their salts, and pharmaceutical preparations which contain these compounds and salts, as antihypertensive agents and coronary dilators for the treatment of cardiovascular conditions, such as hypertonia, vascular constrictions, Angina pectoris and cardiac insufficiency.

    摘要翻译： 本发明涉及具有心血管特性，特别是抗高血压活性的新型N-氧化物化合物，其对应于其中Py表示未取代或取代的N-氧化吡啶基的式（I），R 1表示氢或未取代的或未取代的 取代的低级烷基，基团R2和R3之一表示低级烷基，另一个表示氢; 低级烷基 含有游离的醚化或酯化的羟基，氧代，官能改性的羧基或游离或取代的氨基或亚氨基的低级烷基; 官能改性羧基; 或游离或取代的氨基，氨基R2或R3可以与低级烷基R1键合，或者如果R2或R3表示例如羟基 - 低级烷基，对于该羟基 - 低级烷基，连同 相邻的酰基Ac1或Ac2形成2-氧杂-1-氧代 - 低级亚烷基，其羰基与1,4-二氢吡啶环的3-或5-环碳原子键合，以及 Ac1和Ac2各自独立地表示酸的酰基，以及具有成盐基团的式I化合物的盐，这些化合物的制备方法，这些化合物的用途及其制备方法 盐，以及含有这些化合物和盐的药物制剂作为抗高血压剂和用于治疗心血管疾病如高血压，血管收缩，心绞痛和心功能不全的冠状动脉扩张剂。

    Slipform Paver
    8.
    发明申请
    Slipform Paver 有权
    滑移摊铺机

    公开(公告)号：US20120128417A1

    公开(公告)日：2012-05-24

    申请号：US13292271

    申请日：2011-11-09

    申请人： Markus Zimmermann ,  Ralf Schug ,  Cyrus Barimani ,  Guenter Haehn

    发明人： Markus Zimmermann ,  Ralf Schug ,  Cyrus Barimani ,  Guenter Haehn

    IPC分类号： E01C19/22 ,  E01C11/00 ,  E04G21/10

    CPC分类号： E01C19/4886 ,  E01C7/00 ,  E01C19/004 ,  E01C19/4893 ,  E01C19/502 ,  E01C23/00 ,  E01C2301/00

    摘要： The invention relates to a slipform paver having a chassis 2 able to be adjusted in the heightwise direction and having a mounting unit 10 arranged on the chassis for fastening on an arrangement 8 for molding flowable material. The slipform paver according to the invention is characterised in that the mounting unit 10 for fastening on the concrete mold 8 is mounted on the chassis 2 of the paver to be pivotable on an axis 14 extending in the direction of operation of the slipform paver. To produce parts of a structure whose orientation varies along their length, the concrete mold fastened 8 to the mounting unit is pivoted on the axis of pivot 14 by means of a pivoter unit 15 whereas the chassis of the paver maintains its orientation.

    摘要翻译： 本发明涉及一种具有能够在高度方向上调节的底盘2的滑动摊铺机，并且具有布置在底盘上的安装单元10，用于紧固在用于模制可流动材料的装置8上。 根据本发明的滑模摊铺机的特征在于，用于紧固在混凝土模具8上的安装单元10安装在摊铺机的底盘2上，以便在滑动摊铺机的操作方向上延伸的轴线14上枢转。 为了生产其取向沿其长度方向变化的结构的部件，通过枢轴单元15将紧固在安装单元8上的混凝土模具枢转在枢轴14的轴线上，而摊铺机的底盘保持其定向。

    3,5-Diacyl-4-aryl-1,4 dihydropyridine derivatives, their uses and compositions
    9.
    发明授权
    3,5-Diacyl-4-aryl-1,4 dihydropyridine derivatives, their uses and compositions 失效
    3,5-二酰基-4-芳基-1,4-二氢吡啶衍生物，其用途和组成

    公开(公告)号：US4853393A

    公开(公告)日：1989-08-01

    申请号：US139407

    申请日：1987-12-30

    申请人： Markus Zimmermann

    发明人： Markus Zimmermann

    IPC分类号： C07D211/14 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/455 ,  A61P3/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/12 ,  A61P25/02 ,  A61P43/00 ,  C07D211/32 ,  C07D211/90 ,  C07D333/00 ,  C07D401/12 ,  C07D401/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14

    CPC分类号： C07D401/12 ,  C07D211/90 ,  C07D409/14 ,  C07D413/14

    摘要： Compounds of the formula ##STR1## in which R represents a carbocyclic or heterocyclic aryl radical,R.sub.1 represents lower alkyl, one of the groups R.sub.2 and R.sub.3 represents lower alkyl and the other represents lower alkyl, cyano or amino,X represents oxygen or the group --NH--, andAlk represents lower alkylene which separates the group X from the ring nitrogen atom by at least two carbon atoms,Y represents the group --CHOH-- or --(C.dbd.O)--, andAr.sub.1 represents a monocyclic aryl or heteroaryl radical,Ar.sub.1 being other than unsubstituted phenyl ifR.sub.1, R.sub.2 and R.sub.3 each represents lower alkyl, X represents oxygen, Alk represents straight-chain alkylene having from 2 to 4 carbon atoms, Y represents the group --(C.dbd.O)-- and R has the meaning given, and salts thereof have cardiovascular, especially coronary-dilatory and antihypertensive properties.

    摘要翻译： 式（I）的化合物，其中R表示碳环或杂环芳基，R1表示低级烷基，R2和R3之一表示低级烷基，另一个表示低级烷基，氰基或氨基，X表示氧 或基团-NH-，Alk表示将基团X与环氮原子分开至少两个碳原子的低级亚烷基，Y表示基团-CHOH-或 - （C = O） - ，Ar1表示单环 芳基或杂芳基，如果R 1，R 2和R 3表示低级烷基，则X 1表示未被取代的苯基，X代表氧，Alk表示具有2至4个碳原子的直链亚烷基，Y表示 - （C = O） - 并且R具有给定的含义，并且其盐具有心血管，特别是冠状血管扩张和抗高血压特性。

    Unit for laminating a first web onto a second web in a laminating machine and method for manufacturing a multi-layer composite
    10.
    发明授权
    Unit for laminating a first web onto a second web in a laminating machine and method for manufacturing a multi-layer composite 有权
    用于在层压机中将第一纤维网层压到第二纤维网上的单元和用于制造多层复合材料的方法

    公开(公告)号：US09327485B2

    公开(公告)日：2016-05-03

    申请号：US13623993

    申请日：2012-09-21

    申请人： Alex Mann ,  Markus Zimmermann ,  Adrianus Jongmans

    发明人： Alex Mann ,  Markus Zimmermann ,  Adrianus Jongmans

    IPC分类号： B32B41/00 ,  B32B38/18 ,  B31F1/28 ,  B32B37/00 ,  B32B37/10 ,  B32B38/00

    CPC分类号： B32B38/1841 ,  B31F1/2836 ,  B31F1/2881 ,  B32B37/0053 ,  B32B37/1054 ,  B32B38/145 ,  B32B38/1858 ,  B32B2309/72 ,  B32B2317/127 ,  B32B2553/00

    摘要： A laminating unit to manufacture a multi-layer composite (2) in a laminating machine (1), comprising a laminating rotating roll (16), laminating a first web (3) onto a second web (4), is characterized in that it further comprises: driving means (42), rotating (R) the roll (16); gripping means (39, 41), maintaining the first web (3) in contact with the roll (16); first detection means (43, 46) emitting first detection signals (44, 47) in accordance with detected longitudinal positions of the first web (3); second detection means (48, 51) emitting second detection signals (49, 52) in accordance with detected longitudinal positions of the second web (4); and control means (53), regulating a rotation speed of the driving means (42) and of the roll (16) as a function of the first and second signals (44, 47, 49, 52), to convey, correct longitudinally positions of the first web (3), and laminate the first web (3) in register onto the second web (4).

    摘要翻译： 一种用于在层压机（1）中制造多层复合材料（2）的层压单元，其包括层压旋转辊（16），将第一纤维网（3）层压到第二纤维网（4）上，其特征在于： 进一步包括：旋转辊（16）的驱动装置（42）; 夹持装置（39,41），保持第一卷筒纸（3）与卷筒（16）接触; 第一检测装置（43,46）根据检测到的第一幅材（3）的纵向位置发射第一检测信号（44,47）; 第二检测装置（48,51）根据检测到的第二幅材（4）的纵向位置发射第二检测信号（49,52）。 以及根据所述第一和第二信号（44,47,49,52）调节所述驱动装置（42）和所述卷（16）的旋转速度的控制装置（53），以传送，校正纵向位置 的第一网（3），并且将第一网（3）对准到第二网（4）上。