利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

20 条记录 (耗时 0.026 秒)

    Amino acid and peptide conjugates of amiloride and methods of use thereof
    1.
    发明授权
    Amino acid and peptide conjugates of amiloride and methods of use thereof 有权
    阿米洛利的氨基酸和肽缀合物及其使用方法

    公开(公告)号：US07863415B2

    公开(公告)日：2011-01-04

    申请号：US11040831

    申请日：2005-01-21

    申请人： Fredric A. Gorin ,  Michael H. Nantz

    发明人： Fredric A. Gorin ,  Michael H. Nantz

    IPC分类号： A61K38/04 ,  A61K38/00

    CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K47/542 ,  A61K47/555 ,  A61K47/64

    摘要： The present invention provides compositions comprising amiloride amino acid and peptide conjugates. Efficient methods are also provided for administering the amiloride conjugates of the present invention for treating cancer or a central nervous system disease or disorder or for preventing or reducing ischemia-reperfusion injury. Further, kits are provided for the treatment of a central nervous system disease or disorder or for the prevention or reduction of ischemia-reperfusion injury using the amiloride conjugates of the present invention.

    摘要翻译： 本发明提供了包含阿米洛利氨基酸和肽缀合物的组合物。 还提供了有效的方法用于施用本发明的用于治疗癌症或中枢神经系统疾病或病症或用于预防或减少缺血再灌注损伤的阿米洛利共轭物。 此外，提供了用于治疗中枢神经系统疾病或病症或使用本发明的阿米洛利共轭物预防或减少缺血再灌注损伤的试剂盒。

    AMINO ACID AND PEPTIDE CONJUGATES OF AMILORIDE AND METHODS OF USE THEREOF
    4.
    发明申请
    AMINO ACID AND PEPTIDE CONJUGATES OF AMILORIDE AND METHODS OF USE THEREOF 审中-公开
    氨基酸和胰岛素联合用药及其使用方法

    公开(公告)号：US20110195907A1

    公开(公告)日：2011-08-11

    申请号：US12983850

    申请日：2011-01-03

    申请人： Fredric A. Gorin ,  Michael H. Nantz

    发明人： Fredric A. Gorin ,  Michael H. Nantz

    IPC分类号： A61K38/08 ,  A61P35/00 ,  A61K31/4965 ,  A61P25/00

    CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K47/542 ,  A61K47/555 ,  A61K47/64

    摘要： The present invention provides compositions comprising amiloride amino acid and peptide conjugates. Efficient methods are also provided for administering the amiloride conjugates of the present invention for treating cancer or a central nervous system disease or disorder or for preventing or reducing ischemia-reperfusion injury. Further, kits are provided for the treatment of a central nervous system disease or disorder or for the prevention or reduction of ischemia-reperfusion injury using the amiloride conjugates of the present invention.

    摘要翻译： 本发明提供了包含阿米洛利氨基酸和肽缀合物的组合物。 还提供了有效的方法用于施用本发明的用于治疗癌症或中枢神经系统疾病或病症或用于预防或减少缺血再灌注损伤的阿米洛利共轭物。 此外，提供了用于治疗中枢神经系统疾病或病症或使用本发明的阿米洛利共轭物预防或减少缺血再灌注损伤的试剂盒。

    Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin: polynucleotide transfection complexes
    6.
    发明授权
    Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin: polynucleotide transfection complexes 失效
    多功能阳离子细胞增生素，用于产生活性细胞色素的制剂和方法：多核苷酸转染复合物

    公开(公告)号：US5824812A

    公开(公告)日：1998-10-20

    申请号：US710350

    申请日：1996-09-17

    申请人： Michael H. Nantz ,  Michael J. Bennett ,  Rajiv P. Balasubramaniam ,  Alfred M. Aberle ,  Robert W. Malone

    发明人： Michael H. Nantz ,  Michael J. Bennett ,  Rajiv P. Balasubramaniam ,  Alfred M. Aberle ,  Robert W. Malone

    IPC分类号： A61K9/127 ,  A61K47/48 ,  C07C217/28 ,  C07C217/42 ,  C07C219/06 ,  C07C219/08 ,  C07H21/00 ,  C07C101/00

    CPC分类号： C07H21/00 ,  A61K47/48023 ,  A61K47/48046 ,  A61K9/1272 ,  C07C217/28 ,  C07C217/42 ,  C07C219/06 ,  C07C219/08

    摘要： Amine containing compounds and their use in the generation of cytofectin:polynucleotide complexes for transfection of cells, formulations, counterions, and reaction conditions for maximizing the transfection include using cationic amine compounds that have the general structure: ##STR1## wherein R.sub.4 and R.sub.5 are a pair of same or different lipoyl moieties selected from a group consisting of an alkyl, alkenyl, alkynyl, alkanoyl, alkenoyl, or alkynoyl groups and for R.sub.1, R.sub.2, and R.sub.3 at least two are hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl groups or at least one amine bonded halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group or a mixture of at least one halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group and at least one hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl group, and X.sup.- is an oxyanion or halide counterion or ##STR2## wherein a, b, or d are the same or different and are from 0-10, usually between 0 and 3, preferably 0 or 1; R.sub.4 and R.sub.5 are the same or different with each an alkyl group, an alkenyl group, an alkynyl group, or an alkyl, alkenyl, or alkynyl containing acyl group; R.sub.8, R.sub.9, or R.sub.10 are the same or different with each an alkyl, alkenyl, or alkynyl group or halogenated alkyl, alkenyl, or alkynyl group as long as one is halogen containing; and X.sup.- is an anion, usually an oxyanion or halide counterion.

    摘要翻译： 含胺化合物及其在产生细胞分裂素中的用途：用于转染细胞的多核苷酸复合物，制剂，抗衡离子和用于使转染最大化的反应条件包括使用具有以下通用结构的阳离子胺化合物：其中R 4和R 5为 一对相同或不同的选自烷基，烯基，炔基，烷酰基，烯酰基或炔酰基的脂酰基部分，对于R1，R2和R3至少两个是羟基化的，含醚的或含酰氧基的烷基，烯基 ，或炔基或至少一个与胺键合的含卤素的部分，其选自卤代烷基，烯基或炔基，或至少一种含卤素部分的混合物，所述部分选自卤代烷基，烯基， 或炔基和至少一个羟基化的含醚或含酰氧基的烷基，烯基或炔基，X是氧阴离子或卤化物 其中a，b或d相同或不同，为0-10，通常为0至3，优选为0或1; R4和R5与烷基，烯基，炔基或含酰基的烷基，链烯基或炔基相同或不同; R8，R9或R10与烷基，烯基或炔基或卤代烷基，烯基或炔基相同或不同，只要一个为含卤素; X-是阴离子，通常是氧阴离子或卤离子抗衡离子。

    Site specific fluorescence and contrast marker for same
    7.
    发明授权
    Site specific fluorescence and contrast marker for same 有权
    场地特异性荧光和对比度标记相同

    公开(公告)号：US08758727B2

    公开(公告)日：2014-06-24

    申请号：US12935336

    申请日：2009-03-31

    申请人： Kyung A. Kang ,  Michael H. Nantz

    发明人： Kyung A. Kang ,  Michael H. Nantz

    IPC分类号： A61B5/00 ,  C12Q1/02

    CPC分类号： A61K49/0065 ,  A61K47/54 ,  A61K47/6923 ,  A61K49/0034

    摘要： A contrast marker for indicating a presence of a target cell in an environment comprises a fluorophore, an NMP, and a short spacer and a long spacer linking the fluorophore to the NMP. The short spacer holds the fluorophore at a quenching distance from the NMP and the long spacer holds the fluorophore at a fluorescence enhancing distance from the NMP. The short spacer is configured to be cleaved by a molecule characterizing the target cells.

    摘要翻译： 用于指示环境中靶细胞存在的对比标记物包括荧光团，NMP和短间隔物以及将荧光团连接到NMP的长间隔物。 短间隔物将荧光团保持在与NMP的淬灭距离处，并且长间隔物使荧光团保持与NMP的荧光增强距离。 短间隔物被构造成被表征靶细胞的分子裂解。

    SITE SPECIFIC FLUORESCENCE AND CONTRAST MARKER FOR SAME
    8.
    发明申请
    SITE SPECIFIC FLUORESCENCE AND CONTRAST MARKER FOR SAME 有权
    同一地点特定荧光和对比标记

    公开(公告)号：US20110104070A1

    公开(公告)日：2011-05-05

    申请号：US12935336

    申请日：2009-03-31

    申请人： Kyung A. Kang ,  Michael H. Nantz

    发明人： Kyung A. Kang ,  Michael H. Nantz

    IPC分类号： A61K49/00 ,  C12Q1/02 ,  C12M1/34 ,  G01N33/53

    CPC分类号： A61K49/0065 ,  A61K47/54 ,  A61K47/6923 ,  A61K49/0034

    摘要： A contrast marker for indicating a presence of a target cell in an environment comprises a fluorophore, an NMP, and a short spacer and a long spacer linking the fluorophore to the NMP. The short spacer holds the fluorophore at a quenching distance from the NMP and the long spacer holds the fluorophore at a fluorescence enhancing distance from the NMP. The short spacer is configured to be cleaved by a molecule characterizing the target cells.

    摘要翻译： 用于指示环境中靶细胞存在的对比标记物包括荧光团，NMP和短间隔物以及将荧光团连接到NMP的长间隔物。 短间隔物将荧光团保持在与NMP的淬灭距离处，并且长间隔物使荧光团保持与NMP的荧光增强距离。 短间隔物被构造成被表征靶细胞的分子裂解。