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公开(公告)号：US20170153223A1
公开(公告)日：2017-06-01
申请号：US14956067
申请日：2015-12-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
CPC classification number: G01N33/5002 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L3/502769 , B01L2200/0647 , B01L2300/16 , C12Q1/24 , G01N33/491
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US09150907B2
公开(公告)日：2015-10-06
申请号：US14277836
申请日：2014-05-15
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kashan Ali Shaikh , Mengli Wang , Adriana Ines Larriera Moreno , Jessica Godin Karp , Christine Lynne Pitner
IPC: G01N1/28 , G01N21/64 , C12Q1/68 , G01N33/543 , B01L3/00 , B01L9/00 , B32B37/00 , B32B37/18 , B32B38/00
CPC classification number: C12Q1/6813 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B32B37/0076 , B32B37/182 , B32B38/0008 , B32B2535/00 , G01N33/54306
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 流体连接器是能够连接到流体输送系统的薄膜流体连接器。 子组件可以密封在固体支撑件上以形成流动池。 还公开了使用方法。
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公开(公告)号：US20140248618A1
公开(公告)日：2014-09-04
申请号：US14277836
申请日：2014-05-15
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kashan Ali Shaikh , Mengli Wang , Adriana Ines Larriera Moreno , Jessica Godin Karp , Christine Lynne Pitner
IPC: C12Q1/68 , G01N33/543
CPC classification number: C12Q1/6813 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B32B37/0076 , B32B37/182 , B32B38/0008 , B32B2535/00 , G01N33/54306
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 流体连接器是能够连接到流体输送系统的薄膜流体连接器。 子组件可以密封在固体支撑件上以形成流动池。 还公开了使用方法。
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Patent Agency Ranking
公开(公告)号：US10859563B2
公开(公告)日：2020-12-08
申请号：US14956067
申请日：2015-12-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US11821891B2
公开(公告)日：2023-11-21
申请号：US17113527
申请日：2020-12-07
Applicant: General Electric Company
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
CPC classification number: G01N33/5002 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L3/502769 , C12Q1/24 , G01N33/491 , B01D2313/18 , B01D2313/50 , B01L2200/0647 , B01L2300/16 , G01N2001/4088
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US20210088503A1
公开(公告)日：2021-03-25
申请号：US17113527
申请日：2020-12-07
Applicant: General Electric Company
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US09080941B2
公开(公告)日：2015-07-14
申请号：US14277503
申请日：2014-05-14
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kashan Ali Shaikh , Mengli Wang , Adriana Ines Larriera Moreno , Jessica Godin Karp , Christine Lynne Pitner
CPC classification number: G01N21/05 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0655 , B32B37/0076 , B32B37/182 , B32B38/0008 , B32B2535/00 , C12Q1/6841 , G01N2021/058
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. As configured, the subassembly comprises a substrate layer forms a flexible optically transparent lid which is capable of bending in either direction to alter the internal dimensions of the subassembly. Methods of use are also disclosed.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 如所配置的，子组件包括基底层，形成柔性的光学透明盖，该盖能够沿任一方向弯曲以改变子组件的内部尺寸。 还公开了使用方法。
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公开(公告)号：US20140248617A1
公开(公告)日：2014-09-04
申请号：US14277503
申请日：2014-05-14
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kashan Ali Shaikh , Mengli Wang , Adriana Ines Larriera Moreno , Jessica Godin Karp , Christine Lynne Pitner
CPC classification number: G01N21/05 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0655 , B32B37/0076 , B32B37/182 , B32B38/0008 , B32B2535/00 , C12Q1/6841 , G01N2021/058
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. As configured, the subassembly comprises a substrate layer forms a flexible optically transparent lid which is capable of bending in either direction to alter the internal dimensions of the subassembly. Methods of use are also disclosed.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 如所配置的，子组件包括基底层，形成柔性的光学透明盖，该盖能够沿任一方向弯曲以改变子组件的内部尺寸。 还公开了使用方法。
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