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公开(公告)号：US10139259B2
公开(公告)日：2018-11-27
申请号：US15332757
申请日：2016-10-24
Applicant: General Electric Company
Inventor： Nannan Chen , Ertugrul Berkcan , Mengli Wang , Roman Leon Artiuch
Abstract: A system for metering gas a fluid stream includes a primary conduit and a secondary conduit coupled to the primary conduit such that the secondary conduit receives a portion of a fluid stream passing through the primary conduit. A flow manager disposed in the primary conduit is configured to maintain a predetermined relationship between at least one first physical characteristic of the fluid stream and at least one second physical characteristic of the portion of the fluid stream. A sensor measures a flow characteristic of the portion of the fluid stream and a processor determines a flow parameter of the fluid stream based, at least in part, on the predetermined relationship and one of an amplitude or temporal characteristic of the electrical signal.
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公开(公告)号：US20170038237A1
公开(公告)日：2017-02-09
申请号：US15332757
申请日：2016-10-24
Applicant: General Electric Company
Inventor： Nannan Chen , Ertugrul Berkcan , Mengli Wang , Roman Leon Artiuch
CPC classification number: G01F5/00 , E21B43/34 , F17D1/00 , G01F25/0007 , G01N33/0062
Abstract: A system for metering gas a fluid stream includes a primary conduit and a secondary conduit coupled to the primary conduit such that the secondary conduit receives a portion of a fluid stream passing through the primary conduit. A flow manager disposed in the primary conduit is configured to maintain a predetermined relationship between at least one first physical characteristic of the fluid stream and at least one second physical characteristic of the portion of the fluid stream. A sensor measures a flow characteristic of the portion of the fluid stream and a processor determines a flow parameter of the fluid stream based, at least in part, on the predetermined relationship and one of an amplitude or temporal characteristic of the electrical signal.
Abstract translation: 用于计量流体流的气体的系统包括主导管和耦合到主导管的次级导管，使得次级导管接收通过主导管的流体流的一部分。 布置在主导管中的流动管理器构造成保持流体流的至少一个第一物理特性与流体流的该部分的至少一个第二物理特性之间的预定关系。 传感器测量流体流的该部分的流动特性，并且处理器至少部分地基于电信号的预定关系和振幅或时间特性之一来确定流体流的流动参数。
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公开(公告)号：US20140248618A1
公开(公告)日：2014-09-04
申请号：US14277836
申请日：2014-05-15
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kashan Ali Shaikh , Mengli Wang , Adriana Ines Larriera Moreno , Jessica Godin Karp , Christine Lynne Pitner
IPC: C12Q1/68 , G01N33/543
CPC classification number: C12Q1/6813 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B32B37/0076 , B32B37/182 , B32B38/0008 , B32B2535/00 , G01N33/54306
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 流体连接器是能够连接到流体输送系统的薄膜流体连接器。 子组件可以密封在固体支撑件上以形成流动池。 还公开了使用方法。
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公开(公告)号：US10859563B2
公开(公告)日：2020-12-08
申请号：US14956067
申请日：2015-12-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US20170276527A1
公开(公告)日：2017-09-28
申请号：US15081265
申请日：2016-03-25
Applicant: General Electric Company
Inventor： Cheng-Po Chen , Nannan Chen , Mengli Wang
IPC: G01F1/684
CPC classification number: G01F1/6847 , G01F1/32 , G01F1/6842 , G01F1/6965 , G01F1/6986 , G01F5/00 , G01F7/00 , G01F25/0007
Abstract: A system for metering gas includes a flow sensor and a controller. The flow sensor is disposed in a conduit in fluid connection with a flow of a gas through the conduit. The flow sensor includes a heater and a temperature sensing element, and generates an electrical output based on the flow of the gas. The controller controls operation of the heater and is operable in a pre-measurement mode and multiple measurement modes. The controller in the pre-measurement mode operates the heater at a pre-measurement setting. The controller in the measurement modes operates the heater at corresponding measurement settings that have increased power levels and/or increased operating durations relative to the pre-measurement setting. The controller in the measurement modes is configured to determine a flow rate of the gas based on an amplitude characteristic and/or a temporal characteristic of the electrical output of the flow sensor.
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Patent Agency Ranking
公开(公告)号：US20190257853A1
公开(公告)日：2019-08-22
申请号：US15968668
申请日：2018-05-01
Applicant: General Electric Company
Inventor： William Albert Challener , Mengli Wang
IPC: G01P15/093 , G02B26/02 , G01H9/00
Abstract: An accelerometer includes a membrane, an energy source producing a laser beam which is directed at the membrane causing it to vibrate, and a transparent cap disposed at one end of the energy source. The accelerometer includes a first controller for adjusting an output power of the energy source in a first feedback loop, a second controller for controlling the wavelength of the laser beam in a second feedback loop, and a detector sensing a reflected portion of the laser beam. An acceleration signal is based in part on the frequency of the reflected portion of the laser beam.
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公开(公告)号：US20170153223A1
公开(公告)日：2017-06-01
申请号：US14956067
申请日：2015-12-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
CPC classification number: G01N33/5002 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L3/502769 , B01L2200/0647 , B01L2300/16 , C12Q1/24 , G01N33/491
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US09150907B2
公开(公告)日：2015-10-06
申请号：US14277836
申请日：2014-05-15
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kashan Ali Shaikh , Mengli Wang , Adriana Ines Larriera Moreno , Jessica Godin Karp , Christine Lynne Pitner
IPC: G01N1/28 , G01N21/64 , C12Q1/68 , G01N33/543 , B01L3/00 , B01L9/00 , B32B37/00 , B32B37/18 , B32B38/00
CPC classification number: C12Q1/6813 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B32B37/0076 , B32B37/182 , B32B38/0008 , B32B2535/00 , G01N33/54306
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 流体连接器是能够连接到流体输送系统的薄膜流体连接器。 子组件可以密封在固体支撑件上以形成流动池。 还公开了使用方法。
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公开(公告)号：US11821891B2
公开(公告)日：2023-11-21
申请号：US17113527
申请日：2020-12-07
Applicant: General Electric Company
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
CPC classification number: G01N33/5002 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L3/502769 , C12Q1/24 , G01N33/491 , B01D2313/18 , B01D2313/50 , B01L2200/0647 , B01L2300/16 , G01N2001/4088
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US11580430B2
公开(公告)日：2023-02-14
申请号：US16257367
申请日：2019-01-25
Applicant: General Electric Company
Inventor： Lembit Salasoo , Vipul K. Gupta , Xiaohu Ping , Subhrajit Roychowdhury , Justin Gambone, Jr. , Naresh Iyer , Xiaolei Shi , Mengli Wang
Abstract: Determining a quality score for a part manufactured by an additive manufacturing machine based on build parameters and sensor data without the need for extensive physical testing of the part. Sensor data is received from the additive manufacturing machine during manufacture of the part using a first set of build parameters. The first set of build parameters is received. A first algorithm is applied to the first set of build parameters and the received sensor data to generate a quality score. The first algorithm is trained by receiving a reference derived from physical measurements performed on at least one reference part built using a reference set of build parameters. The quality score is output via the communication interface of the device.
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