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公开(公告)号：US20170153223A1
公开(公告)日：2017-06-01
申请号：US14956067
申请日：2015-12-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
CPC classification number: G01N33/5002 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L3/502769 , B01L2200/0647 , B01L2300/16 , C12Q1/24 , G01N33/491
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US09150907B2
公开(公告)日：2015-10-06
申请号：US14277836
申请日：2014-05-15
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kashan Ali Shaikh , Mengli Wang , Adriana Ines Larriera Moreno , Jessica Godin Karp , Christine Lynne Pitner
IPC: G01N1/28 , G01N21/64 , C12Q1/68 , G01N33/543 , B01L3/00 , B01L9/00 , B32B37/00 , B32B37/18 , B32B38/00
CPC classification number: C12Q1/6813 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B32B37/0076 , B32B37/182 , B32B38/0008 , B32B2535/00 , G01N33/54306
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 流体连接器是能够连接到流体输送系统的薄膜流体连接器。 子组件可以密封在固体支撑件上以形成流动池。 还公开了使用方法。
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公开(公告)号：US10859563B2
公开(公告)日：2020-12-08
申请号：US14956067
申请日：2015-12-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US09817221B2
公开(公告)日：2017-11-14
申请号：US14410890
申请日：2013-06-26
Applicant: General Electric Company
Inventor： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
CPC classification number: G02B21/008 , G01N1/30 , G01N1/312 , G01N35/00029 , G01N35/0092 , G01N35/0099
Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.
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公开(公告)号：US20150185453A1
公开(公告)日：2015-07-02
申请号：US14410890
申请日：2013-06-26
Applicant: General Electric Company
Inventor： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
CPC classification number: G02B21/008 , G01N1/30 , G01N1/312 , G01N35/00029 , G01N35/0092 , G01N35/0099
Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.
Abstract translation: 一种用于处理和成像第一和第二多个样品的方法，包括处理来自所述第一多个样品的至少一个样品，对来自所述第一多个样品的所述至少一个样品进行成像，同时能够同时处理至少一个样品 从第二多个样本; 以及对来自所述第二多个样本的所述至少一个处理的样品进行成像。
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Patent Agency Ranking
公开(公告)号：US20140248618A1
公开(公告)日：2014-09-04
申请号：US14277836
申请日：2014-05-15
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kashan Ali Shaikh , Mengli Wang , Adriana Ines Larriera Moreno , Jessica Godin Karp , Christine Lynne Pitner
IPC: C12Q1/68 , G01N33/543
CPC classification number: C12Q1/6813 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B32B37/0076 , B32B37/182 , B32B38/0008 , B32B2535/00 , G01N33/54306
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 流体连接器是能够连接到流体输送系统的薄膜流体连接器。 子组件可以密封在固体支撑件上以形成流动池。 还公开了使用方法。
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公开(公告)号：US11821891B2
公开(公告)日：2023-11-21
申请号：US17113527
申请日：2020-12-07
Applicant: General Electric Company
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
CPC classification number: G01N33/5002 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L3/502769 , C12Q1/24 , G01N33/491 , B01D2313/18 , B01D2313/50 , B01L2200/0647 , B01L2300/16 , G01N2001/4088
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US20210088503A1
公开(公告)日：2021-03-25
申请号：US17113527
申请日：2020-12-07
Applicant: General Electric Company
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US20190105609A1
公开(公告)日：2019-04-11
申请号：US15726013
申请日：2017-10-05
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kashan Ali Shaikh , Reginald Donovan Smith , Weston Blaine Griffin
Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.
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10.发明申请公开(公告)号：US20160123926A1
公开(公告)日：2016-05-05
申请号：US14865478
申请日：2015-09-25
Applicant: General Electric Company
Inventor： John Richard Nelson , Christopher Michael Puleo , Erin Jean Finehout , Patrick McCoy Spooner , Kashan Ali Shaikh , Xiaohui Chen , Li Zhu
IPC: G01N27/447
CPC classification number: G01N27/44791 , C07H1/08 , C07H21/00 , C12N15/1017 , G01N27/44747
Abstract: A method of isolating nucleic acids from a biological material, comprises applying the biological material on a substrate comprising one or more cell lysis reagents impregnated therein; applying a fluid to the biological material applied on the substrate; extracting the nucleic acids from the biological material applied on the substrate; and collecting the extracted nucleic acids in a substantially intact form, wherein the collected nucleic acid has a molecular weight greater than or equal to 20 kb.
Abstract translation: 从生物材料中分离核酸的方法包括将生物材料应用于包含其中浸渍的一种或多种细胞裂解试剂的底物; 将液体施加到施加在基底上的生物材料; 从施加在基底上的生物材料中提取核酸; 并以基本上完整的形式收集所提取的核酸，其中所收集的核酸具有大于或等于20kb的分子量。
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