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    Method for preparing fluorescent-labeled DNA
    3.
    发明授权
    Method for preparing fluorescent-labeled DNA 失效
    荧光标记DNA的制备方法

    公开(公告)号：US5639874A

    公开(公告)日：1997-06-17

    申请号：US267575

    申请日：1994-06-28

    申请人： Lyle Richard Middendorf ,  Gabor Patonay

    发明人： Lyle Richard Middendorf ,  Gabor Patonay

    IPC分类号： C07D209/60 ,  C09B23/01 ,  C12Q1/68 ,  G01N21/64 ,  G01N27/447 ,  C07H21/00 ,  C07D209/56 ,  C07D217/22

    CPC分类号： C07D209/60 ,  C09B23/0066 ,  C12Q1/6816 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N27/447 ,  G01N27/44721 ,  G01N27/44726 ,  G01N2021/6417

    摘要： To sequence DNA automatically, DNA marked with near infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a scanning light frequency within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission frequency of the marked DNA. The light is modulated from said laser at a predetermined modulation frequency and fluorescent light emitted by said DNA bands at said modulation frequency is detected, whereby background noise from the medium through which the light is transmitted is discriminated against.

    摘要翻译： 为了自动序列DNA，用近红外荧光染料标记的DNA通过凝胶电泳板在多个通道中进行电泳，其中根据凝胶电泳板中DNA片段的大小将DNA样品分解成荧光标记的DNA条带。 分离的样品用激光二极管和传感器进行光电扫描，其中激光以扫描光频率在所述荧光标记的DNA样品的吸收光谱内以扫描光扫描，并以标记的DNA的发射频率感测光。 以预定的调制频率从所述激光器调制光，并且检测由所述DNA条带以所述调制频率发射的荧光，从而区分来自发射光的介质的背景噪声。

    METHOD AND DYES FOR DETECTING AND DESTROYING CANCER CELLS
    5.
    发明申请
    METHOD AND DYES FOR DETECTING AND DESTROYING CANCER CELLS 审中-公开
    用于检测和破坏癌细胞的方法和方法

    公开(公告)号：US20150376209A1

    公开(公告)日：2015-12-31

    申请号：US12778569

    申请日：2010-05-12

    申请人： JAMES J. KRUTAK ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    发明人： JAMES J. KRUTAK ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    IPC分类号： C07F1/00 ,  A61N1/40 ,  C09B23/01 ,  A61K49/00 ,  A61K41/00

    CPC分类号： C07F1/00 ,  A61K41/0052 ,  A61K41/0057 ,  A61K49/0032 ,  A61K49/0093 ,  A61N1/406 ,  C09B23/0016 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/086

    摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.

    摘要翻译： 本发明涉及新的碳菁染料组合物，包含这种组合物的药物组合物，通过近红外荧光成像检测初始癌细胞的方法和通过施用这种药物组合物鉴定的癌细胞的选择性破坏。 一种检测和破坏癌细胞的方法包括将金染料引入怀疑具有癌细胞的生物体中。 金染料是共价连接到金纳米颗粒上的碳菁染料。 近红外光照射在怀疑患有癌细胞的区域。 检测到来自金色染料的荧光。 射频能量束被引导到该区域以诱导癌细胞中的高热。 碳菁染料具有MHI-148和结构6和22的最基本结构，在赋予癌细胞活性的环己烯环上具有Aun- [CH 2（CH 2）9 CH 2 - （OCH 2 CH 2）4 O] COCH 2 CH 2 - 苯基-O基团 绑定和销毁过程。

    Method and apparatus for the stabilization of direct current arc lamps
    7.
    发明授权
    Method and apparatus for the stabilization of direct current arc lamps 失效
    用于稳定直流电弧灯的方法和装置

    公开(公告)号：US4602193A

    公开(公告)日：1986-07-22

    申请号：US639383

    申请日：1984-08-10

    申请人： Gabor Patonay ,  Isiah M. Warner ,  Philip B. Oldham

    发明人： Gabor Patonay ,  Isiah M. Warner ,  Philip B. Oldham

    IPC分类号： G01J3/10 ,  H05B41/34 ,  H05B37/00 ,  H05B39/00

    CPC分类号： H05B41/34 ,  Y10T307/50

    摘要： A system for stabilizing the arc in a DC arc lamp. An AC signal is superimposed on the DC power source of the lamp to cause small regular fluctuations in the arc. The small fluctuations prevent large fluctuations while the small regular fluctuations may be averaged to obtain a constant average value. The average is taken over 5 to 10 periods of the AC signal to produce a constant average signal with a very small standard deviation.

    摘要翻译： 用于稳定直流弧光灯中的电弧的系统。 交流信号叠加在灯的直流电源上，导致电弧的小规则波动。 小的波动防止大的波动，而小的正常波动可以被平均以获得恒定的平均值。 平均值为5到10个周期的交流信号，以产生具有非常小的标准偏差的恒定平均信号。

    Method and dyes for detecting and destroying cancer cells
    10.
    发明授权
    Method and dyes for detecting and destroying cancer cells 有权

    公开(公告)号：US10030036B2

    公开(公告)日：2018-07-24

    申请号：US12778569

    申请日：2010-05-12

    申请人： James J. Krutak ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    发明人： James J. Krutak ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    IPC分类号： A61N1/40 ,  C07F1/00 ,  A61K49/00 ,  A61K41/00 ,  C09B23/01 ,  C09B23/08

    摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.