公开(公告)号：US5571388A

公开(公告)日：1996-11-05

申请号：US204627

申请日：1994-03-01

申请人： Gabor Patonay ,  Narasimhachari Narayanan ,  Lucjan Strekowski ,  Lyle R. Middendorf ,  Malgorzata Lipowska

发明人： Gabor Patonay ,  Narasimhachari Narayanan ,  Lucjan Strekowski ,  Lyle R. Middendorf ,  Malgorzata Lipowska

IPC分类号： C07D209/12 ,  C07D209/60 ,  C09B23/00 ,  C09B23/01 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/64 ,  G01N27/447 ,  G01N33/58 ,  G01N27/26

CPC分类号： C07D209/60 ,  C09B23/0066 ,  C12Q1/6816 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N21/6458 ,  G01N27/447 ,  G01N27/44721 ,  G01N27/44726 ,  Y10S435/968 ,  Y10S436/80

摘要： To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.

摘要翻译： 为了自动序列DNA，用远红外线，近红外或红外荧光染料标记的DNA通过凝胶电泳板或毛细管在多个通道中进行电泳，其中根据凝胶中DNA片段的大小来分离DNA样品 电泳板或毛细管进入荧光标记的DNA条带。 分离的样品用激光二极管和传感器进行光电扫描，其中激光扫描具有在所述荧光标记的DNA样品的吸收光谱内的波长的扫描光，并且在标记的DNA的发射波长处感测光。

公开(公告)号：US5800995A

公开(公告)日：1998-09-01

申请号：US706004

申请日：1996-08-30

申请人： Gabor Patonay ,  Narasimhachari Narayanan ,  Lucjan Strekowski ,  Lyle Richard Middendorf ,  Malgorzata Lipowska

发明人： Gabor Patonay ,  Narasimhachari Narayanan ,  Lucjan Strekowski ,  Lyle Richard Middendorf ,  Malgorzata Lipowska

IPC分类号： C07D209/12 ,  C07D209/60 ,  C09B23/00 ,  C09B23/01 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/64 ,  G01N27/447 ,  G01N33/58 ,  G01N33/53

CPC分类号： C07D209/60 ,  C09B23/0066 ,  C12Q1/6816 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N21/6458 ,  G01N27/447 ,  G01N27/44721 ,  G01N27/44726 ,  Y10S435/968 ,  Y10S436/80

摘要： To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.

公开(公告)号：US20110262354A1

公开(公告)日：2011-10-27

申请号：US12668460

申请日：2008-07-10

申请人： Leland W. K. Chung ,  Ruoxiang Wang ,  Haiyen E. Zhau ,  Lucjan Strekowski ,  Maged Henary ,  Gabor Patonay ,  James J. Krutak ,  Xiaojian Yang ,  Guodong Zhu

发明人： Leland W. K. Chung ,  Ruoxiang Wang ,  Haiyen E. Zhau ,  Lucjan Strekowski ,  Maged Henary ,  Gabor Patonay ,  James J. Krutak ,  Xiaojian Yang ,  Guodong Zhu

IPC分类号： A61K49/00 ,  A61P35/00 ,  C12N5/00 ,  A61K31/404 ,  C07D403/08 ,  C12Q1/02

CPC分类号： A61K49/00 ,  A61K31/404 ,  C07D209/10 ,  C07D209/60 ,  C07D209/92 ,  G01N33/5008

摘要： This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.

摘要翻译： 本发明一般涉及含花青化合物; 包含含花青化合物的药物组合物; 以及使用含花青素化合物进行癌细胞成像，癌细胞生长抑制，以及检测癌细胞的方法等。 与正常细胞相比，本发明的化合物优先被癌细胞吸收。 这可以在癌症治疗，诊断，跟踪和成像领域的许多用途。

公开(公告)号：US5230781A

公开(公告)日：1993-07-27

申请号：US763230

申请日：1991-09-20

申请人： Lyle R. Middendorf ,  Gabor Patonay

发明人： Lyle R. Middendorf ,  Gabor Patonay

IPC分类号： C07D209/60 ,  C09B23/01 ,  C12Q1/68 ,  G01N21/64 ,  G01N27/447

CPC分类号： G01N27/447 ,  C07D209/60 ,  C09B23/0066 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N27/44721 ,  G01N27/44726 ,  G01N2021/6417 ,  G01N21/6458

摘要： To sequence DNA automatically, DNA marked with near infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a scanning light frequency within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission frequency of the marked DNA. The light is modulated from said laser at a predetermined modulation frequency and fluorescent light emitted by said DNA bands at said modulation frequency is detected, whereby background noise from the medium through which the light is transmitted is discriminated against.

摘要翻译： 为了自动序列DNA，用近红外荧光染料标记的DNA通过凝胶电泳板在多个通道中进行电泳，其中根据凝胶电泳板中DNA片段的大小将DNA样品分解成荧光标记的DNA条带。 分离的样品用激光二极管和传感器进行光电扫描，其中激光以扫描光频率在所述荧光标记的DNA样品的吸收光谱内以扫描光扫描，并以标记的DNA的发射频率感测光。 以预定的调制频率从所述激光器调制光，并且检测由所述DNA条带以所述调制频率发射的荧光，从而区分来自发射光的介质的背景噪声。

公开(公告)号：US5366603A

公开(公告)日：1994-11-22

申请号：US860140

申请日：1992-03-30

申请人： Lyle R. Middendorf ,  Gabor Patonay

发明人： Lyle R. Middendorf ,  Gabor Patonay

IPC分类号： C07D209/60 ,  C09B23/01 ,  C12Q1/68 ,  G01N21/64 ,  G01N27/447 ,  G01N27/26 ,  B01D57/02

CPC分类号： C07D209/60 ,  C09B23/0066 ,  C12Q1/6816 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N27/447 ,  G01N27/44721 ,  G01N27/44726 ,  G01N2021/6417

摘要： To sequence DNA automatically, DNA marked with near infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a scanning light frequency within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission frequency of the marked DNA. The light is modulated from said laser at a predetermined modulation frequency and fluorescent light emitted by said DNA bands at said modulation frequency is detected, whereby background noise from the medium through which the light is transmitted is discriminated against.

摘要翻译： 为了自动序列DNA，用近红外荧光染料标记的DNA通过凝胶电泳板在多个通道中进行电泳，其中根据凝胶电泳板中DNA片段的大小将DNA样品分解成荧光标记的DNA条带。 分离的样品用激光二极管和传感器进行光电扫描，其中激光以扫描光频率在所述荧光标记的DNA样品的吸收光谱内以扫描光扫描，并以标记的DNA的发射频率感测光。 以预定的调制频率从所述激光器调制光，并且检测由所述DNA条带以所述调制频率发射的荧光，从而区分来自发射光的介质的背景噪声。

公开(公告)号：US06086737A

公开(公告)日：2000-07-11

申请号：US500691

申请日：1995-07-11

申请人： Gabor Patonay ,  Narasimhachari Narayanan ,  John A. Brumbaugh ,  Lyle Richard Middendorf

发明人： Gabor Patonay ,  Narasimhachari Narayanan ,  John A. Brumbaugh ,  Lyle Richard Middendorf

IPC分类号： C12N15/09 ,  C07D209/12 ,  C07D209/60 ,  C07D209/62 ,  C09B23/01 ,  C12Q1/68 ,  G01N21/64 ,  G01N27/447 ,  G01N27/26

CPC分类号： G01N21/6458 ,  C07D209/12 ,  C07D209/62 ,  C09B23/0025 ,  C09B23/0066 ,  C12Q1/6816 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N27/447 ,  G01N27/44721 ,  G01N27/44726 ,  Y10S435/968 ,  Y10S436/80

摘要： To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.

摘要翻译： 为了自动序列DNA，用远红外线，近红外或红外荧光染料标记的DNA通过凝胶电泳板或毛细管在多个通道中进行电泳，其中根据凝胶中DNA片段的大小来分离DNA样品 电泳板或毛细管进入荧光标记的DNA条带。 分离的样品用激光二极管和传感器进行光电扫描，其中激光扫描具有在所述荧光标记的DNA样品的吸收光谱内的波长的扫描光，并且在标记的DNA的发射波长处感测光。

公开(公告)号：US20150376209A1

公开(公告)日：2015-12-31

申请号：US12778569

申请日：2010-05-12

申请人： JAMES J. KRUTAK ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

发明人： JAMES J. KRUTAK ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

IPC分类号： C07F1/00 ,  A61N1/40 ,  C09B23/01 ,  A61K49/00 ,  A61K41/00

CPC分类号： C07F1/00 ,  A61K41/0052 ,  A61K41/0057 ,  A61K49/0032 ,  A61K49/0093 ,  A61N1/406 ,  C09B23/0016 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/086

摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.

摘要翻译： 本发明涉及新的碳菁染料组合物，包含这种组合物的药物组合物，通过近红外荧光成像检测初始癌细胞的方法和通过施用这种药物组合物鉴定的癌细胞的选择性破坏。 一种检测和破坏癌细胞的方法包括将金染料引入怀疑具有癌细胞的生物体中。 金染料是共价连接到金纳米颗粒上的碳菁染料。 近红外光照射在怀疑患有癌细胞的区域。 检测到来自金色染料的荧光。 射频能量束被引导到该区域以诱导癌细胞中的高热。 碳菁染料具有MHI-148和结构6和22的最基本结构，在赋予癌细胞活性的环己烯环上具有Aun- [CH 2（CH 2）9 CH 2 - （OCH 2 CH 2）4 O] COCH 2 CH 2 - 苯基-O基团 绑定和销毁过程。

公开(公告)号：US5553714A

公开(公告)日：1996-09-10

申请号：US339318

申请日：1994-11-14

申请人： Michael R. Cushman ,  James J. Krutak ,  William W. Parham ,  Clarence A. Coates ,  Max A. Weaver ,  Gabor Patonay

发明人： Michael R. Cushman ,  James J. Krutak ,  William W. Parham ,  Clarence A. Coates ,  Max A. Weaver ,  Gabor Patonay

IPC分类号： C07D487/22 ,  B07C5/342 ,  C07D209/60 ,  C07F5/06 ,  C07F7/02 ,  C07F7/08 ,  C08K5/00 ,  C08K5/34 ,  C08K5/3412 ,  C08K5/3415 ,  C08L67/00 ,  C08L101/00 ,  C09B47/06 ,  C09B47/067 ,  C09B47/073 ,  C09B47/08 ,  C09B47/18 ,  C09B57/00 ,  C09B67/20 ,  C09K11/06 ,  B07C5/10

CPC分类号： C09B47/063 ,  B07C5/342 ,  B07C5/365 ,  C07D209/60 ,  C07F5/069 ,  C07F7/025 ,  C07F7/0858 ,  C08K5/0008 ,  C08K5/0041 ,  C08K5/34 ,  C09B47/0675 ,  C09B47/0676 ,  C09B47/073 ,  C09B47/08 ,  C09B47/18 ,  C09B57/007 ,  C09B67/0061 ,  B29B2017/0279 ,  Y02W30/622

摘要： Provided is a method for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. Also provided is a method for identifying a thermoplastic container. Also provided are thermoplastic polymer compositions comprised of the near infrared fluorescing compounds or residues and articles comprised of such compositions.

摘要翻译： 提供了使用近红外荧光化合物或易于检测的共聚残基来标记热塑性容器的方法。 还提供了一种用于识别热塑性容器的方法。 还提供了由近红外荧光化合物或由这些组合物组成的残余物和制品组成的热塑性聚合物组合物。

公开(公告)号：US4602193A

公开(公告)日：1986-07-22

申请号：US639383

申请日：1984-08-10

申请人： Gabor Patonay ,  Isiah M. Warner ,  Philip B. Oldham

发明人： Gabor Patonay ,  Isiah M. Warner ,  Philip B. Oldham

IPC分类号： G01J3/10 ,  H05B41/34 ,  H05B37/00 ,  H05B39/00

CPC分类号： H05B41/34 ,  Y10T307/50

摘要： A system for stabilizing the arc in a DC arc lamp. An AC signal is superimposed on the DC power source of the lamp to cause small regular fluctuations in the arc. The small fluctuations prevent large fluctuations while the small regular fluctuations may be averaged to obtain a constant average value. The average is taken over 5 to 10 periods of the AC signal to produce a constant average signal with a very small standard deviation.

摘要翻译： 用于稳定直流弧光灯中的电弧的系统。 交流信号叠加在灯的直流电源上，导致电弧的小规则波动。 小的波动防止大的波动，而小的正常波动可以被平均以获得恒定的平均值。 平均值为5到10个周期的交流信号，以产生具有非常小的标准偏差的恒定平均信号。

公开(公告)号：US5703229A

公开(公告)日：1997-12-30

申请号：US609011

申请日：1996-02-29

申请人： James J. Krutak ,  Michael R. Cushman ,  Clarence A. Coates ,  William W. Parham ,  Max A. Weaver ,  Gabor Patonay

发明人： James J. Krutak ,  Michael R. Cushman ,  Clarence A. Coates ,  William W. Parham ,  Max A. Weaver ,  Gabor Patonay

IPC分类号： C07D487/22 ,  B07C5/342 ,  C07D209/60 ,  C07F5/06 ,  C07F7/02 ,  C07F7/08 ,  C08K5/00 ,  C08K5/34 ,  C08K5/3412 ,  C08K5/3415 ,  C08L67/00 ,  C08L101/00 ,  C09B47/06 ,  C09B47/067 ,  C09B47/073 ,  C09B47/08 ,  C09B47/18 ,  C09B57/00 ,  C09B67/20 ,  C09K11/06 ,  C07B47/24

CPC分类号： C09B47/063 ,  B07C5/342 ,  B07C5/365 ,  C07D209/60 ,  C07F5/069 ,  C07F7/025 ,  C07F7/0858 ,  C08K5/0008 ,  C08K5/0041 ,  C08K5/34 ,  C09B47/0675 ,  C09B47/0676 ,  C09B47/073 ,  C09B47/08 ,  C09B47/18 ,  C09B57/007 ,  C09B67/0061 ,  B29B2017/0279 ,  Y02W30/622

摘要： Provided are new compounds useful as near infrared fluorophoric markers. In the practice of this invention a method is also provided for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. The new compounds are phthalocyanine and naphthalocyanine derivatives which are covalently bonded to substituted silicon and aluminum compounds. The methods, compositions, and compounds described herein thus provide a total system useful for marking, for identification purposes, the various classes of thermoplastic wastes, so that they can be identified, sorted, and subsequently recycled.

摘要翻译： 提供用作近红外荧光标记的新化合物。 在本发明的实践中，还提供了使用近红外荧光化合物或易于检测的共聚残基来标记热塑性容器的方法。 新化合物是与取代的硅和铝化合物共价键合的酞菁和萘酞菁衍生物。 因此，本文所述的方法，组合物和化合物提供了用于标识目的的各种类型的热塑性废物的总体系统，以便可以鉴定，分类和随后再循环。