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    Methods and procedures for stabilization and performance optimization of multi-layer sol-gel chemical and biochemical sensors
    1.
    发明授权
    Methods and procedures for stabilization and performance optimization of multi-layer sol-gel chemical and biochemical sensors 有权
    多层溶胶 - 凝胶化学和生物化学传感器的稳定和性能优化的方法和程序

    公开(公告)号：US07393693B2

    公开(公告)日：2008-07-01

    申请号：US10159301

    申请日：2002-05-31

    申请人： David J. Anvar ,  Ganapati R. Mauze ,  Dan-Hui Yang

    发明人： David J. Anvar ,  Ganapati R. Mauze ,  Dan-Hui Yang

    IPC分类号： G01N30/00

    CPC分类号： G01N33/6803 ,  Y10T436/25 ,  Y10T436/2525

    摘要： A sensor and method for making a sensor includes providing a substrate having an adhesion layer with a first functional group operatively associated with a sol-gel composition having a second functional group, and at least one linker material for connecting the first functional group to the second functional group. In another embodiment, a sensor and method for making the sensor includes providing a sol-gel layer operatively associated with a sol-gel precursor solution that includes at least one co-polymer and at least one solvent adapted to resist the deformation of the sol-gel layer by decreasing evaporation, decreasing cross-linking, increasing intermolecular forces, or increasing elasticity.

    摘要翻译： 用于制造传感器的传感器和方法包括提供具有粘附层的基底，其具有与具有第二官能团的溶胶 - 凝胶组合物操作性相关联的第一官能团，以及用于将第一官能团连接到第二官能团的至少一种连接材料 功能组。 在另一个实施方案中，用于制造传感器的传感器和方法包括提供可操作地与溶胶 - 凝胶前体溶液相关联的溶胶 - 凝胶层，所述溶胶 - 凝胶层包括至少一种共聚物和至少一种适于抵抗溶胶 - 凝胶前体溶液变形的溶剂 - 凝胶层通过减少蒸发，减少交联，增加分子间力或增加弹性。

    Electro-optical devices and methods for hybridization and detection
    2.
    发明授权
    Electro-optical devices and methods for hybridization and detection 失效
    电光装置和杂交和检测方法

    公开(公告)号：US07049129B2

    公开(公告)日：2006-05-23

    申请号：US10414719

    申请日：2003-04-15

    申请人： Ganapati R. Mauze ,  Dan-Hui Yang

    发明人： Ganapati R. Mauze ,  Dan-Hui Yang

    IPC分类号： C12M1/34 ,  C12Q1/68 ,  G01N33/20 ,  G01N33/00

    CPC分类号： C12Q1/6825 ,  Y10S435/81 ,  Y10S436/80 ,  Y10S436/805 ,  Y10T436/143333 ,  C12Q2565/607 ,  C12Q2563/137

    摘要： The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction. The method of the invention teaches the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.

    摘要翻译： 本发明提供了用于检测靶分子的装置和方法。 该装置包括标记有过渡金属 - 配体络合物的探针，其与靶杂交以形成初始复合物，用于掺杂初始络合物并形成最终复合物的金属离子，以及为最终复合物提供潜力的潜在手段 以产生表明氧化还原反应后靶的存在的可检测信号。 本发明的方法教导了将探针与附着的标记物杂交到靶标以产生初始复合物的步骤，向最初的复合物中加入金属离子以形成最终的复合物并向潜在的复合物施加潜能以产生可测量的 信号。

    Electro-optical devices and methods for hybridization and detection
    3.
    发明授权
    Electro-optical devices and methods for hybridization and detection 失效
    电光装置和杂交和检测方法

    公开(公告)号：US06974703B2

    公开(公告)日：2005-12-13

    申请号：US10798982

    申请日：2004-03-11

    申请人： Ganapati R. Mauze ,  Dan-Hui Yang

    发明人： Ganapati R. Mauze ,  Dan-Hui Yang

    IPC分类号： C07H21/04 ,  C12M1/34 ,  C12Q1/68 ,  G01N33/00

    CPC分类号： C12Q1/6825 ,  Y10S435/81 ,  Y10S436/80 ,  Y10S436/805 ,  Y10T436/143333 ,  C12Q2565/607 ,  C12Q2563/137

    摘要： The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction. The method of the invention teaches the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.

    摘要翻译： 本发明提供了用于检测靶分子的装置和方法。 该装置包括标记有过渡金属 - 配体络合物的探针，其与靶杂交以形成初始复合物，用于掺杂初始络合物并形成最终复合物的金属离子，以及为最终复合物提供潜力的潜在手段 以产生表明氧化还原反应后靶的存在的可检测信号。 本发明的方法教导了将探针与附着的标记物杂交到靶标以产生初始复合物的步骤，向最初的复合物中加入金属离子以形成最终的复合物并向潜在的复合物施加潜能以产生可测量的 信号。

    Fluorescence immunoassays using organo-metallic complexes for energy transfer
    4.
    发明授权
    Fluorescence immunoassays using organo-metallic complexes for energy transfer 有权
    荧光免疫法使用有机金属配合物进行能量转移

    公开(公告)号：US06939721B2

    公开(公告)日：2005-09-06

    申请号：US09740660

    申请日：2000-12-18

    申请人： Ganapati R. Mauze ,  Dan-Hui Yang

    发明人： Ganapati R. Mauze ,  Dan-Hui Yang

    IPC分类号： G01N33/542 ,  G01N33/58 ,  G01N33/545 ,  G01N33/533 ,  G01N33/552

    CPC分类号： G01N33/582 ,  G01N33/542 ,  G01N2458/40 ,  Y10S436/80 ,  Y10S436/805 ,  Y10S436/829

    摘要： The invention includes a composition of matter and method that utilizes energy transfer between one or more donor and acceptor molecules. The composition of matter includes an encapsulation vesicle having a matrix, a surface coating of an organo-metallic complex and a transparent protection layer. The transparent protection layer is capable of modification by addition of biomolecules to the surface in order to bind other molecules. The proximity of the bound biomolecules to the protective layer allows for energy transfer from a donor molecule internal to the protection layer to an acceptor molecule outside the protection layer. The protection layer acts to diminish the effects of collisional quenching on the donor molecules caused by ubiquitous small molecules such as molecular oxygen. The application also teaches a method of making and applying the complexes to immunoassays.

    摘要翻译： 本发明包括利用一个或多个供体和受体分子之间的能量转移的物质和方法的组合物。 物质的组成包括具有基质的包封囊泡，有机金属络合物的表面涂层和透明保护层。 透明保护层能够通过向表面添加生物分子来进行修饰，以便结合其他分子。 结合的生物分子与保护层的接近允许从保护层内部的施主分子到保护层外部的受体分子的能量转移。 保护层起到减少由普遍存在的小分子（如分子氧）引起的激发猝灭对供体分子的影响。 本申请还教导了制备和应用复合物免疫测定法的方法。

    Optical sensor for sensing multiple analytes
    10.
    发明授权
    Optical sensor for sensing multiple analytes 有权
    用于感测多种分析物的光学传感器

    公开(公告)号：US06379969B1

    公开(公告)日：2002-04-30

    申请号：US09517259

    申请日：2000-03-02

    申请人： Ganapati R. Mauze ,  Bo Curry

    发明人： Ganapati R. Mauze ,  Bo Curry

    IPC分类号： G01N2164

    CPC分类号： G01N21/6454 ,  G01N21/6428 ,  G01N21/77 ,  G01N2021/7786 ,  G01N2021/7793 ,  Y10T436/144444 ,  Y10T436/147777

    摘要： A device for analyzing simultaneously multiple analytes in a fluid of unknown composition. The device includes a plurality of sensors, a light source for providing light to shine on the sensors, light detectors, and a processor. The sensors are exposed to a sample of the fluid of unknown composition. The plurality of sensors includes groups of sensors, each group targeting a specific analyte and including one or more sensors that contain an analyte-specific chemical that interacts more specifically with one analyte than with some other analytes to be analyzed. Each sensor in each group has a different chemical interacting with the analyte to target it. The light source shines light on the sensors of the plurality of sensors to cause light interaction with the sensors. The differences in the sensors lead to differences in the light interaction. The light detectors detects the light interaction by the sensors. The processor analyzes the light interaction by the sensors to take into account interference in light interaction among the analytes, thereby determining the concentration of each of the analytes in the fluid.

    摘要翻译： 用于同时分析未知组成的流体中的多种分析物的装置。 该装置包括多个传感器，用于提供光照射在传感器，光检测器和处理器上的光源。 传感器暴露于未知组成的流体样品。 多个传感器包括传感器组，每个组针对特定分析物并且包括一个或多个传感器，其包含特异性分析物的化学物质，其与一种分析物更具体地与一种分析物相互作用。 每组中的每个传感器都具有与分析物相互作用的不同的化学物质来靶向它。 光源将光照射到多个传感器的传感器上，以使光与传感器相互作用。 传感器的差异导致光相互作用的差异。 光检测器通过传感器检测光的相互作用。 处理器分析传感器的光相互作用，以考虑到分析物之间的光相互作用的干扰，从而确定流体中每种分析物的浓度。