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公开(公告)号:US06972340B2
公开(公告)日:2005-12-06
申请号:US09941471
申请日:2001-08-29
IPC分类号: A61P3/00 , A61P3/10 , C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18 , C07C321/00 , C07C69/76 , C07C229/00 , C07C271/00
CPC分类号: C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18
摘要: Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
摘要翻译: 式(I)化合物或其治疗上可接受的盐是选择性蛋白酪氨酸激酶-B(PTP1B)抑制剂。 公开了化合物的制备,含有该化合物的组合物和使用该化合物治疗病症。
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公开(公告)号:US07169797B2
公开(公告)日:2007-01-30
申请号:US10771926
申请日:2004-02-04
申请人: Zhili Xin , Gang Liu , Zhonghua Pei , Bruce G. Szczepankiewicz , Michael D. Serby , Hongyu Zhao
发明人: Zhili Xin , Gang Liu , Zhonghua Pei , Bruce G. Szczepankiewicz , Michael D. Serby , Hongyu Zhao
IPC分类号: A61K31/445 , A61K31/41 , C07D211/32 , C07D285/12 , C07D271/06
CPC分类号: C07D413/04 , C07D261/18 , C07D413/12
摘要: The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.
摘要翻译: 本发明涉及可用于选择性抑制蛋白酪氨酸磷酸酶1B(PTP1B)的式(I)化合物或其药学上合适的盐或前药,并且可用于治疗由过表达 或改变的蛋白酪氨酸磷酸酶1B。
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公开(公告)号:US07888374B2
公开(公告)日:2011-02-15
申请号:US11337862
申请日:2006-01-23
申请人: Gang Liu , Hing L. Sham , Bruce G. Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael D. Serby , Bo Liu , Mei Liu
发明人: Gang Liu , Hing L. Sham , Bruce G. Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael D. Serby , Bo Liu , Mei Liu
IPC分类号: C07D213/84 , A61K31/44
CPC分类号: C07D417/12 , C07D213/73 , C07D213/81 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
摘要: The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
摘要翻译: 本发明涉及作为c-jun N-末端激酶1,2或3(JNK1,JNK2或JNK3)的抑制剂的化合物,含有这些化合物的组合物和该化合物在预防或治疗调节疾病中的用途 通过激活JNK1,JNK2和JNK3。
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4.PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 失效
标题翻译: 作为DIPPTIDYL PEPTIDASE-IV(DPP-IV)抑制剂的药物组合物公开(公告)号:US20130059873A1
公开(公告)日:2013-03-07
申请号:US13437999
申请日:2012-04-03
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/40 , C07D401/08 , A61K31/4725 , C07D401/14 , A61K31/4545 , C07D401/12 , A61K31/454 , A61K31/4439 , C07D403/08 , A61K31/4025 , C07D405/06 , A61K31/506 , A61P3/10 , A61P3/04 , C07D207/16
CPC分类号: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)的化合物,其可用于预防或治疗糖尿病,特别是II型糖尿病,以及高血糖症,X综合征,高胰岛素血症,肥胖,动脉粥样硬化和各种免疫调节疾病 。
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5.Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效
标题翻译: 药物组合物作为二肽基肽酶-IV(DPP-IV)的抑制剂公开(公告)号:US08119664B2
公开(公告)日:2012-02-21
申请号:US12727558
申请日:2010-03-19
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/445 , C07D295/00
CPC分类号: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)的化合物,其可用于预防或治疗糖尿病,特别是II型糖尿病,以及高血糖症,X综合征,高胰岛素血症,肥胖,动脉粥样硬化和各种免疫调节疾病 。
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6.Pharmaceutical Compositions As Inhibitors of Dipeptidyl Peptidase-IV (DPP-IV) 失效
标题翻译: 药物组合物作为二肽基肽酶-IV(DPP-IV)的抑制剂公开(公告)号:US20100190822A1
公开(公告)日:2010-07-29
申请号:US12727558
申请日:2010-03-19
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/4725 , C07D207/16 , A61K31/40 , A61P3/10 , A61P3/04 , A61P3/08 , C07D401/08 , C07D401/14 , A61K31/4545 , C07D401/12 , A61K31/454 , A61K31/4439 , C07D403/08 , A61K31/4025
CPC分类号: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)的化合物,其可用于预防或治疗糖尿病,特别是II型糖尿病,以及高血糖症,X综合征,高胰岛素血症,肥胖,动脉粥样硬化和各种免疫调节疾病 。
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7.Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效
标题翻译: 药物组合物作为二肽基肽酶-IV(DPP-IV)的抑制剂公开(公告)号:US07262207B2
公开(公告)日:2007-08-28
申请号:US10788993
申请日:2004-02-27
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/445 , C07D401/00
CPC分类号: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)的化合物,其可用于预防或治疗糖尿病,特别是II型糖尿病,以及高血糖症,X综合征,高胰岛素血症,肥胖,动脉粥样硬化和各种免疫调节疾病 。
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8.Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DDP-IV) 失效
标题翻译: 作为二肽基肽酶-IV(DDP-IV)抑制剂的药物组合物公开(公告)号:US08637546B2
公开(公告)日:2014-01-28
申请号:US13437999
申请日:2012-04-03
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/445 , C07D295/00
CPC分类号: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)的化合物,其可用于预防或治疗糖尿病,特别是II型糖尿病,以及高血糖症,X综合征,高胰岛素血症,肥胖,动脉粥样硬化和各种免疫调节疾病 。
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9.Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效
标题翻译: 药物组合物作为二肽基肽酶-IV(DPP-IV)的抑制剂公开(公告)号:US07238724B2
公开(公告)日:2007-07-03
申请号:US11036258
申请日:2005-01-13
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/40 , A61K31/401 , A61K31/454 , A61K31/4545 , A61K31/506 , C07D405/12 , C07D401/12 , C07D211/58 , C07D239/42
CPC分类号: C07D207/16 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)并可用于预防或治疗糖尿病,特别是II型糖尿病以及高血糖症,X综合症,高胰岛素血症,肥胖症,动脉粥样硬化和各种免疫调节疾病的化合物 。
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公开(公告)号:US07365093B2
公开(公告)日:2008-04-29
申请号:US11063476
申请日:2005-02-23
申请人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号: A01N43/36 , C07D405/00
CPC分类号: C07D207/16 , C07D405/04 , C07D405/14 , C07D413/14
摘要: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐,以及其制备方法和中间体,以及拮抗内皮素的方法。
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