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公开(公告)号:US06972340B2
公开(公告)日:2005-12-06
申请号:US09941471
申请日:2001-08-29
IPC分类号: A61P3/00 , A61P3/10 , C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18 , C07C321/00 , C07C69/76 , C07C229/00 , C07C271/00
CPC分类号: C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18
摘要: Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
摘要翻译: 式(I)化合物或其治疗上可接受的盐是选择性蛋白酪氨酸激酶-B(PTP1B)抑制剂。 公开了化合物的制备,含有该化合物的组合物和使用该化合物治疗病症。
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公开(公告)号:US07169797B2
公开(公告)日:2007-01-30
申请号:US10771926
申请日:2004-02-04
申请人: Zhili Xin , Gang Liu , Zhonghua Pei , Bruce G. Szczepankiewicz , Michael D. Serby , Hongyu Zhao
发明人: Zhili Xin , Gang Liu , Zhonghua Pei , Bruce G. Szczepankiewicz , Michael D. Serby , Hongyu Zhao
IPC分类号: A61K31/445 , A61K31/41 , C07D211/32 , C07D285/12 , C07D271/06
CPC分类号: C07D413/04 , C07D261/18 , C07D413/12
摘要: The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.
摘要翻译: 本发明涉及可用于选择性抑制蛋白酪氨酸磷酸酶1B(PTP1B)的式(I)化合物或其药学上合适的盐或前药,并且可用于治疗由过表达 或改变的蛋白酪氨酸磷酸酶1B。
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公开(公告)号:US06627767B2
公开(公告)日:2003-09-30
申请号:US09934765
申请日:2001-08-22
申请人: Gang Liu , Yihong Li , David A. Janowick , Zhonghua Pei
发明人: Gang Liu , Yihong Li , David A. Janowick , Zhonghua Pei
IPC分类号: C07C22900
CPC分类号: C07D207/26 , C07C233/56 , C07C235/24 , C07C237/22 , C07C259/06 , C07C311/51 , C07C2601/14 , C07D209/48 , C07D211/26 , C07D213/74 , C07D215/12 , C07D215/14 , C07D277/74 , C07D295/13 , C07D295/185 , C07D307/68 , C07D307/91 , C07D319/18 , C07D333/20 , C07D333/28 , C07D405/12
摘要: or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
摘要翻译: 或其可治疗可接受的盐是蛋白酪氨酸激酶PTP1B抑制剂。 公开了化合物的制备,含有该化合物的组合物以及使用该化合物治疗疾病。
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公开(公告)号:USRE39197E1
公开(公告)日:2006-07-18
申请号:US10356794
申请日:2002-08-29
申请人: James T. Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
发明人: James T. Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
IPC分类号: A61K31/505 , A61K31/405 , C07D239/70 , C07D319/14 , C07D319/00
CPC分类号: C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
摘要: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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5.Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds 有权
标题翻译: 细胞粘附抑制抗炎和免疫抑制化合物公开(公告)号:US6110922A
公开(公告)日:2000-08-29
申请号:US222491
申请日:1998-12-29
申请人: James Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
发明人: James Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
IPC分类号: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/505 , A61K31/405 , C07C319/00 , C07D239/70 , C07D319/14
CPC分类号: C07D207/27 , C07C323/62 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10 , C07C2101/02 , C07C2101/04 , C07C2101/08
摘要: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译: 本发明涉及可用于治疗炎性和免疫疾病的新颖的肉桂酰胺化合物,包含这些化合物的药物组合物,以及抑制哺乳动物炎症或抑制免疫应答的方法。
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6.Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效
标题翻译: 药物组合物作为二肽基肽酶-IV(DPP-IV)的抑制剂公开(公告)号:US08119664B2
公开(公告)日:2012-02-21
申请号:US12727558
申请日:2010-03-19
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/445 , C07D295/00
CPC分类号: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)的化合物,其可用于预防或治疗糖尿病,特别是II型糖尿病,以及高血糖症,X综合征,高胰岛素血症,肥胖,动脉粥样硬化和各种免疫调节疾病 。
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7.Pharmaceutical Compositions As Inhibitors of Dipeptidyl Peptidase-IV (DPP-IV) 失效
标题翻译: 药物组合物作为二肽基肽酶-IV(DPP-IV)的抑制剂公开(公告)号:US20100190822A1
公开(公告)日:2010-07-29
申请号:US12727558
申请日:2010-03-19
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/4725 , C07D207/16 , A61K31/40 , A61P3/10 , A61P3/04 , A61P3/08 , C07D401/08 , C07D401/14 , A61K31/4545 , C07D401/12 , A61K31/454 , A61K31/4439 , C07D403/08 , A61K31/4025
CPC分类号: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)的化合物,其可用于预防或治疗糖尿病,特别是II型糖尿病,以及高血糖症,X综合征,高胰岛素血症,肥胖,动脉粥样硬化和各种免疫调节疾病 。
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8.PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 失效
标题翻译: 作为DIPPTIDYL PEPTIDASE-IV(DPP-IV)抑制剂的药物组合物公开(公告)号:US20130059873A1
公开(公告)日:2013-03-07
申请号:US13437999
申请日:2012-04-03
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/40 , C07D401/08 , A61K31/4725 , C07D401/14 , A61K31/4545 , C07D401/12 , A61K31/454 , A61K31/4439 , C07D403/08 , A61K31/4025 , C07D405/06 , A61K31/506 , A61P3/10 , A61P3/04 , C07D207/16
CPC分类号: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)的化合物,其可用于预防或治疗糖尿病,特别是II型糖尿病,以及高血糖症,X综合征,高胰岛素血症,肥胖,动脉粥样硬化和各种免疫调节疾病 。
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9.Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效
标题翻译: 药物组合物作为二肽基肽酶-IV(DPP-IV)的抑制剂公开(公告)号:US07262207B2
公开(公告)日:2007-08-28
申请号:US10788993
申请日:2004-02-27
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/445 , C07D401/00
CPC分类号: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)的化合物,其可用于预防或治疗糖尿病,特别是II型糖尿病,以及高血糖症,X综合征,高胰岛素血症,肥胖,动脉粥样硬化和各种免疫调节疾病 。
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10.Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DDP-IV) 失效
标题翻译: 作为二肽基肽酶-IV(DDP-IV)抑制剂的药物组合物公开(公告)号:US08637546B2
公开(公告)日:2014-01-28
申请号:US13437999
申请日:2012-04-03
申请人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人: David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号: A61K31/445 , C07D295/00
CPC分类号: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译: 本发明涉及抑制二肽基肽酶IV(DPP-IV)的化合物,其可用于预防或治疗糖尿病,特别是II型糖尿病,以及高血糖症,X综合征,高胰岛素血症,肥胖,动脉粥样硬化和各种免疫调节疾病 。
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