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    Process for preparing substituted and unsubstituted arylalkylamines
    7.
    发明授权
    Process for preparing substituted and unsubstituted arylalkylamines 失效
    制备取代和未取代的芳基烷基胺的方法

    公开(公告)号：US5430189A

    公开(公告)日：1995-07-04

    申请号：US185098

    申请日：1994-01-19

    申请人： Joseph A. McDonough ,  Ahmed M. Tafesh ,  Olan S. Fruchey

    发明人： Joseph A. McDonough ,  Ahmed M. Tafesh ,  Olan S. Fruchey

    IPC分类号： C07C209/00 ,  C07C209/40 ,  C07C215/52 ,  C07C249/08 ,  C07C209/38

    CPC分类号： C07C215/52 ,  C07C209/00 ,  C07C209/40 ,  C07C249/08

    摘要： An arylisonitrosoalkanone is hydrogenated in the presence of a noble metal catalyst and a weak carboxylic acid to form an arylalkanolamine which is then hydrogenated in the presence of a strong mineral acid and the transition metal catalyst to form an arylalkylamine. When the arylisonitrosoalkanone is an isonitrosoacetophenone, the isonitrosoacetophenone is prepared by one of two methods.In the first method, a substituted or an unsubstituted isonitrosoacetophenone is prepared from a corresponding substituted or unsubstituted acetophenone by oxidizing the acetophenone to form a substituted or an unsubstituted phenylglyoxalacetal in a reactor, hydrolyzing the phenylglyoxal acetal in the same reactor to form a corresponding substituted or unsubstituted phenylglyoxal, and condensing the phenylglyoxal with hydroxylamine or a salt thereof in the same reactor to form the substituted or unsubstituted isonitrosoacetophenone. Alternatively, the substituted or unsubstituted isonitrosoacetophenone is prepared from the corresponding substituted or unsubstituted acetophenone by reacting the substituted or unsubstituted acetophenone in water with a source of a nitrosonium ion in the presence of a strong acid to form a corresponding substituted or unsubstituted phenylglyoxal, and condensing the phenylglyoxal with hydroxylamine or a salt thereof to form the substituted or unsubstituted isonitrosoacetophenone. In either method, any strong acid that might be present in the reaction mass following the condensation to the isonitrosoacetophenone shall be removed therefrom prior to initiating the hydrogenation of the isonitrosoacetophenone to the arylalkanolamine.

    摘要翻译： 芳基亚硝基烷酮在贵金属催化剂和弱羧酸的存在下氢化形成芳基烷醇胺，然后在强无机酸和过渡金属催化剂的存在下氢化形成芳基烷基胺。 当芳基亚硝基烷酮是异硝基苯乙酮时，通过两种方法之一制备异硝基苯乙酮。 在第一种方法中，通过在反应器中氧化苯乙酮以形成取代或未取代的苯基乙醛缩醛，由相应的取代或未取代的苯乙酮制备取代或未取代的异硝基苯乙酮，在相同的反应器中水解苯乙醛缩醛形成相应的取代或未取代的苯乙酮缩醛， 未取代的苯基乙二醛，并将苯乙醛酸与羟胺或其盐在同一反应器中缩合形成取代或未取代的异硝基苯乙酮。 或者，取代或未取代的异硝基苯乙酮由相应的取代或未取代的苯乙酮通过在强酸存在下使取代或未取代的苯乙酮在水中与亚硝鎓离子源反应形成相应的取代或未取代的苯基乙二醛，并将 苯基乙二醛与羟胺或其盐形成取代或未取代的异硝基苯乙酮。 在任一种方法中，在将异亚氨基苯乙酮氢化成芳基烷醇胺之前，任何在与异亚硝基苯乙酮缩合后可能存在于反应物质中的强酸应从其中除去。

    Process for preparing substituted and unsubstituted arylalkylamines
    8.
    发明授权
    Process for preparing substituted and unsubstituted arylalkylamines 失效
    制备取代和未取代的芳基烷基胺的方法

    公开(公告)号：US5319142A

    公开(公告)日：1994-06-07

    申请号：US957335

    申请日：1992-10-06

    申请人： Joseph A. McDonough ,  Ahmed M. Tafesh ,  Olan S. Fruchey

    发明人： Joseph A. McDonough ,  Ahmed M. Tafesh ,  Olan S. Fruchey

    IPC分类号： C07C209/00 ,  C07C209/40 ,  C07C215/52 ,  C07C249/08 ,  C07C209/38

    CPC分类号： C07C215/52 ,  C07C209/00 ,  C07C209/40 ,  C07C249/08

    摘要： An arylisonitrosoalkanone is hydrogenated in the presence of a noble metal catalyst and a weak carboxylic acid to form an arylalkanolamine which is then hydrogenated in the presence of a strong mineral acid and the transition metal catalyst to form an arylalkylamine. When the arylisonitrosoalkanone is an isonitrosoacetophenone, the isonitrosoacetophenone is prepared by one of two methods.In the first method, a substituted or an unsubstituted isonitrosoacetophenone is prepared from a corresponding substituted or unsubstituted acetophenone by oxidizing the acetophenone to form a substituted or an unsubstituted phenylglyoxalacetal in a reactor, hydrolyzing the phenylglyoxal acetal in the same reactor to form a corresponding substituted or unsubstituted phenylglyoxal, and condensing the phenylglyoxal with hydroxylamine or a salt thereof in the same reactor to form the substituted or unsubstituted isonitrosoacetophenone. Alternatively, the substituted or unsubstituted isonitrosoacetophenone is prepared from the corresponding substituted or unsubstituted acetophenone by reacting the substituted or unsubstituted acetophenone in water with a source of a nitrosonium ion in the presence of a strong acid to form a corresponding substituted or unsubstituted phenylglyoxal, and condensing the phenylglyoxal with hydroxylamine or a salt thereof to form the substituted or unsubstituted isonitrosoacetophenone. In either method, any strong acid that might be present in the reaction mass following the condensation to the isonitrosoacetophenone shall be removed therefrom prior to initiating the hydrogenation of the isonitrosoacetophenone to the arylalkanolamine.

    摘要翻译： 芳基亚硝基烷酮在贵金属催化剂和弱羧酸的存在下氢化形成芳基烷醇胺，然后在强无机酸和过渡金属催化剂的存在下氢化形成芳基烷基胺。 当芳基亚硝基烷酮是异硝基苯乙酮时，通过两种方法之一制备异硝基苯乙酮。 在第一种方法中，通过在反应器中氧化苯乙酮以形成取代或未取代的苯基乙醛缩醛，由相应的取代或未取代的苯乙酮制备取代或未取代的异硝基苯乙酮，在相同的反应器中水解苯乙醛缩醛形成相应的取代或未取代的苯乙酮缩醛， 未取代的苯基乙二醛，并将苯乙醛酸与羟胺或其盐在同一反应器中缩合形成取代或未取代的异硝基苯乙酮。 或者，取代或未取代的异硝基苯乙酮由相应的取代或未取代的苯乙酮通过在强酸存在下使取代或未取代的苯乙酮在水中与亚硝鎓离子源反应形成相应的取代或未取代的苯基乙二醛，并将 苯基乙二醛与羟胺或其盐形成取代或未取代的异硝基苯乙酮。 在任一种方法中，在将异亚氨基苯乙酮氢化成芳基烷醇胺之前，任何在与异亚硝基苯乙酮缩合后可能存在于反应物质中的强酸应从其中除去。