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1.发明授权Cloning and expression of yeast STE13 and Dpp2 genes encoding dipeptidyl aminopeptidase A and B 失效克隆和表达编码二肽基氨基肽酶A和B的酵母STE13和Dpp2基因
公开(公告)号：US4977085A
公开(公告)日：1990-12-11
申请号：US584619
申请日：1984-02-29
申请人： George Sprague , Ira Herskowitz , Jeremy Thorner , David Julius , Lindley Blair , Anthony Brake
发明人： George Sprague , Ira Herskowitz , Jeremy Thorner , David Julius , Lindley Blair , Anthony Brake
摘要： A method is provided for expressing the proteases dipeptidyl aminopeptidases A and B which are useful for processing precursor proteins. Genes controlling these proteases may be insdrted into appropriate vectors and transformed into cultures. The proteases may either be utilized to process precursor proteins in vivo or may be extracted from cultures and used to process precursor proteins in vitro.
摘要翻译： 提供了用于表达可用于加工前体蛋白质的蛋白酶二肽基氨基肽酶A和B的方法。 控制这些蛋白酶的基因可以被插入适当的载体并转化成培养物。 蛋白酶可以用于体内处理前体蛋白质，也可以从培养物中提取，并用于体外处理前体蛋白质。
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2.发明申请Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof 有权编码辣椒素受体和辣椒素受体相关多肽的核酸序列及其用途公开(公告)号：US20050095650A1
公开(公告)日：2005-05-05
申请号：US10915017
申请日：2004-08-09
申请人： David Julius , Michael Caterina , Anthony Brake
发明人： David Julius , Michael Caterina , Anthony Brake
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61P25/04 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/53
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00
摘要： The present invention features vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2 (VRRP-1), as well as the encoding polynucleotide sequences. In related aspects the invention features expression vectors and host cells comprising such polynucleotides. In other related aspects, the invention features transgenic animals having altered capsaicin receptor expression, due to, for example, the presence of an exogenous wild-type or modified capsaicin receptor-encoding polynucleotide sequence. The present invention also relates to antibodies that bind specifically to a capsaicin receptor polypeptide, and methods for producing these polypeptides. Further, the invention provides methods for using capsaicin receptor, including methods for screening candidate agents for activity as agonists or antagonists of capsaicin receptor activity, as well as assays to determine the amount of a capsaicin receptor-activating agent in a sample. In other related aspects, the invention provides methods for the use of the capsaicin receptor for the diagnosis and treatment of human disease and painful syndromes.
摘要翻译： 本发明特征在于香草素受体多肽和香草素受体相关多肽，特别是辣椒素受体亚型VR1和VR2（VRRP-1）以及编码多核苷酸序列。 在相关方面，本发明的特征在于包含这种多核苷酸的表达载体和宿主细胞。 在其他相关方面，本发明的特征在于具有改变的辣椒素受体表达的转基因动物，这是由于例如外源野生型或修饰的辣椒素受体编码多核苷酸序列的存在。 本发明还涉及与辣椒素受体多肽特异性结合的抗体，以及制备这些多肽的方法。 此外，本发明提供了使用辣椒素受体的方法，包括用于筛选作为辣椒素受体活性的激动剂或拮抗剂的活性的候选药剂的方法，以及测定样品中辣椒素受体激活剂的量的测定法。 在其他相关方面，本发明提供了使用辣椒素受体来诊断和治疗人类疾病和疼痛综合征的方法。
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3.发明授权Methods of identifying modulators of a cold-and-menthol-sensitive receptor (CMR1) and recombinant cells for use thereof 有权识别冷和薄荷醇敏感受体（CMR1）的调节剂和用于其的重组细胞的方法公开(公告)号：US08361733B2
公开(公告)日：2013-01-29
申请号：US12905001
申请日：2010-10-14
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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4.发明授权Methods of modulating cold sensory perception via a cold- and menthol-sensitive receptor (CMR1) 有权通过冷和薄荷醇敏感受体（CMR1）调节感冒感觉的方法公开(公告)号：US08470545B2
公开(公告)日：2013-06-25
申请号：US13340443
申请日：2011-12-29
IPC分类号： G01N33/53 , G01N33/567 , C12Q1/02 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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公开(公告)号：US07834150B2
公开(公告)日：2010-11-16
申请号：US12032287
申请日：2008-02-15
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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公开(公告)号：US5889147A
公开(公告)日：1999-03-30
申请号：US785534
申请日：1997-01-17
申请人： Lourdes J. Cruz , Baldomero M. Olivera , J. Michael McIntosh , Elsie Jimenez , A. Grey Craig , Jean A. Rivier , David Julius , Laura England
发明人： Lourdes J. Cruz , Baldomero M. Olivera , J. Michael McIntosh , Elsie Jimenez , A. Grey Craig , Jean A. Rivier , David Julius , Laura England
IPC分类号： A61K38/00 , C07K5/10 , C07K5/117 , C07K7/06 , C07K14/435 , A61K38/08 , A61K38/10 , A61K38/16 , C07K7/04
CPC分类号： C07K7/06 , C07K14/43504 , C07K5/1024 , C07K5/1027 , A61K38/00
摘要： The present invention is directed to conopeptides having 6-45 amino acids, including one or more bromo-tryptophan residues. More specifically, the present invention is directed to conopeptides having the general formula: R-(Cys).sub.n -R.sup.1 -B-R.sup.2 -Cys-R.sup.3, wherein R is a peptide chain of 0-24 amino acids, R.sup.1 is a peptide chain of 0 to 31 amino acids, R.sup.2 is a peptide chain of 0-29 amino acids, R.sup.3 is a peptide chain of 0 to 26 amino acids, B is 6-bromo-tryptophan, n is 0 or 1 and the total length of the conopeptide is from about 6 to about 45 amino acids. The invention also includes pharmaceutically acceptable salts of the conopeptides. These bromo-tryptophan containing conopeptides invention are useful as antihelminthic agents, anti-vomiting agents, sleep-inducing agents, adjuncts to anesthesia, anticonvulsant or neuroprotective agents.
摘要翻译： 本发明涉及具有6-45个氨基酸的肽，包括一个或多个溴 - 色氨酸残基。 更具体地，本发明涉及具有以下通式的肽：R-（Cys）n -R 1 -B-R 2 -Cys-R 3，其中R是0-24个氨基酸的肽链，R 1是肽链 0至31个氨基酸，R2为0-29个氨基酸的肽链，R3为0至26个氨基酸的肽链，B为6-溴色氨酸，n为0或1，总长度为 肽是约6至约45个氨基酸。 本发明还包括肽的药学上可接受的盐。 这些含有溴代色氨酸的多肽本发明可用作抗凝血剂，抗呕吐剂，睡眠诱导剂，麻醉剂，抗惊厥药或神经保护剂。
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公开(公告)号：US20080241872A1
公开(公告)日：2008-10-02
申请号：US12032485
申请日：2008-02-15
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
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公开(公告)号：US20120100076A1
公开(公告)日：2012-04-26
申请号：US13340443
申请日：2011-12-29
IPC分类号： A61K49/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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公开(公告)号：US20080242841A1
公开(公告)日：2008-10-02
申请号：US12032287
申请日：2008-02-15
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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10.发明授权Yeast endopeptidase for basic amino-acid site cleavage, preparation and use 失效酵母内肽酶用于碱性氨基酸位点切割，制备和使用
公开(公告)号：US5077204A
公开(公告)日：1991-12-31
申请号：US183252
申请日：1988-04-08
摘要： Methods and compositions are provided for endopeptidase production, enhanced efficiencies of processing in vivo and in vitro to provide for process polypeptides, and purified enzyme for in vitro processing of polypeptides. The endopeptidase is specific for dibasic amino acid sites, cleaving at the C-side of the dipeptide.The S. cerevisiae strain pYBCA-5 (truncated KEX2) was deposited at the A.T.C.C. on June 21, 1984 and given Accession No. 20717.
摘要翻译： 提供了用于内肽酶生产的方法和组合物，提高体内和体外加工效率以提供工艺多肽，以及用于体外加工多肽的纯化酶。 内肽酶对二元氨基酸位点是特异性的，在二肽的C侧裂解。 酿酒酵母菌株pYBCA-5（截短的KEX2）保藏在A.T.C.C. 1984年6月21日，加拿大号20717。
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