公开(公告)号：US4605194A

公开(公告)日：1986-08-12

申请号：US505533

申请日：1983-06-17

申请人： Gerd Binnig ,  Christoph Gerber ,  Heinrich Rohrer ,  Edmund Weibel

发明人： Gerd Binnig ,  Christoph Gerber ,  Heinrich Rohrer ,  Edmund Weibel

IPC分类号： F16F15/02 ,  F16F7/10 ,  F16F15/04 ,  G01Q30/18 ,  F16M13/00

CPC分类号： G01Q30/18 ,  B82Y35/00 ,  F16F15/046

摘要： The vibration filter comprises an inner ring (27) on which vibration-sensitive equipment may be installed, the ring (27) being suspended from a plurality of springs (24, 25, 26) elastically supported by posts (18, 19, 20) in turn mounted on an outer ring (1) which is spring-suspended the same as the inner ring (27) from a rigid bench (8). The springs (12, 13, 14; 24, 25, 26) and other elastic members (9, 10, 11; 15, 16, 17; 21, 22, 23; 28, 29, 30) have differing resonant frequencies.Between the bench (8) and the outer ring (1), and between the outer and inner rings (1, 27) there may be provided eddy current brakes consisting of strong permanent magnets (46, 48) arranged opposite individual copper or aluminum blocks (5, 47).

摘要翻译： 振动过滤器包括内环（27），振动敏感设备可以安装在其上，环（27）悬挂在由柱（18,19,20）弹性支撑的多个弹簧（24,25,26）中， 又安装在从刚性工作台（8）弹簧悬挂与内圈（27）相同的外圈（1）上。 弹簧（12,13,14; 24,25,26）和其它弹性构件（9,10,11; 15,16,17; 21,22,23; 28,29,30）具有不同的谐振频率。 在工作台（8）和外圈（1）之间以及在外圈和内圈（1,27）之间，可以设置涡流制动器，其由相对于单独的铜或铝块排列的强永磁体（46,48）组成 （5,47）。

公开(公告)号：US4422002A

公开(公告)日：1983-12-20

申请号：US406653

申请日：1982-08-09

申请人： Gerd Binnig ,  Hermann Nievergelt ,  Heinrich Rohrer ,  Edmund Weibel

发明人： Gerd Binnig ,  Hermann Nievergelt ,  Heinrich Rohrer ,  Edmund Weibel

IPC分类号： H01J37/20 ,  G01Q10/04 ,  G12B1/00 ,  H01L21/68 ,  H01L41/09 ,  H02N2/12 ,  H01L41/08

CPC分类号： G01Q10/04 ,  B82Y35/00 ,  G12B1/00 ,  H02N2/0095 ,  H02N2/023 ,  H02N2/101

摘要： The travelling support (1) comprises a piezo-electric plate (2) resting on three legs (6) whose bottom surface is insulated from the bench (8) on which the support is to travel, by a dielectric (7). The piezo-electric plate (2) can be caused to contract by means of an actuating voltage applied via sliders (9, 10) to top and bottom electrodes on the plate (2). By applying a voltage to the legs (6), these may be clamped selectively by electrostatic forces effective across the dielectric (7). Appropriate control of the actuating and clamping voltages causes the support (1) to either move in a linear or rotary fashion. The displacements the support can perform per step are in the nanometer range.

摘要翻译： 行进支撑件（1）包括一个压电板（2），其位于三个腿部（6）上，底板表面通过电介质（7）与支架所要行进的工作台（8）绝缘。 压电板（2）可以通过通过滑块（9,10）施加到板（2）上的顶部和底部电极的致动电压而收缩。 通过向腿部（6）施加电压，可以通过在电介质（7）上有效的静电力选择性地夹持这些电压。 对致动和钳位电压的适当控制导致支撑件（1）以线性或旋转方式移动。 支撑件可以在每个步骤中执行的位移在纳米范围内。

公开(公告)号：US4343993A

公开(公告)日：1982-08-10

申请号：US186923

申请日：1980-09-12

申请人： Gerd Binnig ,  Heinrich Rohrer

发明人： Gerd Binnig ,  Heinrich Rohrer

IPC分类号： G01B7/34 ,  G01N23/00 ,  G01N27/00 ,  G01N27/62 ,  G01Q10/00 ,  G01Q30/04 ,  G01Q30/16 ,  G01Q30/18 ,  G01Q30/20 ,  G01Q60/10 ,  G01Q60/16 ,  H01J37/28 ,  H01L41/09

CPC分类号： G01Q30/16 ,  B82Y35/00 ,  G01Q60/16 ,  H01J37/28 ,  Y10S505/848 ,  Y10S977/852 ,  Y10S977/861 ,  Y10S977/871

摘要： The vacuum tunnel effect is utilized to form a scanning tunneling microscope. In an ultra-high vacuum at cryogenic temperature, a fine tip is raster scanned across the surface of a conducting sample at a distance of a few Angstroms. The vertical separation between the tip and sample surface is automatically controlled so as to maintain constant a measured variable which is proportional to the tunnel resistance, such as tunneling current. The position of the tip with respect to the surface is controlled preferably by piezo electric drive means acting in three coordinate directions. The spatial coordinates of the scanning tip are graphically displayed. This is conveniently done by displaying the drive currents or voltages of piezo electric drives.

摘要翻译： 利用真空隧道效应形成扫描隧道显微镜。 在低温真空下，在几英尺距离的导电样品表面光栅扫描细尖端。 自动控制尖端和样品表面之间的垂直分离，以保持与隧道电阻成比例的测量变量，例如隧道电流。 尖端相对于表面的位置优选地由三个坐标方向作用的压电驱动装置控制。 图形显示扫描尖端的空间坐标。 这通过显示压电驱动器的驱动电流或电压来方便地完成。

公开(公告)号：US09740912B2

公开(公告)日：2017-08-22

申请号：US13330900

申请日：2011-12-20

申请人： Ralf Schoenmeyer ,  Gerd Binnig ,  Guenter Schmidt ,  Maria Athelogou ,  Peter Ellenberg

发明人： Ralf Schoenmeyer ,  Gerd Binnig ,  Guenter Schmidt ,  Maria Athelogou ,  Peter Ellenberg

IPC分类号： G06K9/00 ,  G06K9/34 ,  G06T17/00 ,  G09G5/00 ,  G06T7/33

CPC分类号： G06K9/0014 ,  G06T7/33 ,  G06T2207/10056 ,  G06T2207/30024

摘要： A method for co-registering images of tissue slices stained with different biomarkers displays a first digital image of a first tissue slice on a graphical user interface such that an area of the first image is enclosed by a frame. Then a portion of a second image of a second tissue slice is displayed such that the area of the first image enclosed by the frame is co-registered with the displayed portion of the second image. The displayed portion of the second image has the shape of the frame. The tissue slices are both z slices of a tissue sample taken at corresponding positions in the x and y dimensions. The displayed portion of the second image is shifted in the x and y dimensions to coincide with the area of the first image that is enclosed by the frame as the user shifts the first image under the frame.

公开(公告)号：US08711149B2

公开(公告)日：2014-04-29

申请号：US13313685

申请日：2011-12-07

申请人： Guenter Schmidt ,  Arno Schaepe ,  Gerd Binnig

发明人： Guenter Schmidt ,  Arno Schaepe ,  Gerd Binnig

IPC分类号： G06T11/20

CPC分类号： G06F19/321 ,  G06F19/00 ,  G06K9/0014 ,  G06T7/0012 ,  G06T11/206 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10056 ,  G06T2207/30024 ,  G06T2207/30072 ,  G06T2210/41

摘要： A method of intuitively displaying values obtained from analyzing bio-medical images includes displaying a table of the values in a first pane of a graphical user interface. The table contains a user selectable row that includes a reference value and two numerical values. The reference value refers to an image of a tissue slice. The first numerical value is generated by performing image analysis on the image, and the second numerical value indicates a health state of the tissue. The image is displayed in a second pane of the graphical user interface in response to the user selecting the user selectable row. A graphical plot with a selectable symbol associated with the image is displayed in a third pane. The symbol has a position in the plot defined by the values. Alternatively, in response to the user selecting the selectable symbol, the image is displayed in the second pane.

摘要翻译： 直观地显示从分析生物医学图像获得的值的方法包括在图形用户界面的第一窗格中显示值的表格。 该表包含用户可选行，其中包含一个参考值和两个数值。 参考值是指组织切片的图像。 通过对图像进行图像分析来生成第一数值，第二数值表示组织的健康状态。 响应于用户选择用户可选行，图像显示在图形用户界面的第二窗格中。 具有与图像相关联的可选符号的图形显示在第三窗格中。 符号在由值定义的图中具有位置。 或者，响应于用户选择可选择符号，在第二窗格中显示图像。

公开(公告)号：US20130108139A1

公开(公告)日：2013-05-02

申请号：US13282450

申请日：2011-10-26

申请人： Gerd Binnig ,  Maria Athelogou ,  Guenter Schmidt

发明人： Gerd Binnig ,  Maria Athelogou ,  Guenter Schmidt

IPC分类号： G06K9/34

CPC分类号： G06T7/0012 ,  G06K9/0014 ,  G06K9/34 ,  G06K9/4652 ,  G06K9/6215 ,  G06T7/11 ,  G06T7/155 ,  G06T7/187 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/30024

摘要： A method for determining whether a test biomarker is a stain for a type of cell component, such as membrane or nucleus, involves performing various segmentation processes on an image of tissue stained with the test biomarker. One segmentation process searches for a first cell component type, and another segmentation process searches for a second cell component type by segmenting only stained pixels. The test biomarker is identified as a stain for each component type if the process identifies the component based only on stained pixels. Whether the test biomarker is a membrane stain or nucleus stain is displayed on a graphical user interface. In addition, the method identifies stained pixels corresponding to a second cell component using pixels determined to correspond to a first cell component. An expression profile for the test biomarker is then displayed that indicates the proportion of stained pixels in each type of cell component.

公开(公告)号：US20130016886A1

公开(公告)日：2013-01-17

申请号：US13546182

申请日：2012-07-11

申请人： Ralf Schoenmeyer ,  Peter Ellenberg ,  Gerd Binnig ,  Maria Athelogou ,  Guenter Schmidt

发明人： Ralf Schoenmeyer ,  Peter Ellenberg ,  Gerd Binnig ,  Maria Athelogou ,  Guenter Schmidt

IPC分类号： G06K9/50

CPC分类号： G06T7/0012 ,  G06T11/206 ,  G06T2207/10061 ,  G06T2207/20016 ,  G06T2207/20021 ,  G06T2207/20221

摘要： High-resolution digital images of adjacent slices of a tissue sample are acquired, and tiles are defined in the images. Values associated with image objects detected in each tile are calculated. The tiles in adjacent images are co-registered. A first hyperspectral image is generated using a first image, and a second hyperspectral image is generated using a second image. A first pixel of the first hyperspectral image has a first pixel value corresponding to a local value obtained using image analysis on a tile in the first image. A second pixel of the second hyperspectral image has a second pixel value corresponding to a local value calculated from a tile in the second image. A third hyperspectral image is generated by combining the first and second hyperspectral images. The third hyperspectral image is then displayed on a computer monitor using a false-color encoding generated using the first and second pixel values.

摘要翻译： 获取组织样本的相邻切片的高分辨率数字图像，并且在图像中定义瓦片。 计算与每个图块中检测到的图像对象相关联的值。 相邻图像中的瓦片共同注册。 使用第一图像生成第一高光谱图像，并且使用第二图像生成第二高光谱图像。 第一高光谱图像的第一像素具有对应于在第一图像中的图块上使用图像分析获得的局部值的第一像素值。 第二高光谱图像的第二像素具有对应于从第二图像中的图块计算的局部值的第二像素值。 通过组合第一和第二高光谱图像来生成第三高光谱图像。 然后，使用使用第一和第二像素值生成的伪色编码，在计算机监视器上显示第三高光谱图像。

公开(公告)号：US07849516B2

公开(公告)日：2010-12-07

申请号：US12187759

申请日：2008-08-07

申请人： Gerd Binnig ,  Evangelos Elefheriou ,  Mark Lantz

发明人： Gerd Binnig ,  Evangelos Elefheriou ,  Mark Lantz

IPC分类号： G01Q80/00

CPC分类号： G11B9/1436 ,  B82Y10/00 ,  G01Q80/00 ,  G11B9/1454

摘要： A method of scanning over a substrate includes implementing a write mode of the substrate by scanning a probe across a substrate, the probe having a spring cantilever probe mechanically fixed to a probe holding structure, a tip with a nanoscale apex, and an actuator for lateral positioning of the tip; the actuator comprising a thermally switchable element and a heating element for heating the thermally switchable element; and heating the heating element to a given temperature so as to locally soften a portion of the substrate and applying a force to the softened portion of the substrate through the tip so as to create one or more indentation marks in the softened portion of the substrate.

摘要翻译： 一种在衬底上扫描的方法包括通过在衬底上扫描探针来实现衬底的写入模式，探针具有机械固定到探针保持结构的弹簧悬臂探针，具有纳米级顶点的尖端和用于侧向的致动器 尖端定位 致动器包括可热切换元件和用于加热热可切换元件的加热元件; 并且将加热元件加热到给定的温度，以局部软化基板的一部分，并通过尖端向基板的软化部分施加力，从而在基板的软化部分中产生一个或多个凹痕。

公开(公告)号：US20060187803A1

公开(公告)日：2006-08-24

申请号：US11329466

申请日：2006-01-11

申请人： Peter Baechtold ,  Johannes Bednorz ,  Gerd Binnig ,  Giovanni Cherubini ,  Evangelos Eleftheriou ,  Michel Despont

发明人： Peter Baechtold ,  Johannes Bednorz ,  Gerd Binnig ,  Giovanni Cherubini ,  Evangelos Eleftheriou ,  Michel Despont

IPC分类号： G11B9/00

CPC分类号： G11B11/007 ,  B82Y10/00 ,  G11B9/1472

摘要： A storage device including a storage medium for storing data in the form of topographic or magnetic marks. At least one probe is mounted on a common frame, the common frame and the storage medium designed for moving relative to each other for creating or detecting said marks. Each probe includes a tip facing the storage medium, a read sensing element, a write element and a capacitive platform, that forms a first electrode and is designed for a voltage potential applied to it independent from a control signal for said read sensing element and for said voltage potential applied to said capacitive platform being independent from a control signal for said write heating element. It further comprises a second electrode arranged in a fixed position relative to the storage medium forming a first capacitor together wherein said first electrode and a medium between the first and second electrode.

摘要翻译： 一种存储装置，包括用于以地形或磁标记的形式存储数据的存储介质。 至少一个探针安装在公共框架上，公共框架和存储介质被设计用于相对于彼此移动以创建或检测所述标记。 每个探针包括面向存储介质的尖端，读取感测元件，写入元件和电容平台，其形成第一电极，并被设计用于独立于用于所述读取感测元件的控制信号的施加于其的电压电位，并且为 施加到所述电容平台的所述电压电位独立于用于所述写入加热元件的控制信号。 它还包括布置在相对于存储介质固定位置的第二电极，形成第一电容器，其中所述第一电极和第一和第二电极之间的介质。

公开(公告)号：US20050280174A1

公开(公告)日：2005-12-22

申请号：US11156839

申请日：2005-06-20

申请人： Gerd Binnig ,  Walter Haeberle ,  Dorothea Wiesmann

发明人： Gerd Binnig ,  Walter Haeberle ,  Dorothea Wiesmann

IPC分类号： B29C37/02 ,  G01Q10/00 ,  G01Q70/16 ,  G01Q80/00 ,  G11B9/00

CPC分类号： G11B9/1454 ,  G01Q70/06 ,  G01Q80/00 ,  G11B9/1481

摘要： Provides surface treatment devices, surface scanning devices, methods of operating a surface treatment device and methods of operating a surface scanning device. An area within a medium comprises at least one sharpening location for sharpening a tip of a probe mechanically. The tip is conically shaped with a radius of an apex smaller than 100 nm. In the case of the surface treatment device the probe is designed for altering the surface of the medium. In the case of the surface scanning device the probe is designed for scanning the medium. The sharpening location is suited for sharpening the tip mechanically. For that purpose the probe and the medium are being moved relative to each other such that the tip is located in the sharpening location. Then the probe and/or the medium are moved relative to each other such, that the tip is mechanically sharpened.

摘要翻译： 提供表面处理装置，表面扫描装置，操作表面处理装置的方法和操作表面扫描装置的方法。 介质内的区域包括至少一个磨削位置，用于机械地磨削探头的尖端。 尖端圆锥形，顶点的半径小于100nm。 在表面处理装置的情况下，探针设计用于改变介质的表面。 在表面扫描装置的情况下，探针设计用于扫描介质。 磨削位置适用于机械地磨尖。 为此，探针和介质相对于彼此移动，使得尖端位于磨刀位置。 然后探针和/或介质相对于彼此移动，使得尖端被机械地磨削。