公开(公告)号：US5747288A

公开(公告)日：1998-05-05

申请号：US909983

申请日：1997-06-12

申请人： Gerry Rubin ,  Marc Therrien ,  Henry Chang ,  Felix Karim ,  David Wassarman

发明人： Gerry Rubin ,  Marc Therrien ,  Henry Chang ,  Felix Karim ,  David Wassarman

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K45/00 ,  A61P43/00 ,  C12N1/15 ,  C12N5/10 ,  C12N9/12 ,  C12N15/54 ,  C12P21/06 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.

摘要翻译： 参与调节细胞生长和分化的新蛋白激酶Ras（Ksr）的激酶抑制剂为治疗干预提供了重要的靶标。 主题组合物还包括编码Ksr激酶的核酸，以及能够与Ksr基因杂交的杂交探针和引物。 这样的探针用于鉴定与疾病相关的突变体Ksr等位基因。 本发明包括用于筛选用于诊断或治疗与疾病相关的Ksr活性或Ksr依赖性信号转导的药理学试剂的化合物的化学文库的方法，包括磷酸化和结合测定。

公开(公告)号：US5700675A

公开(公告)日：1997-12-23

申请号：US571758

申请日：1995-12-13

申请人： Gerry Rubin ,  Marc Therrien ,  Henry Chang ,  Felix Karim ,  David Wassarman

发明人： Gerry Rubin ,  Marc Therrien ,  Henry Chang ,  Felix Karim ,  David Wassarman

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K45/00 ,  A61P43/00 ,  C12N1/15 ,  C12N5/10 ,  C12N9/12 ,  C12N15/54 ,  C07H21/04 ,  C07K1/00 ,  C12P21/06

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.

摘要翻译： 参与调节细胞生长和分化的新蛋白激酶Ras（Ksr）的激酶抑制剂为治疗干预提供了重要的靶标。 主题组合物还包括编码Ksr激酶的核酸，以及能够与Ksr基因杂交的杂交探针和引物。 这样的探针用于鉴定与疾病相关的突变体Ksr等位基因。 本发明包括用于筛选用于诊断或治疗与疾病相关的Ksr活性或Ksr依赖性信号转导的药理学试剂的化合物的化学文库的方法，包括磷酸化和结合测定。

公开(公告)号：US5747275A

公开(公告)日：1998-05-05

申请号：US909984

申请日：1997-08-12

申请人： Gerry Rubin ,  Marc Therrien ,  Henry Chang ,  Felix Karim ,  David Wassarman

发明人： Gerry Rubin ,  Marc Therrien ,  Henry Chang ,  Felix Karim ,  David Wassarman

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K45/00 ,  A61P43/00 ,  C12N1/15 ,  C12N5/10 ,  C12N9/12 ,  C12N15/54 ,  C12Q1/48 ,  C07H21/04 ,  C07K1/00 ,  C12P21/06

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.

摘要翻译： 参与调节细胞生长和分化的新蛋白激酶Ras（Ksr）的激酶抑制剂为治疗干预提供了重要的靶标。 主题组合物还包括编码Ksr激酶的核酸，以及能够与Ksr基因杂交的杂交探针和引物。 这样的探针用于鉴定与疾病相关的突变体Ksr等位基因。 本发明包括用于筛选用于诊断或治疗与疾病相关的Ksr活性或Ksr依赖性信号转导的药理学试剂的化合物的化学文库的方法，包括磷酸化和结合测定。

公开(公告)号：US12048059B2

公开(公告)日：2024-07-23

申请号：US17289668

申请日：2019-11-01

申请人： Kyocera Corporation ,  Amit Kalhan ,  Henry Chang

发明人： Amit Kalhan ,  Henry Chang

IPC分类号： H04W8/00 ,  H04L1/00 ,  H04L1/1867 ,  H04W4/46 ,  H04W84/18

CPC分类号： H04W8/005 ,  H04L1/0003 ,  H04L1/1896 ,  H04W4/46 ,  H04W84/18

摘要： The methods, devices, and systems discussed herein describe a wireless communication device transmitting a discovery channel message, at least a portion of which, is embedded in the control channel of a groupcast transmission. In some examples, the discovery channel message is transmitted using a pre-defined, fixed transmit power and modulation and coding scheme (MCS), which facilitates the receiving wireless communication devices' ability to decode the control channel, including the embedded discovery channel message. If a receiving wireless communication device can decode the discovery channel message above a configured threshold (e.g., a received power threshold and/or a signal-to-noise ratio (SNR)) but is unable to decode the data portion of the groupcast transmission, which was intended for the receiving wireless communication device, then the receiving wireless communication device will transmit a negative-acknowledgement (NACK) to the wireless communication device that transmitted the groupcast transmission.

公开(公告)号：US11153030B2

公开(公告)日：2021-10-19

申请号：US16328643

申请日：2017-09-11

申请人： Kyocera Corporation ,  Amit Kalhan ,  Henry Chang

发明人： Amit Kalhan ,  Henry Chang

IPC分类号： H04L1/00 ,  H04H20/42 ,  H04L27/00 ,  H04W24/04 ,  H04L27/34

摘要： A base station broadcasts information to machine type communication (MTC) devices in the coverage area of the base station using multiple transmissions with layered modulation. Each transmission includes a different sequence of bits representing the information. A MTC device receiving the signals for the transmissions at a sufficiently high quality can recover the information by using a high modulation order on one of the transmissions. A MTC device receiving the signals of the transmissions at less than the sufficient quality can receive the information by applying a lower modulation order to multiple transmissions.

公开(公告)号：US10887789B2

公开(公告)日：2021-01-05

申请号：US16346980

申请日：2017-10-27

申请人： Kyocera Corporation ,  Henry Chang ,  Masato Fujishiro

发明人： Henry Chang ,  Masato Fujishiro

IPC分类号： H04W28/02 ,  H04W28/22 ,  H04W36/00 ,  H04W72/04 ,  H04W72/12

摘要： A base station receives a bitrate query from a first user equipment (UE) device being served by the base station. The bitrate query can be a request for a bitrate increase or decrease. The base station transmits a bitrate recommendation to the first UE device. The bitrate recommendation is to be used for a Voice over Long-Term Evolution (VoLTE) call between the first UE device and a second UE device. In some instances, the first UE device and the second UE device negotiate the bitrate to be used for the VoLTE call, based on the bitrate recommended by the base station. The first and second UE devices implement a bitrate for the VoLTE call and provide feedback to the base station.

公开(公告)号：US09644475B2

公开(公告)日：2017-05-09

申请号：US14687348

申请日：2015-04-15

申请人： Michael A Forsberg ,  Mike Allen Swatek ,  James Joseph Freeman ,  Steve James Coulston ,  Thomas McClain Scott ,  Nicholas L Bayard ,  Henry Chang

发明人： Michael A Forsberg ,  Mike Allen Swatek ,  James Joseph Freeman ,  Steve James Coulston ,  Thomas McClain Scott ,  Nicholas L Bayard ,  Henry Chang

IPC分类号： E21B47/12 ,  E21B47/00 ,  H04L29/08

CPC分类号： E21B47/12 ,  E21B47/0007 ,  H04L67/12

摘要： A method of managing data obtained in a borehole is provided. The method includes monitoring a characteristic with at least one sensor and obtaining raw data therefrom; indexing the raw data with the at least one sensor; recording the indexed data with the at least one sensor; forming a data packet with the at least one sensor, the data packet including at least a portion of the indexed data and index information; and transmitting the data packet in a predetermined segment of a communication protocol.

公开(公告)号：US09596629B2

公开(公告)日：2017-03-14

申请号：US13421648

申请日：2012-03-15

申请人： Douglas Dunn ,  Amit Kalhan ,  David Comstock ,  Henry Chang

发明人： Douglas Dunn ,  Amit Kalhan ,  David Comstock ,  Henry Chang

IPC分类号： H04B7/15 ,  H04W36/00 ,  H04B7/155

CPC分类号： H04W36/0061 ,  H04B7/155 ,  H04B7/15507

摘要： Systems and methods for transparent handovers of mobile relays on high-speed vehicles. In an embodiment, a base station of a wireless communications network transmits identification data to a mobile relay on a high-speed vehicle. The identification data identifies base stations which are configured for transparent handovers. The network also receives data indicative of a scheduled path of the high-speed vehicle, which it uses to select a target base station for communication with the mobile relay. Once the target base station has been selected, the network begins servicing the mobile relay from the second base station, without requiring any measurement values from the mobile relay and without handover signaling.

摘要翻译： 用于高速车辆上移动中继器透明切换的系统和方法。 在一个实施例中，无线通信网络的基站将识别数据发送到高速车辆上的移动中继站。 识别数据识别配置为透明切换的基站。 该网络还接收表示高速车辆的调度路径的数据，该数据用于选择与移动中继通信的目标基站。 一旦选择了目标基站，网络开始从第二基站服务于移动中继，而不需要来自移动中继的任何测量值，而不需要切换信令。

公开(公告)号：US09467886B2

公开(公告)日：2016-10-11

申请号：US13821908

申请日：2010-09-24

申请人： Henry Chang

发明人： Henry Chang

IPC分类号： H04L12/28 ,  H04W24/10 ,  H04J1/16 ,  H04W24/08 ,  H04W28/18 ,  H04W48/08 ,  H04W88/06

CPC分类号： H04W24/10 ,  H04W24/08 ,  H04W28/18 ,  H04W48/08 ,  H04W88/06

摘要： Systems and methods for configuring cross radio access technology minimization of drive testing are presented. In one embodiment, the use of circuit switched fallback is used as a trigger for switching minimization of drive test configurations on a user equipment. After the user equipment returns from circuit switched fallback, the minimization of drive test parameters are reported to the base station.

摘要翻译： 介绍了配置交叉无线电接入技术最小化驱动器测试的系统和方法。 在一个实施例中，电路交换回退的使用被用作用于在用户设备上切换最小化驱动器测试配置的触发器。 在用户设备从电路交换回退之后，驱动测试参数的最小化被报告给基站。

公开(公告)号：US09295000B2

公开(公告)日：2016-03-22

申请号：US11740231

申请日：2007-04-25

申请人： Henry Chang ,  Doug Dunn

发明人： Henry Chang ,  Doug Dunn

IPC分类号： H04W52/02 ,  H04W76/00

CPC分类号： H04W52/0235 ,  H04W4/14 ,  H04W52/0261 ,  H04W76/50 ,  Y02D70/142

摘要： A portable communication device transmits, to a communication network, a radio configuration (RC) request indicator requesting assignment of a power saving radio configuration for reverse link transmissions. The power saving radio configuration is one a plurality of radio configurations including the power saving radio configuration and at least one other radio configuration defined by a communication standard different than the communication standard defining the power saving radio configuration. Average power consumption at the portable device when the portable communication device participates in the call using the power saving radio configuration is less than if the other radio configuration is used for the call.

摘要翻译： 便携式通信设备向通信网络发送请求分配用于反向链路传输的功率节省无线电配置的无线电配置（RC）请求指示符。 省电无线电配置是包括功率节省无线电配置和由与定义省电无线电配置的通信标准不同的通信标准定义的至少一个其他无线电配置的多个无线电配置之一。 当便携式通信设备使用省电无线电配置参与呼叫时便携式设备的平均功耗小于其他无线电配置用于呼叫时的平均功耗。