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公开(公告)号：US20100009426A1
公开(公告)日：2010-01-14
申请号：US12556528
申请日：2009-09-09
申请人： Grace DeSantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Kelly Chatman , Robert Farwell
发明人： Grace DeSantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Kelly Chatman , Robert Farwell
IPC分类号： C12N9/78
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
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2.发明申请Nitrilases, Nucleic Acids Encoding Them and Methods For Making and Using Them 失效Nitrilases，Nucleic Acids编码他们和制造和使用它们的方法公开(公告)号：US20120009637A1
公开(公告)日：2012-01-12
申请号：US13236862
申请日：2011-09-20
申请人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
发明人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
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3.发明申请Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them 有权Nitrilases，编码它们的核酸及其制备和使用方法公开(公告)号：US20100216214A1
公开(公告)日：2010-08-26
申请号：US12773317
申请日：2010-05-04
申请人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
发明人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
IPC分类号： C12N9/78
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
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公开(公告)号：US08318471B2
公开(公告)日：2012-11-27
申请号：US13236862
申请日：2011-09-20
申请人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
发明人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
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5.发明授权Nitrilases, nucleic acids encoding them and methods for making and using them 失效腈水解酶，编码它们的核酸和制备和使用它们的方法公开(公告)号：US07608445B1
公开(公告)日：2009-10-27
申请号：US10514004
申请日：2003-05-15
申请人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
发明人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , A61K38/00 , C07H21/04 , C12Q1/68 , C07H21/02
CPC分类号： C12N9/78 , C12P7/42 , C12P13/04 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
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公开(公告)号：US20090176976A1
公开(公告)日：2009-07-09
申请号：US12397204
申请日：2009-03-03
申请人： Grace DESANTIS , Jennifer Ann Chaplin , Ellen Chi , Aileen Milan , Jay M. Short , David Weiner , Mark Madden , Mark J. Burk , Dan E. Robertson , Darcy Madden
发明人： Grace DESANTIS , Jennifer Ann Chaplin , Ellen Chi , Aileen Milan , Jay M. Short , David Weiner , Mark Madden , Mark J. Burk , Dan E. Robertson , Darcy Madden
IPC分类号： C12N15/11
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
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公开(公告)号：US07651849B2
公开(公告)日：2010-01-26
申请号：US12397204
申请日：2009-03-03
申请人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay M. Short , David Paul Weiner , Mark Madden , Darcy Madden, legal representative , Mark J. Burk , Dan E. Robertson
发明人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay M. Short , David Paul Weiner , Mark Madden , Mark J. Burk , Dan E. Robertson
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , A61K38/00 , C07H21/04 , C12Q1/68 , C07H21/02
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
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8.发明授权P450 enzymes, nucleic acids encoding them and methods of making and using them 有权P450酶，编码它们的核酸以及制备和使用它们的方法公开(公告)号：US07232672B2
公开(公告)日：2007-06-19
申请号：US10214446
申请日：2002-08-05
申请人： David Weiner , Mark J. Burk , Tim Hitchman , Catherine Pujol , Toby Richardson , Jay M. Short
发明人： David Weiner , Mark J. Burk , Tim Hitchman , Catherine Pujol , Toby Richardson , Jay M. Short
CPC分类号： C12N9/0071
摘要： The invention is directed to polypeptides having P450 activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The P450 enzymes can be used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
摘要翻译： 本发明涉及具有P450活性的多肽，编码多肽的多核苷酸，与这些多肽结合的抗体，以及制备和使用这些多核苷酸和多肽的方法。 P450酶可用于催化环氧化物和芳烃氧化物水解成其相应的二醇。
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9.发明授权Epoxide hydrolases, nucleic acids encoding them and methods for making and using them 有权环氧化物水解酶，编码它们的核酸和制备和使用它们的方法公开(公告)号：US06943001B2
公开(公告)日：2005-09-13
申请号：US10272490
申请日：2002-10-10
申请人： Lishan Zhao , Eric J. Mathur , David Weiner , Toby Richardson , Aileen Milan , Mark J. Burk , Bin Han , Jay M. Short
发明人： Lishan Zhao , Eric J. Mathur , David Weiner , Toby Richardson , Aileen Milan , Mark J. Burk , Bin Han , Jay M. Short
IPC分类号： C12N9/14 , C12P7/18 , C12P17/02 , C12P17/04 , C12P17/12 , C12P17/16 , C12N15/54 , C12Q1/34 , C07K2/04
CPC分类号： C12P17/16 , C07K2319/00 , C12N9/14 , C12P7/18 , C12P17/02 , C12P17/04 , C12P17/12 , C12P17/162
摘要： The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
摘要翻译： 本发明涉及具有环氧化物水解酶活性的多肽，编码多肽的多核苷酸，与这些多肽结合的抗体，以及制备和使用这些多核苷酸和多肽的方法。 环氧化物水解酶用于催化环氧化物和芳烃氧化物水解成其相应的二醇。
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10.发明授权Epoxide hydrolases, nucleic acids encoding them and methods of making and using them 有权环氧化物水解酶，编码它们的核酸和制备和使用它们的方法公开(公告)号：US06979733B2
公开(公告)日：2005-12-27
申请号：US10214473
申请日：2002-08-05
申请人： Lishan Zhao , Eric J. Mathur , David Weiner , Toby Richardson , Aileen Milan , Mark J. Burk , Bin Han , Jay M. Short
发明人： Lishan Zhao , Eric J. Mathur , David Weiner , Toby Richardson , Aileen Milan , Mark J. Burk , Bin Han , Jay M. Short
IPC分类号： A01H5/00 , A01K67/027 , C07K16/40 , C12M1/00 , C12M1/34 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/14 , C12N11/00 , C12N15/02 , C12N15/09 , C12P1/00 , C12P7/18 , C12P17/02 , C12P17/04 , C12P17/12 , C12P17/16 , C12P21/08 , C12P41/00 , C12Q1/34 , C12Q1/68 , G01N33/48 , G01N33/566 , G01N33/573 , G01N37/00 , C12N15/55
CPC分类号： C12P17/162 , C07K2319/00 , C12N9/14 , C12P7/18 , C12P17/02 , C12P17/04 , C12P17/12 , C12P17/16
摘要： The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
摘要翻译： 本发明涉及具有环氧化物水解酶活性的多肽，编码多肽的多核苷酸，与这些多肽结合的抗体，以及制备和使用这些多核苷酸和多肽的方法。 环氧化物水解酶用于催化环氧化物和芳烃氧化物水解成其相应的二醇。
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