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    SYSTEMS AND METHODS FOR AMPLIFYING NUCLEIC ACIDS
    8.
    发明申请
    SYSTEMS AND METHODS FOR AMPLIFYING NUCLEIC ACIDS 有权
    用于放大核酸的系统和方法

    公开(公告)号：US20090317874A1

    公开(公告)日：2009-12-24

    申请号：US12144328

    申请日：2008-06-23

    申请人： Gregory A. Dale ,  Kenton C. Hasson ,  Shulin Zeng ,  Michele Stone

    发明人： Gregory A. Dale ,  Kenton C. Hasson ,  Shulin Zeng ,  Michele Stone

    IPC分类号： C12P19/34 ,  C12M1/34 ,  C12M1/36

    CPC分类号： B01L7/525 ,  B01L3/5027 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0883 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1838 ,  B01L2400/0487 ,  G01N21/0332 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2021/6439

    摘要： An apparatus for performing a thermocyclic process, such as amplifying DNA, includes a microfluidic chip with a channel formed therein and one or more thermal distribution elements disposed over portions of the chip. Each thermal distribution element is configured to distribute thermal energy from an external thermal energy source substantially uniformly over the portion of the chip covered by the thermal distribution element. The portion of the chip covered by the thermal distribution element thereby comprises a discrete temperature zone. Other temperature zones can be defined by other thermal distribution elements or by portions of the chip not covered by a thermal distribution element. The channel is configured so that a fluid flowing through the channel would enter and exit the different temperature zones a plurality of times, thereby alternately exposing the fluid to the temperature of each zone for a period of time required for the fluid to traverse the zone.

    摘要翻译： 用于进行热循环过程（例如放大DNA）的装置包括其中形成有通道的微流体芯片和设置在芯片的部分上的一个或多个热分配元件。 每个热分配元件被配置为将来自外部热能源的热能基本均匀地分布在由热分布元件覆盖的芯片的部分上。 由热分配元件覆盖的芯片的部分由此包括离散的温度区。 其他温度区可以由其他热分布元件或未被热分布元件覆盖的芯片的部分限定。 通道被配置成使得流过通道的流体将多次进入和离开不同的温度区域，由此交替地将流体暴露于每个区域的温度一段时间以使流体穿过该区域。