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    METHODS, DEVICES, AND SYSTEMS FOR FLUID MIXING AND CHIP INTERFACE
    3.
    发明申请
    METHODS, DEVICES, AND SYSTEMS FOR FLUID MIXING AND CHIP INTERFACE 有权
    用于流体混合和芯片接口的方法，装置和系统

    公开(公告)号：US20120058571A1

    公开(公告)日：2012-03-08

    申请号：US13222450

    申请日：2011-08-31

    申请人： Ivor T. Knight ,  Scott Corey ,  Ben Lane ,  Conrad Laskowski ,  Alex Flamm ,  Brian Murphy

    发明人： Ivor T. Knight ,  Scott Corey ,  Ben Lane ,  Conrad Laskowski ,  Alex Flamm ,  Brian Murphy

    IPC分类号： G01N1/00 ,  B01L3/02

    CPC分类号： B01L3/022 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2200/10 ,  B01L2300/14 ,  B01L2400/0442 ,  B01L2400/0487 ,  Y10T436/2575

    摘要： In one aspect, the present invention provides methods, devices, and systems for ensuring that multiple components of a mixture are fully mixed in a continuous flow microfluidic system while ensuring that mixing between segments flowing through the chip is minimized. In some embodiments, the present invention includes mixing fluids in a droplet maintained at the tip of a pipette before the mixture is introduced to the microfluidic device. In another aspect, the present invention provides a pipette tip having a ratio of an outside diameter to an inside diameter that provides sufficient surface area for a droplet comprising up to the entire volume of the liquid to suspend from the pipette tip intact. In yet another aspect, the present invention provides methods, devices, and systems for delivering a reaction mixture to a microfluidic chip comprising a docking receptacle, an access tube and a reservoir.

    摘要翻译： 一方面，本发明提供用于确保混合物的多个组分在连续流微流体系统中完全混合的方法，装置和系统，同时确保流过芯片的区段之间的混合最小化。 在一些实施方案中，本发明包括在将混合物引入微流体装置之前将保持在移液管尖端的液滴混合流体。 在另一方面，本发明提供了一种移液管尖端，其具有外径与内径之比，其为包含液体的整个体积的液滴提供足够的表面面积，从而完全悬浮于移液管尖端。 在另一方面，本发明提供用于将反应混合物输送到微流控芯片的方法，装置和系统，所述微流控芯片包括对接插座，进入管和储存器。

    METHOD, DEVICES, AND SYSTEMS FOR FLUID MIXING AND CHIP INTERFACE
    5.
    发明申请
    METHOD, DEVICES, AND SYSTEMS FOR FLUID MIXING AND CHIP INTERFACE 审中-公开
    用于流体混合和芯片接口的方法，装置和系统

    公开(公告)号：US20120058519A1

    公开(公告)日：2012-03-08

    申请号：US13222474

    申请日：2011-08-31

    申请人： Ivor T. Knight ,  Scott Corey ,  Ben Lane ,  Conrad Laskowski ,  Alex Flamm ,  Brian Murphy

    发明人： Ivor T. Knight ,  Scott Corey ,  Ben Lane ,  Conrad Laskowski ,  Alex Flamm ,  Brian Murphy

    IPC分类号： C12P19/34 ,  C12M1/00

    CPC分类号： B01L3/022 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2200/10 ,  B01L2300/14 ,  B01L2400/0442 ,  B01L2400/0487 ,  Y10T436/2575

    摘要： In one aspect, the present invention provides methods, devices, and systems for ensuring that multiple components of a mixture are fully mixed in a continuous flow microfluidic system while ensuring that mixing between segments flowing through the chip is minimized. In some embodiments, the present invention includes mixing fluids in a droplet maintained at the tip of a pipette before the mixture is introduced to the microfluidic device. In another aspect, the present invention provides methods, devices, and systems for creating segments that move through a microfluidic chip with minimal mixing between segments. The microfluidic chip may have an interface chip and a reaction chip. In some embodiments, the present invention includes creating segments that flow through an interface chip and a reaction chip, wherein the interface chip and a reaction chip have separate flow control mechanisms and produce minimal mixing between segments.

    摘要翻译： 一方面，本发明提供用于确保混合物的多个组分在连续流微流体系统中完全混合的方法，装置和系统，同时确保流过芯片的区段之间的混合最小化。 在一些实施方案中，本发明包括在将混合物引入微流体装置之前将保持在移液管尖端的液滴混合流体。 在另一方面，本发明提供用于创建通过微流体芯片移动的段的方法，装置和系统，其中片段之间的混合最小。 微流控芯片可以具有接口芯片和反应芯片。 在一些实施例中，本发明包括创建流过界面芯片和反应芯片的区段，其中界面芯片和反应芯片具有分离的流量控制机制并且在区段之间产生最小的混合。