公开(公告)号：US08289522B2

公开(公告)日：2012-10-16

申请号：US12943762

申请日：2010-11-10

申请人： Guillermo J. Tearney ,  Dvir Yelin ,  Benjamin J. Vakoc ,  Wang-Yuhl Oh ,  Brett E. Bouma

发明人： Guillermo J. Tearney ,  Dvir Yelin ,  Benjamin J. Vakoc ,  Wang-Yuhl Oh ,  Brett E. Bouma

IPC分类号： G01B9/02

CPC分类号： G01N33/4833 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6852 ,  G01B9/02 ,  G01B9/02027 ,  G01B9/02049 ,  G01B9/02064 ,  G01B9/02087 ,  G01B9/02091 ,  G01B9/04 ,  G01N21/25 ,  G01N21/27 ,  G01N21/4795 ,  G01N21/6458 ,  G01N21/6486 ,  G01N23/046 ,  G01N2021/1765 ,  G01N2223/419 ,  G02B21/0028 ,  G02B23/2423 ,  G02B23/243 ,  G02B23/2461 ,  G02B23/2476

摘要： Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality.

摘要翻译： 可以提供根据本发明的示例性实施例的方法和装置。 例如，可以基于第一模态来提供与从至少一个样本的至少一个区域接收的第一信号相关联的第一数据，并且可以基于从至少一个样本接收的与第二信号相关联的第二数据基于 第二种模式与第一种模式不同。 可以接收与参考相关联的第三数据。 可以基于第一，第二和第三数据生成进一步的数据。 此外，可以获得与从至少一个样本接收的第二信号相关联的第三数据。 第三数据中的每一个可以基于与第一模态和第二模态不同的另一模态，并且可以基于第三数据进一步确定另外的数据。 此外，第一模式可以是频谱编码模式，并且第二模态可以是非频谱编码模式。

公开(公告)号：US20110222563A1

公开(公告)日：2011-09-15

申请号：US13112720

申请日：2011-05-20

申请人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

发明人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

IPC分类号： H01S3/10

CPC分类号： H01S3/08063 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/06 ,  G01J3/10 ,  G02B26/002 ,  G02B26/04 ,  H01S3/08 ,  H01S3/08009 ,  H01S3/0805 ,  H01S3/10046 ,  H01S3/105 ,  H01S3/106

摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement, e.g., polygonal scanning mirror and spinning reflector disk scanner, which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

摘要翻译： 可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。 设备和源装置还可以具有至少一个连续旋转的光学装置，例如多边形扫描镜和旋转反射器盘扫描器，其被配置为接收与一个或多个部件相关联的至少一个信号。 此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

公开(公告)号：US20080175280A1

公开(公告)日：2008-07-24

申请号：US12015642

申请日：2008-01-17

申请人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

发明人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

IPC分类号： H01S3/10

CPC分类号： H01S3/08063 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/06 ,  G01J3/10 ,  G02B26/002 ,  G02B26/04 ,  H01S3/08 ,  H01S3/08009 ,  H01S3/0805 ,  H01S3/10046 ,  H01S3/105 ,  H01S3/106

摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement, e.g., polygonal scanning mirror and spinning reflector disk scanner, which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

摘要翻译： 可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。 设备和源装置还可以具有至少一个连续旋转的光学装置，例如多边形扫描镜和旋转反射器盘扫描器，其被配置为接收与一个或多个部件相关联的至少一个信号。 此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

公开(公告)号：US20100254415A1

公开(公告)日：2010-10-07

申请号：US12700552

申请日：2010-02-04

申请人： Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

发明人： Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

IPC分类号： H01S3/10 ,  G21G4/00

CPC分类号： H01S3/08009 ,  G01J3/10 ,  H01S3/08013 ,  H01S3/08059 ,  H01S3/0813 ,  H01S3/083 ,  H01S3/105 ,  H01S5/005 ,  H01S5/06216 ,  H01S5/141

摘要： Exemplary embodiments of apparatus, source arrangement and method for, e.g., providing high-speed wavelength tuning can be provided. According to one exemplary embodiment, at least one arrangement can be provided which is configured to emit an electromagnetic radiation that (i) has a spectrum whose mean frequency changes at an absolute rate that is greater than about 6000 (or 2000) terahertz per millisecond, (ii) whose mean frequency changes over a range that is greater than about 10 terahertz, and/or (iii) has an instantaneous line width that is less than about 15 gigahertz. According to another exemplary embodiment, at least one arrangement can be provided configured to, periodically and as a function of time, select at least one first electro-magnetic radiation based on a mean frequency of the at least one first electro-magnetic radiation, with the periodic selection being performed at a first characteristic period. The mean frequency can vary linearly over time, wherein the apparatus can emit at least one second electromagnetic radiation that has a spectrum whose mean frequency changes periodically as a function of time with a second characteristic period. Further, the first characteristic period can be greater than the second characteristic period.

摘要翻译： 可以提供用于例如提供高速波长调谐的装置，源装置和方法的示例性实施例。 根据一个示例性实施例，可以提供至少一种布置，其被配置为发射电磁辐射，其中（i）具有平均频率以大于每毫秒大约6000（或2000）太赫兹的绝对速率变化的频谱， （ii）其平均频率在大于约10太赫兹的范围内变化，和/或（iii）具有小于约15千兆赫兹的瞬时线宽。 根据另一示例性实施例，可以提供至少一种布置，其被配置为周期性地和作为时间的函数，基于所述至少一个第一电磁辐射的平均频率选择至少一个第一电磁辐射， 在第一特征周期执行周期性选择。 平均频率可以随时间线性变化，其中该装置可以发射至少一个第二电磁辐射，其具有在第二特征周期内平均频率作为时间的函数周期性地改变的频谱。 此外，第一特征周期可以大于第二特征周期。

公开(公告)号：US09178330B2

公开(公告)日：2015-11-03

申请号：US12700552

申请日：2010-02-04

申请人： Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

发明人： Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

IPC分类号： H01S3/10 ,  H01S3/08 ,  H01S3/105 ,  H01S5/14 ,  G01J3/10 ,  H01S3/081 ,  H01S3/083 ,  H01S5/062 ,  H01S5/00

CPC分类号： H01S3/08009 ,  G01J3/10 ,  H01S3/08013 ,  H01S3/08059 ,  H01S3/0813 ,  H01S3/083 ,  H01S3/105 ,  H01S5/005 ,  H01S5/06216 ,  H01S5/141

摘要： Exemplary embodiments of apparatus, source arrangement and method for, e.g., providing high-speed wavelength tuning can be provided. According to one exemplary embodiment, at least one arrangement can be provided which is configured to emit an electromagnetic radiation that (i) has a spectrum whose mean frequency changes at an absolute rate that is greater than about 6000 (or 2000) terahertz per millisecond, (ii) whose mean frequency changes over a range that is greater than about 10 terahertz, and/or (iii) has an instantaneous line width that is less than about 15 gigahertz. According to another exemplary embodiment, at least one arrangement can be provided configured to, periodically and as a function of time, select at least one first electro-magnetic radiation based on a mean frequency of the at least one first electro-magnetic radiation, with the periodic selection being performed at a first characteristic period. The mean frequency can vary linearly over time, wherein the apparatus can emit at least one second electromagnetic radiation that has a spectrum whose mean frequency changes periodically as a function of time with a second characteristic period. Further, the first characteristic period can be greater than the second characteristic period.

摘要翻译： 可以提供用于例如提供高速波长调谐的装置，源装置和方法的示例性实施例。 根据一个示例性实施例，可以提供至少一种布置，其被配置为发射电磁辐射，其中（i）具有平均频率以大于每毫秒大约6000（或2000）太赫兹的绝对速率变化的频谱， （ii）其平均频率在大于约10太赫兹的范围内变化，和/或（iii）具有小于约15千兆赫兹的瞬时线宽。 根据另一示例性实施例，可以提供至少一种布置，其被配置为周期性地和作为时间的函数，基于所述至少一个第一电磁辐射的平均频率选择至少一个第一电磁辐射， 在第一特征周期执行周期性选择。 平均频率可以随时间线性变化，其中该装置可以发射至少一个第二电磁辐射，其具有在第二特征周期内平均频率作为时间的函数周期性地改变的频谱。 此外，第一特征周期可以大于第二特征周期。

公开(公告)号：US07949019B2

公开(公告)日：2011-05-24

申请号：US12015642

申请日：2008-01-17

申请人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

发明人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

IPC分类号： H01S5/14

CPC分类号： H01S3/08063 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/06 ,  G01J3/10 ,  G02B26/002 ,  G02B26/04 ,  H01S3/08 ,  H01S3/08009 ,  H01S3/0805 ,  H01S3/10046 ,  H01S3/105 ,  H01S3/106

摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement, e.g., polygonal scanning mirror and spinning reflector disk scanner, which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

摘要翻译： 可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。 设备和源装置还可以具有至少一个连续旋转的光学装置，例如多边形扫描镜和旋转反射器盘扫描器，其被配置为接收与一个或多个部件相关联的至少一个信号。 此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

公开(公告)号：US08384907B2

公开(公告)日：2013-02-26

申请号：US12946635

申请日：2010-11-15

申请人： Guillermo J. Tearney ,  Dvir Yelin ,  Brett E. Bouma

发明人： Guillermo J. Tearney ,  Dvir Yelin ,  Brett E. Bouma

IPC分类号： G01B9/02 ,  G01J3/45

CPC分类号： G01N33/4833 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6852 ,  G01B9/02 ,  G01B9/02027 ,  G01B9/02049 ,  G01B9/02064 ,  G01B9/02087 ,  G01B9/02091 ,  G01B9/04 ,  G01N21/25 ,  G01N21/27 ,  G01N21/4795 ,  G01N21/6458 ,  G01N21/6486 ,  G01N23/046 ,  G01N2021/1765 ,  G01N2223/419 ,  G02B21/0028 ,  G02B23/2423 ,  G02B23/243 ,  G02B23/2461 ,  G02B23/2476

摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.

摘要翻译： 可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。 例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10μm的横向分辨率的分辨率。 例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。 可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

公开(公告)号：US07809226B2

公开(公告)日：2010-10-05

申请号：US12205787

申请日：2008-09-05

申请人： Brett E. Bouma ,  Guillermo J. Tearney ,  Dvir Yelin

发明人： Brett E. Bouma ,  Guillermo J. Tearney ,  Dvir Yelin

IPC分类号： G02B6/02 ,  G02B6/06

CPC分类号： G01N21/474 ,  G01N21/47 ,  G02B6/02 ,  G02B6/02042 ,  G02B6/036 ,  G02B6/03605 ,  G02B6/03622 ,  G02B6/03638 ,  G02B6/4298 ,  G02B23/2469 ,  G02B23/26 ,  G02B26/10 ,  G02B27/48

摘要： A method and apparatus for imaging using a double-clad fiber is described.

公开(公告)号：US07809225B2

公开(公告)日：2010-10-05

申请号：US12205775

申请日：2008-09-05

申请人： Brett E. Bouma ,  Guillermo J. Tearney ,  Dvir Yelin

发明人： Brett E. Bouma ,  Guillermo J. Tearney ,  Dvir Yelin

IPC分类号： G02B6/02 ,  G02B6/06

CPC分类号： G01N21/474 ,  G01N21/47 ,  G02B6/02 ,  G02B6/02042 ,  G02B6/036 ,  G02B6/03605 ,  G02B6/03622 ,  G02B6/03638 ,  G02B6/4298 ,  G02B23/2469 ,  G02B23/26 ,  G02B26/10 ,  G02B27/48

摘要： A method and apparatus for imaging using a double-clad fiber is described.

摘要翻译： 描述了使用双包层光纤进行成像的方法和装置。

公开(公告)号：US07551293B2

公开(公告)日：2009-06-23

申请号：US10997789

申请日：2004-11-24

申请人： Dvir Yelin ,  Brett E. Bouma ,  Nicusor Iftimia ,  Guillermo J. Tearney

发明人： Dvir Yelin ,  Brett E. Bouma ,  Nicusor Iftimia ,  Guillermo J. Tearney

IPC分类号： G01J3/45 ,  G01B9/02 ,  G01B11/02

CPC分类号： G01B11/2441 ,  A61B1/042 ,  A61B5/1077 ,  G01B9/02027 ,  G01B9/02044 ,  G01B11/2509

摘要： A method and apparatus for providing information associated with at least one portion of a sample can be provided. For example, at least one wavelength of electro-magnetic radiation provided on a sample can be encoded to determine at least one transverse location of the portion. A relative phase between at least one first electro-magnetic radiation electro-magnetic radiation being returned from a sample and at least one second electro-magnetic radiation returned from a reference can be obtained to determine at least one relative depth location of the portion. Further, the information of the portion can be provided based on the transverse location and the relative depth location. For example, the information can be depth information and/or three-dimensional information associated with the portion of the sample.

摘要翻译： 可以提供用于提供与样本的至少一部分相关联的信息的方法和装置。 例如，可以对提供在样品上的至少一个电磁辐射波长进行编码，以确定该部分的至少一个横向位置。 可以获得从样品返回的至少一个第一电磁辐射电磁辐射与从参考物返回的至少一个第二电磁辐射之间的相对相位，以确定该部分的至少一个相对深度位置。 此外，可以基于横向位置和相对深度位置来提供该部分的信息。 例如，信息可以是与样本部分相关联的深度信息和/或三维信息。