公开(公告)号：US20200340957A1

公开(公告)日：2020-10-29

申请号：US16083308

申请日：2016-03-07

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Makoto NOGAMI ,  Shinya ITO

IPC: G01N30/28 ,  G01N30/72 ,  G01N30/14 ,  G01N30/20

Abstract: An analysis device of the present invention is provided with a sample introduction unit that introduces a sample into a mass spectroscope; a sample condensation unit that treats the sample introduced into the device; a detection unit that analyzes the sample treated by a treatment unit; and a control unit that controls the sample introduction unit, the sample condensation unit, and the detection unit. The sample introduction unit includes a sample introduction valve, and the sample condensation unit includes an elution valve and a cleaning valve, and the cleaning valve is disposed between the sample introduction valve and the elution valve.

公开(公告)号：US20150111300A1

公开(公告)日：2015-04-23

申请号：US14578619

申请日：2014-12-22

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Makoto NOGAMI ,  Katsuhiro KANDA ,  Izumi WAKI

IPC: G01N1/40 ,  G01N35/00 ,  G01N35/02

CPC classification number: G01N1/405 ,  G01N35/00663 ,  G01N35/02 ,  G01N35/025 ,  Y10T436/115831

Abstract: A clinical laboratory apparatus includes a pretreating apparatus having a high separation capability and providing high data reproducibility and reliability and a mass spectrometer is provided which executes fully automatic processing from pretreatment to detection. The pretreating apparatus that includes a cartridge for holding an extraction agent for solid-phase extraction, a pressure-loading unit for applying a pressure load to any cartridge mounted on the solid-phase extraction cartridge-retaining unit, a receiving tray mechanism for receiving a sample extracted from the cartridge, and a liquid-level sensor for detecting liquid levels in the receiving tray as well as in the cartridge, conducts feedback control for the pressure-loading unit to open its pressure release valve upon the liquid-level sensor detecting that the liquid level in the receiving tray mechanism has reached a preset liquid-level position.

Abstract translation: 临床实验室装置包括具有高分离能力并且提供高数据再现性和可靠性的预处理装置，并且提供执行从预处理到检测的全自动处理的质谱仪。 该预处理装置包括用于保持固相萃取提取剂的盒，用于对安装在固相提取盒保持单元上的任何盒施加压力负载的压力加载单元，用于接收 从墨盒提取的样品和用于检测接收托盘以及墨盒中的液位的液位传感器，对液位传感器检测到压力加载单元进行反馈控制以打开其压力释放阀， 接收托盘机构中的液位达到预设液位位置。

公开(公告)号：US20150064739A1

公开(公告)日：2015-03-05

申请号：US14535424

申请日：2014-11-07

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Makoto NOGAMI ,  Yuichiro HASHIMOTO ,  Izumi WAKI ,  Katsuhiro KANDA

IPC: G01N33/49

CPC classification number: G01N33/49 ,  G01N1/4055 ,  G01N2001/4083 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/0436

Abstract: An analyzer includes a pretreatment device and a mass spectrometer. The pretreatment device includes a solid phase extraction mechanism. The mass spectrometer performs mass spectrometry on a sample pretreated by the pretreatment device and then subjected to ionization. The analyzer also includes a storage unit that stores data on dependence of signal intensities of the analyte substance to be measured and the internal standard upon the concentration of a substance inhibiting ionization in the sample, and that stores data on a recovery rate. The analyzer also includes a correcting unit that corrects measurement results of the sample and the internal standard on the basis of the data stored in the storage unit.

Abstract translation: 分析仪包括预处理装置和质谱仪。 预处理装置包括固相提取机构。 质谱仪对由预处理装置预处理的样品进行质谱分析，然后进行电离。 分析仪还包括存储单元，其存储关于待测量的待分析物质的信号强度与内标的数据，所述数据在样品中抑制电离物质的浓度，并且存储关于回收率的数据。 分析器还包括校正单元，其基于存储在存储单元中的数据来校正样本的测量结果和内部标准。

公开(公告)号：US20130075603A1

公开(公告)日：2013-03-28

申请号：US13680630

申请日：2012-11-19

Applicant: Hitachi High-Technologies Corporation

Inventor： Katsuhiro KANDA ,  Makoto NOGAMI ,  Izumi WAKI

IPC: G01N1/40 ,  H01J49/26

CPC classification number: G01N1/4077 ,  G01N1/405 ,  G01N30/82 ,  G01N2030/009 ,  H01J49/0431 ,  H01J49/26

Abstract: The present invention relates to a pretreatment apparatus that performs concentration and separation of a sample, and in particular, in order to provide a sample pretreatment apparatus using a solid-phase extraction column, and a mass spectrometer using the same, which is particularly suitable for clinical analysis in which qualitative/quantitative analysis of a biological sample such as blood is performed, according to each operational step for a solid-phase extraction treatment, for example, a collection device serving as flow passages or containers for collection of waste liquid or extracted matter is installed on a bottom face of the solid-phase extraction column, and the extracted matter is separately collected without being mixed with waste liquid by switching the positions of the collection device.

Abstract translation: 本发明涉及一种进行样品浓缩分离的预处理装置，特别是为了提供使用固相萃取柱的样品预处理装置和使用其的质谱仪，特别适用于 根据固相萃取处理的每个操作步骤，例如用作流动通道的收集装置或用于收集废液或提取的容器的容器，进行诸如血液的生物样品的定性/定量分析的临床分析 物质被安装在固相萃取塔的底面上，并且通过切换收集装置的位置而分离地收集提取物而不与废液混合。

公开(公告)号：US20170160273A1

公开(公告)日：2017-06-08

申请号：US15320406

申请日：2015-06-17

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Makoto NOGAMI ,  Shinya ITO ,  Tadao YABUHARA

IPC: G01N33/543 ,  G01N15/12 ,  G01N33/82 ,  G01N30/72

CPC classification number: G01N33/54326 ,  G01N15/12 ,  G01N15/1209 ,  G01N30/7233 ,  G01N33/82 ,  G01N35/025 ,  G01N35/08 ,  G01N35/1095 ,  G01N2015/0065

Abstract: When using an immunological analysis method wherein antigen-antibody reactions are used to form complexes of microparticles and a substance being measured, purifying, then measuring by spectroscopy, and a mass spectrometry method wherein antigen-antibody reactions are used to form complexes of microparticles and a substance being measured, purifying, then measuring with a mass spectrometer, the amount of the complex flowing in the flow path for immunological analysis and the amount of the complex flowing in the flow path for mass spectrometry are unknown, so the substance being measured cannot be accurately quantified even when merging information obtained from immunological analysis and information obtained from mass spectrometry. The invention provides a mechanism for quantifying the complexes after formation of the complexes, on the flow path for mass spectrometry and the flow path for immunological analysis.

公开(公告)号：US20160195561A1

公开(公告)日：2016-07-07

申请号：US14911406

申请日：2014-06-24

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Makoto NOGAMI ,  Shinya ITO ,  Tadao YABUHARA

IPC: G01N35/02 ,  G01N35/10 ,  G01N33/543 ,  G01N35/00

CPC classification number: G01N35/025 ,  G01N33/54366 ,  G01N35/00871 ,  G01N35/1065 ,  G01N2001/2826 ,  G01N2035/0458

Abstract: An analysis device is provided with a first disk on which a sample container and disposable container can be disposed, a second disk on which a solid-phase extraction cartridge and disposable container can be disposed, a first probe capable of transferring a sample of the sample container disposed on the first disk or a solution of the disposable container disposed on the first disk to the solid-phase extraction cartridge or disposable container disposed on the second disk, and a second probe capable of transferring a reagent of a reagent container to the sample container or disposable container disposed on the first disk and the solid-phase extraction cartridge or disposable container disposed on the second disk. Sample preprocessing before solid-phase extraction processing takes place on the first disk.

Abstract translation: 分析装置设置有第一盘，可以在其上放置样品容器和一次性容器;第二盘，其上可以设置固相提取盒和一次性容器;第一探针，其能够将样品的样品 将容器设置在第一盘上，或者将设置在第一盘上的一次性容器的溶液放置在设置在第二盘上的固相提取盒或一次性容器中，以及能够将试剂容器的试剂转移到样品的第二探针 设置在第一盘上的容器或一次性容器以及设置在第二盘上的固相提取盒或一次性容器。 固相萃取处理前的样品预处理在第一个磁盘上进行。