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    Methods and products for delivering biological molecules to cells using multicomponent nanostructures
    6.
    发明授权
    Methods and products for delivering biological molecules to cells using multicomponent nanostructures 失效
    使用多组分纳米结构将生物分子递送到细胞的方法和产品

    公开(公告)号：US07344887B2

    公开(公告)日：2008-03-18

    申请号：US10875543

    申请日：2004-06-24

    申请人： Aliasger Karimjee Salem ,  Kam W. Leong ,  Peter Charles Searson

    发明人： Aliasger Karimjee Salem ,  Kam W. Leong ,  Peter Charles Searson

    IPC分类号： C12N15/64

    CPC分类号： A61K9/5115 ,  A61K47/02 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y30/00 ,  C12N15/87

    摘要： This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired combination of molecules in close proximity. Different molecules can be selectively bonded to discrete regions of different composition in sufficiently close physical relationship to enhance delivery or effectiveness within the cell. The preferred nanostructures are multicomponent nanorods. Important applications include delivery of missing DNA sequences for gene therapy and delivery of antigens or DNA encoding antigens for vaccination.

    摘要翻译： 本发明基于本申请人的发现，包括不同组成的离散区域的纳米结构可以用于向生物细胞递送非常接近的期望的分子组合。 不同分子可以以足够接近的物理关系选择性地键合到不同组成的离散区域，以增强细胞内的递送或有效性。 优选的纳米结构是多组分纳米棒。 重要的应用包括递送缺失的DNA序列用于基因治疗和递送抗原或DNA编码抗原用于疫苗接种。

    Controlled delivery of therapeutic agents by insertable medical devices
    7.
    发明授权
    Controlled delivery of therapeutic agents by insertable medical devices 失效
    通过可插入的医疗设备控制治疗剂的输送

    公开(公告)号：US06899731B2

    公开(公告)日：2005-05-31

    申请号：US09750779

    申请日：2001-01-02

    申请人： Weiping Li ,  Hai-Quan Mao ,  Kam W. Leong

    发明人： Weiping Li ,  Hai-Quan Mao ,  Kam W. Leong

    IPC分类号： A61L29/16 ,  A61L31/16 ,  A61F2/06 ,  A61K48/00

    CPC分类号： A61L31/16 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2300/802

    摘要： A medical device and method for transportation and release of a therapeutic agent into a mammalian body are disclosed. The medical device is coated with alternating layers of a negatively charged therapeutic agent and a cationic polyelectrolyte, following a controlled adsorption technique. The method is simple, with minimal perturbation to the therapeutic agent and uses clinically acceptable biopolymers such as human serum albumin. The amount of the therapeutic agent that can be delivered by this technique is optimized by the number of the layers of the therapeutic agent adsorbed on the surface of medical device. There is a washing step between alternate layers of the therapeutic agent and cationic polyelectrolyte carrier, so that the amount of the therapeutic agent on the insertable medical device represents the portion that is stably entrapped and adsorbed on to the medical device. The insertable medical device and method according to this invention are capable of reproducibly delivering therapeutic agent to a site in a mammalian body, and allow for a highly reproducible and controllable release kinetics of the therapeutic agent.

    摘要翻译： 公开了用于将哺乳动物体内的治疗剂输送和释放的医疗装置和方法。 在受控吸附技术之后，医疗装置涂覆有带负电的治疗剂和阳离子聚电解质的交替层。 该方法简单，对治疗剂的扰动最小，并且使用临床可接受的生物聚合物例如人血清白蛋白。 通过该技术可以递送的治疗剂的量通过吸收在医疗装置表面上的治疗剂的层数来优化。 在治疗剂和阳离子聚电解质载体的交替层之间存在洗涤步骤，使得可插入医疗装置上的治疗剂的量表示稳定地截留并吸附到医疗装置上的部分。 根据本发明的可插入医疗装置和方法能够将治疗剂可再现地递送到哺乳动物体内的部位，并且允许治疗剂的高度可重现和可控的释放动力学。

    Therapeutic nanospheres
    9.
    发明授权
    Therapeutic nanospheres 失效
    治疗纳米球

    公开(公告)号：US06207195B1

    公开(公告)日：2001-03-27

    申请号：US09095882

    申请日：1998-06-11

    申请人： Scott Walsh ,  Ronald Rubenstein ,  Pam Zeitlin ,  Kam W. Leong

    发明人： Scott Walsh ,  Ronald Rubenstein ,  Pam Zeitlin ,  Kam W. Leong

    IPC分类号： C12N1500

    CPC分类号： A61K9/5169 ,  A61K31/192 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6435 ,  A61K47/6929 ,  A61K48/00 ,  B82Y5/00 ,  Y10S977/884 ,  Y10S977/906 ,  Y10S977/915 ,  Y10S977/92 ,  Y10S977/923

    摘要： 4-Phenylbutyrate exerts many beneficial biological effects. It appears to induce the transcription of certain promoters, as well as having a remedial effect on proteins which are aberrantly localized within the cell. In addition, it appears to cause cells to developmentally differentiate. The present invention provides nanosphere formulations of 4-phenylbutyrate and other drugs which remediate defective protein localization intracellularly. These formulations permit lower concentrations of drugs to be administered, providing both cost and safety benefits.

    摘要翻译： 4-苯基丁酸酯具有许多有益的生物学效应。 似乎诱导某些启动子的转录，以及对细胞内异常定位的蛋白质具有补救作用。 此外，它似乎导致细胞发育分化。 本发明提供4-苯基丁酸酯和其它药物的纳米球配方，其可以修复细胞内的缺陷蛋白质定位。 这些制剂允许施用较低浓度的药物，既提供成本和安全性益处。

    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
    10.
    发明授权
    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same 失效
    通过磷酸盐，组合物，制品和制造和使用它们的方法延伸的可生物降解的聚合物

    公开(公告)号：US6166173A

    公开(公告)日：2000-12-26

    申请号：US53649

    申请日：1998-04-02

    申请人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    发明人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    IPC分类号： A61L27/00 ,  A61K9/00 ,  A61K9/16 ,  A61L17/10 ,  A61L17/12 ,  A61L24/00 ,  A61L26/00 ,  A61L27/14 ,  A61L27/18 ,  C08G63/692 ,  C08G63/91 ,  C08G69/42 ,  C08G79/04 ,  C08L67/00 ,  C08L77/00 ,  C08L85/02 ,  C08L101/16 ,  A61K31/80

    CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61L17/12 ,  A61L26/0019 ,  A61L27/18 ,  C08G63/6922 ,  C08G63/912 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is --O-- or --NR'--, where R' is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M.sub.1 and M.sub.2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is --O--, --S-- or --NR'--, where R' is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat.Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

    摘要翻译： 描述包含式I或II所示的重复单体单元的生物可降解聚合物：其中X是-O-或-NR'-，其中R'是H或烷基; L是具有1-20个碳原子的支链或直链脂族基团; M1和M2各自独立地为（1）具有1-20个碳原子的支链或直链脂族基团; 或（2）具有1-20个碳原子的支链或直链，氧基，羧基或氨基 - 脂族基团; Y是-O - ， - S-或-NR'-，其中R'是H或烷基; R是H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; x：y的摩尔比为约1; 摩尔比n：（x或y）在约200:1和1:200之间; 并且摩尔比q：r在约1:99和99:1之间; 其中所述可生物降解聚合物在生物降解之前和之后是生物相容的。 还描述了制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及使用该聚合物可控地释放生物活性物质的方法。