Process for the preparation of N-substituted cyclic imides
    5.
    发明授权
    Process for the preparation of N-substituted cyclic imides 失效
    制备N-取代的环状酰亚胺的方法

    公开(公告)号:US5773630A

    公开(公告)日:1998-06-30

    申请号:US595982

    申请日:1996-02-06

    CPC分类号: C07D207/452 C07D207/40

    摘要: N-Substituted cyclic imides are obtained by reacting a cyclic acid anhydride with an amine in the presence of a solvent and an acid catalyst at 80.degree. to 200.degree. C. and with removal of the water formed, it being particularly advantageous to carry out this reaction in the presence of a stabilizer and an inert, dipolar aprotic cosolvent, optionally to add an inert organic solvent of low or zero polarity to the reaction mixture present after the reaction, to add a non-aqueous base in an amount of 0.5 to 50% by weight, based on the cyclic anhydride of the formula (II) used, and to separate off the precipitate formed to give a filtrate containing the N-substituted cyclic imide.

    摘要翻译: N-取代的环状酰亚胺通过使环酸酐与胺在溶剂和酸催化剂的存在下在80℃至200℃下反应并除去形成的水而获得,特别有利的是进行该 在稳定剂和惰性非质子助溶剂的存在下反应,任选地向反应后存在的反应混合物中加入低或零极性的惰性有机溶剂,加入0.5至50的非水性碱 基于所使用的式(II)的环状酸酐,并分离形成的沉淀物,得到含有N-取代的环状酰亚胺的滤液。