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    Andrographolide derivatives and use thereof in manufacture of medicaments
    2.
    发明授权
    Andrographolide derivatives and use thereof in manufacture of medicaments 有权
    穿心莲内酯衍生物及其在药物制造中的应用

    公开(公告)号：US08367720B2

    公开(公告)日：2013-02-05

    申请号：US12672476

    申请日：2008-08-07

    申请人： Yuqiang Wang ,  Xiaojian Jiang ,  Jie Jiang ,  Zaijun Zhang ,  Zhaoqi Yang ,  Pei Yu

    发明人： Yuqiang Wang ,  Xiaojian Jiang ,  Jie Jiang ,  Zaijun Zhang ,  Zhaoqi Yang ,  Pei Yu

    IPC分类号： A01N43/08 ,  A01N57/00 ,  A61K31/34 ,  A61K31/665 ,  A61K31/585 ,  C07D307/02 ,  C07D307/00

    CPC分类号： C07D307/58 ,  C07D307/60 ,  C07D409/12

    摘要： The present invention relates to an andrographolide derivative of the formula (I), wherein R1, R2 and R3 are same or different substituents selected from hydrogen, substituted or unsubstituted organic acid radicals, inorganic acid radicals, alkyl, aryl or heteroaryl, and at least one of R1, R2 and R3 is R-lipoic acid, S-lipoic acid or a mixture thereof, or corresponding dihydrolipoic acids thereof, or N-acetylcysteine radical. The derivative has good antitumor effect, can induce apoptosis of tumor cells, can directly kill Gram-positive bacteria (staphylococcus aureus) and drug resistance bacteria (MRSA5676 and MRSA5677), can inhibit the QS-system of Gram-negative bacteria (Pseudomonas aeruginosa), can inhibit and destroy the formation of biofilm of Pseudomonas aeruginosa; and exhibits significant hypoglycemic effect, so that it can be used in manufacture of medicaments for treatment of cancers, inflammation, diabetes, and bacterial and viral infections.

    摘要翻译： 本发明涉及式（I）的穿心莲内酯衍生物，其中R 1，R 2和R 3是相同或不同的选自氢，取代或未取代的有机酸基，无机酸基，烷基，芳基或杂芳基的取代基，至少 R1，R2和R3之一是R-硫辛酸，S-硫辛酸或其混合物，或其相应的二氢硫辛酸或N-乙酰半胱氨酸碱基。 该衍生物具有良好的抗肿瘤作用，可诱导肿瘤细胞凋亡，可直接杀死革兰氏阳性菌（金黄色葡萄球菌）和耐药细菌（MRSA5676和MRSA5677），可抑制革兰氏阴性菌（绿脓假单胞菌）的QS系统， ，可以抑制和破坏铜绿假单胞菌生物膜的形成; 并显示出显着的降血糖作用，因此可用于制造用于治疗癌症，炎症，糖尿病以及细菌和病毒感染的药物。

    Clearance measurement system and method of operation
    6.
    发明授权
    Clearance measurement system and method of operation 有权
    间隙测量系统和操作方法

    公开(公告)号：US07333913B2

    公开(公告)日：2008-02-19

    申请号：US11167434

    申请日：2005-06-27

    申请人： Emad Andarawis Andarawis ,  Mahadevan Balasubramaniam ,  Todd Alan Anderson ,  Samhita Dasgupta ,  David Mulford Shaddock ,  Shobhana Mani ,  Jie Jiang

    发明人： Emad Andarawis Andarawis ,  Mahadevan Balasubramaniam ,  Todd Alan Anderson ,  Samhita Dasgupta ,  David Mulford Shaddock ,  Shobhana Mani ,  Jie Jiang

    IPC分类号： G01B5/14

    CPC分类号： G01B7/144

    摘要： A clearance measurement system is provided. The clearance measurement system includes a reference geometry disposed on a first object having an otherwise continuous surface geometry and a sensor disposed on a second object, wherein the sensor is configured to generate a first signal representative of a first sensed parameter from the first object and a second signal representative of a second sensed parameter from the reference geometry. The clearance measurement system also includes a processing unit configured to process the first and second signals to estimate a clearance between the first and second objects based upon a measurement difference between the first and second sensed parameters.

    摘要翻译： 提供了间隙测量系统。 间隙测量系统包括设置在具有另外连续的表面几何形状的第一物体上的参考几何形状和设置在第二物体上的传感器，其中传感器被配置为产生表示来自第一物体的第一感测参数的第一信号，以及 第二信号表示来自参考几何的第二感测参数。 间隙测量系统还包括处理单元，其被配置为基于第一和第二感测参数之间的测量差异来处理第一和第二信号以估计第一和第二对象之间的间隙。

    Rapid and high precision centroiding method and system for spots image
    8.
    发明授权
    Rapid and high precision centroiding method and system for spots image 有权
    快速高精度重心法和斑点图像系统

    公开(公告)号：US08068673B2

    公开(公告)日：2011-11-29

    申请号：US11687338

    申请日：2007-03-16

    申请人： Guangjun Zhang ,  Jie Jiang ,  Qiaoyun Fan ,  Xuetao Hao

    发明人： Guangjun Zhang ,  Jie Jiang ,  Qiaoyun Fan ,  Xuetao Hao

    IPC分类号： G06K9/66

    CPC分类号： G06T7/66

    摘要： The disclosure relates to a rapid and high precision centroiding method for spots image comprising the following steps. First, the method requires convoluting the gray value of a pixel with a Gaussian filter and judging whether the result thereof exceeds a predetermined threshold. If the value exceeds the predetermined threshold, the method requires marking the current pixel with a flag to identify which spot it belongs to, and then accumulating the product of the gray value and a coordinate value of the same spot; and at the same time, accumulating the gray value of the same spot; and saving the results of the accumulation respectively. If the gray value of the pixel does not exceed the predetermined threshold, the method requires marking the current pixel as a background flag. After all pixels of the image has been disposed of completely, the method includes calculating a quotient of the accumulations of the product of the gray value and the coordinate value and the accumulations of the gray value, and outputting the quotients. At the same time, a centroiding system for spots image is also presented.

    摘要翻译： 本公开涉及一种用于斑点图像的快速和高精度重心方法，包括以下步骤。 首先，该方法需要用高斯滤波器对像素的灰度值进行卷积，并判断其结果是否超过预定阈值。 如果该值超过预定阈值，则该方法需要用标志标记当前像素，以标识其属于哪一个点，然后累积灰度值与同一点的坐标值的乘积; 同时累积同一斑点的灰度值; 并分别节省积累的结果。 如果像素的灰度值不超过预定阈值，则该方法需要将当前像素标记为背景标志。 在完全处理图像的所有像素之后，该方法包括计算灰度值与坐标值的乘积的积分和灰度值的积累的商，并输出商。 同时，还提出了斑点图像的重心系统。

    Method and device for calibration of digital celestial sensor
    9.
    发明授权
    Method and device for calibration of digital celestial sensor 有权
    数字天体传感器校准方法和装置

    公开(公告)号：US07822572B2

    公开(公告)日：2010-10-26

    申请号：US12036888

    申请日：2008-02-25

    申请人： Guangjun Zhang ,  Xinguo Wei ,  Qiaoyun Fan ,  Jie Jiang

    发明人： Guangjun Zhang ,  Xinguo Wei ,  Qiaoyun Fan ,  Jie Jiang

    IPC分类号： G01C25/00

    CPC分类号： G01S3/7867 ,  B64G1/361 ,  B64G1/363

    摘要： A method for calibration of a digital celestial sensor is disclosed. First, an integrated mathematic model for imaging of a celestial sensor is established according to external and internal parameters of the calibration system of the celestial sensor. Second, by rotating two axes of a rotator by different angles, calibration points data are acquired and sent to a processing computer through an interface circuit. Finally, a two-step calibration program is implemented to calculate the calibration parameters by substituting calibration points' data to the integrated mathematic model. An application device of the calibration method is also provided. The device may include a celestial simulator to provide simulated sunlight or starlight, a two-axis rotator to acquire different calibration points' data, and a processing computer to record the calibration points' data and calculate the calibration parameters.

    摘要翻译： 公开了一种用于校准数字天体传感器的方法。 首先，根据天体传感器校准系统的外部参数和内部参数建立了天体传感器成像的综合数学模型。 第二，通过旋转不同角度旋转两个轴，获取校准点数据，并通过接口电路发送到处理计算机。 最后，通过将校准点的数据代入综合数学模型，实施了两步校准程序来计算校准参数。 还提供了校准方法的应用装置。 该装置可以包括用于提供模拟太阳光或星光的天体模拟器，用于获取不同校准点数据的双轴旋转器，以及记录校准点数据并计算校准参数的处理计算机。

    Signal processing method and device for multi aperture sun sensor
    10.
    发明授权
    Signal processing method and device for multi aperture sun sensor 有权
    多光圈太阳传感器信号处理方法及装置

    公开(公告)号：US07615728B2

    公开(公告)日：2009-11-10

    申请号：US11967772

    申请日：2007-12-31

    申请人： Guangjun Zhang ,  Jie Jiang ,  Qiaoyun Fan

    发明人： Guangjun Zhang ,  Jie Jiang ,  Qiaoyun Fan

    IPC分类号： G01C21/02 ,  G01J1/20

    CPC分类号： G01J1/42 ,  G01C21/02 ,  G01J1/04 ,  G01J1/0437 ,  G01J2001/4266 ,  G01S3/784 ,  G01S3/7862

    摘要： The disclosure relates to a signal processing method for multi aperture sun sensor comprising the following steps: reading the information of sunspots in a row from a centroid coordinate memory, judging the absence of sunspots in that row, identifying the row and column index of the sunspots in the complete row, selecting the corresponding calibration parameter based on the row and column index, calculating attitude with the attitude calculation module the corresponding to identified sunspots, averaging the accumulated attitude of all sunspots and outputting the final attitude. At the same time, a signal processing device for multi aperture sun sensor is also presented. It is comprised of a sunspot absence judgment and an identification module and an attitude calculation module. The disclosure implements the integration of sun sensors without additional image processor or attitude processor, reduces field programmable gate array resource and improves the reliability of sun sensors.

    摘要翻译： 本发明涉及一种用于多孔径太阳传感器的信号处理方法，包括以下步骤：从质心坐标存储器读取一行中的太阳黑子的信息，判断该行中没有太阳黑子，识别太阳黑子的行和列索引 在完整的行中，根据行和列索引选择相应的校准参数，使用姿态计算模块计算对应于确定的太阳黑子的姿态，对所有太阳黑子的累积姿态进行平均并输出最终姿态。 同时，还提出了一种用于多光圈太阳传感器的信号处理装置。 它由无太阳黑子判断和识别模块和姿态计算模块组成。 该公开实现了太阳传感器的集成，而没有附加的图像处理器或姿态处理器，减少了现场可编程门阵列资源并且提高了太阳传感器的可靠性。