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    COMPOSITION FOR PROMOTING THE PROLIFERATION OF LACTOBACILLUS CASEI SUBSP. CASEI
    4.
    发明申请
    COMPOSITION FOR PROMOTING THE PROLIFERATION OF LACTOBACILLUS CASEI SUBSP. CASEI 失效
    促进Lactobacillus CASEI SUBSP增殖的组合物。 CASEI

    公开(公告)号：US20080305090A1

    公开(公告)日：2008-12-11

    申请号：US12190121

    申请日：2008-08-12

    申请人： Kenji Yasuda ,  Tomohiko Ogawa ,  Masakatsu Hasegawa

    发明人： Kenji Yasuda ,  Tomohiko Ogawa ,  Masakatsu Hasegawa

    IPC分类号： A61K35/74 ,  A61K31/721

    CPC分类号： C12N1/38 ,  A23K20/163 ,  A23L29/273 ,  A23L33/135 ,  A23V2002/00 ,  C12N1/20 ,  A23V2200/3204 ,  A23V2250/5042 ,  A23V2200/3202

    摘要： A composition for promoting bacterial proliferation and selectively proliferating Lactobacillus casei subsp. casei is disclosed, which includes a dextran. A variety of biological activities originating from L. casei subsp. casei can be sustained in a living body by selectively growing-proliferating and colonizing L. casei subsp. casei in the intestine of a human being, animal, or the like or by selectively growing-proliferating L. casei subsp. casei in the intestine, without supplying L. casei subsp. casei at all times.

    摘要翻译： 用于促进细菌增殖和选择性增殖的干酪乳杆菌亚种的组合物。 公开了干酪素，其包括葡聚糖。 来自干酪乳杆菌亚种的各种生物活性 干酪素可以通过选择性生长增殖和殖民化的干酪乳杆菌亚种，维持在活体内。 在人，动物等的肠中或通过选择性增殖增殖的干酪乳杆菌 肠道中的酪蛋白，不提供干酪乳杆菌。 干酪素在任何时候。

    Composition for promoting the proliferation of lactobacillus casei subsp. casei
    5.
    发明申请
    Composition for promoting the proliferation of lactobacillus casei subsp. casei 审中-公开
    用于促进干酪乳杆菌亚种增殖的组合物 干酪

    公开(公告)号：US20060127378A1

    公开(公告)日：2006-06-15

    申请号：US10521947

    申请日：2003-07-22

    申请人： Kenji Yasuda ,  Tomohiko Ogawa ,  Masakatsu Hasegawa

    发明人： Kenji Yasuda ,  Tomohiko Ogawa ,  Masakatsu Hasegawa

    IPC分类号： A61K35/74 ,  A61K31/721

    CPC分类号： C12N1/38 ,  A23K20/163 ,  A23L29/273 ,  A23L33/135 ,  A23V2002/00 ,  C12N1/20 ,  A23V2200/3204 ,  A23V2250/5042 ,  A23V2200/3202

    摘要： The present invention relates to a composition for promoting bacterial proliferation for selectively proliferating Lactobacillus casei subsp. casei, which includes a dextran. According to the present invention, a variety of biological activities originated from L. casei subsp. casei can be sustained in a living body by selectively growing-proliferating and colonizing L. casei subsp. casei in the intestine of a human being, animal, or the like or by selectively growing-proliferating L. casei subsp. casei in the intestine, without supplying L. casei subsp. casei at all times.

    摘要翻译： 本发明涉及用于促进细菌增殖以选择性增殖干酪乳杆菌亚种的组合物。 其中包括葡聚糖。 根据本发明，起源于干酪乳杆菌的各种生物活性。 干酪素可以通过选择性生长增殖和殖民化的干酪乳杆菌亚种，维持在活体内。 在人，动物等的肠中或通过选择性增殖增殖的干酪乳杆菌 肠道中的酪蛋白，不提供干酪乳杆菌。 干酪素在任何时候。

    Method and apparatus for testing cardiotoxicity and evaluating cardiomyocytes
    6.
    发明授权
    Method and apparatus for testing cardiotoxicity and evaluating cardiomyocytes 有权
    用于测试心脏毒性和评估心肌细胞的方法和装置

    公开(公告)号：US09447447B2

    公开(公告)日：2016-09-20

    申请号：US13876992

    申请日：2011-09-30

    申请人： Kenji Yasuda ,  Tomoyuki Kaneko ,  Fumimasa Nomura

    发明人： Kenji Yasuda ,  Tomoyuki Kaneko ,  Fumimasa Nomura

    IPC分类号： C12M1/34 ,  C12Q1/02 ,  C12M1/42 ,  C12M1/36 ,  G01N33/50

    CPC分类号： C12Q1/025 ,  C12M35/02 ,  C12M41/46 ,  C12M41/48 ,  G01N33/48728 ,  G01N33/5061 ,  G01N33/5088 ,  G01N2800/32

    摘要： In the present invention, a cardiomyocyte cluster is disposed on a transparent substrate, and the quality of the cardiomyocytes is evaluated from the response of the cells to a forced pulsation stimulus applied to the cardiomyocytes. The cardiomyocyte cluster is disposed on the transparent substrate, and is exposed to the flow of a liquid containing an agent in a manner so that the agent acts on the cells, which configure a network. The extent of cardiac toxicity resulting from the agent is evaluated from measuring the fluctuations obtained from a comparison of adjacent cardiomyocytes of the network.

    摘要翻译： 在本发明中，将心肌细胞簇设置在透明基质上，根据细胞对施加于心肌细胞的强制脉动刺激的反应来评价心肌细胞的质量。 将心肌细胞簇设置在透明基板上，并且以使得试剂作用于构成网络的细胞的方式暴露于含有试剂的液体的流动。 通过测量从网络的相邻心肌细胞的比较获得的波动来评估由该试剂产生的心脏毒性的程度。

    Cell measuring and sorting chip
    7.
    发明授权
    Cell measuring and sorting chip 有权
    电池测量和分选芯片

    公开(公告)号：US08361412B2

    公开(公告)日：2013-01-29

    申请号：US11317004

    申请日：2005-12-27

    申请人： Kenji Yasuda ,  Akihiro Hattori ,  Kazunori Okano

    发明人： Kenji Yasuda ,  Akihiro Hattori ,  Kazunori Okano

    IPC分类号： B01L3/00

    CPC分类号： G01N15/147 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12M47/04 ,  G01N35/085 ,  G01N2015/149 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30024

    摘要： A cell sorting device using an inexpensive chip capable of being exchanged for each sample. The chip includes: a first flow path allowing buffer fluid containing cells to flow down; second and third flow paths which put the first flow path therebetween and allow buffer fluid not containing cells to flow down; a fourth flow path which allows the buffer fluid as a single flow path formed by joining the buffer fluids in the other three flow paths; a cell detecting region for detecting cells flowing with the buffer fluid down the fourth flow path; and a cell sorting region for sorting the cells according to a type of the cells detected. The first to fourth flow paths are cascaded, are supplied with the buffer fluid from reservoirs with the same fluid level, and have substantially the same width or cross-section area.

    摘要翻译： 一种使用廉价芯片的细胞分选装置，能够对每个样品进行交换。 芯片包括：允许包含电池的缓冲流体向下流动的第一流动路径; 第二和第三流动路径，其中第一流动路径在其间并且允许不包含电池的缓冲流体向下流动; 第四流路，其允许缓冲流体作为通过连接其它三个流动路径中的缓冲流体形成的单个流动路径; 细胞检测区域，用于检测沿着第四流动路径流动的缓冲液的细胞; 以及用于根据检测到的细胞的类型对细胞进行分选的细胞分选区域。 第一至第四流动路径级联，从具有相同流体水平的储存器提供缓冲流体，并且具有基本上相同的宽度或横截面面积。

    Micro-chamber processing apparatus for cell culture and method
    8.
    发明授权
    Micro-chamber processing apparatus for cell culture and method 有权
    用于细胞培养和方法的微室处理装置

    公开(公告)号：US08247222B2

    公开(公告)日：2012-08-21

    申请号：US13036600

    申请日：2011-02-28

    申请人： Akihiro Hattori ,  Kenji Yasuda

    发明人： Akihiro Hattori ,  Kenji Yasuda

    IPC分类号： C12M1/00 ,  C12M1/34

    CPC分类号： C12M23/16 ,  B01J2219/00317 ,  B01J2219/00441 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00743 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/12 ,  B01L2300/163

    摘要： This invention relates to a method and apparatus for processing cell cultures. The apparatus comprises a micro-chamber comprising no more than one absorption layer and at least one gel layer, in this order, laminated on a transparent base plate having no conspicuous absorbency in visible and infrared regions, and at least one light source, the absorption layer having absorbency in visible and infrared regions, and the gel-like material being a substance which has a gel dissolution temperature of 100 degree C. or less, solates when heated and is in a gel state at room temperature and has absorbency for a specific wave length of visible and infrared regions, and the light source having a monochromatic light in the specific wave length, wherein the light source is disposed such that it irradiates on the absorption layer and/or the gel layer, with the exception that when no absorption layer is provided, at least two layers each composed of a gel-like material are laminated on the transparent base plate.

    摘要翻译： 本发明涉及一种用于处理细胞培养物的方法和装置。 该装置包括一个微室，该微室包括不超过一个吸收层和至少一个凝胶层，依次层叠在透明基板上，在可见光和红外区域中没有明显的吸收性，以及至少一个光源，吸收 在可见光和红外区域具有吸收性的层，凝胶状材料是凝胶溶解温度为100℃以下的物质，加热时的溶胶化物，在室温下处于凝胶状态，具有特定的吸光度 可见光和红外区域的波长，以及具有特定波长的单色光的光源，其中光源被设置成使其照射在吸收层和/或凝胶层上，除了当没有吸收 在透明基板上层叠由凝胶状材料构成的至少两层。

    Cell separation chip and cell culturing method using the same
    9.
    发明申请
    Cell separation chip and cell culturing method using the same 审中-公开
    细胞分离芯片和细胞培养方法使用相同

    公开(公告)号：US20080003678A1

    公开(公告)日：2008-01-03

    申请号：US11819681

    申请日：2007-06-28

    申请人： Akihiro Hattori ,  Hideyuki Terazono ,  Kenji Yasuda

    发明人： Akihiro Hattori ,  Hideyuki Terazono ,  Kenji Yasuda

    IPC分类号： C12N5/06 ,  C12M1/00

    CPC分类号： B01L3/502761 ,  B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0415 ,  C12M45/00 ,  C12M47/04 ,  G01N15/1031 ,  G01N15/12 ,  G01N15/1459 ,  G01N15/1463 ,  G01N15/1484 ,  G01N2015/1081 ,  G01N2015/149

    摘要： An inexpensive cell analysis and separation apparatus using a flow channel formed on one surface of a substrate and a chip replaceable for each sample, and a method for culturing the separated cells without contamination, are provided. A flow channel for allowing a cell-containing buffer solution to flow is provided. Cells are detected in the middle of the flow channel, and separated to a plurality of downstream flow channels based on whether each cell fulfills a predetermined condition. A culturing tank for collecting the condition-fulfilling cells is covered with a semipermeable membrane at a top surface so as to prevent contamination during cell separation. When the cell separation is finished, the flow channel communicated with the culturing tank accommodating the condition-fulfilling cells is closed, and the culturing tank is cut off from the apparatus and put into a culturing device containing a predetermined medium to culture the cells.

    摘要翻译： 提供了使用形成在基板的一个表面上的流动通道和可替代每个样品的芯片的便宜的电池分析和分离装置，以及用于培养分离的电池而不被污染的方法。 提供了允许含细胞的缓冲溶液流动的流动通道。 基于每个小区是否满足预定条件，在流信道的中间检测小区，并将其分离成多个下游流信道。 用于收集状态满足细胞的培养槽在顶表面被半透膜覆盖，以防止细胞分离过程中的污染。 当细胞分离完成时，与容纳条件满足细胞的培养箱连通的流动通道关闭，并将培养箱从装置中切下并放入含有预定培养基的培养装置中以培养细胞。

    Method of inspecting a DNA chip
    10.
    发明授权
    Method of inspecting a DNA chip 有权
    检查DNA芯片的方法

    公开(公告)号：US07217573B1

    公开(公告)日：2007-05-15

    申请号：US09678652

    申请日：2000-10-04

    申请人： Yoshitada Oshida ,  Toshihiko Nakata ,  Tomoaki Sakata ,  Kenji Yasuda ,  Satoshi Takahashi

    发明人： Yoshitada Oshida ,  Toshihiko Nakata ,  Tomoaki Sakata ,  Kenji Yasuda ,  Satoshi Takahashi

    IPC分类号： G01N33/00 ,  G01N33/53 ,  C12Q1/68 ,  C12M3/00 ,  C07H21/04 ,  H01J3/14

    CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  Y10S436/80 ,  Y10T436/143333

    摘要： A method of inspecting a DNA chip and an apparatus therefor that allow a picture to be reconstructed in the following steps: A plurality of irradiation spots are formed on a DNA probe array mounted on a stage. Then, the stage is displaced in X, Y directions so as to execute a scanning, thereby irradiating substantially all the entire surface of the DNA probe array. Next, a plurality of emitted fluorescent lights, which are generated from the plurality of irradiation spot portions on the DNA probe array, are converged and are then detected simultaneously by multi detectors. Finally, a data processing apparatus processes the detected signals, thereby reconstructing the picture.

    摘要翻译： 一种用于检查DNA芯片的方法及其装置，其允许以下列步骤重建图像：在安装在平台上的DNA探针阵列上形成多个照射点。 然后，在X，Y方向上移位台，以进行扫描，从而基本上照射DNA探针阵列的整个表面。 接下来，从DNA探针阵列上的多个照射点部分产生的多个发射荧光灯被会聚，然后由多个检测器同时检测。 最后，数据处理装置处理检测到的信号，从而重建图像。