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    HYDROGEL
    2.
    发明申请
    HYDROGEL 审中-公开

    公开(公告)号：US20130034592A1

    公开(公告)日：2013-02-07

    申请号：US13641836

    申请日：2011-04-21

    申请人： Yuka Yamamoto ,  Hiroaki Kaneko ,  Masaya Ito ,  Taishi Tanaka

    发明人： Yuka Yamamoto ,  Hiroaki Kaneko ,  Masaya Ito ,  Taishi Tanaka

    IPC分类号： A61K9/14 ,  A61Q19/00 ,  A61K8/02 ,  B82Y5/00

    CPC分类号： A61L27/52 ,  A61L15/28 ,  A61L15/60 ,  A61L27/20 ,  A61L31/042 ,  A61L31/145 ,  C08B11/20 ,  C08B15/06 ,  C08J3/075 ,  C08J2301/28 ,  C08L1/286 ,  C08L1/26

    摘要： A hydrogel composed of a polyanionic polysaccharide derivative having a hydrophobic group introduced by covalent bonding and a salt solution with a salt concentration of 50 mM or more and 200 mM or less, the hydrogel having an aggregate structure with an average particle diameter of 100 to 2000 nm in the diluted solution, as well as a method for manufacturing the hydrogel comprising the steps of preparing a mixture containing a polyanionic polysaccharide derivative having a hydrophobic group introduced and a salt solution with a salt concentration of 50 mM or more and 200 mM or less and subjecting the mixture to heat treatment. The hydrogel of the present invention has a long-term stability and may be filtered using a porous filter having a pore diameter of 5 μm or more.

    摘要翻译： 由具有通过共价键引入的疏水基团的聚阴离子多糖衍生物和盐浓度为50mM以上且200mM以下的盐溶液构成的水凝胶，所述水凝胶具有平均粒径为100〜2000的聚集体结构 nm，以及制造该水凝胶的方法，包括以下步骤：制备含有引入疏水基团的聚阴离子多糖衍生物和盐浓度为50mM以上且200mM以下的盐溶液的混合物 并对混合物进行热处理。 本发明的水凝胶具有长期稳定性，可以使用孔径为5μm以上的多孔过滤器进行过滤。

    Cellulose derivative and hydrogel thereof
    3.
    发明授权
    Cellulose derivative and hydrogel thereof 失效
    纤维素衍生物及其水凝胶

    公开(公告)号：US08709450B2

    公开(公告)日：2014-04-29

    申请号：US12808613

    申请日：2008-12-17

    申请人： Hiroaki Kaneko ,  Nobuyuki Endo ,  Masaya Ito

    发明人： Hiroaki Kaneko ,  Nobuyuki Endo ,  Masaya Ito

    IPC分类号： C08B11/193 ,  C08B1/00 ,  C08B11/15 ,  C08B11/12 ,  A61K9/00

    CPC分类号： A61L27/20 ,  A61L27/52 ,  A61L31/042 ,  A61L31/145 ,  C08B11/12 ,  C08L1/26

    摘要： The invention is a cellulose derivative wherein some of the carboxyl groups of the cellulose derivative carboxymethylcellulose are replaced with —CO—NH—X—CO—Y—Z, and a hydrogel of the same. In the formula, X is a C1-10 divalent hydrocarbon group, Y is a divalent group derived from polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R4, where R4 is a C1-23 hydrocarbon group. The hydrogel has excellent viscoelasticity and can be injected into prescribed sites with injecting devices such as syringes, and it can thus be utilized as a medical gel or adhesion barrier.

    摘要翻译： 本发明是纤维素衍生物羧甲基纤维素的一些羧基被-CO-NH-X-CO-Y-Z代替的纤维素衍生物及其水凝胶。 在该式中，X是C 1-10二价烃基，Y是衍生自在两端具有氧原子的聚环氧烷烃，Z是C1-24烃基或-CO-R4的二价基团，其中R4是C1 -23烃基。 水凝胶具有优异的粘弹性，并且可以用诸如注射器的注射装置注射到规定的位置，因此可以用作医用凝胶或粘附屏障。

    HYDROGEL OF POLYSACCHARIDE DERIVATIVE
    4.
    发明申请
    HYDROGEL OF POLYSACCHARIDE DERIVATIVE 审中-公开
    多糖衍生物的氢化物

    公开(公告)号：US20110301121A1

    公开(公告)日：2011-12-08

    申请号：US13202234

    申请日：2009-09-18

    申请人： Nobuyuki Endo ,  Masaya Ito ,  Hiroaki Kaneko ,  Hitoshi Hirata ,  Michiro Yamamoto

    发明人： Nobuyuki Endo ,  Masaya Ito ,  Hiroaki Kaneko ,  Hitoshi Hirata ,  Michiro Yamamoto

    IPC分类号： A61K31/717 ,  A61P25/00 ,  A61P41/00

    CPC分类号： A61L31/042 ,  A61K31/715 ,  A61K31/717 ,  A61L31/145 ,  A61L2430/32 ,  C08B15/05

    摘要： A nerve dysfunction repairing material including a hydrogel of a polysaccharide derivative that has, in a 0.5 wt % aqueous solution, a complex modulus of 1 to 1000 N/m2 and a loss factor of 0.01 to 2.0 as measured at an angular velocity of 10 rad/sec using a dynamic viscoelasticity measuring apparatus. The nerve dysfunction repairing material can be a hydrogel injectable through a syringe, has excellent retention in the body, and has a restorative effect on the function of damaged or degenerated nerves.

    摘要翻译： 一种神经功能障碍修复材料，其包括多糖衍生物的水凝胶，所述多糖衍生物在0.5重量％水溶液中的复数模量为1〜1000N / m 2，损失因子为0.01〜2.0，以角速度为10rad /秒，使用动态粘弹性测量装置。 神经功能障碍修复材料可以是通过注射器注射的水凝胶，在身体中具有优异的保留性，并且对损伤或退化的神经的功能具有恢复性作用。

    CELLULOSE DERIVATIVE AND HYDROGEL THEREOF
    5.
    发明申请
    CELLULOSE DERIVATIVE AND HYDROGEL THEREOF 失效
    纤维素衍生物和水合物

    公开(公告)号：US20110129505A1

    公开(公告)日：2011-06-02

    申请号：US12808613

    申请日：2008-12-17

    申请人： Hiroaki Kaneko ,  Nobuyuki Endo ,  Masaya Ito

    发明人： Hiroaki Kaneko ,  Nobuyuki Endo ,  Masaya Ito

    IPC分类号： C08B11/193 ,  C08B1/00 ,  C08B11/15 ,  C08B11/12 ,  A61K9/00

    CPC分类号： A61L27/20 ,  A61L27/52 ,  A61L31/042 ,  A61L31/145 ,  C08B11/12 ,  C08L1/26

    摘要： The invention is a cellulose derivative wherein some of the carboxyl groups of the cellulose derivative carboxymethylcellulose are replaced with —CO—NH—X—CO—Y—Z, and a hydrogel of the same. In the formula, X is a C1-10 divalent hydrocarbon group, Y is a divalent group derived from polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R4, where R4 is a C1-23 hydrocarbon group.The hydrogel has excellent viscoelasticity and can be injected into prescribed sites with injecting devices such as syringes, and it can thus be utilized as a medical gel or adhesion barrier.

    摘要翻译： 本发明是纤维素衍生物羧甲基纤维素的一些羧基被-CO-NH-X-CO-Y-Z代替的纤维素衍生物及其水凝胶。 在该式中，X是C 1-10二价烃基，Y是衍生自在两端具有氧原子的聚环氧烷烃，Z是C1-24烃基或-CO-R4的二价基团，其中R4是C1 -23烃基。 水凝胶具有优异的粘弹性，并且可以用诸如注射器的注射装置注射到规定的位置，因此可以用作医用凝胶或粘附屏障。

    Cellulose derivative and method for production thereof
    6.
    发明授权
    Cellulose derivative and method for production thereof 失效
    纤维素衍生物及其制造方法

    公开(公告)号：US08455001B2

    公开(公告)日：2013-06-04

    申请号：US12525464

    申请日：2008-02-06

    申请人： Masaya Ito ,  Hiroaki Kaneko ,  Yukako Fukuhira ,  Nobuyuki Endo

    发明人： Masaya Ito ,  Hiroaki Kaneko ,  Yukako Fukuhira ,  Nobuyuki Endo

    IPC分类号： A61K47/36 ,  A61K31/715 ,  C08B1/00 ,  C08B3/00 ,  C08B5/00 ,  C08B7/00 ,  C08B13/00

    CPC分类号： A61K31/717 ,  C08B11/12 ,  C08B11/145

    摘要： The invention provides a cellulose derivative having a repeating unit of the formula below, a composition including the cellulose derivative and a phospholipid, a method for production thereof, and an adhesion barrier including the cellulose derivative or the composition. In the formula, R1, R2, and R3 are —H, —CH2—COOH, —CH2—COOX, or —CH2CO-phosphatidylethanolamine, and X is an alkali metal or an alkali earth metal. The degree of substitution of —CH2—COOH and —CH2—COOX is 0.3 to 2.0 in total, and the degree of substitution of —CH2CO-phosphatidylethanolamine is 0.001 to 0.05.

    摘要翻译： 本发明提供一种具有下式重复单元的纤维素衍生物，包含纤维素衍生物和磷脂的组合物，其制备方法和包含纤维素衍生物或组合物的粘合屏障。 在该式中，R 1，R 2和R 3是-H，-CH 2 -COOH，-CH 2 -COO x或-CH 2 CO-磷脂酰乙醇胺，X是碱金属或碱土金属。 -CH 2 -COOH和-CH 2 -COOX的取代度总计为0.3〜2.0，-CH 2 CO-磷脂酰乙醇胺的取代度为0.001〜0.05。

    CELLULOSE DERIVATIVE AND METHOD FOR PRODUCTION THEREOF
    7.
    发明申请
    CELLULOSE DERIVATIVE AND METHOD FOR PRODUCTION THEREOF 失效
    纤维素衍生物及其生产方法

    公开(公告)号：US20100129452A1

    公开(公告)日：2010-05-27

    申请号：US12525464

    申请日：2008-02-06

    申请人： Masaya Ito ,  Hiroaki Kaneko ,  Yukako Fukuhira ,  Nobuyuki Endo

    发明人： Masaya Ito ,  Hiroaki Kaneko ,  Yukako Fukuhira ,  Nobuyuki Endo

    IPC分类号： A61K31/717 ,  C08B1/00 ,  C08B3/00 ,  A61K9/10 ,  A61P43/00

    CPC分类号： A61K31/717 ,  C08B11/12 ,  C08B11/145

    摘要： The invention provides a cellulose derivative having a repeating unit of the formula below, a composition including the cellulose derivative and a phospholipid, a method for production thereof, and an adhesion barrier including the cellulose derivative or the composition. In the formula, R1, R2, and R3 are —H, —CH2—COOH, —CH2—COOX, or —CH2CO-phosphatidylethanolamine, and X is an alkali metal or an alkali earth metal. The degree of substitution of —CH2—COOH and —CH2—COOX is 0.3 to 2.0 in total, and the degree of substitution of —CH2CO-phosphatidylethanolamine is 0.001 to 0.05.

    摘要翻译： 本发明提供一种具有下式重复单元的纤维素衍生物，包含纤维素衍生物和磷脂的组合物，其制备方法和包含纤维素衍生物或组合物的粘合屏障。 在该式中，R 1，R 2和R 3是-H，-CH 2 -COOH，-CH 2 -COO x或-CH 2 CO-磷脂酰乙醇胺，X是碱金属或碱土金属。 -CH 2 -COOH和-CH 2 -COOX的取代度总计为0.3〜2.0，-CH 2 CO-磷脂酰乙醇胺的取代度为0.001〜0.05。

    Cellulose derivative
    8.
    发明授权
    Cellulose derivative 有权
    纤维素衍生物

    公开(公告)号：US08378091B2

    公开(公告)日：2013-02-19

    申请号：US11997830

    申请日：2006-08-03

    申请人： Hiroaki Kaneko ,  Eiichi Kitazono ,  Masaya Ito ,  Yoshihiko Sumi

    发明人： Hiroaki Kaneko ,  Eiichi Kitazono ,  Masaya Ito ,  Yoshihiko Sumi

    IPC分类号： C08B7/00 ,  C07H1/00

    CPC分类号： C08B11/20 ,  A61L31/042 ,  C08B15/05 ,  C08L1/00

    摘要： A cellulose derivative which has a suitable elastic modulus and viscosity when it is dissolved in water and is useful as an adhesion barrier.The cellulose derivative has a molecular weight of 5×103 to 5×106 and is composed of a repeating unit represented by the following formula (1): wherein R1, R2 and R3 are each independently selected from the group consisting of the following formulas (a), (b), (c) and (d) in predetermined amount: (X in the formula (c) is an alkali metal, and R4 and R5 in the formula (d) are each independently an alkyl group or alkenyl group having 10 to 28 carbon atoms).

    摘要翻译： 当纤维素衍生物溶于水中时具有合适的弹性模量和粘度并且可用作粘合屏障。 纤维素衍生物的分子量为5×10 3〜5×10 6，由下述式（1）表示的重复单元构成：其中，R 1，R 2，R 3各自独立地选自下述式 a），（b），（c）和（d））：（式（c）中的X是碱金属，式（d）中的R 4和R 5各自独立地为烷基或烯基 具有10至28个碳原子）。