摘要:
The present invention provides TLR9 agonists comprising, as an active ingredient, a compound represented by formula (I): (wherein a represents 0 or 1; n represents an integer of 0 to 2; m represents an integer of 0 to 5; X1 and X2 each independently represent a hydrogen atom or hydroxy; Y represents an oxygen atom or a sulfur atom; -Q1-represents —O— or the like; -Q2- represents —O— or the like; -Z- represents —O— or the like; R1, R3 and R4 each independently represent hydroxy or the like; R2 and R5 each independently represent a hydrogen atom, hydroxy or the like; and A represents 6-aminopurin-9-yl or the like) or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译:本发明提供TLR9激动剂,其包含作为活性成分的由式(I)表示的化合物:(其中a表示0或1; n表示0〜2的整数; m表示0〜5的整数; X1和 X2各自独立地表示氢原子或羟基; Y表示氧原子或硫原子; -Q1表示-O-等; -Q2-表示-O-等; -Z-表示-O-或 类似物; R 1,R 3和R 4各自独立地表示羟基等; R 2和R 5各自独立地表示氢原子,羟基等; A表示6-氨基嘌呤-9-基等)或药学上可接受的盐 等等。
摘要:
The present invention solves the problem of melting of Al in heating before hot-stamping, which had been a problem in the past in applying hot-stamping to Al-plated steel sheet, and provides Al-plated steel sheet for hot-stamping and a method of hot-stamping using that Al-plated steel sheet to solve the problem of delayed fracture due to residual hydrogen, and, furthermore, a method of a rapid heating hot-stamping using that Al-plated steel sheet.The Al-plated steel sheet of the present invention is produced by annealing the Al-plated steel sheet as coiled in a box-anneal furnace for the time and at the temperature indicated in FIG. 5, and alloying of a plated Al and a steel sheet.Further, a method of rapid heating hot-stamping in the present invention is characterized by cutting out a stamping blank of an Al-plated steel sheet, and heating that blank in heating before hot-stamping by an average temperature with a rising rate of 40° C./sec or more and a time of exposure to an environment of 700° C. or more of 20 seconds or less, and then hot-stamping it.
摘要:
This steel plate for cold forging includes a hot-rolled steel plate, wherein the hot-rolled steel plate includes: in terms of percent by mass, C: 0.13% to 0.20%; Si: 0.01% to 0.8%; Mn: 0.1% to 2.5%; P: 0.003% to 0.030%; S: 0.0001% to 0.008%; Al: 0.01% to 0.07%; N: 0.0001% to 0.02%; and O: 0.0001% to 0.0030%, with a remainder being Fe and inevitable impurities, an A value represented by the following formula (1) is in a range of 0.0080 or less, a thickness of the hot-rolled steel plate is in a range of 2 mm to 25 mm, and an area percentage of pearlite bands having lengths of 1 mm or more in a region of 4/10t to 6/10t when a plate thickness is indicated by t in a cross section of a plate thickness that is parallel to a rolling direction of the hot-rolled steel plate is in a range of not more than a K value represented by the following formula (2), A value=O%+S%+0.033Al% (1) K value=25.5×C%+4.5×Mn%−6 (2).
摘要:
An apparatus for extracting the contents from a refill pouch comprises a holding member for holding the pouch with its extraction port facing downward, and a pump attached to the extraction port of the pouch. The pump has a pump body defining a housing space having an inlet opening and an outlet opening, an inlet-side valve which communicates with the extraction port to open and close the inlet opening so that the contents can be introduced into the housing space from the pouch, and an outlet-side valve to open and close the outlet opening so that the contents in the housing space can be discharged through a nozzle that communicates with the outlet-side valve. The pump wall portion is constituted by a resiliently compressible, restorable and flexible material so that the contents in the housing space can be extracted through the nozzle by manually squeezing the pump wall portion thereby pressurizing the housing space.
摘要:
An image projection apparatus is disclosed which projects an image having a good color by reducing the influence of a lateral electric field in a liquid crystal display element (LCD). The apparatus includes three LCDs, each including two opposite electrodes. As the voltage applied to a liquid crystal layer is increased, retardation provided for light in each color band is increased. A controller controls an electrode application voltage in the first LCD such that, in a white display state, a liquid crystal application voltage (LCAV) in the first LCD is lower than the LCAVs in the second and third LCDs, and such that, in a black display state, the LCAV in the first LCD is higher than the LCAVs in the second and third LCDs and has a value from 1% to 30% of the LCAV in the first LCD in the white display state.
摘要:
At least one exemplary embodiment is directed to a reflective liquid crystal display apparatus which includes a polarization beam splitter having a polarization split film used as both a polarizer and an analyzer; a reflective liquid crystal display device; a quarter wave plate; and a projection optical system; where the absolute value of phase difference of diffracted light generated by the reflective liquid crystal display device in a black display state is reduced by the phase difference of the quarter wave plate, and thus the amount of stray light of the diffracted light guided from the polarizing beam splitter to the projection optical system decreases.
摘要:
An exemplary embodiment of an aluminum type plated steel sheet which excels in discoloration resistance, and weldability, which does not decorate after re-heating and which can prevent increasing of strength, and a heat shrink band using the same are provided. For example, the heat shrink band can be made of an aluminum type plated steel sheet consisting of a steel sheet being composed of, e.g., not more than about 0.005 mass % of C; not more than about 0.005 mass % of N; not less than about 0.1 mass % and not more than about 0.5 mass % of Si; not more than about 0.1 mass % of P; not more than about 0.02 mass % of S; not less than about 1.05 mass % and not more than 2.0 mass % of Mn; not more than 1.0 mass % of sol Al; a residual amount of Fe and inevitable impurities, and an aluminum type plated layer mainly consisting of Al being deposited thereon. Such exemplary sheet can be prevented from a discoloration upon, e.g., being re-heated at a temperature of not less than about 500° C. to not more than about 700° C.
摘要:
At least one exemplary embodiment is directed to a reflective liquid crystal display apparatus which includes a polarization beam splitter having a polarization split film used as both a polarizer and an analyzer; a reflective liquid crystal display device; a quarter wave plate; and a projection optical system; where the absolute value of phase difference of diffracted light generated by the reflective liquid crystal display device in a black display state is reduced by the phase difference of the quarter wave plate, and thus the amount of stray light of the diffracted light guided from the polarizing beam splitter to the projection optical system decreases.
摘要:
There is disclosed a display apparatus including a polarizing beam splitter for splitting light from a light source, a reflective liquid crystal display element illuminated by light of a predetermined polarizing direction through the polarizing beam splitter, and a double refractive phase compensation element arranged between the polarizing beam splitter and the reflective liquid crystal display element.
摘要:
In a projection type image display apparatus, when the angle of light incident on the multi-layer film of a polarizing beam splitter for synthesizing an optical path becomes uneven, the loss of the light occurs. So, the projection type image display apparatus of the present invention is provided with an illuminating optical system 1-5b, a color separating and synthesizing optical system 7 for separating illuminating light from the illuminating optical system into a plurality of color lights and making the respective color lights enter image display elements 8r-8b provided for the respective color lights, and synthesizing a plurality of image lights emerging from these image display elements, a projection optical system 10 for projecting and displaying the image lights synthesized by the color separating and synthesizing optical system, and polarizing elements Pr, Pg, Pb for transmitting only a particular polarized component light therethrough disposed between the color separating and synthesizing optical system and the image display elements.