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公开(公告)号：US08653141B2
公开(公告)日：2014-02-18
申请号：US13451370
申请日：2012-04-19
Applicant: Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
Inventor： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
IPC: A61K31/18 , C07D307/00
CPC classification number: C07D417/12 , C07C311/18 , C07C311/29 , C07C311/41 , C07C311/47 , C07C317/18 , C07D209/14 , C07D213/30 , C07D213/40 , C07D233/36 , C07D233/64 , C07D233/72 , C07D277/24 , C07D277/28 , C07D307/14 , C07D307/20 , C07D307/52 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D409/10 , C07D417/06 , C07D417/10 , C07D471/04 , C07D493/04
Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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公开(公告)号：US20050159469A1
公开(公告)日：2005-07-21
申请号：US11010177
申请日：2004-12-10
Applicant: John Randolph , Hui-Ju Chen , David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Peggy Huang , Douglas Hutchinson , Dale Kempf , Larry Klein , Ming Yeung
Inventor： John Randolph , Hui-Ju Chen , David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Peggy Huang , Douglas Hutchinson , Dale Kempf , Larry Klein , Ming Yeung
IPC: A61K31/4166 , A61K31/4178 , C07C243/24 , C07C271/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D43/02
CPC classification number: C07C271/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14
Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号：US20170119196A1
公开(公告)日：2017-05-04
申请号：US15407269
申请日：2017-01-17
Applicant: Hui-Ju Chen , Hsiu-Lan Chen Lu , Han Tsung Chen , Wei Fu Chen
Inventor： Hui-Ju Chen , Hsiu-Lan Chen Lu , Han Tsung Chen , Wei Fu Chen
CPC classification number: A47J31/005 , A47J31/0605 , A47J41/02
Abstract: A thermo tea maker includes a tea cup and a tea infuser. The exterior of the tea cup has a first isolation gap in a vacuum state to block the heat conduction from an inner part to an outer part of the cup part. The exterior of the tea infuser has a second isolation gap in a vacuum state to block the heat conduction from an inner segment to an outer segment of the tea infuser. The tea cup and the tea infuser are able to keep the tea warm. When the tea infuser is turned, the tea infuser will not scald the user's hand.
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公开(公告)号：US08748374B2
公开(公告)日：2014-06-10
申请号：US13154721
申请日：2011-06-07
Applicant: Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarllla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
Inventor： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarllla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
IPC: A61K38/00
CPC classification number: C07K5/081 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US20130131085A1
公开(公告)日：2013-05-23
申请号：US13713903
申请日：2012-12-13
Applicant: Larry L. Klein , Hui-Ju Chen , Ming C. Yeung , Charles A. Flentge , John T. Randolph , Peggy P. Huang , Douglas K. Hutchinson , Dale J. Kempf
Inventor： Larry L. Klein , Hui-Ju Chen , Ming C. Yeung , Charles A. Flentge , John T. Randolph , Peggy P. Huang , Douglas K. Hutchinson , Dale J. Kempf
IPC: C07D417/12 , C07D213/79 , C07D277/593
CPC classification number: A61K31/5377 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/506 , A61K45/06 , C07D213/79 , C07D277/24 , C07D277/30 , C07D277/593 , C07D417/12
Abstract: The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.
Abstract translation: 本发明的特征在于式I化合物或其药学上可接受的盐，溶剂合物或前药，以及使用该化合物抑制CYP酶代谢活性的方法。 本发明还涉及使用这些化合物，盐，溶剂合物或前药来改善由CYP酶代谢的药物的药代动力学的方法。
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Patent Agency Ranking
公开(公告)号：US07902203B2
公开(公告)日：2011-03-08
申请号：US10699513
申请日：2003-10-31
Applicant: John K. Pratt , David A. Betebenner , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Keith F. McDaniel , Clarence J. Maring , Vincent S. Stoll , Rong Zhang , Hui-Ju Chen , William J. Flosi , Larry L. Klein , Allan C. Krueger , Dachun Liu , Darold L. Madigan , Laura M. Maymon , Todd W. Rockway , Kent D. Stewart , Ming C. Yeung , Qinghua Xie
Inventor： John K. Pratt , David A. Betebenner , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Keith F. McDaniel , Clarence J. Maring , Vincent S. Stoll , Rong Zhang , Hui-Ju Chen , William J. Flosi , Larry L. Klein , Allan C. Krueger , Dachun Liu , Darold L. Madigan , Laura M. Maymon , Todd W. Rockway , Kent D. Stewart , Ming C. Yeung , Qinghua Xie
IPC: A01N43/54 , A01N43/90 , C07D285/00 , C07D285/22
CPC classification number: C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.
Abstract translation: 本发明提供具有式（I）的HCV聚合酶抑制化合物和包含治疗有效量的所述化合物的组合物。 本发明还提供了抑制丙型肝炎病毒（HCV）聚合酶，抑制HCV病毒复制的方法以及治疗或预防HCV感染的方法。 还提供了用于制备所述化合物的方法和在所述方法中使用的合成中间体。
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公开(公告)号：US06455571B1
公开(公告)日：2002-09-24
申请号：US09421787
申请日：1999-10-19
Applicant: Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
Inventor： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
IPC: A61K3140
CPC classification number: C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
Abstract translation: 公开了下式的化合物：其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。
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公开(公告)号：US08937041B2
公开(公告)日：2015-01-20
申请号：US13339440
申请日：2011-12-29
Applicant: Keith F. McDaniel , Hui-Ju Chen , Ming Yeung , Timothy Middleton , Liangjun Lu , Kevin Kurtz
Inventor： Keith F. McDaniel , Hui-Ju Chen , Ming Yeung , Timothy Middleton , Liangjun Lu , Kevin Kurtz
CPC classification number: C07K5/02 , A61K38/00 , C07K5/0804 , C07K5/0827
Abstract: The present invention relates to novel fluorinated macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Abstract translation: 本发明涉及新的氟化大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US08420596B2
公开(公告)日：2013-04-16
申请号：US12584716
申请日：2009-09-10
Applicant: Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik
Inventor： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik
IPC: A61K38/00
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US20120196792A1
公开(公告)日：2012-08-02
申请号：US13439551
申请日：2012-04-04
Applicant: Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Ken Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
Inventor： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Ken Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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