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公开(公告)号：US20210208055A1
公开(公告)日：2021-07-08
申请号：US17191612
申请日：2021-03-03
发明人： James Tsay , Anmiv Prabhu , David Heiner , Edwin Li , Alexandre Richez , John M. Beierle , Kevan Samiee , Kristina Munoz , Leonid Malevanchik , Ludovic Vincent , Naiqian Zhan , Peyton Shieh , Robert Yang , Samantha Schmitt , Sang Park , Scott Bailey , Sean M. Ramirez , Sunmin Ahn , Valerie Uzzell , Wei Wei , Yuxiang Huang , Tyler Jamison Dill
IPC分类号： G01N15/14 , C12Q1/6874 , B01L3/00 , C09D133/24 , C09D133/26 , B01J19/00
摘要： A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized molecule bound to a first silane or silane derivative in at least some of the first depressions, and a first primer grafted to the first functionalized molecule in the at least some of the first depressions. The second surface-modified patterned wafer includes second depressions separated by second interstitial regions, a second functionalized molecule bound to a second silane or silane derivative in at least some of the second depressions, and a second primer grafted to the second functionalized molecule in the at least some of the second depressions. The spacer layer bonds at least some first interstitial regions to at least some second interstitial regions, and at least partially defines respective fluidic chambers of the flow cell package.
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公开(公告)号：US20180178416A1
公开(公告)日：2018-06-28
申请号：US15847150
申请日：2017-12-19
发明人： Alexandre Richez , Andrew A. Brown , Julia Morrison , Wayne N. George , Timothy J. Merkel , Audrey Rose Zak
摘要： An imprinting apparatus includes a silicon master having a plurality of nanofeatures defined therein. An anti-stick layer coats the silicon master, the anti-stick layer including a molecule having a cyclosiloxane with at least one silane functional group. A method includes forming a master template by: depositing a formulation on a silicon master including a plurality of nanofeatures defined therein, the formulation including a solvent and a molecule having a cyclosiloxane with at least one silane functional group; and curing the formulation, thereby forming an anti-stick layer on the silicon master, the anti-stick layer including the molecule. The method further includes depositing a silicon-based working stamp material on the anti-stick layer of the master template; curing the silicon-based working stamp material to form a working stamp including a negative replica of the plurality of nanofeatures; and releasing the working stamp from the master template.
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公开(公告)号：US20160122816A1
公开(公告)日：2016-05-05
申请号：US14927252
申请日：2015-10-29
发明人： Andrew A. Brown , Wayne N. George , Alexandre Richez , Anne-Cecile Dingwall , Xavier von Hatten
IPC分类号： C12Q1/68 , C08F220/56
CPC分类号： C08F20/60 , B01J2219/00637 , B01J2219/00722 , C08F8/32 , C08F220/56 , C08F293/005 , C08F2438/03 , C12Q1/6874 , C40B50/18 , C08F220/60 , C08F2220/603 , C08F222/385 , C08F220/22 , C08F2220/346
摘要： Some embodiments described herein relate to new polymer coatings for surface functionalization and new processes for grafting pre-grafted DNA-copolymers to surface(s) of substrates for use in DNA sequencing and other diagnostic applications.
摘要翻译： 本文描述的一些实施方案涉及用于表面官能化的新聚合物涂层和用于将预接枝的DNA共聚物接枝到用于DNA测序和其它诊断应用的底物表面的新方法。
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公开(公告)号：US20230102870A1
公开(公告)日：2023-03-30
申请号：US17934394
申请日：2022-09-22
IPC分类号： C08G77/445
摘要： Some of the resin compositions are ultraviolet light or thermally curable, while others are ultraviolet light curable. One example of the ultraviolet light or thermally curable resin composition consists of a predetermined mass ratio of a (meth)acrylate cyclosiloxane monomer and a non-siloxane (meth)acrylate based monomer ranging from about >0:
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公开(公告)号：US11199540B2
公开(公告)日：2021-12-14
申请号：US16892097
申请日：2020-06-03
发明人： Xavier von Hatten , Wayne N. George , Alexandre Richez , Anne-Cecile Dingwall , Andrew A. Brown
IPC分类号： G01N33/543 , C12Q1/6834 , C12Q1/6869 , G01N33/551 , C12N11/10 , C09D183/04
摘要： Some examples described herein relate to a substrate comprising a silane functionalized surface for reversibly immobilizing a biological molecule of interest, such as oligonucleotides, polynucleotides, or protein. Methods for immobilizing the biological molecule and the use in DNA sequencing and other diagnostic applications are also disclosed.
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公开(公告)号：US20210339457A1
公开(公告)日：2021-11-04
申请号：US17235244
申请日：2021-04-20
发明人： Alexandre Richez
摘要： An example of a flow cell includes a substrate and a cured, patterned resin on the substrate. The cured, patterned resin has nano-depressions separated by interstitial regions. Each nano-depression has a largest opening dimension ranging from about 10 nm to about 1000 nm. The cured, patterned resin also includes an interpenetrating polymer network. The interpenetrating polymer network of the cured, patterned resin includes an epoxy-based polymer and a (meth)acryloyl-based polymer.
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公开(公告)号：US10684281B2
公开(公告)日：2020-06-16
申请号：US15970702
申请日：2018-05-03
发明人： Xavier von Hatten , Wayne N. George , Alexandre Richez , Anne-Cecile Dingwall , Andrew A. Brown
IPC分类号： G01N33/543 , C12Q1/6834 , C12Q1/6869 , G01N33/551 , C12N11/10 , C09D183/04
摘要： Some embodiments described herein relate to a substrate comprising a silane functionalized surface for reversibly immobilizing a biological molecule of interest, such as oligonucleotides, polynucleotides, or protein. Methods for immobilizing the biological molecule and the use in DNA sequencing and other diagnostic applications are also disclosed.
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公开(公告)号：US20180267034A1
公开(公告)日：2018-09-20
申请号：US15970702
申请日：2018-05-03
发明人： Xavier von Hatten , Wayne N. George , Alexandre Richez , Anne-Cecile Dingwall , Andrew A. Brown
IPC分类号： G01N33/543 , C12Q1/6834 , G01N33/551 , C09D183/04
CPC分类号： G01N33/54393 , C09D183/04 , C12N11/10 , C12Q1/6834 , C12Q1/6869 , C12Q2563/131 , C12Q2565/543 , G01N33/543 , G01N33/54353 , G01N33/551
摘要： Some embodiments described herein relate to a substrate comprising a silane functionalized surface for reversibly immobilizing a biological molecule of interest, such as oligonucleotides, polynucleotides, or protein. Methods for immobilizing the biological molecule and the use in DNA sequencing and other diagnostic applications are also disclosed.
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公开(公告)号：US20220088834A1
公开(公告)日：2022-03-24
申请号：US17541089
申请日：2021-12-02
发明人： Alexandre Richez , Andrew A. Brown , Julia Morrison , Wayne N. George , Timothy J. Merkel , Audrey Rose Zak
IPC分类号： B29C33/38 , C09D133/26 , B29C59/02 , G03F7/00 , B29C33/40
摘要： An imprinting apparatus includes a silicon master having a plurality of nanofeatures defined therein. An anti-stick layer coats the silicon master, the anti-stick layer including a molecule having a cyclosiloxane with at least one silane functional group. A method includes forming a master template by: depositing a formulation on a silicon master including a plurality of nanofeatures defined therein, the formulation including a solvent and a molecule having a cyclosiloxane with at least one silane functional group; and curing the formulation, thereby forming an anti-stick layer on the silicon master, the anti-stick layer including the molecule. The method further includes depositing a silicon-based working stamp material on the anti-stick layer of the master template; curing the silicon-based working stamp material to form a working stamp including a negative replica of the plurality of nanofeatures; and releasing the working stamp from the master template.
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公开(公告)号：US10955332B2
公开(公告)日：2021-03-23
申请号：US15848450
申请日：2017-12-20
发明人： James Tsay , Anmiv Prabhu , David Heiner , Edwin Li , Alexandre Richez , John M. Beierle , Kevan Samiee , Kristina Munoz , Leonid Malevanchik , Ludovic Vincent , Naiqian Zhan , Peyton Shieh , Robert Yang , Samantha Schmitt , Sang Park , Scott Bailey , Sean M. Ramirez , Sunmin Ahn , Valerie Uzzell , Wei Wei , Yuxiang Huang , Tyler Jamison Dill
IPC分类号： G01N15/14 , C12Q1/6874 , B01L3/00 , C09D133/24 , C09D133/26 , B01J19/00 , G01N15/10
摘要： A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized molecule bound to a first silane or silane derivative in at least some of the first depressions, and a first primer grafted to the first functionalized molecule in the at least some of the first depressions. The second surface-modified patterned wafer includes second depressions separated by second interstitial regions, a second functionalized molecule bound to a second silane or silane derivative in at least some of the second depressions, and a second primer grafted to the second functionalized molecule in the at least some of the second depressions. The spacer layer bonds at least some first interstitial regions to at least some second interstitial regions, and at least partially defines respective fluidic chambers of the flow cell package.
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