Method for Imaging Objects Contained in a Droplet

    公开(公告)号:US20250085665A1

    公开(公告)日:2025-03-13

    申请号:US18882206

    申请日:2024-09-11

    Applicant: Imec vzw

    Abstract: Examples include imaging one or more objects contained inside a droplet. A method includes generating at least one hologram of the one or more objects contained in the droplet by using in-line lens-free imaging. The at least one hologram includes at least one artifact that is caused by the droplet and that affects the at least one characteristic of the one or more objects contained in the droplet. The method includes at least partially removing the at least one artifact or the cause of the at least one artifact. The method further includes generating an image, after or during removing the at least one artifact or the cause of the at least one artifact. The image includes the one or more objects. The method also comprises recognizing the at least one characteristic of the one or more objects based on the image.

    System and Method for Label-Free Cell Identification and/or Classification and/or Selection

    公开(公告)号:US20250114793A1

    公开(公告)日:2025-04-10

    申请号:US18909640

    申请日:2024-10-08

    Applicant: IMEC VZW

    Abstract: A system for label-free identification and/or classification and/or selection of at least one cell is provided. The system comprises a microfluidic environment configured to be traversable by the at least one cell, an imaging sensor configured to gather imaging information with respect to at least a part of the microfluidic environment, and a processing unit connected to the imaging sensor. In this context, the microfluidic environment comprises at least one sub-environment configured to interact with the at least one cell. Furthermore, the processing unit is configured to detect at least one sub-environment interaction event based on persistence of the at least one cell imaged by the imaging sensor in the temporal domain. In addition to this, the processing unit is configured to identify and/or classify and/or select the at least one cell based on the at least one sub-environment interaction event.

    Micro-mirror arrays
    3.
    发明授权
    Micro-mirror arrays 有权
    微镜阵列

    公开(公告)号:US09217861B2

    公开(公告)日:2015-12-22

    申请号:US14373071

    申请日:2013-01-18

    Applicant: IMEC VZW

    Abstract: Micro-mirror arrays configured for use in a variable focal length lens are described herein. An example variable focal length lens comprises a micro-mirror array having a plurality of micro-mirror elements arranged in at least a first section and a second section. Each micro-mirror element has a tilt axis and comprises, on each of two opposing sides of the tilt axis, (i) at least one actuation electrode, (ii) at least one measurement electrode, and (iii) at least one stopper. Additionally, each micro-mirror element in the first section has a first tilt angle range, and each micro-mirror element in the second section has a second tilt angle range, with the first tilt angle range being less than the second tilt angle range.

    Abstract translation: 这里描述了配置用于可变焦距透镜的微镜阵列。 示例性可变焦距透镜包括具有布置在至少第一部分和第二部分中的多个微反射镜元件的微反射镜阵列。 每个微镜元件具有倾斜轴线,并且在倾斜轴线的两个相对侧的每一侧上包括(i)至少一个致动电极,(ii)至少一个测量电极,和(iii)至少一个止动器。 此外,第一部分中的每个微镜元件具有第一倾斜角范围,并且第二部分中的每个微镜元件具有第二倾斜角范围,其中第一倾斜角度范围小于第二倾斜角范围。

    Micro-Mirror Arrays
    4.
    发明申请
    Micro-Mirror Arrays 有权
    微镜阵列

    公开(公告)号:US20140368920A1

    公开(公告)日:2014-12-18

    申请号:US14373071

    申请日:2013-01-18

    Applicant: IMEC VZW

    Abstract: Micro-mirror arrays configured for use in a variable focal length lens are described herein. An example variable focal length lens comprises a micro-mirror array having a plurality of micro-mirror element arranged in at least a first section and a second section. Each micro-mirror element has a tilt axis and comprises, on each of two opposing sides of the tilt axis, (i) at least one actuation electrode, (ii) at least one measurement electrode, and (iii) at least one stopper. Additionally, each micro-mirror element in the first section has a first tilt axis range, and each micro-mirror element in the second section has a second tilt axis range, with the first tilt axis range being less than the second tilt axis range.

    Abstract translation: 这里描述了配置用于可变焦距透镜的微镜阵列。 示例性可变焦距透镜包括具有布置在至少第一部分和第二部分中的多个微反射镜元件的微反射镜阵列。 每个微镜元件具有倾斜轴线,并且在倾斜轴线的两个相对侧的每一侧上包括(i)至少一个致动电极,(ii)至少一个测量电极,和(iii)至少一个止动器。 此外,第一部分中的每个微镜元件具有第一倾斜轴范围,并且第二部分中的每个微镜元件具有第二倾斜轴范围,其中第一倾斜轴范围小于第二倾斜轴范围。

    Imaging device for in-line holographic imaging of an object

    公开(公告)号:US11307533B2

    公开(公告)日:2022-04-19

    申请号:US16648987

    申请日:2018-09-19

    Applicant: IMEC VZW

    Abstract: Example embodiments relate to imaging devices for in-line holographic imaging of objects. One embodiment includes an imaging device for in-line holographic imaging of an object. The imaging device includes a set of light sources configured to output light in confined illumination cones. The imaging device also includes an image sensor that includes a set of light-detecting elements. The set of light sources are configured to output light such that the confined illumination cones are arranged side-by-side and illuminate a specific part of the object. The image sensor is arranged such that the light-detecting elements detect a plurality of interference patterns. Each interference pattern is formed by diffracted light from the object originating from a single light source and undiffracted light from the same single light source. At least a subset of the set of light-detecting elements is arranged to detect light relating to not more than one interference pattern.

    Apparatus and Method for Performing In-Line Lens-Free Digital Holography of an Object
    8.
    发明申请
    Apparatus and Method for Performing In-Line Lens-Free Digital Holography of an Object 有权
    用于执行对象的在线无镜头数字全息摄影的装置和方法

    公开(公告)号:US20170031318A1

    公开(公告)日:2017-02-02

    申请号:US15039549

    申请日:2014-12-02

    Applicant: IMEC VZW

    Abstract: The present disclosure relates to apparatuses and methods for performing in-line lens-free digital holography of objects. At least one embodiment relates to an apparatus for performing in-line lens-free digital holography of an object. The apparatus includes a point light source adapted for emitting coherent light. The apparatus also includes an image sensing device adapted and arranged for recording interference patterns resulting from interference from light waves directly originating from the point light source and object light waves. The object light waves originate from light waves from the point light source that are scattered or reflected by the object. The image sensing device comprises a plurality of pixels. The point light source comprises a broad wavelength spectrum light source and a pinhole structure. The image sensing device comprises a respective narrow band wavelength filter positioned above each pixel that filters within a broad wavelength spectrum of the point light source.

    Abstract translation: 本公开涉及用于执行物体的无线透镜数字全息术的装置和方法。 至少一个实施例涉及一种用于执行物体的直线无镜头数字全息术的装置。 该装置包括适于发射相干光的点光源。 该装置还包括适于和布置用于记录由直接源自点光源和物体光波的光波的干扰引起的干涉图案的图像感测装置。 物体光波源自被物体散射或反射的点光源的光波。 图像感测装置包括多个像素。 点光源包括宽波长光谱光源和针孔结构。 图像感测装置包括位于每个像素上方的相应的窄带波长滤波器,其在点光源的宽波长光谱内进行滤波。

    Device and a method for imaging of microscopic objects

    公开(公告)号:US12196942B2

    公开(公告)日:2025-01-14

    申请号:US17555792

    申请日:2021-12-20

    Applicant: IMEC VZW

    Abstract: According to an aspect of the present inventive concept there is provided a device for imaging of a microscopic object, the device comprising: an array of light sensitive areas sensitive to detect light spanning a wavelength range of at least 400-1200 nm; at least one light source comprising at least a first point of operation in which the at least one light source is configured to generate visible light, and a second point of operation in which the at least one light source is configured to generate infrared light, and being arranged to illuminate the microscopic object such that light is scattered by the microscopic object; wherein the array of light sensitive areas is configured to detect an interference pattern formed between the scattered light and non-scattered light; the device being configured to be set in a selected point of operation from the at least first and second points of operation, for detecting the interference pattern for imaging the microscopic object at a wavelength defined by the selected point of operation.

    Multi-spectral microscopic imaging spanning the visible and short-wave infrared range

    公开(公告)号:US12117342B2

    公开(公告)日:2024-10-15

    申请号:US17555785

    申请日:2021-12-20

    Applicant: IMEC VZW

    CPC classification number: G01J3/2823 G01J3/2803 G01J2003/2826

    Abstract: According to an aspect of the present inventive concept there is provided a device for imaging of a microscopic object, the device comprising:



    an array of light sensitive areas, each being sensitive to detect light spanning a wavelength range of at least 400-1200 nm;
    at least one light source configured to generate light at a plurality of wavelengths within the wavelength range, comprising at least one wavelength in a visible part of the wavelength range and at least one wavelength in a short-wave infrared, SWIR, part of the wavelength range, and arranged to illuminate the microscopic object with the generated light such that at least part of the light is scattered by the microscopic object;
    wherein the device is configured to transmit the scattered light and non-scattered light, from the same light source, to the array of light sensitive areas configured to detect an interference pattern formed between the scattered light and the non-scattered light, for each wavelength.

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