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公开(公告)号：US20100284944A1
公开(公告)日：2010-11-11
申请号：US12593114
申请日：2008-03-27
申请人： Ioana Maria Ungureanu , Nicole Erna Irene Brune , Jay Patrick Slack , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
发明人： Ioana Maria Ungureanu , Nicole Erna Irene Brune , Jay Patrick Slack , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
IPC分类号： A61K9/68 , C07C61/08 , C07C61/04 , A23L1/22 , A23L1/236 , A23L2/56 , A23G4/06 , A23P1/00 , A23L1/302 , A23G1/32 , A23F5/46 , A23L1/222 , C12G3/06 , A23L1/304 , A23L1/227 , A61K31/522 , A61K31/714 , A61K38/16 , A61K31/192 , A61K31/60 , A61K31/4164 , A61K31/167 , A61K31/485 , A61K31/7048 , A61K31/341 , A61K31/43 , A61K33/30 , A61K31/451 , A61K31/015 , A61K31/352 , A61K31/05 , A61K31/19 , A61K36/00 , A61K36/537 , A61K36/534 , A61K31/715 , A61K38/02 , A61K31/17 , A61K31/7004
CPC分类号： A23L27/70 , A23L2/56 , A23L2/60 , A23L27/2028 , A23L27/30 , A23L27/84 , A23L27/86 , A61K8/36 , A61K8/361 , C07C53/134 , C07C53/136 , C07C57/26 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/18 , C07C2602/50
摘要： Disclosed are Compounds that block off-notes in consumables and methods of blocking off-notes in consumables including off-notes provided by artificial sweeteners including aspartame, Saccharin, acesulfame K (Acesulfame potassium), sucralose and cyclamate; and including stevioside, swingle extract, glyccerhizin, perillartine, naringin dihydrochalcone, neohesperidine dihydrochalcone, mogroside V, rubusoside, rubus extract, and rebaudioside A.
摘要翻译： 公开了阻止消耗品中的纸币的化合物和阻断消耗品中的纸屑的方法，包括由人造甜味剂（包括阿斯巴甜，糖精，乙酰磺胺酸钾（醋酸磺酰胺钾）），三氯蔗糖和环己基氨基磺酸酯提供的脱模剂; 包括甜菊糖苷，吐温，甘草苷，perillartine，柚苷二氢查耳酮，新橙皮苷二氢查耳酮，罗汉果苷V，鲁氏皂苷，芦丁提取物和莱鲍迪甙A.
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公开(公告)号：US20100311786A1
公开(公告)日：2010-12-09
申请号：US12669393
申请日：2008-07-28
申请人： Ioana Maria Ungureanu , Nicole Erna Irene Brune , Jay Patrick Slack , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
发明人： Ioana Maria Ungureanu , Nicole Erna Irene Brune , Jay Patrick Slack , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
IPC分类号： A61K31/4748 , C07C61/06 , C07C61/08 , A61K47/12 , A61K31/445 , A61P11/14 , A61P29/00 , A23L1/226 , A23G4/06 , A23L1/302
CPC分类号： A23L27/84 , A23L27/30 , A23L27/86 , A23V2002/00
摘要： Disclosed are compounds that block off-notes in consumables and methods of blocking off-notes in consumables including off-notes provided by sweeteners such as stevioside, swingle extract, glyccerhizin, perillartine, naringin dihydrochalcone, neohesperidine dihydrochalcone, mogroside V, rubusoside, rubus extract, and rebaudioside A, and artificial sweeteners such as aspartame, saccharin, acesulfame K (Acesulfame potassium), sucralose and cyclamate.
摘要翻译： 公开了阻止消耗品中的纸屑的化合物以及阻断消耗品中的纸屑的方法，包括由甜味剂如甜菊糖苷，葡聚糖提取物，甘草酸，perillartine，柚皮苷二氢查耳酮，新月桂哌啶二氢查耳酮，罗汉果苷V，鲁鲁斯苷，罗汉果提取物 和莱鲍迪甙A，以及人造甜味剂如阿斯巴甜，糖精，乙酰磺胺酸钾（乙酰磺胺酸钾），三氯蔗糖和环己基氨基磺酸盐。
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公开(公告)号：US08409649B2
公开(公告)日：2013-04-02
申请号：US12593114
申请日：2008-03-27
申请人： Ioana Maria Ungureanu , Nicole Erna Irene Brune , Jay Patrick Slack , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
发明人： Ioana Maria Ungureanu , Nicole Erna Irene Brune , Jay Patrick Slack , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
CPC分类号： A23L27/70 , A23L2/56 , A23L2/60 , A23L27/2028 , A23L27/30 , A23L27/84 , A23L27/86 , A61K8/36 , A61K8/361 , C07C53/134 , C07C53/136 , C07C57/26 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/18 , C07C2602/50
摘要： Disclosed are compounds that block off-notes in consumables and methods of blocking off-notes in consumables including off-notes provided by artificial sweeteners including aspartame, saccharin, acesulfame K (Acesulfame potassium), sucralose and cyclamate; and including stevioside, swingle extract, glyccerhizin, perillartine, naringin dihydrochalcone, neohesperidine dihydrochalcone, mogroside V, rubusoside, rubus extract, and rebaudioside A.
摘要翻译： 公开了阻止消耗品中的纸币的化合物和阻止消耗品中的纸屑的方法，包括由人造甜味剂（包括阿斯巴甜，糖精，乙酰磺胺酸钾（二甲基卡巴酸钾），三氯蔗糖和环己基氨基磺酸酯）提供的离纸。 包括甜菊糖苷，吐温，甘草苷，perillartine，柚苷二氢查耳酮，新橙皮苷二氢查耳酮，罗汉果苷V，鲁氏皂苷，芦丁提取物和莱鲍迪甙A.
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公开(公告)号：US08597896B2
公开(公告)日：2013-12-03
申请号：US13481797
申请日：2012-05-26
申请人： Nicole Erna Irene Brune , Jay Patrick Slack , Ioana Maria Ungureanu , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
发明人： Nicole Erna Irene Brune , Jay Patrick Slack , Ioana Maria Ungureanu , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
IPC分类号： G01N33/567 , C07K14/705
摘要： Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose, and an inhibitor, are provided.
摘要翻译： 已经鉴定了三氯蔗糖结合的TAS2R苦味受体。 提供了鉴定调节剂的新方法，特别是三氯半乳蔗糖的苦味和抑制剂的抑制剂。
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公开(公告)号：US08187822B2
公开(公告)日：2012-05-29
申请号：US12593155
申请日：2008-03-27
申请人： Nicole Erna Irene Brune , Jay Patrick Slack , Ioana Maria Ungureanu , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
发明人： Nicole Erna Irene Brune , Jay Patrick Slack , Ioana Maria Ungureanu , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
IPC分类号： G01N33/567 , C07K14/705
摘要： Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose, and an inhibitor, are provided.
摘要翻译： 已经鉴定了三氯蔗糖结合的TAS2R苦味受体。 提供了鉴定调节剂的新方法，特别是三氯半乳蔗糖的苦味和抑制剂的抑制剂。
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公开(公告)号：US20100129833A1
公开(公告)日：2010-05-27
申请号：US12593155
申请日：2008-03-27
申请人： Nicole Erna Irene Brune , Jay Patrick Slack , Ioana Maria Ungureanu , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evens Pennimpede
发明人： Nicole Erna Irene Brune , Jay Patrick Slack , Ioana Maria Ungureanu , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evens Pennimpede
IPC分类号： G01N33/53
摘要： Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose and an inhibitor, are provided.
摘要翻译： 已经鉴定了三氯蔗糖结合的TAS2R苦味受体。 提供了鉴定调节剂的新方法，特别是三氯半乳蔗糖和抑制剂的苦味的抑制剂。
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公开(公告)号：US08557530B2
公开(公告)日：2013-10-15
申请号：US13059730
申请日：2009-08-27
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： G01N33/502 , G01N33/566 , G01N2333/726 , G01N2500/02
摘要： TAS2R7 was identified as a menthol-binding bitter taste receptor. Novel methods to identify modulators and in particular inhibitors to the bitter taste of menthol are provided.
摘要翻译： TAS2R7被鉴定为薄荷醇结合苦味受体。 提供了鉴定调节剂的新方法，特别是抑制薄荷醇苦味的方法。
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公开(公告)号：US20130123135A1
公开(公告)日：2013-05-16
申请号：US13695332
申请日：2011-05-06
CPC分类号： C12Q1/025 , C12Q1/6897 , G01N33/5041 , G01N2500/02 , G01N2500/10
摘要： Disclosed are compounds that activate the human G-protein coupled receptor TAS2R48, and methods of using these compounds for identifying compounds that modulate the response of the TAS2R48 receptor. Compounds identified as modulators of the response of the receptor TAS2R48 may be used to decrease or mask the bitter taste of foods or drugs.
摘要翻译： 公开了激活人G蛋白偶联受体TAS2R48的化合物，以及使用这些化合物鉴定调节TAS2R48受体反应的化合物的方法。 鉴定为受体TAS2R48的反应调节剂的化合物可用于降低或掩盖食物或药物的苦味。
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公开(公告)号：US20100178389A1
公开(公告)日：2010-07-15
申请号：US12663321
申请日：2008-06-06
申请人： Zhonghua Jia , Xiaogen Yang , Chad Allen Hansen , Charles Benjamin Naman , Christopher Todd Simons , Jay Patrick Slack , Kimberley Gray
发明人： Zhonghua Jia , Xiaogen Yang , Chad Allen Hansen , Charles Benjamin Naman , Christopher Todd Simons , Jay Patrick Slack , Kimberley Gray
CPC分类号： A23L5/00 , A23C9/156 , A23G1/40 , A23G1/48 , A23G9/34 , A23G9/42 , A23L2/60 , A23L7/126 , A23L27/30 , A23L27/34 , A23L29/30 , A23L33/125 , A23V2002/00 , A23V2250/60 , A23V2250/25
摘要： Disclosed are sweetened consumables and methods of forming said sweetened consumables that comprise certain sweeteners and a compound of formula (1), wherein R1 is selected from the group consisting of OH and OCH3, and R2 is selected from the group consisting of H and OH, R1 and R2 comprise at least one OH group, and when R1 is OH then R2 is H (trilobtain), and when R1 is OCH3 then R2 is OH (HDG), in a concentration near its sweetness detection threshold. The sweeteners include sucrose, fructose, glucose, high fructose corn syrup, corn syrup, xylose, arabinose, rhamnose, erythritol, xylitol, mannitol, sorbitol, inositol, acesulfame potassium, aspartame, neotame, sucralose, saccharine, or combinations thereof.
摘要翻译： 本发明公开了形成含有某些甜味剂和式（1）化合物的所述增甜消耗品的甜味消耗品和方法，其中R 1选自OH和OCH 3，R 2选自H和OH， R1和R2包含至少一个OH基团，当R 1为OH时，R 2为H（三氟甲基），当R 1为OCH 3时，R 2为OH（HDG），浓度接近其甜味检测阈值。 甜味剂包括蔗糖，果糖，葡萄糖，高果糖玉米糖浆，玉米糖浆，木糖，阿拉伯糖，鼠李糖，赤藓糖醇，木糖醇，甘露醇，山梨糖醇，肌醇，乙酰磺胺酸钾，阿斯巴甜，纽甜，三氯蔗糖，糖精或其组合。
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10.发明授权Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor TAS2R46 有权识别右美沙芬与苦味受体TAS2R46之间相互作用的调节剂的方法公开(公告)号：US08603762B2
公开(公告)日：2013-12-10
申请号：US13057912
申请日：2009-08-06
IPC分类号： G01N33/567
CPC分类号： G01N33/5008 , G01N33/566 , G01N33/6872 , G01N33/74 , G01N33/9486 , G01N2333/726 , G01N2500/00
摘要： TAS2R46 was identified as a dextromethorphan-binding bitter taste receptor. Novel methods to identify modulators and in particular inhibitors to the bitter taste of dextromethorphan are provided.
摘要翻译： TAS2R46被鉴定为右美沙芬结合苦味受体。 提供了鉴定调节剂的新方法，特别是抑制右美沙芬苦味的抑制剂。
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