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公开(公告)号：US4252759A
公开(公告)日：1981-02-24
申请号：US029229
申请日：1979-04-11
CPC分类号： B28B1/26 , A61F2/062 , A61L27/24 , B29C41/16 , A61F2310/00365
摘要： A cross flow filtration molding apparatus and method are disclosed which are particularly useful for forming complicated shapes from dispersions of particles in a liquid medium. Dispersion is pumped through a mold which has porous walls and a sufficient pressure differential is applied to drive a portion of the liquid medium through the porous walls which results in deposition of particles on the walls to form a shaped article. The shaped article may inherently have sufficient structural integrity, or it may be post-treated to provide additional structural integrity.
摘要翻译： 公开了一种交叉流过滤成型装置和方法，其特别可用于从液体介质中的颗粒分散形成复杂形状。 将分散体泵送通过具有多孔壁的模具，并且施加足够的压差以通过多孔壁驱动一部分液体介质，导致颗粒沉积在壁上以形成成型制品。 成型制品本来可以具有足够的结构完整性，或者可以进行后处理以提供额外的结构完整性。
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公开(公告)号：US08318902B2
公开(公告)日：2012-11-27
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： A61K38/17
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译： 一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机 所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。
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公开(公告)号：US4947840A
公开(公告)日：1990-08-14
申请号：US87772
申请日：1987-08-21
申请人： Ioannis V. Yannas , Elaine Lee , Ariel Ferdman
发明人： Ioannis V. Yannas , Elaine Lee , Ariel Ferdman
CPC分类号： A61L27/24 , A61L27/20 , A61L27/56 , A61L27/58 , A61F2310/00365 , Y10S424/13
摘要： This invention relates to porous, biodegradable materials in which the pore size, biodegradation rate, and pore volume fraction are controlled and within values at which skin contraction rates around an implant-containing wound are delayed or slowed.
摘要翻译： 本发明涉及多孔，可生物降解的材料，其中细孔径，生物降解速率和孔体积分数被控制，并且在含有植入物的伤口周围的皮肤收缩速率被延迟或减缓的值内。
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公开(公告)号：US4522753A
公开(公告)日：1985-06-11
申请号：US287930
申请日：1981-07-29
CPC分类号： C08J9/28 , A61F13/00008 , A61L15/425 , A61L17/08 , A61L27/24 , A61F2013/00255 , A61F2013/0074 , A61F2013/00863 , A61F2310/00365 , C08J2201/048 , C08J2389/00 , Y10S602/90
摘要： A method for preserving the porosity of porous materials is disclosed. In this method, the porous material is subjected to elevated temperature and vacuum conditions to thereby produce a dimensionally-stable, non-collapsible porous material.
摘要翻译： 公开了一种保存多孔材料孔隙率的方法。 在该方法中，多孔材料经历升高的温度和真空条件，从而产生尺寸稳定的，不可折叠的多孔材料。
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公开(公告)号：US4458678A
公开(公告)日：1984-07-10
申请号：US315233
申请日：1981-10-26
申请人： Ioannis V. Yannas , John F. Burke
发明人： Ioannis V. Yannas , John F. Burke
IPC分类号： A61K35/36 , A61F2/00 , A61K31/715 , A61K38/00 , A61L15/00 , A61L15/64 , A61L27/24 , A61L27/60 , A61P17/00 , A61F13/00
CPC分类号： A61L27/60 , A61L27/24 , A61F2310/00365
摘要： This invention relates to the introduction of viable cells into a fibrous lattice by surgical, force-utilizing, or other manipulative techniques, all of which are referred to herein as "seeding." One embodiment comprises an autografting technique which involves intact tissue. Other embodiments which involve the distribution of an aqueous suspension of cells comprise centrifugal, spraying, pipetting and syringe emplacement. Each cell that survives the seeding process may reproduce into a colony of cells which grow until they reach confluence, thereby creating a uniform layer or volume of tissue. By proper placement of cells capable of generating such colonies, the period of recovery of a wound may be drastically reduced. In addition, research by the Applicants indicates that tissue that is regenerated using the methods of this invention to seed a lattice comprising collagen and glycosaminoglycan tends to be smoother, more uniform, less fibrotic, less scarred and more flexible than tissue that is regenerated by wound contraction or conventional autografting.
摘要翻译： 本发明涉及通过手术，强力利用或其他操作技术将活细胞引入纤维网格，所有这些在本文中称为“播种”。 一个实施例包括涉及完整组织的自动移植技术。 涉及细胞水性悬浮液分布的其它实施方案包括离心，喷雾，移液和注射器放置。 在接种过程中存活的每个细胞可以再生成细胞的集落，其生长直到它们达到汇合，从而产生均匀的组织或体积的组织。 通过适当放置能够产生这种菌落的细胞，伤口的恢复时间可以大大降低。 此外，申请人的研究表明，使用本发明的方法再生的组织使含有胶原蛋白和糖胺聚糖的晶格种子的组织趋于比由伤口再生的组织更平滑，更均匀，更少的纤维化，更少的伤痕和更灵活 收缩或常规自动移植。
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6.发明申请公开(公告)号：US20100145473A1
公开(公告)日：2010-06-10
申请号：US12084569
申请日：2006-11-07
IPC分类号： A61F2/06
CPC分类号： A61L27/3804 , A61L27/56 , A61L27/58
摘要： This invention relates to highly porous scaffolding and methods of producing the same. Specifically, the scaffolding comprises a pore volume fraction of no less than 80% (v/v) of the total volume of the scaffold and interconnecting pores forming channels in the scaffold.
摘要翻译： 本发明涉及高度多孔的脚手架及其制造方法。 具体地说，脚手架包括支架总体积的不小于80％（v / v）的孔体积分数和在支架中形成通道的互连孔。
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7.发明授权Procedures for preparing composite materials from collagen and glycosaminoglycan 失效从胶原和糖胺聚糖制备复合材料的程序
公开(公告)号：US4350629A
公开(公告)日：1982-09-21
申请号：US287998
申请日：1981-07-29
IPC分类号： A61F2/00 , A61L27/24 , A61L27/26 , A61L33/00 , A61L33/12 , C08L89/06 , C07G7/00 , C08H1/00 , C08H1/06
CPC分类号： A61L33/122 , A61L27/24 , A61L27/26 , A61L33/0011 , C08L89/06 , A61F2310/00365 , Y10S128/08
摘要： This invention relates to crosslinked collagen and glycosaminoglycan materials, and to procedures for preparing such materials. It has been discovered that if collagen fibrils in an aqueous acidic solution are contacted with a crosslinking agent before being contacted with glycosaminoglycan, the materials produced have extremely low levels of thrombogenicity. Such materials are well suited for in-dwelling catheters, blood vessel grafts, and other devices that are in continuous contact with blood for long periods of time.
摘要翻译： 本发明涉及交联胶原和糖胺聚糖材料，以及制备这些材料的方法。 已经发现，如果将酸性水溶液中的胶原纤维在与糖胺聚糖接触之前与交联剂接触，则所生产的材料具有非常低的血栓形成水平。 这种材料非常适用于长时间与血液持续接触的住宅导管，血管移植物和其他装置。
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公开(公告)号：US4280954A
公开(公告)日：1981-07-28
申请号：US30183
申请日：1979-04-16
CPC分类号： C08H1/00 , A23J1/10 , A61L17/10 , A61L27/24 , A61L27/26 , C08B37/0063 , A61F2310/00365
摘要： Composite materials are disclosed which are formed by contacting collagen with a mucopolysaccharide and subsequently covalently crosslinking the resultant polymer. These composite materials have a balance of mechanical, chemical and physiological properties which make them useful in surgical sutures and prostheses of controlled biodegradability (resorption) and controlled ability to prevent development of a foreign body reaction, and many are also useful in applications in which blood compatibility is required.
摘要翻译： 公开了通过使胶原与粘多糖接触并随后共价交联所得聚合物而形成的复合材料。 这些复合材料具有机械，化学和生理特性的平衡，使得它们可用于可控生物降解性（吸收）的手术缝线和假体以及防止异物反应发展的受控能力，并且许多也可用于血液 需要兼容性。
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公开(公告)号：US20100248368A1
公开(公告)日：2010-09-30
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： C12N5/071
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译： 一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机 所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。
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10.发明授权
公开(公告)号：US5716411A
公开(公告)日：1998-02-10
申请号：US596060
申请日：1996-02-06
申请人： Dennis P. Orgill , Charles E. Butler , Mark Barlow , Scott Ritterbush , Ioannis V. Yannas , Carolyn C. Compton
发明人： Dennis P. Orgill , Charles E. Butler , Mark Barlow , Scott Ritterbush , Ioannis V. Yannas , Carolyn C. Compton
CPC分类号： A61L27/60 , A61L27/24 , A61F2/105 , A61F2310/00365 , Y10S623/915
摘要： The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels from healthy underlying tissue and applying a cultured epithelial autograft sheet grown from epidermal cells taken from the animal or human at a wound free site on the animal's or human's body surface. The resulting graft has excellent take rates and has the appearance, growth, maturation and differentiation of normal skin.
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