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公开(公告)号：US20090111808A1
公开(公告)日：2009-04-30
申请号：US11912816
申请日：2006-04-25
申请人： Isabelle Bertrand , Marc Capet , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Olivia Poupardin-Olivier , Philippe Robert , Jean-Charles Schwartz , Olivier Labeeuw
发明人： Isabelle Bertrand , Marc Capet , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Olivia Poupardin-Olivier , Philippe Robert , Jean-Charles Schwartz , Olivier Labeeuw
IPC分类号： A61K31/5377 , C07D401/12 , A61K31/4545 , C07D207/04 , A61K31/40 , C07D211/20 , A61K31/445 , A61K31/496 , C07D413/12
CPC分类号： C07D213/30 , C07D207/20 , C07D207/30 , C07D207/335 , C07D211/22 , C07D211/42 , C07D211/46 , C07D211/68 , C07D211/70 , C07D213/61 , C07D213/64 , C07D213/89 , C07D231/12 , C07D295/088 , C07D295/192 , C07D333/16 , C07D333/20 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12
摘要： The present patent application concerns compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.
摘要翻译： 本发明涉及式（I）化合物，其中R 1和R 2与它们所连接的氮原子一起形成单或双环饱和含氮环; 它们的制备及其作为H3受体配体的用途，用于治疗例如 中枢神经系统疾病如阿尔茨海默病。
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公开(公告)号：US08076329B2
公开(公告)日：2011-12-13
申请号：US11912816
申请日：2006-04-25
申请人： Isabelle Bertrand , Marc Capet , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Olivia Poupardin-Olivier , Philippe Robert , Jean-Charles Schwartz , Olivier Labeeuw
发明人： Isabelle Bertrand , Marc Capet , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Olivia Poupardin-Olivier , Philippe Robert , Jean-Charles Schwartz , Olivier Labeeuw
IPC分类号： A61K31/4418 , A61K31/4453 , A61K31/4545 , A61K31/5355 , C07D213/30 , C07D211/14 , C07D413/12
CPC分类号： C07D213/30 , C07D207/20 , C07D207/30 , C07D207/335 , C07D211/22 , C07D211/42 , C07D211/46 , C07D211/68 , C07D211/70 , C07D213/61 , C07D213/64 , C07D213/89 , C07D231/12 , C07D295/088 , C07D295/192 , C07D333/16 , C07D333/20 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12
摘要： The present patent application concerns compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.
摘要翻译： 本发明涉及式（I）化合物，其中R 1和R 2与它们所连接的氮原子一起形成单或双环饱和含氮环; 它们的制备及其作为H3受体配体的用途，用于治疗例如 中枢神经系统疾病如阿尔茨海默病。
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公开(公告)号：US20080182876A1
公开(公告)日：2008-07-31
申请号：US11912812
申请日：2006-04-26
申请人： Isabelle Bertrand , Marc Capet , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Olivia Poupardin-Olivier , Philippe Robert , Jean-Charles Schwartz
发明人： Isabelle Bertrand , Marc Capet , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Olivia Poupardin-Olivier , Philippe Robert , Jean-Charles Schwartz
IPC分类号： A61K31/40 , C07D207/04 , A61K31/4025 , A61K31/4453 , A61K31/453 , C07D211/20 , C07D407/12 , A61P25/00
CPC分类号： C07D295/088 , C07D307/79 , C07D317/54 , C07D319/18
摘要： The present patent application concerns new compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a saturated nitrogen-containing ring, A is a saturated C1-4 alkylene and B a C3-4 alkylene or alkenylene chain; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.
摘要翻译： 本专利申请涉及具有R 1和R 2的新的式（I）化合物与它们所连接的氮原子一起形成饱和含氮的 环，A是饱和C 1-4亚烷基和B a C 3-4亚烷基或亚烯基链; 它们的制备及其作为H3受体配体的用途，用于治疗例如 中枢神经系统疾病如阿尔茨海默病。
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公开(公告)号：US08017646B2
公开(公告)日：2011-09-13
申请号：US11912812
申请日：2006-04-26
申请人： Isabelle Bertrand , Marc Capet , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Olivia Poupardin-Olivier , Philippe Robert , Jean-Charles Schwartz
发明人： Isabelle Bertrand , Marc Capet , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Olivia Poupardin-Olivier , Philippe Robert , Jean-Charles Schwartz
IPC分类号： A61K31/40 , C07D207/08
CPC分类号： C07D295/088 , C07D307/79 , C07D317/54 , C07D319/18
摘要： The present patent application concerns new compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a saturated nitrogen-containing ring, A is a saturated C1-4 alkylene and B a C3-4 alkylene or alkenylene chain; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.
摘要翻译： 本发明涉及新的式（I）化合物，其中R 1和R 2与它们所连接的氮原子一起形成饱和含氮环，A是饱和C 1-4亚烷基和B a C 3-4 亚烷基或亚烯基链; 它们的制备及其作为H3受体配体的用途，用于治疗例如 中枢神经系统疾病如阿尔茨海默病。
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公开(公告)号：US08802664B2
公开(公告)日：2014-08-12
申请号：US13825989
申请日：2011-09-27
申请人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Denis Danvy , Stephane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
发明人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Denis Danvy , Stephane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
IPC分类号： C07D417/12 , C07D401/12 , C07D401/14 , A61K31/5377 , A61K31/454 , A61K31/428
CPC分类号： C07D417/14 , A61K31/428 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/04 , C07D417/12
摘要： The present patent application concerns new ligands of the H4-receptor of formula (I), their process of preparation and their therapeutic use.
摘要翻译： 本专利申请涉及式（I）的H 4受体的新配体，其制备方法及其治疗用途。
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公开(公告)号：US20130231329A1
公开(公告)日：2013-09-05
申请号：US13825989
申请日：2011-09-27
申请人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Denis Danvy , Stéphane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
发明人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Denis Danvy , Stéphane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
IPC分类号： C07D417/12 , C07D401/12 , C07D401/14 , A61K31/5377 , A61K31/454 , A61K31/428 , A61K31/4545 , A61K31/496 , C07D417/14 , A61K45/06
CPC分类号： C07D417/14 , A61K31/428 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/04 , C07D417/12
摘要： The present patent application concerns new ligands of the H4-receptor of formula (I), their process of preparation and their therapeutic use.
摘要翻译： 本专利申请涉及式（I）的H 4受体的新配体，其制备方法及其治疗用途。
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公开(公告)号：US08802678B2
公开(公告)日：2014-08-12
申请号：US12306044
申请日：2007-06-21
申请人： Marc Capet , Denis Danvy , Nicolas Levoin , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jeanne-Marie Lecomte , Jean-Charles Schwartz , Xavier Ligneau
发明人： Marc Capet , Denis Danvy , Nicolas Levoin , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jeanne-Marie Lecomte , Jean-Charles Schwartz , Xavier Ligneau
IPC分类号： A61K31/497 , A61K31/4965 , C07D401/06 , C07D413/06 , C07D403/06
CPC分类号： C07D213/74 , C07D211/26 , C07D211/60 , C07D211/70 , C07D215/40 , C07D217/02 , C07D239/42 , C07D295/10 , C07D295/112 , C07D295/135 , C07D295/14 , C07D295/155 , C07D307/24
摘要： The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.
摘要翻译： 本发明涉及通式（I）的化合物：其制备方法及其作为治疗剂的用途。
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8.发明申请公开(公告)号：US20090286801A1
公开(公告)日：2009-11-19
申请号：US12306044
申请日：2007-06-21
申请人： Marc Capet , Denis Danvy , Nicolas Levoin , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jeanne-Marie Lecomte , Jean-Charles Schwartz , Xavier Ligneau
发明人： Marc Capet , Denis Danvy , Nicolas Levoin , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jeanne-Marie Lecomte , Jean-Charles Schwartz , Xavier Ligneau
IPC分类号： A61K31/496 , C07D241/04 , C07D401/06 , C07D403/04 , C07D401/10 , A61P25/00
CPC分类号： C07D213/74 , C07D211/26 , C07D211/60 , C07D211/70 , C07D215/40 , C07D217/02 , C07D239/42 , C07D295/10 , C07D295/112 , C07D295/135 , C07D295/14 , C07D295/155 , C07D307/24
摘要： The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.
摘要翻译： 本发明涉及通式（I）的化合物：其制备方法及其作为治疗剂的用途。
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9.发明授权公开(公告)号：US07432269B2
公开(公告)日：2008-10-07
申请号：US11252870
申请日：2005-10-19
申请人： Marc Capet , Denis Danvy , Nicolas Levoin , Marcel Morvan , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte
发明人： Marc Capet , Denis Danvy , Nicolas Levoin , Marcel Morvan , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte
IPC分类号： A61K31/497 , C07D401/00 , C07D413/00 , C07D417/00
CPC分类号： C07D217/22 , C07D215/38
摘要： The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands for the dopamine D3 receptor. These selective D3 ligands are useful as medicines in neuropsychiatry, in particular in the treatment of psychotic or depressive states, or in the treatment of motor disorders, such as dyskinesia or essential tremor. They are furthermore useful in the treatment of dependency on nicotine, cocaine, alcohol, opioids and for facilitating withdrawal in drug-dependent individuals.
摘要翻译： 本发明涉及通式（I）的化合物：其制备方法及其作为具有作为多巴胺D3受体的选择性配体的性质的治疗剂的用途。 这些选择性D3配体可用作神经精神病学中的药物，特别是用于治疗精神病或抑郁状态，或用于治疗运动障碍，例如运动障碍或原发性震颤。 它们还可用于治疗对尼古丁，可卡因，酒精，阿片样物质的依赖，并有利于药物依赖个体的戒断。
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公开(公告)号：US20080167320A1
公开(公告)日：2008-07-10
申请号：US12044243
申请日：2008-03-07
申请人： Marc Capet , Denis Danvy , Nicolas Levoin , Marcel Morvan , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte
发明人： Marc Capet , Denis Danvy , Nicolas Levoin , Marcel Morvan , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte
IPC分类号： A61K31/497 , C07D401/02 , A61P15/10 , A61P25/28 , C07D401/14
CPC分类号： C07D217/22 , C07D215/38
摘要： Compounds of the general formula (I) below: are provided along with a process for preparing them, and these compounds may be used as therapeutic agents, e.g., for prevention and/or treatment of a neuropsychiatric illness or any illness involving the dopamine D3 receptor.
摘要翻译： 以下通式（I）的化合物与其制备方法一起提供，并且这些化合物可用作治疗剂，例如用于预防和/或治疗神经精神疾病或涉及多巴胺D3受体的任何疾病 。
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