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    Methods and systems for treating injured cardiac tissue
    4.
    发明申请
    Methods and systems for treating injured cardiac tissue 审中-公开
    治疗受伤心脏组织的方法和系统

    公开(公告)号：US20070093748A1

    公开(公告)日：2007-04-26

    申请号：US11643359

    申请日：2006-12-20

    申请人： Asha Nayak ,  James Keogh

    发明人： Asha Nayak ,  James Keogh

    IPC分类号： A61M31/00 ,  A61M37/00

    CPC分类号： A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00495 ,  A61B2017/0243 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2018/00392 ,  A61N1/306 ,  A61N1/325 ,  A61N1/36014

    摘要： Methods and systems are disclosed for treating injury to cardiac tissue by delivering a composition which provides structural support to the cardiac tissue. The composition helps to prevent chamber remodeling by providing structural reinforcement of the tissue or structural reinforcement of the tissue combined with biological therapy. The structurally reinforcing composition can thicken the wall of a heart, or act to prevent further thinning and thereby provide resistance against further remodeling. A number of compositions are disclosed, including multi-component substances such as autologous platelet gel, and other substances. The compositions disclosed can contain additives to augment/enhance the desired effects of the injection.

    摘要翻译： 公开了通过递送向心脏组织提供结构支持的组合物来治疗心脏组织损伤的方法和系统。 该组合物通过提供结合组织或组织结构加强组织结合生物疗法来防止室重塑。 结构上增强的组合物可以增厚心脏的壁，或用于防止进一步变薄，从而提供抵抗进一步重塑的抵抗力。 公开了许多组合物，包括多组分物质如自体血小板凝胶和其它物质。 所公开的组合物可以含有添加剂以增强/增强注射的期望效果。

    Devices and methods for interstitial injection of biologic agents into tissue
    5.
    发明申请
    Devices and methods for interstitial injection of biologic agents into tissue 有权
    将生物制剂间插注入组织的装置和方法

    公开(公告)号：US20070049863A1

    公开(公告)日：2007-03-01

    申请号：US11545197

    申请日：2006-10-10

    申请人： Scott Jahns ,  Gary Oehme ,  Matthew Bonner ,  James Keogh

    发明人： Scott Jahns ,  Gary Oehme ,  Matthew Bonner ,  James Keogh

    IPC分类号： A61M31/00

    CPC分类号： A61B17/3478 ,  A61B17/00234 ,  A61B17/205 ,  A61B2017/00247 ,  A61B2017/00876 ,  A61B2017/2936 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M5/32 ,  A61M2025/0086 ,  A61M2025/0087

    摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for transversely driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force transverse to the shaft. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.

    摘要翻译： 将生物制剂注入组织的装置和方法。 设备具有细长的轴和远端注射头，用于将针横向驱动到组织中，并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以平移到与轴垂直的针驱动力​​。 一些装置提供可控的可变针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

    Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure
    9.
    发明申请
    Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure 审中-公开
    在医疗过程之前和期间神经刺激和心脏感知的方法和系统

    公开(公告)号：US20070208388A1

    公开(公告)日：2007-09-06

    申请号：US11796663

    申请日：2007-04-27

    申请人： Scott Jahns ,  Michael Hill ,  James Keogh

    发明人： Scott Jahns ,  Michael Hill ,  James Keogh

    IPC分类号： A61N1/362

    CPC分类号： A61N1/36114 ,  A61N1/362 ,  A61N1/385

    摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. A sensor to sense a characteristic of a fluid or tissue, such as an impending contraction, may be also used during the medical procedure. Systems and devices for performing the medical procedure are also provided.

    摘要翻译： 提供了一种执行诸如手术的医疗程序的方法。 刺激神经以将心脏的跳动调节到第一状态，例如停止或减缓的状态。 医疗程序在心脏或另一个器官上进行。 停止对神经的刺激，以便将心脏的跳动调节到第二状态，例如打浆状态。 心脏本身也可能被刺激到跳动状态，例如通过起搏。 可以继续刺激神经以允许继续医疗手术。 也可以在医疗过程中使用用于感测流体或组织的特征的传感器，例如即将收缩的收缩。 还提供用于执行医疗程序的系统和设备。

    Methods and Systems for Treating Injured Cardiac Tissue
    10.
    发明申请
    Methods and Systems for Treating Injured Cardiac Tissue 审中-公开
    治疗受伤的心脏组织的方法和系统

    公开(公告)号：US20070042016A1

    公开(公告)日：2007-02-22

    申请号：US11426211

    申请日：2006-06-23

    申请人： Asha Nayak ,  James Keogh

    发明人： Asha Nayak ,  James Keogh

    IPC分类号： A61N1/30 ,  A61F2/00 ,  A61B1/32 ,  A61B17/08

    CPC分类号： A61L27/52 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00495 ,  A61B2017/0243 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2018/00392 ,  A61L2400/16 ,  A61L2430/20 ,  A61M5/19 ,  A61N1/306 ,  A61N1/36017 ,  A61N1/362

    摘要： Methods and systems are disclosed for treating injury to cardiac tissue by delivering a composition which provides structural support to the cardiac tissue. The composition helps to prevent chamber remodeling by providing structural reinforcement of the tissue or structural reinforcement of the tissue combined with biological therapy. The structurally reinforcing composition can thicken the wall of a heart, or act to prevent further thinning and thereby provide resistance against further remodeling. A number of compositions are disclosed, including multi-component substances such as autologous platelet gel, and other substances. The compositions disclosed can contain additives to augment/enhance the desired effects of the injection.

    摘要翻译： 公开了通过递送向心脏组织提供结构支持的组合物来治疗心脏组织损伤的方法和系统。 该组合物通过提供结合组织或组织结构加强组织结合生物疗法来防止室重塑。 结构上增强的组合物可以增厚心脏的壁，或用于防止进一步变薄，从而提供抵抗进一步重塑的抵抗力。 公开了许多组合物，包括多组分物质如自体血小板凝胶和其它物质。 所公开的组合物可以含有添加剂以增强/增强注射的期望效果。