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    Microspheres capable of binding radioisotopes, optionally comprising metallic microparticles, and methods of use thereof
    1.
    发明申请
    Microspheres capable of binding radioisotopes, optionally comprising metallic microparticles, and methods of use thereof 审中-公开
    能够结合放射性同位素的微球，任选地包含金属微粒，及其使用方法

    公开(公告)号：US20060067883A1

    公开(公告)日：2006-03-30

    申请号：US11185449

    申请日：2005-07-19

    申请人： James Krom ,  Alexander Schwarz

    发明人： James Krom ,  Alexander Schwarz

    IPC分类号： A61K51/00

    CPC分类号： A61K51/1255 ,  A61K2121/00

    摘要： One aspect of the present invention relates to a microsphere, comprising a hydrophilic polymer comprising a plurality of pendant anionic groups; a transition-metal, lanthanide or group 13-14 metal oxide, polyoxometalate or metal hydroxide or combination thereof; and a first radioisotope that emits a therapeutic β-particle. In certain embodiments, the microsphere further comprsies a second radioisotope that emits a diagnostic γ-ray; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In certain embodiments, the microsphere is composed of polymer impregnated with zirconia bound to 32p as the source of the therapeutic β-emissions and 67Ga as the source of the diagnostic γ-emissions. Another aspect of the present invention relates to the preparation of a microsphere impregnated with a radioisotope that emits therapeutic β-particles and a radioisotope that emits diagnostic β-emitting radioisotope and a γ-emitting radioistope; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In certain embodiments, said microspheres are administered to the patient through a catheter. In another embodiment, the microsphere is combined with the radioisotopes at the site of treatment.

    摘要翻译： 本发明的一个方面涉及一种微球，其包含含有多个侧阴离子基团的亲水性聚合物; 过渡金属，镧系元素或第13-14族金属氧化物，多金属氧酸盐或金属氢氧化物或其组合; 和发射治疗性β粒子的第一种放射性同位素。 在某些实施方案中，微球进一步包含发射诊断性γ射线的第二放射性同位素; 其中第一放射性同位素的原子序号与第二放射性同位素的原子序号不同。 在某些实施方案中，微球由浸渍有与作为治疗性β-发射源和作为诊断性γ发射源的<！ - SIPO