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公开(公告)号：US20100069447A1
公开(公告)日：2010-03-18
申请号：US12582535
申请日：2009-10-20
申请人： Jay P. POWERS , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
发明人： Jay P. POWERS , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
IPC分类号： A61K31/44 , C07C233/00 , C07D213/02 , A61K31/166 , A61P37/06
CPC分类号： C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
摘要： Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.
摘要翻译： 描述了式I和II的苯甲酰胺衍生物及其药学上可接受的盐，溶剂化物，立体异构体和前药，以及包含其的药物组合物，并具有治疗用途，特别是治疗糖尿病，肥胖症和相关病症和病症： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所提供。
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公开(公告)号：US07605289B2
公开(公告)日：2009-10-20
申请号：US11448986
申请日：2006-06-08
申请人： Jay P. Powers , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
发明人： Jay P. Powers , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
IPC分类号： C07C233/65 , A61K31/165
CPC分类号： C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
摘要： Benzamide derivatives of formula I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.
摘要翻译： 描述了式I和II的苯甲酰胺衍生物及其药学上可接受的盐，溶剂合物，立体异构体和前药，以及包含其的药物组合物，具有治疗用途，特别是治疗糖尿病，肥胖症和相关病症和病症： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所提供。
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公开(公告)号：US20080269283A1
公开(公告)日：2008-10-30
申请号：US12163088
申请日：2008-06-27
申请人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kukutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
发明人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kukutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
IPC分类号： A61K31/47 , A61K31/40 , A61K31/277 , A61K31/165 , A61K31/10 , C07C317/26 , C07D215/12 , C07D207/06 , C07C255/00 , C07C381/00 , C07C317/14 , C07D233/56 , A61K31/4164 , C07D277/02 , C07D409/00 , A61K31/4439 , A61K31/426 , A61K31/427 , A61P3/04 , A61P3/10 , C12N5/00
CPC分类号： C07C317/44 , C07C317/14 , C07C317/22 , C07C2601/02 , C07D215/36 , C07D233/54 , C07D277/36 , C07D277/54 , C07D277/56 , C07D295/096 , C07D295/112 , C07D417/04
摘要： Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I和II的芳基砜化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US07402704B2
公开(公告)日：2008-07-22
申请号：US11105583
申请日：2005-04-14
申请人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kakutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
发明人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kakutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
IPC分类号： C07C317/14 , A61K31/255 , A61K31/275
CPC分类号： C07C317/44 , C07C317/14 , C07C317/22 , C07C2601/02 , C07D215/36 , C07D233/54 , C07D277/36 , C07D277/54 , C07D277/56 , C07D295/096 , C07D295/112 , C07D417/04
摘要： Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I和II的芳基砜化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US08637576B2
公开(公告)日：2014-01-28
申请号：US12582535
申请日：2009-10-20
申请人： Jay P. Powers , Michael R. Degraffenreid , Xiao He , Lisa D. Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
发明人： Jay P. Powers , Michael R. Degraffenreid , Xiao He , Lisa D. Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
IPC分类号： A61K31/165 , A61K31/44
CPC分类号： C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
摘要： Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.
摘要翻译： 描述了式I和II的苯甲酰胺衍生物及其药学上可接受的盐，溶剂化物，立体异构体和前药，以及包含其的药物组合物，并具有治疗用途，特别是治疗糖尿病，肥胖症和相关病症和病症： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所提供。
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公开(公告)号：US07754890B2
公开(公告)日：2010-07-13
申请号：US12163088
申请日：2008-06-27
申请人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kakutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
发明人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kakutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
IPC分类号： C07D277/26 , A61K31/425
CPC分类号： C07C317/44 , C07C317/14 , C07C317/22 , C07C2601/02 , C07D215/36 , C07D233/54 , C07D277/36 , C07D277/54 , C07D277/56 , C07D295/096 , C07D295/112 , C07D417/04
摘要： Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I和II的芳基砜化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US07635695B2
公开(公告)日：2009-12-22
申请号：US11709895
申请日：2007-02-21
申请人： Simon A. Burkitt , Mario G. Cardozo , Timothy D. Cushing , Michael R. DeGraffenreid , Christopher N. Farthing , Xiaolin Hao , Juan C. Jaen , Xian Yun Jiao , David J. Kopecky , Marc Labelle , Sarah E. Lively , Dustin L. McMinn , Sven P. Rasmussen , Youngsook Shin , Marie-Louise Smith , Andrew Smith
发明人： Simon A. Burkitt , Mario G. Cardozo , Timothy D. Cushing , Michael R. DeGraffenreid , Christopher N. Farthing , Xiaolin Hao , Juan C. Jaen , Xian Yun Jiao , David J. Kopecky , Marc Labelle , Sarah E. Lively , Dustin L. McMinn , Sven P. Rasmussen , Youngsook Shin , Marie-Louise Smith , Andrew Smith
IPC分类号： A61K31/5377 , A61K31/4365 , C07D413/14 , C07D495/04
CPC分类号： C07D231/56 , C07D239/74 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.
摘要翻译： 本文提供了可用于治疗炎症，免疫调节，代谢，感染和细胞增殖性疾病或病症的化合物，组合物和方法。 特别地，本发明提供调节参与炎症，代谢，感染和细胞增殖的蛋白质的表达和/或功能的化合物。 主题化合物含有稠合的杂双环。
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8.发明授权Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors 有权融合的吡啶，嘧啶和三嗪化合物作为细胞周期抑制剂公开(公告)号：US08841312B2
公开(公告)日：2014-09-23
申请号：US12808621
申请日：2008-12-18
申请人： Richard V. Connors , Dai Kang , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. McGee , Rajiv Sharma , Xiaodong Wang , Dustin L. McMinn , Jeffrey T. Mihalic , Jeffrey Deignan
发明人： Richard V. Connors , Dai Kang , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. McGee , Rajiv Sharma , Xiaodong Wang , Dustin L. McMinn , Jeffrey T. Mihalic , Jeffrey Deignan
IPC分类号： A61K31/519 , A61K31/5377 , A61K31/5386 , C07D403/14 , C07D413/14
CPC分类号： C07D471/14 , A61K31/519 , A61K31/5377 , A61K31/5386 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D491/107 , C07D491/147 , C07D498/04 , C07D498/10 , C07D513/14
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.
摘要翻译： 提供了可用于治疗CDK4介导的疾病如癌症的化合物，药物组合物和方法。 本发明化合物是吡啶，吡嗪酰亚胺和三嗪衍生物。
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公开(公告)号：US08153633B2
公开(公告)日：2012-04-10
申请号：US12214901
申请日：2008-06-23
IPC分类号： A61K31/50 , A61K31/501 , C07D237/30
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
摘要翻译： 本发明一般涉及式I表示的化合物，包含它们的药物组合物和治疗诸如癌症的疾病或病症的方法。
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公开(公告)号：US07244727B2
公开(公告)日：2007-07-17
申请号：US10720844
申请日：2003-11-21
申请人： Brian M. Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon M. Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin L. McMinn , Nobuya Ogawa , Steven M. Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
发明人： Brian M. Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon M. Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin L. McMinn , Nobuya Ogawa , Steven M. Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
IPC分类号： C07D498/04 , A61K31/542 , A61P3/04 , A61P3/08 , C07D491/04 , C07D495/04 , A61K31/538 , A61K31/519
CPC分类号： C07D491/04
摘要： Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the activity of proteins involved in lipid metabolism and cell proliferation.
摘要翻译： 本文提供了可用于治疗或预防代谢和细胞增殖性疾病或病症的化合物，药物组合物和方法。 特别地，本发明提供调节参与脂质代谢和细胞增殖的蛋白质的活性的化合物。
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