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公开(公告)号：US20100331204A1
公开(公告)日：2010-12-30
申请号：US12695447
申请日：2010-01-28
申请人： Jeff Jeddeloh , Todd Richmond , Matthew Rodesch , Daniel Gerhardt , Paul Marrione , Thomas Albert
发明人： Jeff Jeddeloh , Todd Richmond , Matthew Rodesch , Daniel Gerhardt , Paul Marrione , Thomas Albert
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/6837 , C12Q2565/515 , C12Q2539/101 , C12Q2563/131 , C12Q2537/149
摘要： The present invention provides methods and systems for targeted nucleic acid sequence enrichment in a sample. In particular, the present invention provides for enriching for targeted nucleic acid sequences during hybridizations in hybridization assays by first depleting non-target nucleic acid sequences.
摘要翻译： 本发明提供了样品中目标核酸序列富集的方法和系统。 特别地，本发明提供了通过首先消耗非靶核酸序列在杂交测定中的杂交期间富集靶向的核酸序列。
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公开(公告)号：US20090221438A1
公开(公告)日：2009-09-03
申请号：US12391001
申请日：2009-02-23
申请人： Jacob Kitzman , Todd Richmond , Mark D'Ascenzo , Thomas Albert , Matthew Rodesch , Jeffrey Jeddeloh , Christina Middle
发明人： Jacob Kitzman , Todd Richmond , Mark D'Ascenzo , Thomas Albert , Matthew Rodesch , Jeffrey Jeddeloh , Christina Middle
CPC分类号： C12Q1/6834 , C12N15/1093
摘要： The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules.
摘要翻译： 本发明提供了用于在微阵列系统中富集靶核酸的方法和组合物。 特别地，本发明提供了以微阵列形式均匀富集靶核酸分子的方法和组合物。 本发明还提供靶核酸分子之间有意的不均匀的富集。
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公开(公告)号：US08383338B2
公开(公告)日：2013-02-26
申请号：US12391001
申请日：2009-02-23
申请人： Jacob Kitzman , Todd Richmond , Mark D'Ascenzo , Thomas Albert , Matthew Rodesch , Jeffrey Jeddeloh , Christina Middle
发明人： Jacob Kitzman , Todd Richmond , Mark D'Ascenzo , Thomas Albert , Matthew Rodesch , Jeffrey Jeddeloh , Christina Middle
CPC分类号： C12Q1/6834 , C12N15/1093
摘要： The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules.
摘要翻译： 本发明提供了用于在微阵列系统中富集靶核酸的方法和组合物。 特别地，本发明提供了以微阵列形式均匀富集靶核酸分子的方法和组合物。 本发明还提供靶核酸分子之间有意的不均匀的富集。
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公开(公告)号：US20120046175A1
公开(公告)日：2012-02-23
申请号：US13239585
申请日：2011-09-22
申请人： Matthew Rodesch , Thomas Albert
发明人： Matthew Rodesch , Thomas Albert
CPC分类号： C12Q1/6813 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , C12Q2565/501 , C12Q2537/159
摘要： The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format.
摘要翻译： 本发明提供用于捕获和富集靶核酸的方法和系统以及富集的靶核酸的分析。 特别地，本发明提供了以基于溶液的格式富集目标序列。
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公开(公告)号：US20090105081A1
公开(公告)日：2009-04-23
申请号：US12194574
申请日：2008-08-20
申请人： Matthew Rodesch , Thomas Albert
发明人： Matthew Rodesch , Thomas Albert
CPC分类号： C12Q1/6813 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , C12Q2565/501 , C12Q2537/159
摘要： The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format.
摘要翻译： 本发明提供用于捕获和富集靶核酸的方法和系统以及富集的靶核酸的分析。 特别地，本发明提供了以基于溶液的格式富集目标序列。
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公开(公告)号：US09790543B2
公开(公告)日：2017-10-17
申请号：US13239585
申请日：2011-09-22
申请人： Matthew Rodesch , Thomas Albert
发明人： Matthew Rodesch , Thomas Albert
CPC分类号： C12Q1/6813 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , C12Q2565/501 , C12Q2537/159
摘要： The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format.
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公开(公告)号：US20100167952A1
公开(公告)日：2010-07-01
申请号：US12553251
申请日：2009-09-03
申请人： Thomas Albert , Jeff Jeddeloh , Bradley Swanson
发明人： Thomas Albert , Jeff Jeddeloh , Bradley Swanson
CPC分类号： C12Q1/6837 , C12Q1/6832 , C12Q2537/163 , C12Q2525/191 , C12Q2525/151 , C12Q2549/126
摘要： The present invention provides for compositions, methods and systems for targeted sequence enrichment. In particular, the present invention provides for enriching for targeted nucleic acid sequences during hybridizations in microarray assays by suppressing secondary capture of non-target nucleic acid sequences.
摘要翻译： 本发明提供用于靶向序列富集的组合物，方法和系统。 特别地，本发明提供了通过抑制非靶核酸序列的二次捕获在微阵列测定中杂交期间富集目标核酸序列。
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公开(公告)号：US07904250B2
公开(公告)日：2011-03-08
申请号：US11043294
申请日：2005-01-26
申请人： Michael Molla , Todd Richmond , Steven Smith , Thomas Albert
发明人： Michael Molla , Todd Richmond , Steven Smith , Thomas Albert
IPC分类号： G01N33/50
CPC分类号： G06F19/24 , G06F19/20 , G06F19/22 , Y10S977/792
摘要： The present invention is a method to assist in the identification of single nucleotide polymorphisms (SNP) from microarray hybridization data. Data from hybridization protocols run on microarrays often have variations in the data resulting from variations in hybridization conditions and efficiencies and variations in optical intensities. An algorithm is described to screen the results to identify those data points most likely to be real SNPs as opposed to variations in the hybridization or sensing data.
摘要翻译： 本发明是一种帮助从微阵列杂交数据鉴定单核苷酸多态性（SNP）的方法。 在微阵列上运行的杂交方案的数据通常在杂交条件和效率的变化以及光学强度的变化中导致的数据变化。 描述了一种算法来筛选结果以识别最可能是真实SNP的那些数据点，而不是杂交或感测数据的变化。
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公开(公告)号：US20060014164A1
公开(公告)日：2006-01-19
申请号：US11043294
申请日：2005-01-26
申请人： Michael Molla , Todd Richmond , Steven Smith , Thomas Albert
发明人： Michael Molla , Todd Richmond , Steven Smith , Thomas Albert
CPC分类号： G06F19/24 , G06F19/20 , G06F19/22 , Y10S977/792
摘要： The present invention is a method to assist in the identification of single nucleotide polymorphisms (SNP) from microarray hybridization data. Data from hybridization protocols run on microarrays often have variations in the data resulting from variations in hybridization conditions and efficiencies and variations in optical intensities. An algorithm is described to screen the results to identify those data points most likely to be real SNPs as opposed to variations in the hybridization or sensing data.
摘要翻译： 本发明是一种帮助从微阵列杂交数据鉴定单核苷酸多态性（SNP）的方法。 在微阵列上运行的杂交方案的数据通常在杂交条件和效率的变化以及光学强度的变化中导致的数据变化。 描述了一种算法来筛选结果以识别最可能是真实SNP的那些数据点，而不是杂交或感测数据的变化。
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公开(公告)号：US20120071357A1
公开(公告)日：2012-03-22
申请号：US13267964
申请日：2011-10-07
申请人： Jacob Kitzman , Todd Richmond , Mark D'Ascanzo , Thomas Albert , Jeffrey Jeddeloh , Christina Middle
发明人： Jacob Kitzman , Todd Richmond , Mark D'Ascanzo , Thomas Albert , Jeffrey Jeddeloh , Christina Middle
IPC分类号： C40B40/06
CPC分类号： C12Q1/6834 , C12N15/1093
摘要： The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules.
摘要翻译： 本发明提供了用于在微阵列系统中富集靶核酸的方法和组合物。 特别地，本发明提供了以微阵列形式均匀富集靶核酸分子的方法和组合物。 本发明还提供靶核酸分子之间有意的不均匀的富集。
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