利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

382 条记录 (耗时 0.028 秒)

    Surface nanoreplication using polymer nanomasks
    1.
    发明授权
    Surface nanoreplication using polymer nanomasks 有权
    使用聚合物纳米掩模的表面纳米应用

    公开(公告)号：US09566609B2

    公开(公告)日：2017-02-14

    申请号：US13748827

    申请日：2013-01-24

    申请人： Jennifer Lynn Lyon ,  Jianguo Wang ,  Ruchirej Yongsunthon ,  Ying Zhang

    发明人： Jennifer Lynn Lyon ,  Jianguo Wang ,  Ruchirej Yongsunthon ,  Ying Zhang

    IPC分类号： C08J7/04 ,  B05D5/00 ,  G03F7/00 ,  B82Y10/00 ,  B82Y40/00

    CPC分类号： B05D5/00 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002

    摘要： Methods for replicating a nanopillared surface include applying a nanopillar-forming material to a surface of a replica substrate to form a precursor layer on the replica-substrate surface. A template surface of a nanomask may be contacted to the precursor layer. The nanomask may include a self-assembled polymer layer on a nanomask-substrate surface, the template surface being defined in the self-assembled polymer layer. The self-assembled polymer layer may have nano-sized pores with openings at the template surface. The precursor layer may be cured while the template surface remains in contact with the precursor layer. The nanomask is removed to expose a nanopillared surface having a plurality of nanopillars on the replica-substrate surface. The nanopillars on the replica-substrate surface may correspond to the pores in the template surface. Nanopillared surfaces may be replicated on one side of the replica substrate or on two opposing sides of the replica substrate.

    摘要翻译： 用于复制纳米孔径表面的方法包括将纳米柱形成材料施加到复制基底的表面以在复制基底表面上形成前体层。 纳米掩模的模板表面可以与前体层接触。 纳米掩模可以包括在纳米掩模 - 衬底表面上的自组装聚合物层，模板表面限定在自组装聚合物层中。 自组装聚合物层可以具有在模板表面处具有开口的纳米尺寸的孔。 当模板表面保持与前体层接触时，前体层可以被固化。 去除纳米掩模以暴露在复制衬底表面上具有多个纳米柱的纳米圆柱形表面。 复制衬底表面上的纳米柱可以对应于模板表面中的孔。 纳米球形表面可以在复制基底的一侧或复制基底的两个相对侧上复制。

    SURFACE NANOREPLICATION USING POLYMER NANOMASKS
    2.
    发明申请
    SURFACE NANOREPLICATION USING POLYMER NANOMASKS 有权
    使用聚合物纳米颗粒的表面纳米粒子

    公开(公告)号：US20140205766A1

    公开(公告)日：2014-07-24

    申请号：US13748827

    申请日：2013-01-24

    申请人： Jennifer Lynn Lyon ,  Jianguo Wang ,  Ruchirej Yongsunthon ,  Ying Zhang

    发明人： Jennifer Lynn Lyon ,  Jianguo Wang ,  Ruchirej Yongsunthon ,  Ying Zhang

    IPC分类号： B05D5/00

    CPC分类号： B05D5/00 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002

    摘要： Methods for replicating a nanopillared surface include applying a nanopillar-forming material to a surface of a replica substrate to form a precursor layer on the replica-substrate surface. A template surface of a nanomask may be contacted to the precursor layer. The nanomask may include a self-assembled polymer layer on a nanomask-substrate surface, the template surface being defined in the self-assembled polymer layer. The self-assembled polymer layer may have nano-sized pores with openings at the template surface. The precursor layer may be cured while the template surface remains in contact with the precursor layer. The nanomask is removed to expose a nanopillared surface having a plurality of nanopillars on the replica-substrate surface. The nanopillars on the replica-substrate surface may correspond to the pores in the template surface. Nanopillared surfaces may be replicated on one side of the replica substrate or on two opposing sides of the replica substrate.

    摘要翻译： 用于复制纳米孔径表面的方法包括将纳米柱形成材料施加到复制基底的表面以在复制基底表面上形成前体层。 纳米掩模的模板表面可以与前体层接触。 纳米掩模可以包括在纳米掩模 - 衬底表面上的自组装聚合物层，模板表面限定在自组装聚合物层中。 自组装聚合物层可以具有在模板表面处具有开口的纳米尺寸的孔。 当模板表面保持与前体层接触时，前体层可以被固化。 去除纳米掩模以暴露在复制衬底表面上具有多个纳米柱的纳米圆柱形表面。 复制衬底表面上的纳米柱可以对应于模板表面中的孔。 纳米球形表面可以在复制基底的一侧或复制基底的两个相对侧上复制。

    SURFACE NANOFABRICATION METHODS USING SELF-ASSEMBLED POLYMER NANOMASKS
    4.
    发明申请
    SURFACE NANOFABRICATION METHODS USING SELF-ASSEMBLED POLYMER NANOMASKS 有权
    使用自组装聚合物纳米颗粒的表面纳米化方法

    公开(公告)号：US20140202984A1

    公开(公告)日：2014-07-24

    申请号：US13748840

    申请日：2013-01-24

    申请人： Mark Alejandro Quesada ,  Jianguo Wang ,  Ying Zhang

    发明人： Mark Alejandro Quesada ,  Jianguo Wang ,  Ying Zhang

    IPC分类号： B05D5/00

    CPC分类号： B05D5/00 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  Y10S977/888

    摘要： Methods for fabricating a nanopillared substrate surface include applying a polymer solution containing an amphiphilic block copolymer and a hydrophilic homopolymer to a substrate surface. The amphiphilic block copolymer and the hydrophilic homopolymer in the polymer solution self-assemble on the substrate surface to form a self-assembled polymer layer having hydrophobic domains adjacent to the substrate surface and hydrophilic domains extending into the self-assembled polymer layer. At least a portion of the hydrophilic domains may be removed to form a plurality of pores in the exposed surface of the self-assembled polymer layer. A protective layer may be deposited on the exposed surface as a mask for etching through the plurality of pores to form through-holes. A nanopillar-forming material may be deposited onto the substrate surface via the through-holes. Then, the remaining portion of the self-assembled polymer layer may be removed to expose a nanopillared substrate surface.

    摘要翻译： 制造纳米圆柱形基底表面的方法包括将含有两亲嵌段共聚物和亲水均聚物的聚合物溶液施加到基底表面。 聚合物溶液中的两亲性嵌段共聚物和亲水均聚物自组装在基材表面上以形成具有与基材表面相邻的疏水区域和延伸到自组装聚合物层中的亲水区域的自组装聚合物层。 亲水区域的至少一部分可以被去除以在自组装聚合物层的暴露表面中形成多个孔。 可以在暴露的表面上沉积保护层作为用于通过多个孔蚀刻的掩模以形成通孔。 可以通过通孔将纳米柱形成材料沉积到衬底表面上。 然后，可以除去自组装聚合物层的剩余部分以暴露出纳米圆柱形的衬底表面。

    Surface nanofabrication methods using self-assembled polymer nanomasks
    5.
    发明授权
    Surface nanofabrication methods using self-assembled polymer nanomasks 有权
    使用自组装聚合物纳米掩模的表面纳米加工方法

    公开(公告)号：US09050621B2

    公开(公告)日：2015-06-09

    申请号：US13748840

    申请日：2013-01-24

    申请人： Mark Alejandro Quesada ,  Jianguo Wang ,  Ying Zhang

    发明人： Mark Alejandro Quesada ,  Jianguo Wang ,  Ying Zhang

    IPC分类号： C25F3/00 ,  H01B13/00 ,  B44C1/22 ,  H01L21/302 ,  H01L21/461 ,  B05D5/00 ,  B82Y40/00 ,  G03F7/00 ,  B82Y10/00

    CPC分类号： B05D5/00 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  Y10S977/888

    摘要： Methods for fabricating a nanopillared substrate surface include applying a polymer solution containing an amphiphilic block copolymer and a hydrophilic homopolymer to a substrate surface. The amphiphilic block copolymer and the hydrophilic homopolymer in the polymer solution self-assemble on the substrate surface to form a self-assembled polymer layer having hydrophobic domains adjacent to the substrate surface and hydrophilic domains extending into the self-assembled polymer layer. At least a portion of the hydrophilic domains may be removed to form a plurality of pores in the exposed surface of the self-assembled polymer layer. A protective layer may be deposited on the exposed surface as a mask for etching through the plurality of pores to form through-holes. A nanopillar-forming material may be deposited onto the substrate surface via the through-holes. Then, the remaining portion of the self-assembled polymer layer may be removed to expose a nanopillared substrate surface.

    摘要翻译： 制造纳米圆柱形基底表面的方法包括将含有两亲嵌段共聚物和亲水均聚物的聚合物溶液施加到基底表面。 聚合物溶液中的两亲性嵌段共聚物和亲水均聚物自组装在基材表面上以形成具有与基材表面相邻的疏水区域和延伸到自组装聚合物层中的亲水区域的自组装聚合物层。 亲水区域的至少一部分可以被去除以在自组装聚合物层的暴露表面中形成多个孔。 可以在暴露的表面上沉积保护层作为用于通过多个孔蚀刻的掩模以形成通孔。 可以通过通孔将纳米柱形成材料沉积到衬底表面上。 然后，可以除去自组装聚合物层的剩余部分以暴露出纳米圆柱形的衬底表面。

    RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR
    8.
    发明申请
    RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR 审中-公开

    公开(公告)号：US20200062847A1

    公开(公告)日：2020-02-27

    申请号：US16488667

    申请日：2017-03-04

    申请人： Ying ZHANG ,  Xiangtan Tenghua Bioscience

    发明人： Ying Zhang

    IPC分类号： C07K16/28

    摘要： Provided are monoclonal antibody, particularly rabbit recombinant antibody, which specifically binds to human PD-1 with biological functions and super high affinity, and methods of use. In various embodiments, the antibodies are fully humanized antibodies that bind to human PD-1. Nucleic acid molecules encoding the antibodies and methods for expressing the antibodies are also provided. In some embodiments, the antibodies are useful for inhibiting or neutralizing PD-1 activity, thus providing a means of treating, preventing and/or diagnosing a disease or disorder such as cancer or a viral infection.