Vascular endothelial growth factor 2
    1.
    发明授权
    Vascular endothelial growth factor 2 失效
    血管内皮生长因子2

    公开(公告)号:US07227005B1

    公开(公告)日:2007-06-05

    申请号:US09257272

    申请日:1999-02-25

    摘要: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

    摘要翻译: 公开了人VEGF2多肽,生物活性,诊断学或治疗上有用的片段,类似物或衍生物,以及编码这种VEGF2多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生,从而抑制肿瘤生长,炎症,糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。

    Vascular endothelial growth factor 2
    2.
    发明授权
    Vascular endothelial growth factor 2 失效
    血管内皮生长因子2

    公开(公告)号:US6040157A

    公开(公告)日:2000-03-21

    申请号:US42105

    申请日:1998-03-13

    摘要: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeuticall sefl fragments, analogs, or derivatives thereof, and DNA (RNA) enco such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

    摘要翻译: 公开了人类VEGF2多肽,生物学活性,诊断学或治疗学的sefl片段,类似物或其衍生物,和遇到这种VEGF2多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生,从而抑制肿瘤生长,炎症,糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。

    Vascular Endothelial Growth Factor 2
    3.
    发明申请
    Vascular Endothelial Growth Factor 2 审中-公开
    血管内皮生长因子2

    公开(公告)号:US20090192088A1

    公开(公告)日:2009-07-30

    申请号:US12396033

    申请日:2009-03-02

    摘要: Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases. Also provided are methods of using the antibodies and antagonists to inhibit the action of VEGF2 for therapeutic purposes.

    摘要翻译: 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以与合适的药物载体或稀释剂组合以提供针对各种疾病的诊断,治疗和/或预防效果。 还提供了使用抗体和拮抗剂抑制VEGF2作用于治疗目的的作用的方法。

    Vascular endothelial growth factor 2 and methods of use
    4.
    发明授权
    Vascular endothelial growth factor 2 and methods of use 失效
    血管内皮生长因子2及其使用方法

    公开(公告)号:US07153827B1

    公开(公告)日:2006-12-26

    申请号:US09219442

    申请日:1998-12-23

    摘要: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

    摘要翻译: 公开了人VEGF2多肽,生物活性,诊断学或治疗上有用的片段,类似物或衍生物,以及编码这种VEGF2多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生,从而抑制肿瘤生长,炎症,糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。

    Polynucleotides encoding human vascular endothelial growth factor 2
    5.
    发明授权
    Polynucleotides encoding human vascular endothelial growth factor 2 失效
    编码人血管内皮生长因子2的多核苷酸

    公开(公告)号:US07115392B2

    公开(公告)日:2006-10-03

    申请号:US10127551

    申请日:2002-04-23

    摘要: Disclosed is a human VEGF2 polypeptide and DNA (RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.

    摘要翻译: 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还公开了使用这种多肽刺激伤口愈合和维持血管组织修复的方法。 还提供了使用拮抗剂抑制肿瘤生长,炎症和治疗糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。 还公开了用于检测VEGF2编码序列中的突变和来自宿主的样品中VEGF2蛋白浓度变化的诊断方法。

    Fibroblast growth factor 11
    8.
    发明授权
    Fibroblast growth factor 11 失效
    成纤维细胞生长因子11

    公开(公告)号:US6110893A

    公开(公告)日:2000-08-29

    申请号:US93585

    申请日:1998-06-08

    CPC分类号: C07K14/50

    摘要: Disclosed is a human Fibroblast growth factor-11 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译: 公开了人成纤维细胞生长因子-11多肽和编码这种多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽促进伤口愈合的方法,例如作为烧伤和溃疡的结果,以防止与中风相关的神经元损伤以及由于神经元紊乱并促进神经元生长,并且防止皮肤老化和脱发,以刺激 血管生成,早期胚胎中胚层诱导和肢体再生。 还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖,高血管疾病和上皮细胞增殖的治疗剂的用途。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。