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公开(公告)号:US07227005B1
公开(公告)日:2007-06-05
申请号:US09257272
申请日:1999-02-25
申请人: Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人: Jing-Shan Hu , Craig A. Rosen , Liang Cao
CPC分类号: C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译: 公开了人VEGF2多肽,生物活性,诊断学或治疗上有用的片段,类似物或衍生物,以及编码这种VEGF2多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生,从而抑制肿瘤生长,炎症,糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。
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公开(公告)号:US6040157A
公开(公告)日:2000-03-21
申请号:US42105
申请日:1998-03-13
申请人: Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人: Jing-Shan Hu , Craig A. Rosen , Liang Cao
CPC分类号: C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeuticall sefl fragments, analogs, or derivatives thereof, and DNA (RNA) enco such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译: 公开了人类VEGF2多肽,生物学活性,诊断学或治疗学的sefl片段,类似物或其衍生物,和遇到这种VEGF2多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生,从而抑制肿瘤生长,炎症,糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。
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公开(公告)号:US20090192088A1
公开(公告)日:2009-07-30
申请号:US12396033
申请日:2009-03-02
申请人: Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人: Jing-Shan Hu , Craig A. Rosen , Liang Cao
IPC分类号: A61K38/18 , C07H21/04 , C12N15/63 , C12N5/10 , C12N15/09 , C07K14/475 , C07K16/22 , A61P9/00
CPC分类号: C07K14/52 , A61K38/00 , A61K39/00 , C07K2319/00
摘要: Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases. Also provided are methods of using the antibodies and antagonists to inhibit the action of VEGF2 for therapeutic purposes.
摘要翻译: 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以与合适的药物载体或稀释剂组合以提供针对各种疾病的诊断,治疗和/或预防效果。 还提供了使用抗体和拮抗剂抑制VEGF2作用于治疗目的的作用的方法。
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公开(公告)号:US07153827B1
公开(公告)日:2006-12-26
申请号:US09219442
申请日:1998-12-23
申请人: Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人: Jing-Shan Hu , Craig A. Rosen , Liang Cao
CPC分类号: C07K14/475 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C07K2319/00 , C12N2799/026
摘要: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译: 公开了人VEGF2多肽,生物活性,诊断学或治疗上有用的片段,类似物或衍生物,以及编码这种VEGF2多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生,从而抑制肿瘤生长,炎症,糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。
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公开(公告)号:US07115392B2
公开(公告)日:2006-10-03
申请号:US10127551
申请日:2002-04-23
申请人: Craig A. Rosen , Jing-Shan Hu , Liang Cao
发明人: Craig A. Rosen , Jing-Shan Hu , Liang Cao
CPC分类号: C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要: Disclosed is a human VEGF2 polypeptide and DNA (RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.
摘要翻译: 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还公开了使用这种多肽刺激伤口愈合和维持血管组织修复的方法。 还提供了使用拮抗剂抑制肿瘤生长,炎症和治疗糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。 还公开了用于检测VEGF2编码序列中的突变和来自宿主的样品中VEGF2蛋白浓度变化的诊断方法。
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公开(公告)号:US06590075B2
公开(公告)日:2003-07-08
申请号:US09148545
申请日:1998-09-04
申请人: Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
发明人: Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
IPC分类号: C07K100
CPC分类号: C07K14/4702 , A61K38/00 , C07K14/47 , C07K14/4718 , C12N15/11 , G01N33/68
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US06525174B1
公开(公告)日:2003-02-25
申请号:US09205258
申请日:1998-12-04
申请人: Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
发明人: Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
IPC分类号: C07K1447
CPC分类号: G01N33/68 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US6110893A
公开(公告)日:2000-08-29
申请号:US93585
申请日:1998-06-08
申请人: Jing-Shan Hu , Craig A. Rosen
发明人: Jing-Shan Hu , Craig A. Rosen
IPC分类号: C07K14/50 , C07K14/475 , A61K38/18
CPC分类号: C07K14/50
摘要: Disclosed is a human Fibroblast growth factor-11 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译: 公开了人成纤维细胞生长因子-11多肽和编码这种多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽促进伤口愈合的方法,例如作为烧伤和溃疡的结果,以防止与中风相关的神经元损伤以及由于神经元紊乱并促进神经元生长,并且防止皮肤老化和脱发,以刺激 血管生成,早期胚胎中胚层诱导和肢体再生。 还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖,高血管疾病和上皮细胞增殖的治疗剂的用途。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。
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公开(公告)号:US20120122762A1
公开(公告)日:2012-05-17
申请号:US13359199
申请日:2012-01-26
申请人: Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人: Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号: A61K38/17 , C12N15/63 , C07K14/435 , C07K16/18 , G01N33/53 , C12Q1/68 , C12P21/00 , G01N33/68 , C12N15/85 , C12N15/70 , C12N1/21 , C12N5/10 , A61P7/00 , A61P35/00 , A61P13/12 , A61P9/00 , A61P11/00 , A61P17/02 , A61P25/00 , A61P5/00 , A61P15/00 , A61P31/00 , A61P1/00 , C12N15/12
CPC分类号: C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20090011983A1
公开(公告)日:2009-01-08
申请号:US11745580
申请日:2007-05-08
申请人: Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人: Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号: A61K38/00 , C12N15/11 , C12N15/00 , C12N15/63 , C12N5/06 , C12Q1/00 , A61P43/00 , G01N33/566 , C12Q1/68 , C07K14/00 , C07K16/18 , C12P21/04
CPC分类号: C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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