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    DENTAL COMPOSITION
    1.
    发明申请
    DENTAL COMPOSITION 审中-公开
    牙科成分

    公开(公告)号：US20120149801A1

    公开(公告)日：2012-06-14

    申请号：US13388393

    申请日：2010-03-09

    申请人： Joachim E. Klee ,  Stefan Brugger ,  Helmut Ritter ,  Christoph Weber ,  Oliver Elsner ,  Mareike Bardts ,  Andreas Facher ,  Sven Pohle

    发明人： Joachim E. Klee ,  Stefan Brugger ,  Helmut Ritter ,  Christoph Weber ,  Oliver Elsner ,  Mareike Bardts ,  Andreas Facher ,  Sven Pohle

    IPC分类号： A61K6/083 ,  B82Y5/00

    CPC分类号： A61K6/0835 ,  A61K6/0023 ,  A61K6/0038 ,  C08L33/00

    摘要： An aqueous dental glass ionomer composition comprising (a) a reactive particulate glass, and (b) a linear or branched polymer comprising acidic groups, which is reactive with the particulate glass in a cement reaction, whereby the linear or branched polymer comprising acidic groups has a polymer backbone and optionally pendant side chains, (c) optionally dispersed nanoparticles, and (d) optionally a low molecular compound, characterized in that the glass ionomer composition comprises —SxH groups, wherein x is an integer of from 1 to 6, which crosslink the particulate glass and/or the linear polycarboxylic acid and/or the optional dispersed nanoparticles and/or the optional low molecular compound.

    摘要翻译： 一种水性牙科玻璃离聚物组合物，其包含（a）反应性颗粒玻璃，和（b）包含酸性基团的直链或支链聚合物，其在水泥反应中与颗粒状玻璃反应，由此包含酸性基团的直链或支链聚合物具有 聚合物主链和任选的侧链，（c）任选分散的纳米颗粒，和（d）任选的低分子化合物，其特征在于玻璃离聚物组合物包含-SxH基团，其中x是1至6的整数，其中 交联颗粒状玻璃和/或线性多元羧酸和/或任选的分散纳米颗粒和/或任选的低分子化合物。

    Dental cement composition
    3.
    发明授权
    Dental cement composition 有权

    公开(公告)号：US10117810B2

    公开(公告)日：2018-11-06

    申请号：US13979806

    申请日：2011-10-18

    申请人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    发明人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    IPC分类号： A61K6/083 ,  A61K6/00 ,  A61K6/09 ,  C07C233/09 ,  C07C233/20 ,  C08F122/38

    摘要： Dental cement composition comprising (i) a particulate filler reactive with a polyacid in a cement reaction; (ii) a water-soluble polymerizable compound of the following formula (1), AXn (1) wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic groups, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, which X may be the same or different and are represented by the following formula (2) wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group —(CH2)m—Z, wherein Z is COOM, OPO3M2, PO3M2, SO3M, and M is independently a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond or a C1-6 alkylene group; and n is an integer of at least 1; provided that at least one X cannot be a (meth)acryl group; and (iii) an initiator system; optionally a polyacidic polymer having polymerizable double bonds; and optionally water.

    Dental composition
    4.
    发明授权
    Dental composition 有权

    公开(公告)号：US09603780B2

    公开(公告)日：2017-03-28

    申请号：US13979811

    申请日：2011-10-18

    申请人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    发明人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    IPC分类号： B29C47/92 ,  A61K6/083 ,  A61K6/00 ,  A61K6/02 ,  C07C233/31 ,  C08F290/06 ,  C07C233/20

    CPC分类号： A61K6/083 ,  A61K6/0023 ,  A61K6/0835 ,  C07C233/20 ,  C08L33/00

    摘要： Dental composition comprising a water-soluble polymerizable compound of the following formula (1): wherein A is a linear or branched linker group represented by the following formula (3), wherein the nitrogen atom of at least two of the termini forms an amide bond with an X moiety; wherein R′ represents a hydrogen atom or a substituted or unsubstituted aliphatic or cycloaliphatic hydrocarbon group, wherein each R may be the same or different L1, L2, and L3 which may be the same or different, independently represent a single bond, or a C2-20 straight-chain, branched or cyclic hydrocarbon group optionally containing from 1 to 6 heteroatoms selected from nitrogen and oxygen in the backbone of the hydrocarbon group, and optionally from 1 to 6 functional groups selected from carboxylic acid groups or a salt thereof, hydroxyl groups, thiol groups and amino groups, and in case a plurality of L1 and L2 are present, each of L1 and L2 may be the same or different; Q1 and Q2, which may be the same or different, independently represent a single bond or a linkage selected from an amide, a urethane, a urea and a thiourea linkage; k is an integer of at least 0, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, wherein each X may be the same or different and are represented by the following formula (2): wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group —(CH2)m—COOM, wherein M represents a hydrogen atom or a metal atom, m is an integer of from 0 to 6, L is a bond or a C1-6 alkylene group; and n is an integer of at least 2; (ii) an initiator system; optionally a polyacidic polymer; optionally water and/or a water soluble solvent; and optionally a particulate filler.

    DENTAL COMPOSITION
    6.
    发明申请
    DENTAL COMPOSITION 审中-公开
    牙科成分

    公开(公告)号：US20140039088A1

    公开(公告)日：2014-02-06

    申请号：US13979815

    申请日：2011-10-18

    申请人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    发明人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    IPC分类号： A61K6/087 ,  A61K6/083

    CPC分类号： A61K6/0091 ,  A61K6/0023 ,  A61K6/08 ,  A61K6/083 ,  A61K6/0835 ,  A61K6/087 ,  A61K6/09 ,  C07C231/02 ,  C08L33/00 ,  C08L75/16 ,  C08L33/10 ,  C07C233/38

    摘要： Dental composition comprising (i) a particulate filler; (ii) a polymerizable hydrolysis-stable compound of the following formula (1) AXn wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic groups, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, which X may be the same or different and are represented by the following formula (2) wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group —(CH2)m—Z, wherein Z is COOM, OPO3M2, PO3M2, SO3M, and M is independently a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond, a C1-6 alkylene group; and n is an integer of at least 1; provided that at least one X cannot be a (meth)acryl group; and (iii) an initiator system.

    摘要翻译： 牙科组合物，其包含（i）颗粒填料; （ii）下式（1）的可聚合水解稳定化合物AXn其中A是至少含有n个氮原子和任选一个或多个酸性基团的连接基团，X是含有可聚合双键并形成酰胺键的部分 与A的氮原子一起，X可以相同或不同，并由下式（2）表示，其中R 1和R 2彼此独立地表示氢原子，C 1-6烷基或基团 - （CH 2）m Z，其中Z为COOM，OPO3M2，PO3M2，SO3M和M独立地为氢原子或金属原子，m为0-6的整数，L为键，C1-6亚烷基 ; n为1以上的整数。 条件是至少一个X不能是（甲基）丙烯酰基; 和（iii）引发剂体系。

    DENTAL COMPOSITION
    7.
    发明申请
    DENTAL COMPOSITION 有权
    牙科成分

    公开(公告)号：US20140039087A1

    公开(公告)日：2014-02-06

    申请号：US13979811

    申请日：2011-10-18

    申请人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    发明人： Simon Stelzig ,  Joachim E. Klee ,  Andreas Facher ,  Christoph Weber

    IPC分类号： A61K6/083

    CPC分类号： A61K6/083 ,  A61K6/0023 ,  A61K6/0835 ,  C07C233/20 ,  C08L33/00

    摘要： Dental composition comprising a water-soluble polymerizable compound of the following formula (1): wherein A is a linear or branched linker group represented by the following formula (3), wherein the nitrogen atom of at least two of the termini forms an amide bond with an X moiety; wherein R′ represents a hydrogen atom or a substituted or unsubstituted aliphatic or cycloaliphatic hydrocarbon group, wherein each R may be the same or different L1, L2, and L3 which may be the same or different, independently represent a single bond, or a C2-20 straight-chain, branched or cyclic hydrocarbon group optionally containing from 1 to 6 heteroatoms selected from nitrogen and oxygen in the backbone of the hydrocarbon group, and optionally from 1 to 6 functional groups selected from carboxylic acid groups or a salt thereof, hydroxyl groups, thiol groups and amino groups, and in case a plurality of L1 and L2 are present, each of L1 and L2 may be the same or different; Q1 and Q2, which may be the same or different, independently represent a single bond or a linkage selected from an amide, a urethane, a urea and a thiourea linkage; k is an integer of at least 0, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, wherein each X may be the same or different and are represented by the following formula (2): wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group —(CH2)m—COOM, wherein M represents a hydrogen atom or a metal atom, m is an integer of from 0 to 6, L is a bond or a C1-6 alkylene group; and n is an integer of at least 2; (ii) an initiator system; optionally a polyacidic polymer; optionally water and/or a water soluble solvent; and optionally a particulate filler.

    摘要翻译： 1.一种牙科用组合物，其含有下述式（1）所示的水溶性聚合性化合物：式中，A为下述通式（3）所示的直链或支链连接基团，其中，所述末端中的至少2个的氮原子形成酰胺键 与X部分; 其中R'表示氢原子或取代或未取代的脂族或脂环族烃基，其中每个R可以相同或不同，可以相同或不同的L1，L2和L3独立地表示单键，或C2 -20个直链，支链或环状烃基，任选地含有1至6个选自氮原子和氧的杂原子在烃基的主链中，以及任选地1-6个选自羧酸基团或其盐的官能团，羟基 基团，硫醇基和氨基，并且在存在多个L1和L2的情况下，L1和L2中的每一个可以相同或不同; Q1和Q2可以相同或不同，独立地表示单键或选自酰胺，氨基甲酸酯，脲和硫脲键的键; k是至少为0的整数，X是含有可聚合双键并与A的氮原子形成酰胺键的部分，其中每个X可以相同或不同，并由下式（2）表示：其中 R 1和R 2彼此独立地表示氢原子，C 1-6烷基或基团 - （CH 2）m -COOM，其中M表示氢原子或金属原子，m表示0〜 6，L是键或C1-6亚烷基; 且n为至少2的整数; （ii）引发剂体系; 任选的多酸聚合物; 任选的水和/或水溶性溶剂; 和任选的颗粒填料。

    Process for the preparation of a polymerizable dental composition
    9.
    发明申请
    Process for the preparation of a polymerizable dental composition 审中-公开
    制备可聚合牙科组合物的方法

    公开(公告)号：US20080237907A1

    公开(公告)日：2008-10-02

    申请号：US12156794

    申请日：2008-06-04

    申请人： Joachim E. Klee ,  Uwe Walz ,  Andreas Facher ,  Christoph Weber ,  Rolf Mulhaupt ,  Holger Frey ,  Ekkehard Muh

    发明人： Joachim E. Klee ,  Uwe Walz ,  Andreas Facher ,  Christoph Weber ,  Rolf Mulhaupt ,  Holger Frey ,  Ekkehard Muh

    IPC分类号： A61C13/20

    CPC分类号： A61K6/083 ,  A61K6/093 ,  C08L33/00 ,  C08L83/10

    摘要： A process for the preparation of a polymerizable dental composition comprising the steps of (a) preparing a liquid mixture comprising (i) 1 to 99% w/w of a hybrid monomer component containing at least one hybrid monomer compound having one hydrolysable siloxane group and at least one polymerizable organic moiety, and (ii) 99 to 1% w/w of a monomer component polymerizable with the polymerizable organic moiety of the hybrid monomer compounds; and (b) adding at least a stoichiometrically sufficient amount of water to the mixture to hydrolyse the hydrolysable siloxane group of the hybrid monomer compound and to form spherical polymerizable nanoparticles having an average particle size of from 1 to 100 nm dispersed in the monomer component, whereby the nanoparticles have a structure with Si—O—Si bonds and peripherally exposed polymerizable organic moieties.

    摘要翻译： 一种制备可聚合牙科用组合物的方法，包括以下步骤：（a）制备液体混合物，其包含（i）1至99％w / w的含有至少一种具有一个可水解硅氧烷基团的杂化单体化合物的杂化单体组分和 至少一个可聚合的有机部分，和（ii）99-1％w / w的可与所述杂化单体化合物的可聚合有机部分聚合的单体组分; 和（b）向所述混合物中加入至少一种化学计量的足够量的水以水解所述杂化单体化合物的可水解硅氧烷基团并形成分散在单体组分中的平均粒度为1至100nm的球形可聚合纳米颗粒， 由此纳米颗粒具有具有Si-O-Si键和外围暴露的可聚合有机部分的结构。

    Dental cement composition containing composite particles with grafted polyacidic polymer chains
    10.
    发明申请
    Dental cement composition containing composite particles with grafted polyacidic polymer chains 审中-公开
    含有接枝多酸聚合物链的复合颗粒的牙科水泥组合物

    公开(公告)号：US20090030110A1

    公开(公告)日：2009-01-29

    申请号：US12284275

    申请日：2008-09-19

    申请人： Joachim E. Klee ,  Stefan Brugger ,  Christoph Weber ,  Axel H. E. Muller ,  Hideharu Mori

    发明人： Joachim E. Klee ,  Stefan Brugger ,  Christoph Weber ,  Axel H. E. Muller ,  Hideharu Mori

    IPC分类号： A61K6/08

    CPC分类号： A61K6/0835 ,  C08L33/00 ,  C08L25/04

    摘要： A dental cement composition comprising (i) a particulate reactive inorganic filler capable of leaching metal ions in the presence of an acid, and (ii) composite particles with grafted polyacidic polymer chains, which are obtainable by a process comprising the following steps: (a) polymerizing one or more free radically polymerizable monomers containing optionally protected acidic groups in the presence of (a1) an initiatior system comprising initiator particles displaying a moiety comprising a radically transferable atom or group as a polymerization initiation site; and (a2) a catalyst facilitating controlledliving polymerisation, and (a3) optionally further polymerizable monomers, for forming a composite particle with grafted optionally protected polyacidic polymer chains; and (b) optionally deprotecting protected acidic groups, for forming composite particles with grafted polyacidic polymer chains.

    摘要翻译： 一种牙科水泥组合物，其包含（i）能够在酸存在下浸出金属离子的颗粒状反应性无机填料，和（ii）具有接枝多酸聚合物链的复合颗粒，其可通过包括以下步骤的方法获得：（a ）在（a1）包含引发颗粒的引发剂体系的存在下聚合含有任选保护的酸性基团的一种或多种可自由基聚合的单体，所述引发剂颗粒显示包含可自由基转移的原子或基团的部分作为聚合引发位点; 和（a2）促进受控聚合的催化剂，和（a3）任选的其它可聚合单体，用于形成具有接枝的任选保护的多酸聚合物链的复合颗粒; 和（b）任选地去保护受保护的酸性基团，以形成具有接枝的多酸聚合物链的复合颗粒。