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公开(公告)号:US20090311250A1
公开(公告)日:2009-12-17
申请号:US12300156
申请日:2007-05-11
申请人: John Chant , Anthony S. Guerrero , Peter Haverty , Cynthia Honchell , Kenneth Jung , Thomas Wu
发明人: John Chant , Anthony S. Guerrero , Peter Haverty , Cynthia Honchell , Kenneth Jung , Thomas Wu
IPC分类号: A61K39/395 , C12Q1/68 , A61K38/02 , A61K31/7088
CPC分类号: C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要: Methods and compositions are provided for the diagnosis and treatment of colorectal cancers associated with amplification or overexpression of the FGFR2 gene.
摘要翻译: 提供了用于诊断和治疗与FGFR2基因的扩增或过表达相关的结肠直肠癌的方法和组合物。
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2.
公开(公告)号:US08945572B2
公开(公告)日:2015-02-03
申请号:US12300156
申请日:2007-05-11
申请人: John Chant , Anthony S. Guerrero , Peter Haverty , Cynthia Honchell , Kenneth Jung , Thomas Wu
发明人: John Chant , Anthony S. Guerrero , Peter Haverty , Cynthia Honchell , Kenneth Jung , Thomas Wu
CPC分类号: C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要: Methods and compositions are provided for the diagnosis and treatment of colorectal cancers associated with amplification or overexpression of the FGFR2 gene.
摘要翻译: 提供了用于诊断和治疗与FGFR2基因的扩增或过表达相关的结肠直肠癌的方法和组合物。
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3.
公开(公告)号:US20100028365A1
公开(公告)日:2010-02-04
申请号:US12373869
申请日:2007-07-18
申请人: John Chant , Anthony S. Guerrero , Peter Haverty , Cynthia Honchell , Kenneth Jung , Thomas Wu
发明人: John Chant , Anthony S. Guerrero , Peter Haverty , Cynthia Honchell , Kenneth Jung , Thomas Wu
IPC分类号: A61K39/395 , C12Q1/68 , C12N5/07 , A61K31/7088 , A61P35/00
CPC分类号: C12Q1/6886 , C12Q2600/106 , C12Q2600/112
摘要: Methods and compositions are provided for the diagnosis and treatment of gastric cancers associated with amplification or overexpression of the c-Myb gene.
摘要翻译: 提供了用于诊断和治疗与c-Myb基因的扩增或过表达相关的胃癌的方法和组合物。
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4.
公开(公告)号:US20100008910A1
公开(公告)日:2010-01-14
申请号:US12440501
申请日:2007-09-10
申请人: John Chant , Anthony S. Guerrero , Peter Haverty , Cynthia Honchell , Kenneth Jung , Thomas Wu
发明人: John Chant , Anthony S. Guerrero , Peter Haverty , Cynthia Honchell , Kenneth Jung , Thomas Wu
IPC分类号: A61K39/395 , C12Q1/68 , A61K38/02 , A61K31/7088
CPC分类号: C07K16/30 , A61K38/177 , A61K47/6849 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C12N15/1135 , C12N2310/11 , C12Q1/6886 , C12Q2600/106
摘要: Methods and compositions are provided for the diagnosis and treatment of lung cancers in particular NSCLC associated with amplification or overexpression of the PRO gene, i.e. any of PDGFRA, KIT or KDR.
摘要翻译: 提供了用于诊断和治疗肺癌特别是与PRO基因(即PDGFRA,KIT或KDR中的任一种)的扩增或过表达有关的NSCLC的诊断和治疗。
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5.
公开(公告)号:US20060216706A1
公开(公告)日:2006-09-28
申请号:US10484603
申请日:2002-07-16
申请人: Y Tang , Vicki Elliott , Mariah Baughn , Henry Yue , Aaron Klammer , April Hafalia , Elizabeth Stewart , Cynthia Honchell , Ann Gorvard , Ian Forsythe , Li Ding , Uyen Tran , Jennifer Griffin , Yeganeh Zebarjadian , Anna Chinn , Anne Curtis , Mark Borowsky , Anita Swarnakar , Neil Burford , Wen Luo , Ernestine Lee , Brooke Emerling , Soo Lee , Junming Yang , Farrah Khan , Jayalaxmi Ramkumar , Yan Lu , Narinder Chawla , Brendan Duggan , Kimberly Gietzen , Karen Jones
发明人: Y Tang , Vicki Elliott , Mariah Baughn , Henry Yue , Aaron Klammer , April Hafalia , Elizabeth Stewart , Cynthia Honchell , Ann Gorvard , Ian Forsythe , Li Ding , Uyen Tran , Jennifer Griffin , Yeganeh Zebarjadian , Anna Chinn , Anne Curtis , Mark Borowsky , Anita Swarnakar , Neil Burford , Wen Luo , Ernestine Lee , Brooke Emerling , Soo Lee , Junming Yang , Farrah Khan , Jayalaxmi Ramkumar , Yan Lu , Narinder Chawla , Brendan Duggan , Kimberly Gietzen , Karen Jones
IPC分类号: C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号: C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , G01N33/574 , G01N2510/00
摘要: Various embodiments of the invention provide human proteins associated with cell growth, differentiation, and death (CGDD) and polynucleotides which identify and encode CGDD. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CGDD.
摘要翻译: 本发明的各种实施方案提供与细胞生长,分化和死亡(CGDD)相关的人类蛋白质和鉴定和编码CGDD的多核苷酸。 本发明的实施方案还提供表达载体,宿主细胞,抗体,激动剂和拮抗剂。 其他实施方案提供用于诊断,治疗或预防与CGDD异常表达相关的紊乱的方法。
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公开(公告)号:US20050176927A1
公开(公告)日:2005-08-11
申请号:US10450186
申请日:2001-12-12
申请人: Jennifer Griffin , Monique Yao , Brendan Duggan , Henry Yue , Li Ding , Preeti Lal , Ernestine Lee , Jayalaxmi Ramkumar , Kavitha Thangavelu , Yuming Xu , Sally Lee , Y. Tang , Danniel Nguyen , Bridget Warren , Cynthia Honchell , Kimberly Gietzen , Mariah Baughn , Ameena Gandhi , Chandra Arvizu , Narinder Chawla , Yan Lu , Vicki Elliott , Dyung Lu , April J A Hafalia , Yalda Azimzai , Farrah Khan , Uyen Tran
发明人: Jennifer Griffin , Monique Yao , Brendan Duggan , Henry Yue , Li Ding , Preeti Lal , Ernestine Lee , Jayalaxmi Ramkumar , Kavitha Thangavelu , Yuming Xu , Sally Lee , Y. Tang , Danniel Nguyen , Bridget Warren , Cynthia Honchell , Kimberly Gietzen , Mariah Baughn , Ameena Gandhi , Chandra Arvizu , Narinder Chawla , Yan Lu , Vicki Elliott , Dyung Lu , April J A Hafalia , Yalda Azimzai , Farrah Khan , Uyen Tran
IPC分类号: G01N33/50 , A61K38/00 , A61K45/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/14 , A61P5/38 , A61P7/00 , A61P7/02 , A61P7/06 , A61P7/08 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/16 , A61P19/00 , A61P19/02 , A61P19/04 , A61P19/06 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/12 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/08 , A61P39/00 , A61P41/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号: C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K2317/24
摘要: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
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公开(公告)号:US20050176944A1
公开(公告)日:2005-08-11
申请号:US10487092
申请日:2002-08-16
申请人: Henry Yue , Dyung Lu , Anita Swarnakar , Y. Tang , Jennifer Griffin , Brooke Emerling , Ian Forsythe , Monique Yao , Jayalaxmi Ramkumar , Thomas Richardson , Shanya Becha , Ernestine Lee , Bridget Warren , Patricia Lehr-Mason , Mariah Baughn , Joana Li , Brendan Duggan , Kimberly Gietzen , Preeti Lal , Mark Borowsky , Craig Ison , Kavitha Thangavelu , Yuming Xu , Sally Lee , Vicki Elliott , William Sprague , Yalda Azimzai , April Hafalia , Li Ding , Danniel Nguyen , Cynthia Honchell , Wen Luo , Narinder Chawla , Joseph Marquis , Jennifer Jackson , Uyen Tran
发明人: Henry Yue , Dyung Lu , Anita Swarnakar , Y. Tang , Jennifer Griffin , Brooke Emerling , Ian Forsythe , Monique Yao , Jayalaxmi Ramkumar , Thomas Richardson , Shanya Becha , Ernestine Lee , Bridget Warren , Patricia Lehr-Mason , Mariah Baughn , Joana Li , Brendan Duggan , Kimberly Gietzen , Preeti Lal , Mark Borowsky , Craig Ison , Kavitha Thangavelu , Yuming Xu , Sally Lee , Vicki Elliott , William Sprague , Yalda Azimzai , April Hafalia , Li Ding , Danniel Nguyen , Cynthia Honchell , Wen Luo , Narinder Chawla , Joseph Marquis , Jennifer Jackson , Uyen Tran
IPC分类号: G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61K49/00 , A61P1/00 , A61P5/00 , A61P5/14 , A61P15/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07H21/04 , C07K1/22 , C07K14/47 , C07K16/18 , C07K16/46 , C12M1/00 , C12M1/34 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/02 , C12N9/12 , C12N9/14 , C12N9/16 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/32 , C12Q1/34 , C12Q1/42 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N37/00
CPC分类号: C07K14/4702 , A61K38/00 , C07K14/47 , G01N2500/04
摘要: Various embodiments of the invention provide human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of INTSIG.
摘要翻译: 本发明的各种实施方案提供了识别和编码INTSIG的人细胞内信号分子(INTSIG)和多核苷酸。 本发明的实施方案还提供表达载体,宿主细胞,抗体,激动剂和拮抗剂。 其他实施方案提供用于诊断,治疗或预防与INTSIG的异常表达相关的紊乱的方法。
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公开(公告)号:US20050064543A1
公开(公告)日:2005-03-24
申请号:US10487078
申请日:2002-08-15
申请人: Y. Tang , Bridget Warren , Kimberly Gietzen , Preeti Lal , Henry Yue , Cynthia Honchell , Patricia Lehr-Mason , Neil Burford , Yuming Xu , Mariah Baughn , Brendan Duggan , Uyen Tran , Ernestine Lee , Ian Forsythe , Thomas Richardson , Sally Lee , Kavitha Thangavelu , Huibin Yue , Brooke Emerling , Narinder Chawla , Yalda Azimzai , Bharati Sanjanwala , April Hafalia , Mark Borowsky , Danniel Nguyen , Craig Ison , Anna Astromoff , Li Ding , Soo Yeun Lee , Shanya Becha , Jayalaxmi Ramkumar , Ameena Gandhi , Pei Jin , Glenn Fu , Anita Swarnakar
发明人: Y. Tang , Bridget Warren , Kimberly Gietzen , Preeti Lal , Henry Yue , Cynthia Honchell , Patricia Lehr-Mason , Neil Burford , Yuming Xu , Mariah Baughn , Brendan Duggan , Uyen Tran , Ernestine Lee , Ian Forsythe , Thomas Richardson , Sally Lee , Kavitha Thangavelu , Huibin Yue , Brooke Emerling , Narinder Chawla , Yalda Azimzai , Bharati Sanjanwala , April Hafalia , Mark Borowsky , Danniel Nguyen , Craig Ison , Anna Astromoff , Li Ding , Soo Yeun Lee , Shanya Becha , Jayalaxmi Ramkumar , Ameena Gandhi , Pei Jin , Glenn Fu , Anita Swarnakar
IPC分类号: G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61P9/00 , A61P25/00 , A61P29/00 , A61P37/06 , A61P43/00 , C07K1/22 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/46 , C07K19/00 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N9/16 , C12N9/64 , C12N15/02 , C12N15/09 , C12N15/11 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N37/00 , C07H21/04 , C12N9/00
CPC分类号: C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C12N9/1205 , C12N9/16 , C12N9/6421
摘要: Various embodiments of the invention provide human secreted proteins(SECP) and polynucleotides which identify and encode SECP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
摘要翻译: 本发明的各种实施方案提供鉴定和编码SECP的人分泌蛋白(SECP)和多核苷酸。 本发明的实施方案还提供表达载体,宿主细胞,抗体,激动剂和拮抗剂。 其它实施方案提供用于诊断,治疗或预防与SECP异常表达相关的疾病的方法。
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公开(公告)号:US20050123912A1
公开(公告)日:2005-06-09
申请号:US10486977
申请日:2002-08-14
申请人: Ines Barroso , Mariah Baughn , Shanya Becha , Julie Blake , Mark Borowsky , Neil Burford , Brendan Duggan , Vicki Elliott , Brooke Emerling , Ian Forsythe , Kimberly Gietzen , Ann Gorvad , Jennifer Griffin , April Hafalia , Cynthia Honchell , Craig Ison , Farrah Khan , Preeti Lal , Ernestine Lee , Sally Lee , Soo Lee , Joana Li , Dyung Lu , Yan Lu , Patricia Lehr-Mason , Danniel Nguyen , Jayalaxmi Ramkumar , William Sprague , Y Tang , Kavitha Thangavelu , Michael Thornton , Uyen Tran , Narinder Chawla , Bridget Warren , Yuming Xu , Monique Yao , Henry Yue , Huibin Yue , Yeganeh Zebarjadian
发明人: Ines Barroso , Mariah Baughn , Shanya Becha , Julie Blake , Mark Borowsky , Neil Burford , Brendan Duggan , Vicki Elliott , Brooke Emerling , Ian Forsythe , Kimberly Gietzen , Ann Gorvad , Jennifer Griffin , April Hafalia , Cynthia Honchell , Craig Ison , Farrah Khan , Preeti Lal , Ernestine Lee , Sally Lee , Soo Lee , Joana Li , Dyung Lu , Yan Lu , Patricia Lehr-Mason , Danniel Nguyen , Jayalaxmi Ramkumar , William Sprague , Y Tang , Kavitha Thangavelu , Michael Thornton , Uyen Tran , Narinder Chawla , Bridget Warren , Yuming Xu , Monique Yao , Henry Yue , Huibin Yue , Yeganeh Zebarjadian
IPC分类号: G01N33/50 , A61K38/00 , A61K45/00 , A61K49/00 , A61P1/00 , A61P1/16 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K14/47 , C07K16/18 , C12M1/00 , C12M1/34 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N37/00 , C07H21/04 , C12N9/22
CPC分类号: C07K14/4702 , A61K38/00 , G01N2500/00
摘要: Various embodiments of the invention provide human nucleic acid-associated proteins (NAAP) and polynucleotides which identify and encode NAAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NAAP.
摘要翻译: 本发明的各种实施方案提供了识别和编码NAAP的人核酸相关蛋白(NAAP)和多核苷酸。 本发明的实施方案还提供表达载体,宿主细胞,抗体,激动剂和拮抗剂。 其他实施方案提供用于诊断,治疗或预防与NAAP异常表达相关的紊乱的方法。
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公开(公告)号:US20050033018A1
公开(公告)日:2005-02-10
申请号:US10477714
申请日:2002-05-16
申请人: Preeti Lal , Bridget Warren , Yuming Xu , Brendan Duggan , Cynthia Honchell , Deborah Kallick , Mariah Baughn , Y. Tang , Henry Yue , Olga Bandman , Karen Jones , Shanya Becha , Uyen Tran , Janice Au-Young , Jennifer Griffin , Yeganeh Zebarjadian , Ernestie Lee , Vicki Elliott , Kavitha Thangavelu , Jayalaxmi Ramkumar , Yan Lu , April Hafalia , Narinder Chawla , Craig Ison , Michael Thornton , Anita Swarnakar , Junming Yang , Thomas Richardson , Brooke Emerling , Monique Yao , Benjamin Cocks , Bharati Sanjanwala , Patricia Mason , Ameena Gandhi , Joana Li , Rajagopal Gururajan , Kimberly Gietzen , Ian Forsythe
发明人: Preeti Lal , Bridget Warren , Yuming Xu , Brendan Duggan , Cynthia Honchell , Deborah Kallick , Mariah Baughn , Y. Tang , Henry Yue , Olga Bandman , Karen Jones , Shanya Becha , Uyen Tran , Janice Au-Young , Jennifer Griffin , Yeganeh Zebarjadian , Ernestie Lee , Vicki Elliott , Kavitha Thangavelu , Jayalaxmi Ramkumar , Yan Lu , April Hafalia , Narinder Chawla , Craig Ison , Michael Thornton , Anita Swarnakar , Junming Yang , Thomas Richardson , Brooke Emerling , Monique Yao , Benjamin Cocks , Bharati Sanjanwala , Patricia Mason , Ameena Gandhi , Joana Li , Rajagopal Gururajan , Kimberly Gietzen , Ian Forsythe
IPC分类号: G01N33/50 , A61K45/00 , A61K49/00 , A61P1/00 , A61P3/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , C07K14/47 , C07K14/705 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04
CPC分类号: C07K14/705 , C07K14/47
摘要: The invention provides human receptors and membrane-associated proteins (REMAP) and polynucleotides which identify and encode REMAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of REMAP.
摘要翻译: 本发明提供鉴定和编码REMAP的人受体和膜相关蛋白(REMAP)和多核苷酸。 本发明还提供表达载体,宿主细胞,抗体,激动剂和拮抗剂。 本发明还提供用于诊断,治疗或预防与REMAP的异常表达相关的紊乱的方法。
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