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    Methods and apparatus for revision of obesity procedures
    1.
    发明申请
    Methods and apparatus for revision of obesity procedures 有权
    肥胖程序修订方法和手段

    公开(公告)号：US20070175488A1

    公开(公告)日：2007-08-02

    申请号：US11342288

    申请日：2006-01-27

    申请人： John Cox ,  Tracy Maahs ,  Richard Ewers ,  Eugene Chen ,  Cang Lam ,  Lee Swanstrom

    发明人： John Cox ,  Tracy Maahs ,  Richard Ewers ,  Eugene Chen ,  Cang Lam ,  Lee Swanstrom

    IPC分类号： A61B17/138

    CPC分类号： A61B17/1114 ,  A61B17/29 ,  A61B2017/00278 ,  A61B2017/00349 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/1103 ,  A61B2017/1125 ,  A61B2017/1142 ,  A61B2017/2905 ,  A61F5/0083 ,  A61F5/0086

    摘要： Methods and apparatus for the endoluminal revision of previously performed obesity procedures which have failed are described. One or more endoluminal instruments may be advanced per-orally into the previously formed failed pouch where a number of different procedures can be performed. One or more tissue folds can be formed and secured to reduce the size of the pouch, or the stoma connecting the pouch to the intestinal tract can be reduced in size using endoluminally deployed tissue anchors. These procedures can be performed entirely from within the pouch lumen or upon the exterior surface of the pouch via transgastric entry of the instruments into the peritoneal cavity of a patient. Alternatively, the interior tissue within the pouch can be injured or sclerosed to shrink the pouch lumen. In another alterative, a length of the Roux limb can be shortened endoluminally to create a malabsorptive region.

    摘要翻译： 描述了先前进行的失败的肥胖程序的腔内修复的方法和装置。 一个或多个腔内器械可以每次口服进入先前形成的失败的小袋，其中可以执行许多不同的程序。 可以形成和固定一个或多个组织折叠以减小小袋的尺寸，或者使用内腔部署的组织锚固件将小袋连接到肠道的造口减小。 这些程序可以完全从袋内腔或袋的外表面通过仪器经腹进入患者的腹膜腔进行。 或者，袋内的内部组织可以被损伤或硬化以收缩袋腔。 在另一个替代方案中，Roux肢体的长度可以被内在缩短以产生吸收不良的区域。

    Apparatus and methods for endoluminal advancement
    2.
    发明申请
    Apparatus and methods for endoluminal advancement 审中-公开
    用于腔内推进的装置和方法

    公开(公告)号：US20060287666A1

    公开(公告)日：2006-12-21

    申请号：US11154168

    申请日：2005-06-15

    申请人： Vahid Saadat ,  Eugene Chen ,  Tung Le ,  Tracy Maahs ,  Richard Ewers ,  John Cox ,  Chris Rothe

    发明人： Vahid Saadat ,  Eugene Chen ,  Tung Le ,  Tracy Maahs ,  Richard Ewers ,  John Cox ,  Chris Rothe

    IPC分类号： A61M29/00

    CPC分类号： A61M25/1011 ,  A61B2017/22068 ,  A61B2017/22069 ,  A61M2025/1015 ,  A61M2025/1052

    摘要： Apparatus and methods for endoluminal advancement are described herein. A shape-lockable tissue anchoring assembly generally has an elongate body, a handle assembly, and an anchoring assembly positioned at or proximal to a distal tip of the elongate body. A distal portion of the elongate body may optionally be steerable or curvable. The anchoring assembly may include various expandable or projecting anchoring features to contact and retain tissue relative to the elongate body such that pleated tissue is temporarily immobile relative to the elongate body. This anchoring can be actuated simultaneously with or independently from shape-locking of elongate body. The anchoring assembly can be actuated simultaneously with the shape-locking of the elongate body. Alternatively, the steerable distal portion of the elongate body can be angled against the pleated tissue to retain it while the endoscope is advanced relative to the pleated tissue.

    摘要翻译： 本文描述了腔内前进的装置和方法。 可锁定形状的组织锚固组件通常具有细长主体，手柄组件和定位在细长主体的远侧末端处或近侧的锚固组件。 细长主体的远端部分可以可选地是可操纵的或可调节的。 锚定组件可以包括各种可膨胀或突出的锚固特征，以相对于细长体接触和保持组织，使得褶皱组织相对于细长体临时固定不动。 这种锚固可以与细长体的形状锁定同时或独立地致动。 锚固组件可以与细长体的形状锁定同时致动。 或者，细长主体的可转向远端部分可以相对于打褶组织成角度，以在内窥镜相对于打褶组织前进时保持它。

    Methods and apparatus for maintaining sterility during transluminal procedures
    5.
    发明申请
    Methods and apparatus for maintaining sterility during transluminal procedures 审中-公开
    在宫腔手术过程中保持不育的方法和装置

    公开(公告)号：US20060258909A1

    公开(公告)日：2006-11-16

    申请号：US11400297

    申请日：2006-04-07

    申请人： Vahid Saadat ,  John Cox ,  Tracy Maahs

    发明人： Vahid Saadat ,  John Cox ,  Tracy Maahs

    IPC分类号： A61B1/00

    CPC分类号： A61B17/3431 ,  A61B1/00142 ,  A61B17/064 ,  A61B17/08 ,  A61B17/3496 ,  A61B46/10 ,  A61B46/17 ,  A61B90/40 ,  A61B2017/00278 ,  A61B2017/0419 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61B2017/3488

    摘要： Methods and apparatus for maintaining sterility during transluminal procedures are described. The sterility is achieved by making use of a membrane in either the form, e.g., of a sheath, cap or umbrella to keep the instruments (endoscopes, overtubes, etc.) sterile while being advanced through lumens in the body and into the various cavities. Methods, such as vacuum acquisition, mechanical tissue anchoring, etc., of the underlying tissue followed by incision of the tissue with, e.g., a needle knife, can be utilized to gain access to the various cavities. It is expected that this procedure will provide the desired level of sterility for transluminal procedures.

    摘要翻译： 描述了在腔内程序中维持不育的方法和装置。 通过使用例如护套，帽或伞的形式的膜来实现无菌性，以将器具（内窥镜，超声波管等）保持无菌，同时通过体内的腔进入各种空腔 。 可以使用诸如真空采集，机械组织锚定等方法，随后用例如针刀切割组织的下面的组织，以便进入各种空腔。 预期该程序将为腔内程序提供所需的无菌水平。

    METHODS AND APPARATUS FOR COLONIC CLEANING
    6.
    发明申请
    METHODS AND APPARATUS FOR COLONIC CLEANING 审中-公开
    方法和装置用于殖民地清洁

    公开(公告)号：US20070015965A1

    公开(公告)日：2007-01-18

    申请号：US11457053

    申请日：2006-07-12

    申请人： John Cox ,  Tracy Maahs

    发明人： John Cox ,  Tracy Maahs

    IPC分类号： A61B1/00

    CPC分类号： A61B1/31 ,  A61B1/00078 ,  A61B1/00082 ,  A61B1/00094 ,  A61B1/00154 ,  A61B1/0052 ,  A61B1/0055 ,  A61B1/0057

    摘要： Apparatus and methods are provided for cleaning a patient's colon in preparation for colonoscopy. A rigidizable overtube is described, as well as several variations of a colon-cleaning element configured for use with the overtube to clean the patient's colon. In one variation, the colon-cleaning element comprises a fluid jet. In another variation, the colon-cleaning element comprises a mechanical brush. Aspiration optionally may be provided for removing blockage material disrupted during colonic cleaning.

    摘要翻译： 提供了用于清洁患者结肠以准备结肠镜检查的装置和方法。 描述了可固化的外套管，以及构造成用于外套管以清洁患者结肠的结肠清洁元件的若干变体。 在一个变型中，结肠清洁元件包括流体射流。 在另一个实施例中，结肠清洁元件包括机械刷。 任选地可以提供吸气以去除在结肠清洁期间被破坏的堵塞物质。

    Helical tissue manipulation instruments and methods of use
    7.
    发明申请
    Helical tissue manipulation instruments and methods of use 审中-公开
    螺旋组织操作仪器和使用方法

    公开(公告)号：US20070142849A1

    公开(公告)日：2007-06-21

    申请号：US11303521

    申请日：2005-12-16

    申请人： Richard Ewers ,  Arvin Chang ,  John Cox

    发明人： Richard Ewers ,  Arvin Chang ,  John Cox

    IPC分类号： A61B17/08

    CPC分类号： A61B17/30 ,  A61B17/22031 ,  A61B17/29 ,  A61B2017/00349 ,  A61B2017/3488 ,  A61B2090/034 ,  A61B2090/062 ,  A61B2090/0811 ,  A61B2090/3614

    摘要： Helical tissue manipulation instruments and methods of their use are described herein. A helical tissue engager is adapted to reversibly engage tissue and is positioned upon a flexible shaft which is advanceable through a rigidizable endoscopic assembly. The flexible shaft defines a marked section proximal to the tissue engager which can include any number of markings, designs, patterns, projections, textures, etc., which acts to provide a visual indication to the user as to the translational movement, rotation, direction of rotation, etc., of the tissue engager and the shaft. An optional guidewire can be advanced through the tissue engager. Additionally, the tissue engager and shaft can be advanced through an optional tubular sheath which may be used for dilating tissue openings prior to passage of the helical engager through the tissue opening.

    摘要翻译： 本文描述了螺旋组织操作仪器及其使用方法。 螺旋组织接合器适于可逆地接合组织并且被定位在柔性轴上，柔性轴可前进通过可硬化的内窥镜组件。 柔性轴限定靠近组织接合器的标记部分，其可以包括任何数量的标记，设计，图案，投影，纹理等，其用于向使用者提供关于平移运动，旋转，方向 旋转等组织接合器和轴。 可选的导丝可以穿过组织夹持器。 此外，组织收集器和轴可以通过可选的管状护套前进，可选的管状护套可用于在螺旋装置通过组织开口之前扩张组织开口。

    Bathroom storage device
    8.
    发明授权
    Bathroom storage device 有权

    公开(公告)号：US10264928B1

    公开(公告)日：2019-04-23

    申请号：US15933029

    申请日：2018-03-22

    申请人： John Cox

    发明人： John Cox

    IPC分类号： A47K10/22 ,  B65D25/10 ,  E03C1/308

    摘要： A bathroom storage device for convenient concealed storage of a toilet plunger and visible storage of multiple vertically stacked rolls of toilet paper. The cup of the toilet plunger is concealed within a base unit having an open top from which the handle of the toilet plunger protrudes. A top member with a hollow vertical spindle is placed over the open top, thereby concealing the cup and handle of the toilet plunger within the base unit and hollow vertical spindle, respectively. Spaced vertical members about the periphery of the top member partially conceal the vertically stacked rolls of toilet paper while still enabling visual ascertainment of their number. The hollow vertical spindle may serve as a handle by which the top member and stacked rolls of toilet paper can be removed to gain access to the toilet plunger.

    Therapeutic antibody purification method and method of use
    9.
    发明授权
    Therapeutic antibody purification method and method of use 有权
    治疗性抗体纯化方法及使用方法

    公开(公告)号：US08466265B2

    公开(公告)日：2013-06-18

    申请号：US12681050

    申请日：2008-10-02

    申请人： John Cox

    发明人： John Cox

    IPC分类号： C07K1/16 ,  C07K1/30 ,  C07K1/34

    CPC分类号： C07K16/18 ,  C07K2317/10 ,  C07K2317/21

    摘要： A method of preparing anti-b amyloid immunoglobulin involves treating human plasma anti-b amyloid immunoglobulin under alkaline conditions, such as at pH 10.25 to 11.75 using diethylamine HCl, to dissociate b amyloid protein therefrom. Typically, the anti-b amyloid immunoglobulin is present in human immunoglobulin preparations obtained from plasma or serum. Anti-b amyloid immunoglobulin prepared by the method is substantially free of b amyloid protein and has therapeutic activity in compositions and/or methods for treating a disease or condition associated with b amyloid plaques, such as Alzheimer's disease.

    摘要翻译： 制备抗-B淀粉样蛋白免疫球蛋白的方法包括在碱性条件下，例如使用二乙胺HCl在pH10.25至11.75处理人血浆抗-B淀粉样蛋白免疫球蛋白，从而从其中解离淀粉样蛋白。 通常，抗-B淀粉样蛋白免疫球蛋白存在于从血浆或血清获得的人免疫球蛋白制剂中。 通过该方法制备的抗-B淀粉样蛋白免疫球蛋白基本上不含β-淀粉样蛋白，并且在用于治疗与淀粉样斑块（例如阿尔茨海默氏病）相关的疾病或病症的组合物和/或方法中具有治疗活性。

    VACCINE COMPOSITIONS
    10.
    发明申请
    VACCINE COMPOSITIONS 审中-公开
    疫苗组合物

    公开(公告)号：US20100047271A1

    公开(公告)日：2010-02-25

    申请号：US12612992

    申请日：2009-11-05

    申请人： Debbi Drane ,  John Cox ,  Michael Houghton ,  Xavier Pallard

    发明人： Debbi Drane ,  John Cox ,  Michael Houghton ,  Xavier Pallard

    IPC分类号： A61K39/29 ,  A61P31/12

    CPC分类号： A61K39/29 ,  A61K39/12 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/57 ,  C12N2770/24234

    摘要： The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen, wherein the charged antigen is a polyprotein of Hepatitis C Virus (HCV), particularly the core protein of HCV, or a fragment thereof, or a fusion protein comprising the polyprotein or a fragment thereof. The complexes of the present invention are useful, inter alia, in vaccine compositions as therapeutic and/or prophylactic agents for facilitating the induction of immune responses, and in particular a cytotoxic T-lymphocyte response, in the treatment of a disease condition which results from an HCV infection.

    摘要翻译： 本发明一般涉及包含带电荷的有机载体和带​​电荷的抗原的免疫原性复合物，更具体地，涉及带负电荷的有机载体和带​​正电荷的抗原，其中带电的抗原是丙型肝炎病毒（HCV）的多蛋白，特别是 HCV的核心蛋白或其片段，或包含该多聚蛋白或其片段的融合蛋白。 本发明的复合物尤其可用于疫苗组合物中，作为促进免疫应答诱导的治疗和/或预防剂，特别是细胞毒性T淋巴细胞应答，用于治疗由 HCV感染。